1326150494000

Small Animal Imaging

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Worcester, Massachusetts, US

About Small Animal Imaging

The Small Animal Imaging Core provides SPECT, PET, CT and Optical imaging to track radiolabeled and/or fluorescent tagged biomolecules (ligands, proteins, peptides, oligomers, nanoparticles, and cells) in mice, rats or rabbits. The Core also provides radioisotope and chemical modification of biomolecules for imaging applications or biodistribution investigations.

Our Services (19)


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Small Animal PET Scan

Small Animal Positron Emission Tomography Scan
Price on request

SPECT and PET Imaging of Small Animals

We provide the labeling of biomolecules (proteins, peptides, oligomers, nanoparticles, as well as cells) with SPECT radionuclides such as 123I, 125I, 111In, or 99mTc to follow their biodistribution by SPECT (NanoSPECT/CT, Bioscan) imaging in mice, rats or other small animals. Image... Show more »

SPECT and PET Imaging of Small Animals

We provide the labeling of biomolecules (proteins, peptides, oligomers, nanoparticles, as well as cells) with SPECT radionuclides such as 123I, 125I, 111In, or 99mTc to follow their biodistribution by SPECT (NanoSPECT/CT, Bioscan) imaging in mice, rats or other small animals. Image resolution is about 1 mm.
Biomolecules labeled with PET radionuclides such as 18F, 64Cu, 89Zr, 124I or 68Ga are acquired on the Mosaic PET (Philips) small animal camera. Resolution is about 2 mm.
The CT component of the NanoSPECT provides anatomical registration for SPECT and PET rodent images or is used alone for high resolution radiographs. Bore size is 10 cm.
Isotope selection is based on the biomolecules anticipated clearance, biological properties, isotope half-life, or client preference. Modification with isotope is by standard chemistries.
Animal models include tumor xenografts or orthotopic implants of various cancers. Also available are bacterial and fungal infection models.
Services include: labeling chemistry of biomolecules; animal models; design of image studies; image acquisition and analysis. Ideal for tracking cells/stem cells in vivo. Dual isotope imaging is also possible.
Pricing is per hour and varies with project.
Images are provided along with study analysis.

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Beckman Coulter Microcentrifuge Microfuge 18 Heraeus Biofuge Fresco Centrifuge Nanodrop ND-1000 Spectrophotometer IVIS Gamma counters Rabbit Mouse Rat Aspergillus Candida Oncology Infectious Disease Colorectal cancer Breast cancer Candida albicans infection Lung Cancer HPLC Fluorescent labeling Immunofluorescence immunohistochemistry radiochemistry Biochemistry HPLC-SEC Dual-stain Immunohistochemistry Biomarker analysis Radioimmunoassay bioactivity testing Absorbance gel filtration chromatography Reverse Phase HPLC RP-HPLC PET Human tumor Antibodies total RNA Cultured Cells Stem Cells Drug Discovery biomarker Show 39 more tags Show less

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NIR Spectroscopy

Price on request

The Pearl NIR Imager is designed for fluorescence in vivo imaging in the nearinfrared (NIR) spectral region where tissue autofluorescence and light scattering are low.

Animals may be illuminated by a 685 nm and a 785 nm laser for excitation and LED white light for registration and all three images may be overlayed in the... Show more »

The Pearl NIR Imager is designed for fluorescence in vivo imaging in the nearinfrared (NIR) spectral region where tissue autofluorescence and light scattering are low.

Animals may be illuminated by a 685 nm and a 785 nm laser for excitation and LED white light for registration and all three images may be overlayed in the display. By permitting deeper penetration, smaller targets can be visualized at greater depths, allowing earlier detection. The imaging bed is temperature controlled to maintain body temperature. The sensitivity is exceptional for small animal receptor and transport targeting, structural and vascular/lymphatic imaging and biodistribution.

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Small Animal SPECT Scan

Small Animal Single Photon Emission Computed Tomography Scan
Price on request

We provide the labeling of biomolecules (proteins, peptides, oligomers, nanoparticles, as well as cells) with SPECT radionuclides such as 123I, 125I, 111In, or 99mTc to follow their biodistribution by SPECT (NanoSPECT/CT, Bioscan) imaging in mice, rats or other small animals. Image resolution is about 1 mm.
Biomolecules labeled... Show more »

We provide the labeling of biomolecules (proteins, peptides, oligomers, nanoparticles, as well as cells) with SPECT radionuclides such as 123I, 125I, 111In, or 99mTc to follow their biodistribution by SPECT (NanoSPECT/CT, Bioscan) imaging in mice, rats or other small animals. Image resolution is about 1 mm.
Biomolecules labeled with PET radionuclides such as 18F, 64Cu, 89Zr, 124I or 68Ga are acquired on the Mosaic PET (Philips) small animal camera. Resolution is about 2 mm.
The CT component of the NanoSPECT provides anatomical registration for SPECT and PET rodent images or is used alone for high resolution radiographs. Bore size is 10 cm.
Isotope selection is based on the biomolecules anticipated clearance, biological properties, isotope half-life, or client preference. Modification with isotope is by standard chemistries.
Animal models include tumor xenografts or orthotopic implants of various cancers. Also available are bacterial and fungal infection models.
Services include: labeling chemistry of biomolecules; animal models; design of image studies; image acquisition and analysis. Ideal for tracking cells/stem cells in vivo. Dual isotope imaging is also possible.
Pricing is per hour and varies with project.
Images are provided along with study analysis.

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In vivo Drug Efficacy Testing

Price on request

We provide labeling of biomolecules or cells with fluorescent tags or radioisotopes for in vivo evaluation in small animal models. Services include small animal disease models; tumor xenografts or orthotopic implants of various cancers; bacterial or fungal infections; pharmacokinetics (PK); tissue distribution; targeting and... Show more »

We provide labeling of biomolecules or cells with fluorescent tags or radioisotopes for in vivo evaluation in small animal models. Services include small animal disease models; tumor xenografts or orthotopic implants of various cancers; bacterial or fungal infections; pharmacokinetics (PK); tissue distribution; targeting and accessibility; therapeutic effect; duration in target or tissue; time in circulation and blood clearance. Ideal for tracking cells/stem cell in vivo.
Chemistry Services include: protein modification/conjugation; peptide modification/conjugation; oligomer (siRNA) modifications/conjugations; protein crosslinking; oligo-peptide crosslinking; protein- peptide immobilization; antibody-drug conjugates (ADC); antibody-HRP conjugations; nanoparticle constructs and conjugations; biotin-streptavidin/ avidin conjugations.
Pricing is per hour and varies with project.

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Gamma counters Rabbit Mouse Rat Oncology Infectious Disease Cancer Colorectal cancer Breast cancer Lung Cancer HPLC radiochemistry Analytical SEC Radioimmunoassay affinity chromatography Reverse Phase HPLC Show 16 more tags Show less

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Radiolabeling/Radiosynthesis

Price on request

We offer radiolabeling of biomolecules: proteins, peptides, oligomers, nanoparticles, and cells with radionuclides such as 123I, 125I, 111In, 99mTc, 64Cu, 89Zr, or 124I for in vivo or in vitro applications, such as biodistribution and PK studies, or bench top assays. Modification with isotope is by standard chemistries.
Pricing is per hour and varies with project.

We offer radiolabeling of biomolecules: proteins, peptides, oligomers, nanoparticles, and cells with radionuclides such as 123I, 125I, 111In, 99mTc, 64Cu, 89Zr, or 124I for in vivo or in vitro applications, such as biodistribution and PK studies, or bench top assays. Modification with isotope is by standard chemistries.
Pricing is per hour and varies with project.

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Gamma counters New Brunswick Scientific Incubator Shakers HPLC Reverse Phase HPLC RNA Nanoparticles Proteins monoclonal antibodies Drug Discovery Show 9 more tags Show less

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Small Animal Optical Imaging

Price on request

We provide bioluminescence and fluorescence longitudinal imaging of rodents. Cameras include IVIS 100 (Caliper Life Sciences) with fluorescence filter set to cover fluorophores with excitation of 445-750 nm and emission of 500-875 nm. The system's light-tight chamber has a heated platform and portals for delivery of gaseous... Show more »

We provide bioluminescence and fluorescence longitudinal imaging of rodents. Cameras include IVIS 100 (Caliper Life Sciences) with fluorescence filter set to cover fluorophores with excitation of 445-750 nm and emission of 500-875 nm. The system's light-tight chamber has a heated platform and portals for delivery of gaseous anesthesia to five mice or two rats at a time. Image acquisition takes only about 30 sec providing a high-throughput longitudinal screening; an optimized means to follow disease progression, therapy or pharmacokinetics. Bioluminescence of gene reporters is sensitive to as low as 100 cells.
A second optical camera, the Pearl Imager (Li-Cor), is designed for fluorescence in the near infra-red where tissue auto fluorescence and light scattering are low. The system has laser excitation at 685 nm and 720 nm with emission at 785 nm and 820 nm, also LED white light for registration. The bed is heated to maintain body temperature with animals under anesthesia. System accommodates a single animal and scan times are about 30-60 sec.
Services include: fluorophore conjugation; animal models; design of image studies; image acquisition and analysis.
Pricing is per hour and varies with project.
Images are provided along with requested study analysis.

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Gamma counters Mouse Rat Aspergillus Candida Infectious Disease Cancer Colorectal cancer Breast cancer Candida albicans infection Lung Cancer HPLC Fluorescent labeling radiochemistry Biochemistry Radioimmunoassay bioactivity testing bioassay chemical modification protein quantification multiple modified oligonucleotides gel filtration chromatography Show 22 more tags Show less

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Infrared Spectroscopy Services

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Animal Imaging

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Chemistry and Materials

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Spectroscopy

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Sequencing data in FASTQ

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Biology Services

Biology Services

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Drug Discovery & Development

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Drug Discovery & Development Services

Drug Discovery & Development Services

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Radiochemistry

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Pharmacology & Toxicology

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Pharmacology & Toxicology Services

Pharmacology & Toxicology Services

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Pharmacology

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Pharmacology Services

Pharmacology Services

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In vivo Pharmacology Studies

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In vivo Pharmacology Studies Services

In vivo Pharmacology Studies Services

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Animal Model in vivo Analyses

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Imaging & Spectroscopy

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Animal Models and Studies

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Mary Rusckowski

Director

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