The Small Animal Imaging Shared Resource (SAISR) is a state-of-the-art, small animal imaging facility available to investigators at OSUCCC–James as well as to other academic and commercial institutions.
The SAISR houses high-resolution imaging equipment and offers assistance from professionals who are experts in operating each imaging modality and small animal handling procedures as well as in analytical software support for quantitative image analysis.
In addition to providing interim animal housing for serial imaging studies, the SAISR also offers on-site suites for surgical procedures and animal care provided by the University Laboratory Animal Resources.
Image reconstruction, multi-modality fusion, high-resolution graphics and networking to the facility's server are also available to investigators using the this shared resource.
The SAISR’s imaging scientists can help design imaging studies for each investigator’s specific research applications. We recommend contacting a SAISR representative prior to setting up an imaging study to determine the most appropriate imaging modality and protocol for each small animal imaging study.
High-Resolution Image Data Acquisition:
The SAISR provides high resolution anatomical and functional imaging of rodent models of disease and ex vivo specimens. Technicians and imaging scientists trained in the use of the specialized image acquisition equipment will collect high quality image data for individual investigators. In-house training of investigator’s laboratory personnel in use of the imaging equipment is also available to those groups who demonstrate a specific need for extensive imaging studies.
The SAISR experts help investigators interpret images obtained from the facility’s instrumentation. Our associates are experienced in distinguishing normal and abnormal features in live animal in vivo images, and have the training and background to identify imaging artifacts from real results. Investigators are encouraged to review their results and data interpretation with SAISR personnel upon imaging study completion.
Image Post-Processing and Quantitative Image Analysis:
The SAISR offers quantitative image analysis, and each imaging instrument has modality-dependent image analysis software. Additional image analysis and data interpretation is provided via open-source image analysis software and custom-designed software developed by the SAISR and OSC.
Magnetic resonance microscopy (MRM) for evaluating phenotypic differences in embryos of genetically engineered mice. This technique can be used to obtain an isotropic 3D MR image of an embryo at a spatial resolution on the order of 30-40 microns. MRM can be performed on the sample prior to histologic staining of the sample and will complement the pathology review provided by the Comparative Pathology and Mouse Phenotyping Shared Resource.
High resolution ex vivo MRI.
Small Animal Imaging Shared Resource has not received any reviews.
Small Animal Imaging Shared Resource has not received any endorsements.