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siTOOLs Biotech

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Planegg/Martinsried, DE

About siTOOLs Biotech

siTOOLs Biotech GmbH is a Munich-Martinsried biotech with core expertise in RNA interference, bioinformatics, and RNA production.

siTOOLs Biotech creates gene function analysis tools with exceptional targeting specificity and efficiency: siPOOLsTM for reliable gene silencing, and raPOOLsTM for targeted... Show more »

siTOOLs Biotech GmbH is a Munich-Martinsried biotech with core expertise in RNA interference, bioinformatics, and RNA production.

siTOOLs Biotech creates gene function analysis tools with exceptional targeting specificity and efficiency: siPOOLsTM for reliable gene silencing, and raPOOLsTM for targeted enrichment of RNA. This is achieved by a unique combination of high complexity pooling, proprietary design algorithms, and quality production processes.

siPOOLs are used extensively by Pharma as a recommended target validation tool and has been mentioned in a growing number of publications by customers world-wide. siPOOLs are high complexity pools of 30 optimally designed siRNAs demonstrated to have a significantly reduced off-target profile and more robust on-target gene knock-down (see attached product information brochure and NARS publication).

siTOOLs Biotech also provides services in the form of customized bioinformatics/experimental projects, making it a favoured research partner for accelerating drug development and scientific discoveries.

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Diversity Certificates

Small business

Our Services (14)


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Cell-Based Assays

Price on request

Cell-based assays with various biological readouts can be developed and performed following functional knockdown with siPOOLs (siRNA). Projects are customized according to needs and involve handling of multiple cell lines, plate arraying of reagents, setup and performance of image-based screens to assay biological readouts, and... Show more »

Cell-based assays with various biological readouts can be developed and performed following functional knockdown with siPOOLs (siRNA). Projects are customized according to needs and involve handling of multiple cell lines, plate arraying of reagents, setup and performance of image-based screens to assay biological readouts, and detailed data analysis and reporting.

Gene expression analysis can be performed by real-time quantitative PCR assays or protein immunoblotting.

Standard assays:

  • siRNA (siPOOL) dose optimization with 7-point dose response curve
  • Transfection optimization for difficult cells (evaluation of 3 different transfection techniques)
  • Gene/isoform/species cross-reactivity (with siPOOLs)

For other custom projects, please enquire

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siRNA assay development western blot cell imaging RT-qPCR Phenotypic screening Functional screens cell based assays Show 8 more tags Show less

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RNAi Screening

Price on request
  • Target discovery screening: High content, high throughput screening with customized cell based assays
  • Target validation using RT-PCR, Western Blotting, immunofluorescence microscopy
  • Design and Production of siPOOLs: customized, complex siRNA pools for high specificity target gene silencing
  • Validation of knock-down... Show more »
  • Target discovery screening: High content, high throughput screening with customized cell based assays
  • Target validation using RT-PCR, Western Blotting, immunofluorescence microscopy
  • Design and Production of siPOOLs: customized, complex siRNA pools for high specificity target gene silencing
  • Validation of knock-down efficiency and specificity
  • Bioinformatics support for RNAi screening and validation data sets (access to Phenovault included)
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RNA Sequencing

Price on request

We design and produce customized ribosomal RNA depletion kits for any species prior to Next-Generation Sequencing. Customized depletion solutions can also be developed for highly expressed genes e.g. globin mRNA removal

We design and produce customized ribosomal RNA depletion kits for any species prior to Next-Generation Sequencing. Customized depletion solutions can also be developed for highly expressed genes e.g. globin mRNA removal

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rRNA depletion Next Generation Sequencing RNA-Seq RNA sequencing

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RNA Services

Price on request
  • Design and production of raPOOLs: complex biotinylated probe sets for the purification and analysis of lncRNA
  • Design and production of raPOOLs: complex biotinylated probe sets for the purification and analysis of lncRNA
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Mammalian Cell Culture

Price on request
  • transfection optimisation
  • assay development
  • expression analysis
  • transfection optimisation
  • assay development
  • expression analysis
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RNAi Technology Development

Price on request
Request a quote for more information about this service.

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Nucleic Acid Services

Price on request

Nucleic Acid Services

Nucleic Acid Services

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Biochemistry & Molecular Biology

Price on request

Biochemistry & Molecular Biology Services

Biochemistry & Molecular Biology Services

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Biology

Price on request

Biology Services

Biology Services

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Cell and Tissue Culture

Price on request

Cell and Tissue Culture Services

Cell and Tissue Culture Services

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RNA Synthesis

Price on request
Request a quote for more information about this service.

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siRNA Synthesis

Price on request
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Cells and Tissues

Price on request

Cells and Tissues Services

Cells and Tissues Services

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Globin mRNA Removal

Price on request
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Michael Hannus

Managing Director

FileType/PDF Created with Sketch. Hannus et al NAR.pdf

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FileType/PDF Created with Sketch. Phenovault2018.pdf

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FileType/PDF Created with Sketch. siTOOLs_riboPOOL181211.pdf

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FileType/PDF Created with Sketch. siTOOLsOverview_180913.pdf

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