siTOOLs Biotech GmbH is a Munich-Martinsried biotech with core expertise in RNA interference, bioinformatics, and RNA production.
siTOOLs Biotech creates gene function analysis tools with exceptional targeting specificity and efficiency: siPOOLsTM for reliable gene silencing, and raPOOLsTM for targeted enrichment of RNA. This is achieved by a unique combination of high complexity pooling, proprietary design algorithms, and quality production processes.
siPOOLs are used extensively by Pharma as a recommended target validation tool and has been mentioned in a growing number of publications by customers world-wide. siPOOLs are high complexity pools of 30 optimally designed siRNAs demonstrated to have a significantly reduced off-target profile and more robust on-target gene knock-down (see attached product information brochure and NARS publication).
siTOOLs Biotech also provides services in the form of customized bioinformatics/experimental projects, making it a favoured research partner for accelerating drug development and scientific discoveries.
Cell-based assays with various biological readouts can be developed and performed following functional knockdown with siPOOLs (siRNA). Projects are customized according to needs and involve handling of multiple cell lines, plate arraying of reagents, setup and performance of image-based screens to assay biological readouts, and detailed data analysis and reporting.
Gene expression analysis can be performed by real-time quantitative PCR assays or protein immunoblotting.
For other custom projects, please enquire
We design and produce customized ribosomal RNA depletion kits for any species prior to Next-Generation Sequencing. Customized depletion solutions can also be developed for highly expressed genes e.g. globin mRNA removal
Biochemistry & Molecular Biology Services
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