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Sinclair Research Center

Auxvasse, Missouri, US

Sinclair Research Center, a preclinical contract research organization (CRO) established in 1964, offers animal efficacy models, IND enabling toxicology services and research capabilities to the human pharmaceutical, animal health and medical device companies. Our clients include large, mid-tier, small and startup companies in both human and animal health markets. With more than 20 years’ experience, Sinclair is the undisputed expert in all breeds of miniature swine. In addition, we manage many standing animal colony models including diabetes, wound healing, irritable bowel disease and general PK, and we have developed and maintain our own unique research breed of mini-swine, “The Sinclair Pig.”

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Dermal Toxicity Studies
Price on request

Sinclair personnel are experts in dermal toxicity testing, conducting GLP-compliant dermal and transdermal toxicology, safety, and drug metabolism and pharmacokinetic (DMPK) studies in an FDA-recommended model, the miniature swine.

-Dermal Toxicity Testing: Acute, short-term (7- to 28-day), subchronic (90-day), or chronic... Show more »

Sinclair personnel are experts in dermal toxicity testing, conducting GLP-compliant dermal and transdermal toxicology, safety, and drug metabolism and pharmacokinetic (DMPK) studies in an FDA-recommended model, the miniature swine.

-Dermal Toxicity Testing: Acute, short-term (7- to 28-day), subchronic (90-day), or chronic exposure
durations. Single or repeat dose, occluded or non-occluded administration site
-Passive and active (iontophoretic) dermal/transdermal patch administration
-Dermal evaluation of irritation and local tolerance
-Phototoxicity model in miniature swine
-Standard toxicology endpoints – clinical observations, clinical pathology, ECG, ophthalmology,
histopathology
-Dermal drug metabolism and pharmacokinetic (DMPK) studies
-Pharmacokinetics and toxicokinetics for dermal/transdermal routes of administration
-Cross-contamination prevention – custom equipment for dermal studies
-Custom large animal enclosures for dermal studies, utilizing stainless steel full barriers
-Dose preparation
-Full-thickness and partial thickness dermal wounds, skin barrier interruption by scarification and tape
stripping of the stratum corneum

Other Skin Models
-Skin allergy, atopy
-Depigmentation
-Iontophoresis

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Hamster
Rabbit
Guinea pig
Sheep
Goat
Mouse
Rat
Cat
Cattle
Beagle
Cynomologus NHP
Yucatan Miniswine
Hanford Miniswine
Sinclair Miniswine
Hound
Nude Rat
Nude Mouse
Ferrets
Horses
Poultry
Diabetes Animal Models
Price on request

We currently maintain more than 250 insulin-dependent diabetic miniature swine in-house, enabling us to offer a wide variety of research services using diabetic models; we additionally make the diabetic miniature swine available to industry and academic clients through our sister company, Sinclair BioResources. We also offer NHP... Show more »

We currently maintain more than 250 insulin-dependent diabetic miniature swine in-house, enabling us to offer a wide variety of research services using diabetic models; we additionally make the diabetic miniature swine available to industry and academic clients through our sister company, Sinclair BioResources. We also offer NHP and rodent diabetic models, and we have experience with dog and cat diabetes testing as well.

Miniature Swine Diabetic Model Flexibility
The diabetic miniature swine model is a very versatile model for studies on diabetes management. Sinclair Research has three breeds of miniature swine, Yucatan, Micro-Yucatan, and Sinclair, available for use in a variety studies targeting diabetes-related research areas and therapy types, as listed below.

Applicable Research Areas
-Type I or Type II diabetes complications
-Insulin resistance
-Wound healing, including delayed healing
-Cataracts and retinopathy
-Obesity
-Atherosclerosis
-Dyslipidemia and hypercholesterolemia
-Hypertension
-Cardiometabolic syndrome

Therapy Types
-Insulin, insulin analogues, insulin sensitizers, β-cell multipliers, cellular therapies
-Small and large molecules, most compounds targeting glucose and lipid activity

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Mouse
Cat
Beagle
Cynomologus NHP
Yucatan Miniswine
Nude Mouse
Metabolic Animal Models
Price on request

Spontaneous/Genetic Models:
-Obesity
-Metabolic syndrome
-Hypertension
-Type II diabetes

Induced Models:
-Specialized diets
-Chemicals
-Surgical
-Type I & II diabetes

Available Clinical Assessments:
-DEXA analysis
-Urine chemistry
-Food and water consumption
-Serum chemistry
-Lipid profiles
-Liver function... Show more »

Spontaneous/Genetic Models:
-Obesity
-Metabolic syndrome
-Hypertension
-Type II diabetes

Induced Models:
-Specialized diets
-Chemicals
-Surgical
-Type I & II diabetes

Available Clinical Assessments:
-DEXA analysis
-Urine chemistry
-Food and water consumption
-Serum chemistry
-Lipid profiles
-Liver function tests
-Kidney function profile
-Hormones and biomarkers
-Glucose disposal (oGTT and ivGTT)
-Hyperinsulinemic-glycemic clamp

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Mouse
Cat
Beagle
Cynomologus NHP
Yucatan Miniswine
Nude Mouse
Target Animal Studies
Price on request

Sinclair Research has a long history of evaluating the efficacy of test articles for human and animal health in a number of therapeutic areas, including nutrition, obesity, diabetes, cardiovascular, wound healing, osteoporosis, ocular, dermal, antibiotics, vaccines, analgesics/anesthetics and parasite control.

Sinclair Research has a long history of evaluating the efficacy of test articles for human and animal health in a number of therapeutic areas, including nutrition, obesity, diabetes, cardiovascular, wound healing, osteoporosis, ocular, dermal, antibiotics, vaccines, analgesics/anesthetics and parasite control.

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Sheep
Goat
Cat
Beagle
GLP Study Monitoring
Price on request

Sinclair Research performs many GLP-compliant studies each year, and we also offer veterinary Good Clinical Practice (vGCP)-compliant studies for veterinary products. Our Quality Assurance (QA) Department performs many types of audits; the QA employees are diligent, thorough, and monitor each study independently of study conduct.... Show more »

Sinclair Research performs many GLP-compliant studies each year, and we also offer veterinary Good Clinical Practice (vGCP)-compliant studies for veterinary products. Our Quality Assurance (QA) Department performs many types of audits; the QA employees are diligent, thorough, and monitor each study independently of study conduct. The senior QA officer is certified as a Registered Quality Assurance Professional in Good Laboratory Practice (RQAP-GLP).

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In vivo PK/PD Studies
Price on request

Services offered include:
-Plasma drug profiles following any route of administration
-Dynamic change in blood glucose or other biochemical or physiological parameters
-Global dog, NHP, and pig protocols, compounds, or formulations tested weekly for timely feedback
-Specialized PK studies for bridging active pharmaceutical ingredient (API) compounds
-Cerebrospinal fluid (CSF) drug levels

Services offered include:
-Plasma drug profiles following any route of administration
-Dynamic change in blood glucose or other biochemical or physiological parameters
-Global dog, NHP, and pig protocols, compounds, or formulations tested weekly for timely feedback
-Specialized PK studies for bridging active pharmaceutical ingredient (API) compounds
-Cerebrospinal fluid (CSF) drug levels

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Rabbit
Mouse
Rat
Cat
Beagle
Cynomologus NHP
Yucatan Miniswine
Hanford Miniswine
Sinclair Miniswine
Nude Mouse
Ferrets
Horses
Preclinical Surgical Efficacy Studies
Price on request

Sinclair Research is supplied with equipment and facilities to provide surgical studies, models, and services ranging from simple, minimally invasive procedures to complex surgery. Whether in support of a pharmacology or toxicology program or the development of a new medical device, our unique combination of technology,... Show more »

Sinclair Research is supplied with equipment and facilities to provide surgical studies, models, and services ranging from simple, minimally invasive procedures to complex surgery. Whether in support of a pharmacology or toxicology program or the development of a new medical device, our unique combination of technology, facilities, and experience amply provide for the surgical study needs of our clients.

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Drug Discovery & Development
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Animal Models and Studies
Price on request

Sinclair takes pride in the fact that we have developed and validated preclinical animal models for surgical studies, osteopenia, diabetes, inflammation, dermal toxicology, pharmacokinetics, and many other uses. Over the past ten years, we have contributed to the development of multiple large animal models of human diseases; we... Show more »

Sinclair takes pride in the fact that we have developed and validated preclinical animal models for surgical studies, osteopenia, diabetes, inflammation, dermal toxicology, pharmacokinetics, and many other uses. Over the past ten years, we have contributed to the development of multiple large animal models of human diseases; we are the only private contract research organization primarily involved in large animal model development.

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Veterinary Laboratory Services
Price on request

-Target animal safety (TAS) studies
-Bioequivalence studies
-Veterinary Oral Health Council (VOHC) oral health and dentistry products
-Internal and external parasite preventatives
-Veterinary analgesics testing.

-Target animal safety (TAS) studies
-Bioequivalence studies
-Veterinary Oral Health Council (VOHC) oral health and dentistry products
-Internal and external parasite preventatives
-Veterinary analgesics testing.

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Transdermal/Transmucosal Drug Delivery Systems
Price on request
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Toxicology
Price on request

Non-GLP (discovery) and GLP studies
-Pilot studies
-Acute dose, single dose, and maximum tolerated dose (MTD)
-Dose range finding (DRF)
-Sub-chronic and chronic toxicity, with recovery phases
-14-day and 28-day repeat dose
-Systemic toxicology
-Specialty toxicology, including but not limited to: ocular, dermal and... Show more »

Non-GLP (discovery) and GLP studies
-Pilot studies
-Acute dose, single dose, and maximum tolerated dose (MTD)
-Dose range finding (DRF)
-Sub-chronic and chronic toxicity, with recovery phases
-14-day and 28-day repeat dose
-Systemic toxicology
-Specialty toxicology, including but not limited to: ocular, dermal and subcutaneous, bone, juvenile, and
phototoxicity
-Miniature swine specialty studies
-Repeat-dose dermal irritation and dermal toxicology
-Phototoxicity
-Reproductive toxicology (Segments l & ll)
-Other studies
-Target animal safety (TAS) studies
-FDA Redbook feeding trials

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Hamster
Rabbit
Mouse
Rat
Beagle
Cynomologus NHP
Yucatan Miniswine
Hanford Miniswine
Sinclair Miniswine
Ferrets
Preclinical Efficacy Studies
Price on request
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Nonclinical Research
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Drug Potency and Efficacy Testing
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Feasibility Studies
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Animal Blood Collection
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Drug Discovery
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Contract Research
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Bioavailability and Bioequivalence Studies
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Bioanalytical Assays
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Bioanalysis
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Experimental Design
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Cytometry
Price on request

Cytometry Services

Cytometry Services

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Cells and Tissues
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Cells and Tissues Services

Cells and Tissues Services

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Biology
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Biology Services

Biology Services

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Flow Cytometry
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Immunology Animal Models
Price on request

Immunology Animal Models Services

Immunology Animal Models Services

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Ophthalmic Drug Development
Price on request

Ocular Studies

Study Services:
-Ocular toxicology
-Ocular pharmacology
-Treatment efficacy
-Drug-eluting implants
-Ocular and periocular infection
-Fundus evaluation
-Vitreo-retinal surgery
-ERG
-Tonometry
-Digital imaging, anterior and posterior segments
-Ocular drug distribution

Specialized Animal... Show more »

Ocular Studies

Study Services:
-Ocular toxicology
-Ocular pharmacology
-Treatment efficacy
-Drug-eluting implants
-Ocular and periocular infection
-Fundus evaluation
-Vitreo-retinal surgery
-ERG
-Tonometry
-Digital imaging, anterior and posterior segments
-Ocular drug distribution

Specialized Animal Models
-Normal intra-ocular pressure (IOP) in rabbits and NHP
-Elevated IOP in rabbits, NHPs, and miniature swine
-Laser-induced glaucoma
-Miniature swine diabetic retinopathy and cataracts
-Transgenic retinal degeneration model

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Bone/Cartilage Animal Models
Price on request

Osteoarthritis, cartilage and bone healing and repair, and osteoporosis are among the orthopedic studies offered at Sinclair Research, as well as implantable devices tested on, in, or adjacent to a variety of bone classes.

Osteoarthritis, cartilage and bone healing and repair, and osteoporosis are among the orthopedic studies offered at Sinclair Research, as well as implantable devices tested on, in, or adjacent to a variety of bone classes.

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Wound Healing Animal Models
Price on request

We offer wound healing studies with a wide variety of dermal wound sizes, shapes, depths, and designs including:

-Incisional
-Excisional – full thickness or partial thickness
-Ischemic wound
-Burn wound
-Delayed wound healing studies in diabetic miniature swine
-Classic wound healing endpoints in miniature swine... Show more »

We offer wound healing studies with a wide variety of dermal wound sizes, shapes, depths, and designs including:

-Incisional
-Excisional – full thickness or partial thickness
-Ischemic wound
-Burn wound
-Delayed wound healing studies in diabetic miniature swine
-Classic wound healing endpoints in miniature swine models
-Digital measurement of serial wound areas
-3D photography for wound depth and volume
-Histopathology evaluation of re-epithelialization
-Large definitive GLP and small pilot studies

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In vivo Pharmacology Studies
Price on request

We perform drug discovery and formulation pharmacology on miniature swine, canines, NHPs, and rodents. We also offer many animal models for preclinical pharmacology, such as immunosuppressed mice and diabetic miniature swine.

We offer in vivo drug metabolism and pharmacokinetic (DMPK), biotransformation, and metabolism studies... Show more »

We perform drug discovery and formulation pharmacology on miniature swine, canines, NHPs, and rodents. We also offer many animal models for preclinical pharmacology, such as immunosuppressed mice and diabetic miniature swine.

We offer in vivo drug metabolism and pharmacokinetic (DMPK), biotransformation, and metabolism studies essential for understanding PK profiles. If warranted, we can also determine if a metabolite of the parent drug is more efficacious, safer, and has a better PK profile than the parent.

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Drug Development
Price on request

Drug Development Services

Drug Development Services

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In vivo Toxicity Testing
Price on request

In vivo Toxicity Testing Services

In vivo Toxicity Testing Services

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Pharmacology
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Pharmacology Services

Pharmacology Services

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