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Sinclair Research Center

3 Orders Completed
Auxvasse, Missouri, US

About Sinclair Research Center

Founded: 1965 Type: Privately Held Size: 51-200 employees

Sinclair Research Center, a preclinical contract research organization (CRO) established in 1964, offers animal efficacy models, IND enabling toxicology services and research capabilities to the human pharmaceutical, animal health and medical device companies. Our clients include large, mid-tier, small... Show more »

Sinclair Research Center, a preclinical contract research organization (CRO) established in 1964, offers animal efficacy models, IND enabling toxicology services and research capabilities to the human pharmaceutical, animal health and medical device companies. Our clients include large, mid-tier, small and startup companies in both human and animal health markets. With more than 20 years’ experience, Sinclair is the undisputed expert in all breeds of miniature swine. In addition, we manage many standing animal colony models including diabetes, wound healing, irritable bowel disease and general PK, and we have developed and maintain our own unique research breed of mini-swine, “The Sinclair Pig.”

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Certifications & Qualifications

AAALAC GLP OLAW USDA

Our Services (37)


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Dose Range Finding (DRF) Studies

Price on request

Sinclair offers a wide range of toxicology services including Dose Range Finding (DRF) Studies which are important in helping determine the maximum tolerated dose (MTD) of a drug product. These studies are usually 5 to 14 day repeat-dose studies and are conducted using a minimum number of animals to provide preliminary... Show more »

Sinclair offers a wide range of toxicology services including Dose Range Finding (DRF) Studies which are important in helping determine the maximum tolerated dose (MTD) of a drug product. These studies are usually 5 to 14 day repeat-dose studies and are conducted using a minimum number of animals to provide preliminary identification of the target organs of toxicity. The output of these studies supports the appropriate dose selection for more definitive studies that are part of an IND enabling package.

We have experience working with 17 species including mice, rats, hamsters, guinea pigs, rabbits, canines, swine, sheep, poultry and large farm animals.

Why partner with Sinclair Research for your Dose Range Finding (DRF) Studies?

  • Dedicated team of toxicologists and technical staff
  • Optimized study designs
  • Rigorous reporting and SEND data ready
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Hamster Rabbit Guinea pig Sheep Chicken Mouse Rat Dog Minipig dose range finding Biopharmaceuticals/Biologics Small molecules Toxicology Show 13 more tags Show less

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Toxicology

Price on request

Non-GLP (discovery) and GLP studies:

  • Pilot studies
  • Acute dose, single dose, and maximum tolerated dose (MTD)
  • Dose range finding (DRF)
  • Sub-chronic and chronic toxicity, with recovery phases
  • 14-day and 28-day repeat dose
  • Systemic toxicology
  • Specialty toxicology, including but not limited to: ocular,... Show more »

Non-GLP (discovery) and GLP studies:

  • Pilot studies
  • Acute dose, single dose, and maximum tolerated dose (MTD)
  • Dose range finding (DRF)
  • Sub-chronic and chronic toxicity, with recovery phases
  • 14-day and 28-day repeat dose
  • Systemic toxicology
  • Specialty toxicology, including but not limited to: ocular, dermal and subcutaneous, bone, juvenile, and
    phototoxicity
  • Miniature swine specialty studies
  • Repeat-dose dermal irritation and dermal toxicology
  • Phototoxicity
  • Reproductive toxicology (Segments l & ll)
  • Other studies
  • Target animal safety (TAS) studies
  • FDA Redbook feeding trials
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Dermal Toxicity Studies

Price on request

Sinclair personnel are experts in dermal toxicity testing, conducting GLP-compliant dermal and transdermal toxicology, safety, and drug metabolism and pharmacokinetic (DMPK) studies in an FDA-recommended model, the miniature swine.

Sinclair offers extensive Dermal Toxicity Testing services:

Sinclair personnel are experts in dermal toxicity testing, conducting GLP-compliant dermal and transdermal toxicology, safety, and drug metabolism and pharmacokinetic (DMPK) studies in an FDA-recommended model, the miniature swine.

Sinclair offers extensive Dermal Toxicity Testing services:

  • Acute, short-term (7- to 28-day)
  • Subchronic (90-day)
  • Chronic exposure
  • Single or repeat dose, occluded or non-occluded administration site
  • Passive and active (iontophoretic) dermal/transdermal patch administration
  • Dermal evaluation of irritation and local tolerance
  • Phototoxicity model in miniature swine
  • Standard toxicology endpoints – clinical observations, clinical pathology, ECG, ophthalmology,
    histopathology
  • Dermal drug metabolism and pharmacokinetic (DMPK) studies
  • Pharmacokinetics and toxicokinetics for dermal/transdermal routes of administration
  • Cross-contamination prevention – custom equipment for dermal studies
  • Custom large animal enclosures for dermal studies, utilizing stainless steel full barriers
  • Dose preparation
  • Full-thickness and partial thickness dermal wounds, skin barrier interruption by scarification and tape
    stripping of the stratum corneum

Other Skin Models

  • Skin allergy, atopy
  • Depigmentation
  • Iontophoresis

Why partner with Sinclair Research for your Dose Range Finding (DRF) Studies?

  • Dedicated team of dermal toxicologists and technical staff
  • Optimized study designs
  • Rigorous reporting and SEND data ready
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Hamster Rabbit Guinea pig Ferret Sheep Goat Chicken Mouse Rat Dog Horse Cat Cow Non-human primates (NHP) Minipig intradermal Dermal toxicity Dermal Buccal/sublingual Pharmacokinetic Studies Dermal Inflammation Delayed type hypersensitivity Beuhler Method Magnusson-Kligman Method Dermal scarring Dermal wound healing Delivery devices Dermal infection Dermal Toxicology Show 29 more tags Show less

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Diabetes Animal Models

Price on request

We currently maintain more than 250 insulin-dependent diabetic miniature swine in-house, enabling us to offer a wide variety of research services using diabetic models; we additionally make the diabetic miniature swine available to industry and academic clients through our sister company, Sinclair BioResources. We also offer NHP... Show more »

We currently maintain more than 250 insulin-dependent diabetic miniature swine in-house, enabling us to offer a wide variety of research services using diabetic models; we additionally make the diabetic miniature swine available to industry and academic clients through our sister company, Sinclair BioResources. We also offer NHP and rodent diabetic models, and we have experience with dog and cat diabetes testing as well.

Miniature Swine Diabetic Model Flexibility

The diabetic miniature swine model is a very versatile model for studies on diabetes management. Sinclair Research has three breeds of miniature swine, Yucatan, Micro-Yucatan, and Sinclair, available for use in a variety studies targeting diabetes-related research areas and therapy types, as listed below.

Applicable Research Areas

  • Type I or Type II diabetes complications
  • Insulin resistance
  • Wound healing, including delayed healing
  • Cataracts and retinopathy
  • Obesity
  • Atherosclerosis
  • Dyslipidemia and hypercholesterolemia
  • Hypertension
  • Cardiometabolic syndrome

Therapy Types

  • Insulin, insulin analogues, insulin sensitizers, β-cell multipliers, cellular therapies
  • Small and large molecules, most compounds targeting glucose and lipid activity

Why partner with Sinclair Research for your Diabetes Animal Models and studies?

  • Dedicated team of scientific and technical staff
  • Unique expertise in diabetic model creation and study execution
  • Colony of diabetic minipigs available for rapid PK screening
  • Optimized study designs
  • Rigorous reporting and SEND data ready
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Mouse Dog Cat Non-human primates (NHP) Minipig Metabolism and Endocrinology Hypertension Obesity Diabetes Dyslipidemia subcutaneous Diet-induced obesity obesity Dermal wound healing Biopharmaceuticals/Biologics Small molecules Drug Discovery Pharmacology Toxicology Show 19 more tags Show less

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In vivo PK/PD Studies

Price on request

Services offered include:

  • Plasma drug profiles following any route of administration
  • Dynamic change in blood glucose or other biochemical or physiological parameters
  • Global dog, NHP, and pig protocols, compounds, or formulations tested weekly for timely feedback
  • Specialized PK studies for bridging active... Show more »

Services offered include:

  • Plasma drug profiles following any route of administration
  • Dynamic change in blood glucose or other biochemical or physiological parameters
  • Global dog, NHP, and pig protocols, compounds, or formulations tested weekly for timely feedback
  • Specialized PK studies for bridging active pharmaceutical ingredient (API) compounds
  • Cerebrospinal fluid (CSF) drug levels
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Metabolic Animal Models

Price on request

Spontaneous/Genetic Models:

  • Obesity
  • Metabolic syndrome
  • Hypertension
  • Type II diabetes

Induced Models:

  • Specialized diets
  • Chemicals
  • Surgical
  • Type I & II diabetes

Available Clinical Assessments:

  • DEXA analysis
  • Urine chemistry
  • Food and water consumption
  • Serum chemistry
    *... Show more »

Spontaneous/Genetic Models:

  • Obesity
  • Metabolic syndrome
  • Hypertension
  • Type II diabetes

Induced Models:

  • Specialized diets
  • Chemicals
  • Surgical
  • Type I & II diabetes

Available Clinical Assessments:

  • DEXA analysis
  • Urine chemistry
  • Food and water consumption
  • Serum chemistry
  • Lipid profiles
  • Liver function tests
  • Kidney function profile
  • Hormones and biomarkers
  • Glucose disposal (oGTT and ivGTT)
  • Hyperinsulinemic-glycemic clamp
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Mouse Dog Cat Non-human primates (NHP) Minipig

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Target Animal Studies

Price on request

Sinclair Research has a long history of evaluating the efficacy of test articles for human and animal health in a number of therapeutic areas, including nutrition, obesity, diabetes, cardiovascular, wound healing, osteoporosis, ocular, dermal, antibiotics, vaccines, analgesics/anesthetics and parasite control.

Sinclair Research has a long history of evaluating the efficacy of test articles for human and animal health in a number of therapeutic areas, including nutrition, obesity, diabetes, cardiovascular, wound healing, osteoporosis, ocular, dermal, antibiotics, vaccines, analgesics/anesthetics and parasite control.

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GLP Study Monitoring

Price on request

Sinclair Research performs many GLP-compliant studies each year, and we also offer veterinary Good Clinical Practice (vGCP)-compliant studies for veterinary products. Our Quality Assurance (QA) Department performs many types of audits; the QA employees are diligent, thorough, and monitor each study independently of study conduct.... Show more »

Sinclair Research performs many GLP-compliant studies each year, and we also offer veterinary Good Clinical Practice (vGCP)-compliant studies for veterinary products. Our Quality Assurance (QA) Department performs many types of audits; the QA employees are diligent, thorough, and monitor each study independently of study conduct. The senior QA officer is certified as a Registered Quality Assurance Professional in Good Laboratory Practice (RQAP-GLP).

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Preclinical Surgical Efficacy Studies

Price on request

Sinclair Research is supplied with equipment and facilities to provide surgical studies, models, and services ranging from simple, minimally invasive procedures to complex surgery. Whether in support of a pharmacology or toxicology program or the development of a new medical device, our unique combination of technology,... Show more »

Sinclair Research is supplied with equipment and facilities to provide surgical studies, models, and services ranging from simple, minimally invasive procedures to complex surgery. Whether in support of a pharmacology or toxicology program or the development of a new medical device, our unique combination of technology, facilities, and experience amply provide for the surgical study needs of our clients.

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Ophthalmic Drug Development

Price on request

Ocular Studies

Study Services:

  • Ocular toxicology
  • Ocular pharmacology
  • Treatment efficacy
  • Drug-eluting implants
  • Ocular and periocular infection
  • Fundus evaluation
  • Vitreo-retinal surgery
  • ERG
  • Tonometry
  • Digital imaging, anterior and posterior segments
  • Ocular drug distribution

Specialized... Show more »

Ocular Studies

Study Services:

  • Ocular toxicology
  • Ocular pharmacology
  • Treatment efficacy
  • Drug-eluting implants
  • Ocular and periocular infection
  • Fundus evaluation
  • Vitreo-retinal surgery
  • ERG
  • Tonometry
  • Digital imaging, anterior and posterior segments
  • Ocular drug distribution

Specialized Animal Models:

  • Normal intra-ocular pressure (IOP) in rabbits and NHP
  • Elevated IOP in rabbits, NHPs, and miniature swine
  • Laser-induced glaucoma
  • Miniature swine diabetic retinopathy and cataracts
  • Transgenic retinal degeneration model
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Drug Discovery & Development

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Animal Models and Studies

Price on request

Sinclair takes pride in the fact that we have developed and validated preclinical animal models for surgical studies, osteopenia, diabetes, inflammation, dermal toxicology, pharmacokinetics, and many other uses. Over the past ten years, we have contributed to the development of multiple large animal models of human diseases; we... Show more »

Sinclair takes pride in the fact that we have developed and validated preclinical animal models for surgical studies, osteopenia, diabetes, inflammation, dermal toxicology, pharmacokinetics, and many other uses. Over the past ten years, we have contributed to the development of multiple large animal models of human diseases; we are the only private contract research organization primarily involved in large animal model development.

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In vivo Pharmacology Studies

Price on request

We perform drug discovery and formulation pharmacology on miniature swine, canines, NHPs, and rodents. We also offer many animal models for preclinical pharmacology, such as immunosuppressed mice and diabetic miniature swine.

We offer in vivo drug metabolism and pharmacokinetic (DMPK), biotransformation, and metabolism studies... Show more »

We perform drug discovery and formulation pharmacology on miniature swine, canines, NHPs, and rodents. We also offer many animal models for preclinical pharmacology, such as immunosuppressed mice and diabetic miniature swine.

We offer in vivo drug metabolism and pharmacokinetic (DMPK), biotransformation, and metabolism studies essential for understanding PK profiles. If warranted, we can also determine if a metabolite of the parent drug is more efficacious, safer, and has a better PK profile than the parent.

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Veterinary Laboratory Services

Price on request

-Target animal safety (TAS) studies
-Bioequivalence studies
-Veterinary Oral Health Council (VOHC) oral health and dentistry products
-Internal and external parasite preventatives
-Veterinary analgesics testing.

-Target animal safety (TAS) studies
-Bioequivalence studies
-Veterinary Oral Health Council (VOHC) oral health and dentistry products
-Internal and external parasite preventatives
-Veterinary analgesics testing.

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Transdermal/Transmucosal Drug Delivery Systems

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In vivo Drug Efficacy Testing

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Nonclinical Research

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Feasibility Studies

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Animal Blood Collection

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Drug Discovery

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Wound Healing Animal Models

Price on request

We offer wound healing studies with a wide variety of dermal wound sizes, shapes, depths, and designs including:

-Incisional
-Excisional – full thickness or partial thickness
-Ischemic wound
-Burn wound
-Delayed wound healing studies in diabetic miniature swine
-Classic wound healing endpoints in miniature swine... Show more »

We offer wound healing studies with a wide variety of dermal wound sizes, shapes, depths, and designs including:

-Incisional
-Excisional – full thickness or partial thickness
-Ischemic wound
-Burn wound
-Delayed wound healing studies in diabetic miniature swine
-Classic wound healing endpoints in miniature swine models
-Digital measurement of serial wound areas
-3D photography for wound depth and volume
-Histopathology evaluation of re-epithelialization
-Large definitive GLP and small pilot studies

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Contract Research

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In vitro Bioavailability/Bioequivalence Studies

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Bioanalytical Assays

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Bone/Cartilage Animal Models

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Osteoarthritis, cartilage and bone healing and repair, and osteoporosis are among the orthopedic studies offered at Sinclair Research, as well as implantable devices tested on, in, or adjacent to a variety of bone classes.

Osteoarthritis, cartilage and bone healing and repair, and osteoporosis are among the orthopedic studies offered at Sinclair Research, as well as implantable devices tested on, in, or adjacent to a variety of bone classes.

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Bioanalysis

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Assay Development

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Cytometry

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Cytometry Services

Cytometry Services

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Cells and Tissues

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Cells and Tissues Services

Cells and Tissues Services

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Biology

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Biology Services

Biology Services

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Flow Cytometry

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Immunology Animal Models

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Immunology Animal Models Services

Immunology Animal Models Services

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Drug Development

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Drug Development Services

Drug Development Services

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Pharmacology

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Pharmacology Services

Pharmacology Services

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In vivo Toxicity Testing

Price on request

In vivo Toxicity Testing Services

In vivo Toxicity Testing Services

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In vivo ADME/DMPK Studies

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In vivo ADME/DMPK Studies Services

In vivo ADME/DMPK Studies Services

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Toxicity Animal Models

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Eric Blair

Director of Business Development
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Andy Brown

Vice President of Commercial Operations
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Danielle Dart

Proposal Specialist
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Rita Maloney

Coordinator
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Jyoti Mundra

Director of Business Development
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Bob Neiswender

Director of Business Development
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Gregory Ochs

Senior Director of Business Development

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