SignalChem has established itself as a leader in the development of innovative cell signaling products to meet the needs of scientist in basic research and drug discovery. The company has utilized its core capabilities of cellular signaling, molecular biology and protein biochemistry to generate more than 750 products as part of its current and continuously expanding product portfolio. One area of particular strength for the company is the production of highly purified human recombinant enzyme and protein targets. With this ever expanding library of enzymes and protein targets, SignalChem has invested additional resources to perform profiling of compounds as well as the production and validation of high quality isoform specific antibodies which are intended to recognize a single target; the protein of interest. We are pleased to provide our clients with access to high quality validated cell signaling products and compound profiling service.
SignalChem's scientists have gained an extensive experience in the cloning, expression, purification and activation of cellular signaling proteins including protein kinases, protein phosphatases and cellular protein substrates, amongst others.
Depending upon the client's needs, SignalChem scientists will work with you to custom develop the target to your desired specifications within a realistic and suitable timeframe.
Highlights of SignalChem's custom protein development capabilities include:
SignalChem scientists can undertake development of a custom protein for a client by adopting a step-wise strategy.
Recombinant antibodies (rAbs) are highly specific biochemical probes, which are gaining popularity for use in life sciences research, diagnostics and clinical therapy. Unlike traditional monoclonal antibodies (mAbs), rAbs are generated in vitro using synthetic genes, and do not require the use or harm to animals during the production process. Due to continuous interest and high demand, more and more rAb sequences are becoming available to give researchers a growing library of affinity probe designs to choose from.
SignalChem is leveraging our years of expertise to produce high-purity recombinant proteins in various cell systems to provide custom recombinant antibody production services.
SignalChem's compound selectivity profiling service determines the respective inhibitory profile and the putative mechanism of action. All compounds are profiled against a panel of targets either using an individual dose, a single concentration or at multiple concentrations in order to allow in-depth IC50 determinations. In addition, the protein kinase assays can be performed under varying ATP concentrations to evaluate the competitive effects of ATP.
The compound selectivity profiling service offered by SignalChem is a very economical and convenient approach to the drug discovery continuum with a two-week turnaround of your specific profiling results. Compounds can be supplied by the client as DMSO stocks of known concentration, as solid material in vials, or in 96-well plates.
Our scientists have an extensive experience in developing the appropriate assay systems for any biological enzyme and protein targets. In particular, SignalChem's validated assay systems can be used in high throughput format to identify potent inhibitor compounds. The identified inhibitor compounds can be counter-screened against SignalChem's expanding panel of diverse enzymes such as protein kinase and protein phosphatase targets. Using these methodologies, SignalChem can identify potent leads as well as determine the selectivity profile of the compound for our clients.
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