1392057838763 e3668036cf39e09f3a1184b1bd75ba7c

Shanghai Medicilon, Inc.

Shanghai, Shanghai, CN

Medicilon offers fully integrated pharmaceutical services for the global scientific community and is focused on providing an exceptional client-centered experience and advancing the drug discovery process. Since the founding of our company in 2004, our integrated services across biology, chemistry and preclinical services are uniquely designed to help clients develop their research and discovery programs from the initial idea stage to the IND filing phase.

Our headquarters is located in Zhangjiang High-Tech Park in Shanghai, China, with an additional facility in Chuansha Economic Park, Shanghai, China. We occupy over 200,000 Sq. ft. in lab space and have over 300 employees across biology, chemistry and preclinical research. Over 50% employees have M.S. and Ph.D. degrees, over 10% have foreign education and/or work experiences.

Medicilon has been recognized as one of the top drug discovery contract research... Show more »

Medicilon offers fully integrated pharmaceutical services for the global scientific community and is focused on providing an exceptional client-centered experience and advancing the drug discovery process. Since the founding of our company in 2004, our integrated services across biology, chemistry and preclinical services are uniquely designed to help clients develop their research and discovery programs from the initial idea stage to the IND filing phase.

Our headquarters is located in Zhangjiang High-Tech Park in Shanghai, China, with an additional facility in Chuansha Economic Park, Shanghai, China. We occupy over 200,000 Sq. ft. in lab space and have over 300 employees across biology, chemistry and preclinical research. Over 50% employees have M.S. and Ph.D. degrees, over 10% have foreign education and/or work experiences.

Medicilon has been recognized as one of the top drug discovery contract research organizations (CRO) in China and is managed by a team of scientists with a wealth of experience in US-based pharmaceutical and biotechnology companies. As our areas of expertise and service capabilities continue to expand, more and more pharmaceutical and biotechnology companies have taken advantage of our integrated drug discovery and development services.

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Shanghai Medicilon, Inc. has not listed any services.

In vivo PK/PD Studies
Price on request

ADMET property optimization

ADMET property optimization

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Acute Inflammation Animal Models
Price on request

Carrageenan-induced paw edema in mouse/rat

Carrageenan-induced paw edema in mouse/rat

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Rheumatoid Arthritis Animal Models
Price on request

Model: adjuvant-induced arthritis (AIA)
Species: rat

Model: collagen-induced arthritis (CIA)
Species: mouse/rat

Model: air pouch
Species: mouse/rat

Model: adjuvant-induced arthritis (AIA)
Species: rat

Model: collagen-induced arthritis (CIA)
Species: mouse/rat

Model: air pouch
Species: mouse/rat

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Autoimmune Disease Animal Models
Price on request

Experimental Autoimmune Encephalomyelitis (EAE)

Model: Antigen-induced
Species: mouse

Experimental Autoimmune Encephalomyelitis (EAE)

Model: Antigen-induced
Species: mouse

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Bacterial Protein Expression
Price on request

E. coli system:
- Protein expression optimization and solubility test
- Refolding
- Small scale expression and purification
- Scale up expression and purification

E. coli system:
- Protein expression optimization and solubility test
- Refolding
- Small scale expression and purification
- Scale up expression and purification

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Custom Cardiovascular Animal Models
Price on request

Model: spontaneous hypertension
Species: SHR rat

Model: myocardial infarction
Species: rat

Model: spontaneous hypertension
Species: SHR rat

Model: myocardial infarction
Species: rat

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Cell Migration Assays
Price on request

Medicilon has established over 100 different cancer cell lines for cell-based assays including:
- breast cancer cell line
- colorectal cancer line
- leukemia cell line
- liver cancer cell line
- kidney cancer cell line
- lung cancer cell line
- melanoma cell line
- ovarian cell line
- pancreas cell line
- gastric cancer cell line

Medicilon has established over 100 different cancer cell lines for cell-based assays including:
- breast cancer cell line
- colorectal cancer line
- leukemia cell line
- liver cancer cell line
- kidney cancer cell line
- lung cancer cell line
- melanoma cell line
- ovarian cell line
- pancreas cell line
- gastric cancer cell line

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Cell Proliferation Assays
Price on request

H-TdR

H-TdR

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Apoptosis Assays
Price on request

Medicilon has established over 100 different cancer cell lines for cell-based assays including:
- breast cancer cell line
- colorectal cancer line
- leukemia cell line
- liver cancer cell line
- kidney cancer cell line
- lung cancer cell line
- melanoma cell line
- ovarian cell line
- pancreas cell line
- gastric cancer cell line

Medicilon has established over 100 different cancer cell lines for cell-based assays including:
- breast cancer cell line
- colorectal cancer line
- leukemia cell line
- liver cancer cell line
- kidney cancer cell line
- lung cancer cell line
- melanoma cell line
- ovarian cell line
- pancreas cell line
- gastric cancer cell line

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Cell Viability Assays
Price on request

Medicilon has established over 100 different cancer cell lines for cell-based assays including:
- breast cancer cell line
- colorectal cancer line
- leukemia cell line
- liver cancer cell line
- kidney cancer cell line
- lung cancer cell line
- melanoma cell line
- ovarian cell line
- pancreas cell line
- gastric cancer cell line

Medicilon has established over 100 different cancer cell lines for cell-based assays including:
- breast cancer cell line
- colorectal cancer line
- leukemia cell line
- liver cancer cell line
- kidney cancer cell line
- lung cancer cell line
- melanoma cell line
- ovarian cell line
- pancreas cell line
- gastric cancer cell line

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Coagulation Profile
Price on request
  • Prothrombin time
  • Activated partial thromboplastin time
  • Thrombin time
  • Fibrinogen
  • Prothrombin time
  • Activated partial thromboplastin time
  • Thrombin time
  • Fibrinogen
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Compound Synthesis
Price on request
  • High quality products from mg to kg scale
  • Reagents, intermediates, building blocks, and scaffolds
  • Preparation of API or reference standards
  • Development of synthetic routes for impurities and metabolites
  • On-site analytical support
  • Product delivered with COA

Medicilon has synthesized over 10,000 individual... Show more »

  • High quality products from mg to kg scale
  • Reagents, intermediates, building blocks, and scaffolds
  • Preparation of API or reference standards
  • Development of synthetic routes for impurities and metabolites
  • On-site analytical support
  • Product delivered with COA

Medicilon has synthesized over 10,000 individual compounds from gram to kilogram quantities, and many compounds are synthesized with more than ten synthetic steps. The overall synthesis success rate is over 95%.

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API Crystallization
Price on request
  • Crystallization condition screening
  • Co-crystallization and soaking
  • 3D structural determination: novel and known structures
  • Crystallization condition screening
  • Co-crystallization and soaking
  • 3D structural determination: novel and known structures
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Custom Immunoassay Development
Price on request

Radioimmunoassay (RIA)
Immunoradiometric assay (IRMA)

Radioimmunoassay (RIA)
Immunoradiometric assay (IRMA)

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Cytotoxicity Assays
Price on request

Medicilon has established over 100 different cancer cell lines for cell-based assays including:
- breast cancer cell line
- colorectal cancer line
- leukemia cell line
- liver cancer cell line
- kidney cancer cell line
- lung cancer cell line
- melanoma cell line
- ovarian cell line
- pancreas cell line
- gastric cancer cell line

Medicilon has established over 100 different cancer cell lines for cell-based assays including:
- breast cancer cell line
- colorectal cancer line
- leukemia cell line
- liver cancer cell line
- kidney cancer cell line
- lung cancer cell line
- melanoma cell line
- ovarian cell line
- pancreas cell line
- gastric cancer cell line

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ELISA
Enzyme-linked immunosorbent assay
Price on request
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Enzyme Assays
Price on request
  • Lance assay
  • Alphascreen assay
  • Z'-LYTE assay
  • Adapta assay
  • Kinase-Glo assay
  • ADP-Glo assay
  • Ligand binding assay
  • ELISA assay
  • HTRF assay
  • Lance assay
  • Alphascreen assay
  • Z'-LYTE assay
  • Adapta assay
  • Kinase-Glo assay
  • ADP-Glo assay
  • Ligand binding assay
  • ELISA assay
  • HTRF assay
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H&E Staining
Hematoxylin and eosin staining
Price on request
  • Routine and special staining techniques
  • Preparation of slides with high quality
  • State-of-the-art automated equipment: slide and cassette printing (Leica), tissue processing (Leica), H&E staining (Leica)
  • Professional microscopic review by domestic and international pathologists
  • Routine and special staining techniques
  • Preparation of slides with high quality
  • State-of-the-art automated equipment: slide and cassette printing (Leica), tissue processing (Leica), H&E staining (Leica)
  • Professional microscopic review by domestic and international pathologists
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Chronic Inflammation Animal Models
Price on request

Sepsis

Model: CLP-induced
Species: mouse

Sepsis

Model: CLP-induced
Species: mouse

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Ligand Binding Assays
Price on request
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Protein Expression in Mammalian Cells
Mammalian cell based recombinant protein production
Price on request

Mammalian System:
- CHO, Vero, BHK, 293 cells, etc.
- Adherence and suspension culture
- Transient expression screen
- Stable cell line generation

Mammalian System:
- CHO, Vero, BHK, 293 cells, etc.
- Adherence and suspension culture
- Transient expression screen
- Stable cell line generation

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Metabolic Disease Animal Models
Price on request

Diabetes

Model: STZ-induced
Species: mouse/rat

Model: genetically engineered
Species: Db/db, ob/ob mouse

Model: High fat diet-induced obesity
Species: DIO mouse

Model: Aged, diet-induced
Species: Rhesus monkey


Obesity

Model: genetically engineered
Species: Db/db, ob/ob mouse

Model: high fat... Show more »

Diabetes

Model: STZ-induced
Species: mouse/rat

Model: genetically engineered
Species: Db/db, ob/ob mouse

Model: High fat diet-induced obesity
Species: DIO mouse

Model: Aged, diet-induced
Species: Rhesus monkey


Obesity

Model: genetically engineered
Species: Db/db, ob/ob mouse

Model: high fat diet-induced obesity (growing/established)
Species: DIO mouse


Dyslipidemia

Model: high-fat/cholesterol/fructose diet induced
Species: mouse

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Neuroscience Animal Models
Price on request

Neurological Disorders Models:

Antinociceptive pain tests

Models: hot-plate, tail flick, formalin test (phase I and phase II)
Species: mouse/rat

Model: acetic acid induced writhing
Species: mouse

Model: LPS-induced thermal hyperalgesia
Species: guinea pig

Model: STZ-induced diabetic neuropathy
Species:... Show more »

Neurological Disorders Models:

Antinociceptive pain tests

Models: hot-plate, tail flick, formalin test (phase I and phase II)
Species: mouse/rat

Model: acetic acid induced writhing
Species: mouse

Model: LPS-induced thermal hyperalgesia
Species: guinea pig

Model: STZ-induced diabetic neuropathy
Species: rat


Sedation

Model: potentiated pentobarbitol-induced sleep
Species: mouse


Antidepressant tests

Model: forced swimming test
Species: mouse/rat

Models: tail suspension test, 5-HTP-induced head twitches potentiation (5-HT), reserpine-induced ptosis, yohimbine-induced lethality
Species: mouse


Anti-Parkinson's tests

Model: oxotremorine-induced tremors/salivation
Species: mouse

Model: reserpine antagonism
Species: mouse

Model: 6-OHDA-induced rotation behavior
Species: rat


Antidementia test

Model: Morris water maze
Species: mouse/rat


Antipsychotic test

Model: apomorphine-induced stereotype
Species: mouse/rat


Anticonvulsant test

Models: MK-801 induced hyperlocomotion, pentylenetetrazol-induced clonic seizure, bicuculline-induced clonic seizure
Species: mouse


Miscellaneous

Models: picrotoxin-induced clonic seizure, rotarod, spontaneous locomotor activity
Species: mouse

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Preclinical PK/PD Studies
in vivo Pharmacokinetics/Pharmacodynamics
Price on request

Our pharmacokinetics department offers the clients a broad spectrum of high quality of services in the areas of in vitro ADME, in vivo pharmacokinetics and bioanalysis services, ranging from small molecules to large molecules, such as protein and antibody. The animal species involved in our services are non-human primate, canine,... Show more »

Our pharmacokinetics department offers the clients a broad spectrum of high quality of services in the areas of in vitro ADME, in vivo pharmacokinetics and bioanalysis services, ranging from small molecules to large molecules, such as protein and antibody. The animal species involved in our services are non-human primate, canine, mice, rat, rabbit and hamster. Meanwhile, non-human primate experimental platform and isotope platform for protein/antibody are certified by the Shanghai government.


Preclinical pharmacokinetics:
- Method development and validation (GLP, non-GLP)
- Bioanalysis
- Pharmacokinetics (tumor bearing rodents, Bioavailability, Crossover studies, Cassette (N in 1) dosing and analysis, effects of gender on pharmacokinetics, BBB penetration)
- Stability in vehicles and plasma
- Drug interaction studies
- In vitro metabolic stability
- CYP 450 inhibition
- Plasma protein binding studies
- Distribution studies
- Excretion studies
- Prediction and identification of major metabolites
- Toxicokinetics analysis


Pharmacokinetics with radiolabeled compounds:
- Protein/antibody drug with 125I labeled for PK
- Tissue distribution
- Mass balance


Pharmacokinetics package for IND filing (DMPK package for SFDA and FDA IND filing):
- Chemical compounds
- Traditional Chinese medicine
- Protein
- Antibody

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Plasmid DNA Preparation
Price on request
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Protein Purification
Price on request
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Random Mutagenesis
Price on request
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Recombinant Protein Expression
Price on request

Baculovirus system:
- Generation of high titre baculovirus stock (BV stock)
- Expression & optimization in in Sf9, Sf21, and Hi5 cell lines
- Pilot protein expression and purification

Baculovirus system:
- Generation of high titre baculovirus stock (BV stock)
- Expression & optimization in in Sf9, Sf21, and Hi5 cell lines
- Pilot protein expression and purification

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Renal Disease Animal Models
Price on request

Renal failure

Model: 5/6 nephrectomy
Species: rat

Renal failure

Model: 5/6 nephrectomy
Species: rat

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Site-Directed Mutagenesis
Price on request
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Special Slide Staining
Price on request
  • Routine and special staining techniques
  • Preparation of slides with high quality
  • State-of-the-art automated equipment: slide and cassette printing (Leica), tissue processing (Leica), H&E staining (Leica)
  • Professional microscopic review by domestic and international pathologists
  • Routine and special staining techniques
  • Preparation of slides with high quality
  • State-of-the-art automated equipment: slide and cassette printing (Leica), tissue processing (Leica), H&E staining (Leica)
  • Professional microscopic review by domestic and international pathologists
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Tissue Preparation
Price on request
  • Routine and special staining techniques
  • Preparation of slides with high quality
  • State-of-the-art automated equipment: slide and cassette printing (Leica), tissue processing (Leica), H&E staining (Leica)
  • Professional microscopic review by domestic and international pathologists
  • Routine and special staining techniques
  • Preparation of slides with high quality
  • State-of-the-art automated equipment: slide and cassette printing (Leica), tissue processing (Leica), H&E staining (Leica)
  • Professional microscopic review by domestic and international pathologists
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Urinalysis
Price on request
  • Volume
  • Specific gravity
  • pH
  • Color and appearance
  • Protein
  • Glucose
  • Bilirubin
  • Ketones
  • Blood
  • Urobilinogen
  • Nitrite
  • Leukocyte
  • Microscopy of centrifuged sediment
  • Volume
  • Specific gravity
  • pH
  • Color and appearance
  • Protein
  • Glucose
  • Bilirubin
  • Ketones
  • Blood
  • Urobilinogen
  • Nitrite
  • Leukocyte
  • Microscopy of centrifuged sediment
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Human Tumor Xenograft Models
Price on request

Cancer Xenograft Models

Model: breast cancer
Cell lines: MDA-MB-435S, MDA-MB-231, MDA-MB-361 (Estrogen-dependent)
Species: Balb/c nude mouse


Model: colon cancer
Cell lines: HT-29, HCT-116, LoVo, RKO, COLO205
Species: Balb/c nude mouse


Model: glioblastoma
Cell line: U87-MG
Species: Balb/c nude... Show more »

Cancer Xenograft Models

Model: breast cancer
Cell lines: MDA-MB-435S, MDA-MB-231, MDA-MB-361 (Estrogen-dependent)
Species: Balb/c nude mouse


Model: colon cancer
Cell lines: HT-29, HCT-116, LoVo, RKO, COLO205
Species: Balb/c nude mouse


Model: glioblastoma
Cell line: U87-MG
Species: Balb/c nude mouse


Model: prostate cancer
Cell lines: DU145, PC-3
Species: Balb/c nude mouse


Model: lung cancer
Cell lines: A549, H460, NCI-H358, NCI-H1650
Species: Balb/c nude mouse

Model: lung cancer
Cell line: LLC
Species: C57BL/6 mouse


Model: melanoma
Cell line: A-375
Species: Balb/c nude mouse

Model: melanoma
Cell line: B16
Species: C57BL/6 mouse


Model: leukemia
Cell line: L1210 (mouse lymphocytic leukemia)
Species: DBA/2 mouse

Model: leukemia
Cell line: K562 (human erythromyeloblastoid leukemia)
Species: Balb/c nude mouse

Model: leukemia
Cell line: HL-60 (human promyelocytic leukemia)
Species: Balb/c nude mouse


Model: lymphoma
Cell line: WSU-luc
Species: SCID mouse


Model: renal cancer
Cell line: 786-O
Species: Balb/c nude mouse


Model: sarcoma
Cell line: S-180
Species: CD-1 (ICR) mouse


Model: pancreatic cancer
Cell line: MIA Paca, Bx-PC3
Species: Balb/c nude mouse

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Biochemical Assays
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Clinical Hematology
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Clinical and Anatomic Pathology
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ADME and DMPK Studies
Drug Metabolism and Pharmacokinetics
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Cell Viability & Proliferation Assays
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Immunology Animal Models
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Formulation & Manufacturing
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Cardiovascular Animal Models
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Oncology Animal Models
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Biology
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CNS/Neurology Animal Models
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Common Histochemical Stains
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Animal Models and Studies
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Chemistry and Materials
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Pharmacology & Toxicology
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Nephrology Animal Models
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Protein Quantification
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Protein Services
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Toxicology
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Cell Invasion & Migration Assays
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Cells and Tissues
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Nucleic Acid Services
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Protein Purification and Quantification
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Histological Staining
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DNA
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Tissue Processing
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Clinical Chemistry
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Synthetic Chemistry
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Animal Models of Disease
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Biospecimens
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Mutagenesis
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Cell Death Assays
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Protein Expression
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Xenograft Models
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Inflammation Animal Models
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Immunoassays
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Metabolic Animal Models
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Biomolecular Interaction Analysis
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Clinical Research
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Clinical Laboratory Services
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Plasmids and Vectors
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Biochemistry & Molecular Biology
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Cell-Based Assays
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