1314212146000

Shakti BioResearch LLC

Woodbridge, Connecticut, US

Shakti BioResearch provides consultant and laboratory services to biotech and pharmaceutical industries as well as academic research laboratories. We bring with us over 10 years of experience in drug discovery and applied research to provide timely, focused, and meaningful results.

Shakti means energy. At Shakti BioResearch we strive to blend Shakti with Science and Sincerity.

We provide services under GLP and FDA guidelines.


Lab Team:

Ajay Bhargava, PhD
Founder and Chief Scientific Officer
- Dr. Bhargava received PhD from Indian Institute of Science, Bangalore, India. After post-doctoral studies with Professor Sherman Weissman at Yale University, Dr. Bhargava joined Bayer Corporation. At Bayer, he worked on target identification, target validation and assay development projects in osteoarthritis, osteoporosis and oncology therapeutic areas. Within oncology, he worked on various drug discovery... Show more »

Shakti BioResearch provides consultant and laboratory services to biotech and pharmaceutical industries as well as academic research laboratories. We bring with us over 10 years of experience in drug discovery and applied research to provide timely, focused, and meaningful results.

Shakti means energy. At Shakti BioResearch we strive to blend Shakti with Science and Sincerity.

We provide services under GLP and FDA guidelines.


Lab Team:

Ajay Bhargava, PhD
Founder and Chief Scientific Officer
- Dr. Bhargava received PhD from Indian Institute of Science, Bangalore, India. After post-doctoral studies with Professor Sherman Weissman at Yale University, Dr. Bhargava joined Bayer Corporation. At Bayer, he worked on target identification, target validation and assay development projects in osteoarthritis, osteoporosis and oncology therapeutic areas. Within oncology, he worked on various drug discovery projects including kinases, cytotoxics and hypoxia pathway inhibitors. Dr. Bhargava led cross functional, preclinical drug discovery project teams towards Phase I clinical trials. Dr. Bhargava has authored several peer-reviewed international scientific publications.

Stanley Menacherry, PhD, MBA
Quality Assurance Officer
- Dr. Menacherry has 25 years of experience in Analytical and Bioanalytical Chemistry. During his career he has worked in diverse industry segments ranging from food /beverages, paper /plastics, and the pharmaceutical industry. He obtained his PhD in Analytical Chemistry from Emory University (1991) while holding a research assistantship at the Centers for Disease Control. Recently employment experience includes Abbott Laboratories and Bayer Pharmaceuticals. His main areas of expertise are the development and validation of LC/MS/MS assays, GLP compliance, Design and conduct of Preclinical Pharmacokinetic studies, planning and conduct of preclinical studies for the ADME section of IND and NDA submissions. He is has an appointment as Professional in Residence at the University of New Haven, CT.


Shakti BioResearch, a Consultancy and Laboratory Service Provider, was established in 2007. It
is located at 1 Bradley Road, Suite 401, Woodbridge CT 06525.

Laboratory is well equipped to support pharmaceutical research and development. We offer a
full array of services in support of research, preclinical, and clinical trials.

Our laboratory is equipped with biological hood and incubators for cell culture work. To support
molecular biology and assay development work, our laboratory is equipped with PCR machines,
MicroLumatPlus Luminometer, Spectramax plate reader with SoftMax PRO software, BioTek
ELx405 plate washer, and other support equipment such as multichannel pipettors, table top
centrifuges, water baths, balances, pH meter, refrigerators and freezers, etc. All laboratory
equipments are calibrated regularly to maintain the integrity of our work.

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RT-PCR
Reverse transcription polymerase chain reaction
Starting at $20.00 per sample

RNA isolation and RT-qPCR

RNA isolation and RT-qPCR

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Antigen Expression and Purification
Price on request

Protein Expression and Purification
• Bacterial, Insect and Mammalian Systems

Protein Expression and Purification
• Bacterial, Insect and Mammalian Systems

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Cell Migration Assays
Price on request
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Cell Proliferation Assays
Starting at $150.00 per cell line

An 8-point curve will be generated. Average of 2 values will be reported.
Price is quoted for a minimum of either 10 compounds or 10 cell lines to be tested at the same time.

$150/- per cell line per compound

An 8-point curve will be generated. Average of 2 values will be reported.
Price is quoted for a minimum of either 10 compounds or 10 cell lines to be tested at the same time.

$150/- per cell line per compound

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Apoptosis Assays
Price on request
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Cell Viability Assays
Price on request
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Cell-Based Compound Screening
Price on request
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Custom Cell-Based Assays
Price on request
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Cytotoxicity Assays
Starting at $1,000.00 per sample

Anti-proliferative IC50 will be determined using Promega's Cell Titer Glo reagent. An 8 point curve will be generated with duplicate values at each point. Experiment will be repeated and an average of two IC50 values will be reported. One compound + one control compound will be tested in three cell lines.

Anti-proliferative IC50 will be determined using Promega's Cell Titer Glo reagent. An 8 point curve will be generated with duplicate values at each point. Experiment will be repeated and an average of two IC50 values will be reported. One compound + one control compound will be tested in three cell lines.

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DNA Library Screening
Price on request
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ELISA
Enzyme-linked immunosorbent assay
Starting at $218.00 per plate

In collaboration with our affiliate NorthEast Bioanalytical Laboratories, we provide services under GLP and FDA guidelines for:

• ELISA based assays
• Translational medicine assays

$218 per ELISA with a minimum of 4 ELISA's assayed at a time.

Capabilities:
- Kit-based, custom designed ELISA
- Sandwich,... Show more »

In collaboration with our affiliate NorthEast Bioanalytical Laboratories, we provide services under GLP and FDA guidelines for:

• ELISA based assays
• Translational medicine assays

$218 per ELISA with a minimum of 4 ELISA's assayed at a time.

Capabilities:
- Kit-based, custom designed ELISA
- Sandwich, competitive, in-Cell ELISA (ICE)
- Homogenization of cell/tissue lysates
- Transfection/Transduction of mammalian/non-mammalian cells
- Optimization of protocols for commercial kits
- Analyze serum, plasma, cells, tissues
- Analyze fluorescent/chemiluminescent/chromogenic/radioactive substrates

Equipment:
- SpectraMax® M5e
- Multi-channel pipets

Number of samples processed in a single experiment: 72

Typical turn-around time: 5 days

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Luciferase Assays
Price on request
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Molecular Cloning
Starting at $300.00 per clone

Subcloning $300

PCR based cloning $0.25/bp (Minimum 1kb gene)

Subcloning $300

PCR based cloning $0.25/bp (Minimum 1kb gene)

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Site-Directed Mutagenesis
Price on request
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T Cell Activation and Proliferation Assays
Price on request
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Western Blot
Price on request

Capabilities:
- Homogenization of cell, tissue lysates
- Sonication of cell, tissue lysates
- Fractionate lysates prior to gel loading
- Transfection/Transduction of mammalian/non-mammalian cells
- In-house cell lines (a collection of 80 cell lines)
- Protein concentration determination
- Strip/reprobe membranes
- Commonly... Show more »

Capabilities:
- Homogenization of cell, tissue lysates
- Sonication of cell, tissue lysates
- Fractionate lysates prior to gel loading
- Transfection/Transduction of mammalian/non-mammalian cells
- In-house cell lines (a collection of 80 cell lines)
- Protein concentration determination
- Strip/reprobe membranes
- Commonly used antibodies available
- Optimize protocols for particular antigen/target

Visualization:
- Chemiluminescent substrates on x-ray film
- Ponceau S staining

Equipment:
- XCell SureLock™
- iBlot®
- Wet/Dry transfers

Number of samples in a single run: 10

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Cell-Based Assays
Price on request
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Drug Discovery & Development
Price on request
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Cell Viability & Proliferation Assays
Price on request
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Specialized Cell-Based Assays
Price on request
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In vitro Reporter Gene Assays
Price on request
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Hit Identification
Price on request
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Antibody Services
Price on request
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Toxicology
Price on request
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Cell Invasion & Migration Assays
Price on request
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Immune Cell Assays
Price on request
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Protein Quantification
Price on request
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Nucleic Acid Services
Price on request
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DNA Extraction and Purification
Price on request
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Protein Services
Price on request
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Protein Expression Visualization
Price on request
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Pharmacology & Toxicology
Price on request
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Mutagenesis
Price on request
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Cell Death Assays
Price on request
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Biology
Price on request
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Drug Discovery
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Functional & Cell Type Specific Assays
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Biochemistry & Molecular Biology
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PCR
Price on request

PCR Services

PCR Services

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DNA
Price on request

DNA Services

DNA Services

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2018-05-05 01:32:20 +1200

Net Promoter Score of 10 received for Western Blot.

Additional Ratings: satisfaction with deliverable: 10, satisfaction with timeliness: 10.
2018-05-02 10:08:17 +1200

Net Promoter Score of 9 received for ELISA.

Additional Ratings: satisfaction with deliverable: 9, satisfaction with timeliness: 8.
2018-05-02 09:52:55 +1200

Net Promoter Score of 10 received for Western Blot.

2018-04-25 08:59:04 +1200

Net Promoter Score of 10 received for Western Blot.

Additional Ratings: satisfaction with deliverable: 10, satisfaction with timeliness: 10.
2018-04-18 17:11:20 +1200

Net Promoter Score of 10 received for Cell-Based Compound Screening.

Additional Ratings: satisfaction with deliverable: 10, satisfaction with timeliness: 10.
2018-04-13 01:32:03 +1200

Net Promoter Score of 10 received for Western Blot.

Additional Ratings: satisfaction with deliverable: 10, satisfaction with timeliness: 10.
2018-04-06 04:20:38 +1200

Net Promoter Score of 10 received for Western Blot.

Additional Ratings: satisfaction with deliverable: 10, satisfaction with timeliness: 10.
2018-04-03 08:22:31 +1200

Net Promoter Score of 10 received for Biology.

Additional Ratings: satisfaction with deliverable: 10, satisfaction with timeliness: 10.
2018-03-27 03:42:53 +1300

Net Promoter Score of 10 received for Cell-Based Compound Screening.

Additional Ratings: satisfaction with deliverable: 10, satisfaction with timeliness: 10.
2018-03-22 04:59:38 +1300

Net Promoter Score of 9 received for Western Blot.

Additional Ratings: satisfaction with deliverable: 9, satisfaction with timeliness: 9.
2018-03-16 05:40:51 +1300

Net Promoter Score of 9 received for ELISA.

Additional Ratings: satisfaction with deliverable: 9, satisfaction with timeliness: 9.
2018-03-08 04:39:54 +1300

Net Promoter Score of 9 received for Western Blot.

Additional Ratings: satisfaction with deliverable: 9, satisfaction with timeliness: 10.
2018-03-05 18:57:30 +1300

Net Promoter Score of 9 received for ELISA.

Additional Ratings: satisfaction with deliverable: 9, satisfaction with timeliness: 9.
2018-03-05 13:20:13 +1300

Net Promoter Score of 10 received for Western Blot.

Additional Ratings: satisfaction with deliverable: 10, satisfaction with timeliness: 10.
2018-02-09 13:15:47 +1300

Net Promoter Score of 10 received for Cell-Based Compound Screening.

Additional Ratings: satisfaction with deliverable: 10, satisfaction with timeliness: 10.
2018-01-21 12:02:39 +1300

Net Promoter Score of 10 received for Cell-Based Compound Screening.

Additional Ratings: satisfaction with deliverable: 10, satisfaction with timeliness: 10.
2017-12-23 15:01:43 +1300

Net Promoter Score of 10 received for Cell-Based Compound Screening.

Additional Ratings: satisfaction with deliverable: 10, satisfaction with timeliness: 10.
2017-12-21 19:16:02 +1300

Net Promoter Score of 9 received for Western Blot.

Additional Ratings: satisfaction with deliverable: 9, satisfaction with timeliness: 9.
2017-12-08 14:23:17 +1300

Net Promoter Score of 9 received for Western Blot.

Additional Ratings: satisfaction with deliverable: 9, satisfaction with timeliness: 9.
2017-12-07 13:20:48 +1300

Net Promoter Score of 9 received for ELISA.

Additional Ratings: satisfaction with deliverable: 9, satisfaction with timeliness: 9.
2017-11-29 13:09:39 +1300

Net Promoter Score of 9 received for Western Blot.

Additional Ratings: satisfaction with deliverable: 9, satisfaction with timeliness: 10.
November 28, 2017

Positive review received for Western Blot:

"Highly recommend Ajay and his team for the quality work and excellent turnaround time."

2017-11-23 06:07:21 +1300

Net Promoter Score of 10 received for Cell-Based Compound Screening.

Additional Ratings: satisfaction with deliverable: 10, satisfaction with timeliness: 10.
November 4, 2017

Positive review received for Cell Proliferation Assays:

"These guys are good. They know their stuff, they don't waste your time and their pricing is fair. Strongly recommend."

2017-11-04 06:02:26 +1300

Net Promoter Score of 10 received for Cell Proliferation Assays.

Additional Ratings: satisfaction with deliverable: 10, satisfaction with timeliness: 10.
2017-07-18 09:07:37 +1200

Net Promoter Score of 9 received for Western Blot.

Additional Ratings: satisfaction with deliverable: 9, satisfaction with timeliness: 9.
2017-07-18 09:07:00 +1200

Net Promoter Score of 9 received for Western Blot.

Additional Ratings: satisfaction with deliverable: 9, satisfaction with timeliness: 9.
2017-07-14 09:20:13 +1200

Net Promoter Score of 8 received for Western Blot.

Additional Ratings: satisfaction with deliverable: 8, satisfaction with timeliness: 10.
2017-07-14 09:19:46 +1200

Net Promoter Score of 8 received for Western Blot.

Additional Ratings: satisfaction with deliverable: 8, satisfaction with timeliness: 10.
2017-07-06 10:45:39 +1200

Net Promoter Score of 8 received for Western Blot.

Additional Ratings: satisfaction with deliverable: 9, satisfaction with timeliness: 9.
2017-06-29 05:22:00 +1200

Net Promoter Score of 9 received for Western Blot.

Additional Ratings: satisfaction with deliverable: 9, satisfaction with timeliness: 9.
2017-06-29 05:20:54 +1200

Net Promoter Score of 9 received for Western Blot.

Additional Ratings: satisfaction with deliverable: 9, satisfaction with timeliness: 9.
2017-06-29 05:17:18 +1200

Net Promoter Score of 9 received for Western Blot.

Additional Ratings: satisfaction with deliverable: 9, satisfaction with timeliness: 9.
2017-06-29 05:16:23 +1200

Net Promoter Score of 9 received for Western Blot.

Additional Ratings: satisfaction with deliverable: 9, satisfaction with timeliness: 9.
2017-06-29 05:15:41 +1200

Net Promoter Score of 9 received for Western Blot.

Additional Ratings: satisfaction with deliverable: 9, satisfaction with timeliness: 9.
2017-06-29 05:14:55 +1200

Net Promoter Score of 9 received for Western Blot.

Additional Ratings: satisfaction with deliverable: 9, satisfaction with timeliness: 9.
2017-06-29 05:14:08 +1200

Net Promoter Score of 9 received for Western Blot.

Additional Ratings: satisfaction with deliverable: 9, satisfaction with timeliness: 9.
2017-06-29 05:13:16 +1200

Net Promoter Score of 9 received for Western Blot.

Additional Ratings: satisfaction with deliverable: 9, satisfaction with timeliness: 9.
2017-06-29 05:12:05 +1200

Net Promoter Score of 9 received for Western Blot.

Additional Ratings: satisfaction with deliverable: 9, satisfaction with timeliness: 9.
2017-06-29 05:11:07 +1200

Net Promoter Score of 9 received for Western Blot.

Additional Ratings: satisfaction with deliverable: 9, satisfaction with timeliness: 9.
2017-06-29 05:10:14 +1200

Net Promoter Score of 9 received for Western Blot.

Additional Ratings: satisfaction with deliverable: 9, satisfaction with timeliness: 9.
2017-06-29 05:04:48 +1200

Net Promoter Score of 9 received for Western Blot.

Additional Ratings: satisfaction with deliverable: 9, satisfaction with timeliness: 9.
May 18, 2017

Positive review received for Western Blot:

"Ajay and his team has been doing excellent work and their deliverable are usually very fast too"

May 17, 2017

Positive review received for Cell-Based Compound Screening:

"These guys are great. Fast, reasonably priced, and they do the job right. Wish a lot more vendors on SE were like this one!"

2017-05-16 10:42:18 +1200

Net Promoter Score of 9 received for Western Blot.

Additional Ratings: satisfaction with deliverable: 9, satisfaction with timeliness: 9.
2017-05-16 08:36:04 +1200

Net Promoter Score of 10 received for ELISA.

Additional Ratings: satisfaction with deliverable: 9, satisfaction with timeliness: 9.
2017-02-25 07:44:47 +1300

Net Promoter Score of 9 received for Western Blot.

Additional Ratings: satisfaction with deliverable: 9, satisfaction with timeliness: 9.
2017-02-25 07:44:00 +1300

Net Promoter Score of 9 received.

Additional Ratings: satisfaction with deliverable: 9, satisfaction with timeliness: 9.
2017-02-25 07:41:45 +1300

Net Promoter Score of 9 received for Western Blot.

Additional Ratings: satisfaction with deliverable: 9, satisfaction with timeliness: 9.
2017-02-25 07:40:14 +1300

Net Promoter Score of 9 received for Western Blot.

Additional Ratings: satisfaction with deliverable: 9, satisfaction with timeliness: 9.
December 30, 2016

Positive review received for Apoptosis Assays:

"I am interested in the work done by Shakti BioResearch. Regarding apoptosis assay I was hoping to see apoptosis in the form of DNA fragmented ladder and I was disappointed when not see this ladder on the gel photo. Regarding"

December 9, 2016

Positive review received for Cell Proliferation Assays:

"Excellent"

November 7, 2016

Positive review received for Western Blot:

"Know their stuff. No nonsense. No games."

November 5, 2016

Positive review received for Western Blot:

"Ajay is very responsive and flexible. Would like to work with him again"

2016-07-12 04:29:29 +1200

Net Promoter Score of 10 received for ELISA.

2016-06-22 10:14:19 +1200

Net Promoter Score of 10 received for Custom Cell-Based Assays.

Additional Ratings: satisfaction with deliverable: 10, satisfaction with timeliness: 10.
2016-06-21 12:08:36 +1200

Net Promoter Score of 10 received for Cell Proliferation Assays.

Additional Ratings: satisfaction with deliverable: 10, satisfaction with timeliness: 8.
February 20, 2016

Positive review received for Custom Cell-Based Assays:

"My work was done on time and responses to enquiries were prompt and am pleased with their service. I recommend them highly"

March 12, 2014

Positive review received for Western Blot:

"Ajay was very communicative, and he went out of his way to accommodate some extra items we needed for these Validation projects. I would definitely recommend working with Ajay."

January 23, 2014

Positive review received for ELISA:

"A very quick turn around time and nicely communicative"

September 26, 2013

Positive review received for ELISA:

"Excellent provider of ELISA kit validation - I would highly recommend."

February 20, 2013

Positive review received for ELISA:

"Very professional and informed."

December 12, 2012

Positive review received for Yeast Strain Construction and Optimization:

"I requested about a dozen yeast deletion strains and received them after 5 weeks with good communication throughout the process. In fairness Ajay's team hadn't worked with this protocol before, and I knew that going into the project. One concern was that the positive control PCR reactions used to validate the constructed strains were not 100% clear. Next time, I would request a test sample before proceeding to the full project phase."

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