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Sengenics

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Singapore, SG

About Sengenics

Our correctly folded spike, nucleocapsid or envelope COVID-19 antigens can be used to produce high-affinity vaccines.

Sengenics is a Functional Proteomics company that was originally spun out from research that was carried out at Cambridge University in the UK. The company has a patented technology called KREX™ which has world renowned customers and collaborators that include top pharma, biotech companies and Ivy League academic institutions in the USA, Europe and Asia. The company is focused on leveraging its KREX™ protein folding technology in the identification of novel biomarkers in a wide variety of human infectious and non-communicable diseases - including those where autoimmune dysfunction is involved - and their translation in to new diagnostic tests and therapies. KREX™ is also being used for a variety of applications that are critical for the Pharmaceutical industry, including: vaccine efficacy studies, predicting toxicity, protein interactions and developing companion diagnostics. The fundamental research for KREX™ was led by Professor Jonathan Blackburn as a collaboration between Oxford and Cambridge University in the early 2000s. Jonathan is the CSO of Sengenics and the inventor of KREX™.

The key application of KREX™ is the discovery of autoantibody biomarkers for two core medical use cases:

1. Drug efficacy, irAEs and CDx
Stratify patients based on autoantibody profiles detected using our KREX™ protein array technology into responders, non-responders and those exhibiting irAEs. This can guide "decision-making" strategies for improvement of drug development success rates as well as enhancing drug efficacy and safety.

2. aAB-based diagnostics and therapeutics
Discover novel autoantibody biomarkers for early diagnosis of cancers, autoimmune and neurodegenerative diseases. Some autoantibodies that identified as diagnostic biomarkers may be protective with potential in themselves as therapeutic biomolecules.

Our Services (3)


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IMMUNOME™ Protein Array

Price on request

Description:
IMMUNOME™ v4 Discovery Array is a protein array which utilises the patented Sengenics KREX™ functional proteomics technology. All proteins on the IMMUNOME™ v4 Discovery Array are correctly folded and functional as they are expressed as fusion proteins with biotin carboxyl carrier protein (BCCP) which acts as a folding marker and solubility enhancer. The IMMUNOME™ v4 Discovery Array contains 1600+ full-length human proteins from biologically significant protein families including kinases, signalling molecules, cytokines, interleukins, chemokines and cancer antigens. The arrays are coated with a proprietary surface which preserves protein folding and inhibits binding of non-specific proteins.

  1. Discovery of autoantibody biomarkers for diagnostics

  2. Discovery of autoantibody biomarkers of risk of adverse drug reactions

  3. Discovery of autoantibody-based therapeutic and prophylactic biologics

  4. Determining effect of citrullination on autoantibody interactions

  5. Functional assays for any protein or any interacting biomolecule

Specifications:

  • Product name: IMMUNOME™ v4 Discovery Array
  • Minimum Order: 30 slides
  • Slide Type: Streptavidin-coated glass slide
  • Species: Human

Contents and Storage:

  • Store for up to 12 months at -20°c.

Offered as:

  • KREX™ TEST Package – IMMUNOME™ V4 Discovery Array Service of 30 samples
  • KREX™ EVAL Package – IMMUNOME™ V4 Discovery Array Service of 50 samples
  • KREX™ EXPLORE Package – IMMUNOME™ V4 Discovery Array Service of 100 samples
  • KREX™ VALIDATE Package – IMMUNOME™ V4 Discovery Array Service of 400 samples

Delivery lead time: 2 – 4 weeks

Oncology Autoimmune disease Neurodegenerative diseases Autism Parkinson's disease (PD) Alzheimers Disease Infectious Disease Dengue virus infection Zika virus infection Serum Proteins DNA RNA Biology Drug Discovery Plasma Ascites Systemic Lupus Erythematosus (SLE) Show 18 more tags Show less

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Custom Protein Arrays

Price on request

Description:

  • The KREX™ Custom Array is a protein array which utilises the patented Sengenics KREX™ functional proteomics technology.
  • The array can be customised with any protein, any number of proteins, any species (bacterial, baculovirus, mammalian) and format (16-plex, 8-plex, 4-plex, 2-plex and single format).
  • Sengenics only offers immobilised proteins onto a specified solid support format for the KREX™ Custom Array.

Specifications:
Product name: KREX™ Custom Array
Minimum Order: 25 slides
Slide Type: Streptavidin-coated glass slide
Species: Customer-specified

Contents and Storage:

  • Each slide can contain up to 16 arrays. Total maximum number of arrays in every kit (16 arrays x 25 slides) = 400 arrays.
  • Store for up to 12 months at -20°c.

Delivery lead time: 3 – 6 months

Alzheimers Disease Autism Autoimmune disease Oncology Dengue virus infection Infectious Disease Neurodegenerative diseases Parkinson's disease (PD) Systemic Lupus Erythematosus (SLE) Zika virus infection Biology Drug Discovery Ascites DNA Plasma Proteins RNA Serum Show 18 more tags Show less

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Cancer-Testis Antigen (CTA) Array

Price on request

Description:

  • KREX™-based protein array for high-throughput quantification of autoantibodies to Cancer-Testis (CT) antigens. CT antigens are a group of unrelated proteins that show highly restricted expression profiles in adult somatic tissues but which are aberrantly expressed in various cancers.

Key applications:

  1. Unique differential profiling of cancer-antigen in various cancer types
  2. Patient stratification in checkpoint inhibitor studies
  3. Determination of epitope recognition in patients or monitor patients in experimental cancer vaccine studies.

Specifications:
Product name: CTA Array
Minimum Order: 5 slides
Slide Type: Streptavidin-coated glass slide
Species: Human

Contents and Storage:

  • Contains 5 slides. Each slide contains 4 microarrays. Total number of arrays in every kit (4 arrays x 5 slides) = 20 arrays. Each array contains 167 CT antigens spotted in triplicate.
  • Store for up to 12 months at -20°c.

Delivery lead time: 4 – 6 weeks

Oncology Biology Drug Discovery Serum Plasma Ascites Proteins DNA RNA Show 9 more tags Show less

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Sharifah Ibrahim

Finance Manager

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