Sengenics

The Sengenics AxCESS research service packages feature three KREX-based functional protein arrays developed for high-throughput and cost-effective immuno-proteomics applications. These protein arrays utilise the patented KREX protein folding technology for the production of full-length, correctly folded and functional proteins.

This range of arrays provide easy access to Sengenics’ KREX technology to enable high-specificity autoantibody characterisation with a focus on autoimmune, cancer and neurodegenerative disorders. All packages are carried out on a standard “fee-for-service” basis that include running of assays with integrated bioinformatics analysis and reporting.

Sengenics AxCESS arrays:

Immunome AxCESS array

Contains over 1600 correctly folded and functional human proteins spotted in duplicate. Screen up to 2 samples per slide. Key applications include:

•         Diagnose cancer and autoimmune diseases early
•         Intra-disease specification
•         Identify drug response signatures
•         Predict ADRs and irAEs

CTA AxCESS array

Contains over 200 correctly folded and functional CT antigens spotted in duplicate. Screen up to 8 samples per slide. Key applications include:

•         High-throughput profiling of cancer antigens
•         Identify drug response signatures
•         Patient stratification in checkpoint inhibitor studies

OncoREX p53 AxCESS array

Contains over 100 correctly folded and functional wild type and mutant p53 spotted in duplicate. Screen up to 8 samples per slide. Key applications include:

•         High-throughput quantification of autoantibodies to wild-type and mutant p53
•         Determine the effect of p53 mutations on antibody binding