Sengenics

Description:
IMMUNOME™ v4 Discovery Array is a protein array which utilises the patented Sengenics KREX™ functional proteomics technology. All proteins on the IMMUNOME™ v4 Discovery Array are correctly folded and functional as they are expressed as fusion proteins with biotin carboxyl carrier protein (BCCP) which acts as a folding marker and solubility enhancer. The IMMUNOME™ v4 Discovery Array contains 1600+ full-length human proteins from biologically significant protein families including kinases, signalling molecules, cytokines, interleukins, chemokines and cancer antigens. The arrays are coated with a proprietary surface which preserves protein folding and inhibits binding of non-specific proteins.

1. Discovery of autoantibody biomarkers for diagnostics

2. Discovery of autoantibody biomarkers of risk of adverse drug reactions

3. Discovery of autoantibody-based therapeutic and prophylactic biologics

4. Determining effect of citrullination on autoantibody interactions

5. Functional assays for any protein or any interacting biomolecule

Specifications:

• Product name: IMMUNOME™ v4 Discovery Array
• Minimum Order: 30 slides
• Slide Type: Streptavidin-coated glass slide
• Species: Human

Contents and Storage:

• Store for up to 12 months at -20°c.

Offered as:

• KREX™ TEST Package – IMMUNOME™ V4 Discovery Array Service of 30 samples
• KREX™ EVAL Package – IMMUNOME™ V4 Discovery Array Service of 50 samples
• KREX™ EXPLORE Package – IMMUNOME™ V4 Discovery Array Service of 100 samples
• KREX™ VALIDATE Package – IMMUNOME™ V4 Discovery Array Service of 400 samples

Delivery lead time: 2 – 4 weeks

Description:

• The KREX™ Custom Array is a protein array which utilises the patented Sengenics KREX™ functional proteomics technology.
• The array can be customised with any protein, any number of proteins, any species (bacterial, baculovirus, mammalian) and format (16-plex, 8-plex, 4-plex, 2-plex and single format).
• Sengenics only offers immobilised proteins onto a specified solid support format for the KREX™ Custom Array.

Specifications:
Product name: KREX™ Custom Array
Minimum Order: 25 slides
Slide Type: Streptavidin-coated glass slide
Species: Customer-specified

Contents and Storage:

• Each slide can contain up to 16 arrays. Total maximum number of arrays in every kit (16 arrays x 25 slides) = 400 arrays.
• Store for up to 12 months at -20°c.

Delivery lead time: 3 – 6 months

Description:

• KREX™-based protein array for high-throughput quantification of autoantibodies to Cancer-Testis (CT) antigens. CT antigens are a group of unrelated proteins that show highly restricted expression profiles in adult somatic tissues but which are aberrantly expressed in various cancers.

Key applications:

1. Unique differential profiling of cancer-antigen in various cancer types
2. Patient stratification in checkpoint inhibitor studies
3. Determination of epitope recognition in patients or monitor patients in experimental cancer vaccine studies.

Specifications:
Product name: CTA Array
Minimum Order: 5 slides
Slide Type: Streptavidin-coated glass slide
Species: Human

Contents and Storage:

• Contains 5 slides. Each slide contains 4 microarrays. Total number of arrays in every kit (4 arrays x 5 slides) = 20 arrays. Each array contains 167 CT antigens spotted in triplicate.
• Store for up to 12 months at -20°c.

Delivery lead time: 4 – 6 weeks