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Sengenics International Pte Ltd

Singapore, SG

Sengenics is a Functional Proteomics company that was originally spun out from research that was carried out at Cambridge University in the UK. The company has a patented technology called KREX™ which has world renowned customers and collaborators that include top pharma, biotech companies and Ivy League academic institutions in the USA, Europe and Asia.

The company is focused on leveraging its KREX™ protein folding technology in the identification of novel biomarkers in a wide variety of human infectious and non-communicable diseases - including those where autoimmune dysfunction is involved - and their translation in to new diagnostic tests and therapies. KREX™ is also being used for a variety of applications that are critical for the Pharmaceutical industry, including: vaccine efficacy studies, predicting toxicity, protein interactions and developing companion diagnostics. The fundamental research for KREX™ was... Show more »

Sengenics is a Functional Proteomics company that was originally spun out from research that was carried out at Cambridge University in the UK. The company has a patented technology called KREX™ which has world renowned customers and collaborators that include top pharma, biotech companies and Ivy League academic institutions in the USA, Europe and Asia.

The company is focused on leveraging its KREX™ protein folding technology in the identification of novel biomarkers in a wide variety of human infectious and non-communicable diseases - including those where autoimmune dysfunction is involved - and their translation in to new diagnostic tests and therapies. KREX™ is also being used for a variety of applications that are critical for the Pharmaceutical industry, including: vaccine efficacy studies, predicting toxicity, protein interactions and developing companion diagnostics. The fundamental research for KREX™ was led by Professor Jonathan Blackburn as a collaboration between Oxford and Cambridge University in the early 2000s. Jonathan is the CSO of Sengenics and the inventor of KREX™.

The 5 key applications of KREX are:
1. Discovery of autoantibody biomarkers for diagnostics
2. Discovery of autoantibody biomarkers of risk of adverse drug reactions
3. Discovery of autoantibody-based therapeutic and prophylactic biologics
4. Selectivity screens for new chemical entities and new biologics
5. Functional assays for any protein and any interacting biomolecule

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Protein Arrays
Starting at $1,760.00 per slide

The Sengenics Immunome protein array contains more than 1600 full-length human proteins.

EVERY protein is correctly folded and functional. This ensures that both conformational and linear epitopes are recognised. Hence, results from using the Immunome array are far more likely to be biologically meaningful.

Every protein on... Show more »

The Sengenics Immunome protein array contains more than 1600 full-length human proteins.

EVERY protein is correctly folded and functional. This ensures that both conformational and linear epitopes are recognised. Hence, results from using the Immunome array are far more likely to be biologically meaningful.

Every protein on the array is cloned in frame with the BCCP folding marker. Misfolded proteins will not become biotinylated and are washed away.

Only correctly folded proteins will become biotinylated and immobilized on the array.

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Custom Protein Array
Price on request

Express proteins

  • Milligram quantities
  • Any number of proteins
  • Any protein
  • Various expression systems

Membrane proteins can be attached embedded in fragments of cell membrane

  • Expressing the full length protein embedded in the insect cell membrane
  • Use differential detergent extractions or sonication to... Show more »

Express proteins

  • Milligram quantities
  • Any number of proteins
  • Any protein
  • Various expression systems

Membrane proteins can be attached embedded in fragments of cell membrane

  • Expressing the full length protein embedded in the insect cell membrane
  • Use differential detergent extractions or sonication to partially disrupt the membranes, allowing the BCCP-tagged protein to be immobilised onto a streptavidin surface
  • Leave protein sitting in fragment of membrane, then don’t have to worry about orientation
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