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Sekisui XenoTech, LLC

Lenexa, Kansas, US

XenoTech offers in vitro and in vivo ADME and PK services including: drug-drug interactions (inhibition and induction), metabolism, reaction phenotyping, metabolite characterization, ID and stability, bioanalysis, transporter services, biologics, radiolabeled synthesis, QWBA and protein binding studies. We also offer a full catalog of in vitro ADME research products including hepatocytes, subcellular fractions, recombinant CYPs, kupffer cells, tritosomes, homogenate, media & reagents, etc.

Sekisui XenoTech, LLC has not listed any services.

Radiolabeling/Radiosynthesis
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In vivo Bioavailability/Bioequivalence Studies
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In vitro ADME/DMPK Studies
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Solute-Linked Carrier (SLC) Transporter Substrate Identification
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Solute-Linked Carrier (SLC) Transporter Inhibition Assays
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Plasma Protein Binding
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Caco-2 Cell Permeability Assay
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MDR1-MDCK Permeability Assay
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In vivo ADME/DMPK Studies
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In vivo ADME lab offerings through Sekisui:
- Drug plasma concentration
- Absorption site investigation
- Tissue distributions
- QWBA (Quantitative Whole Body Autoradiography)
- Plasma protein binding
- Blood/plasma partition rate
- Lymphatic partition rate
- Metabolic profile (plama, urine, bile and tissue)
-... Show more »

In vivo ADME lab offerings through Sekisui:
- Drug plasma concentration
- Absorption site investigation
- Tissue distributions
- QWBA (Quantitative Whole Body Autoradiography)
- Plasma protein binding
- Blood/plasma partition rate
- Lymphatic partition rate
- Metabolic profile (plama, urine, bile and tissue)
- Metabolite Identification
- Excretion rate (urine, feces, expiration air and bile)
- Enterohepatic circulation
- Radiolabeled Synthesis
- Bioanalysis by ECL
- Radioreceptor Assay (RRA)
- Ocular Pharmacokinetics

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Peptide Synthesis
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Chemical Synthesis
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In vivo PK/PD Studies
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Primary Cell Culture
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Cell Line Collections
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Cytotoxicity Assays
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Custom Cell-Based Assays
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In vitro Hepatotoxicity Testing
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Cytotoxicity Assays
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In vitro Toxicity Testing
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Liquid Chromatography Coupled Mass Spectrometry Methods
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Liquid Chromatography
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LC-MS/MS
Liquid chromatography tandem mass spectrometry
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LC-MS
Liquid Chromatography-Coupled Mass Spectrometry
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MS-MS
Tandem Mass Spectrometry
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Receptor Binding Assays
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Ligand Binding Assays
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Drug Transporter Assays
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Analytical Chemistry Services
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Our Analytical Services group offers custom method validation, dose solution analysis, in vivo metabolite profiling studies and small-molecule bioanalytical services. The group's focus is on applying LC/MS technology to maximize both the quality and throughput of the data we generate to ensure that your project needs are met.

Our Analytical Services group offers custom method validation, dose solution analysis, in vivo metabolite profiling studies and small-molecule bioanalytical services. The group's focus is on applying LC/MS technology to maximize both the quality and throughput of the data we generate to ensure that your project needs are met.

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Ocular Irritation Testing
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Toxicology Services: In vitro toxicity testing - XenoTech utilizes the MatTek EpiOcular™ platform, a validated test system for the classification of chemicals for ocular irritation according to the OECD (Organization for Economic Cooperation & Development) Test Guideline 492. The EpiOcular™ platform is a 3D tissue culture... Show more »

Toxicology Services: In vitro toxicity testing - XenoTech utilizes the MatTek EpiOcular™ platform, a validated test system for the classification of chemicals for ocular irritation according to the OECD (Organization for Economic Cooperation & Development) Test Guideline 492. The EpiOcular™ platform is a 3D tissue culture model comprised of non-keratinized epithelium prepared from normal human keratinocytes, which simulate the physiological properties of the cornea epithelium (RhCE) cells. The assay is able to assess test chemicals with a variety of physical properties including liquid, semi-solid, or waxy.

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Compound IC50 Assays
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Salt Screening
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In vitro Hepatotoxicity Testing
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Compound Management Services
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Drug-Excipient Compatibility Studies
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Neuropathic Pain Animal Models
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Custom Pain Animal Models
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Pharmaceutical Formulation
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In vitro Metabolic Stability Assays
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HT ADME
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Natural Product Isolation and Purification
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Equilibrium Dialysis
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Compound Purification
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Diabetes Animal Models
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db/db Diabetic Mice
fa/fa Zucker Diabetic Rats

db/db Diabetic Mice
fa/fa Zucker Diabetic Rats

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In silico Drug-Drug Interaction Modeling
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Reactive Metabolite Assessment
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Blood Partitioning
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Protein Aggregation Analysis
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Compound Sourcing
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Multidrug Resistance (MDR) Testing
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Protein Binding Ultrafiltration
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Label-Free Mass Spectrometry
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Ischemia Animal Models
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Chemistry, Manufacturing and Controls (CMC)
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CYP Inhibition Assay
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Overview

XenoTech's study design evaluates drug candidates as direct, time-dependent and metabolism-dependent inhibitors of CYP enzymes in human liver microsomes. Our design allows us to screen for inhibition due to the drug added to the test system as well as inhibition due to metabolites formed during preincubation.... Show more »

Overview

XenoTech's study design evaluates drug candidates as direct, time-dependent and metabolism-dependent inhibitors of CYP enzymes in human liver microsomes. Our design allows us to screen for inhibition due to the drug added to the test system as well as inhibition due to metabolites formed during preincubation. The design features low protein concentrations and short incubation times to minimize artifacts caused by protein binding, metabolic instability of the test article and excessive metabolism of the marker substrate. We offer various options for follow-up studies to support the further characterization of those drug candidates that are identified as potent direct or metabolism-dependent inhibitors (for example: Ki determinations, XTRA: XenoTech's Reversibility Assay, KI/kinact determinations).

Assay Selection
| Enzyme | Substrate |
|----------------|------------------------------------------------|
| CYP1A2 | Phenacetin O-dealkylation |
| CYP2A6 | Coumarin 7-hydroxylation |
| CYP2B6 | Efavirenz 8-hydroxylation |
| CYP2B6 | Bupropion hydroxylation |
| CYP2C8 | Amodiaquine N-dealkylation |
| CYP2C8 | Paclitaxel 6-hydroxylation |
| CYP2C9 | Diclofenac 4´-hydroxylation |
| CYP2C19 | S-Mephenytoin 4´-hydroxylation |
| CYP2D6 | Dextromethorphan O-demethylation |
| CYP2E1 | Chlorzoxazone 6-hydroxylation |
| CYP3A4/5 | Testosterone 6β-hydroxylation |
| CYP3A4/5 | Nifedipine oxidation |
| CYP3A4/5 | Midazolam 1´-hydroxylation |
| CYP3A4/5 | Atorvastatin ortho-hydroxylation |
| CYP4A11 | Lauric acid 12-hydroxylation |

Test System
XenoTech's inhibition assays are typically performed with a dedicated pool of human liver microsomes (pool of 16) to provide Km and Vmax values for each marker substrate reaction. This allows the same pool of human liver microsomes (and often the same experimental conditions, for example, protein concentrations and incubation time) to be used to study all CYP enzymes of interest.

Incubation Conditions
Protein concentration ≤0.1 mg/mL
Incubation time: 5 minutes
Pre-incubation time (in the presence and absence of NADPH): 30 minutes

Results
Direct, time-dependent and metabolism-dependent IC50 values are determined from seven concentrations of the drug candidate.

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Membrane Protein Expression
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Toxicology
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Radioisotope Production
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Product Stability Testing
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Radiotracers and Radiopharmaceuticals
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Parallel Artificial Membrane Permeability Assay (PAMPA)
Parallel Artificial Membrane Permeability Assay
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Antibody Detection
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In vivo Drug Efficacy Testing
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Small Molecule Bioanalysis
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Preclinical Study Design
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In vivo Pharmacology Studies
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Quality Assurance
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ADME/DMPK Studies
Drug Metabolism and Pharmacokinetics
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Anatomic Pathology
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Histology and Pathology Services
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PK/PD Data Analysis
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Mass Spectrometry
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Off-Target Drug Effects
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Hit to Lead and Lead Optimization
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Microsomal Stability Assay
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Drug Discovery
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Cell Permeability Assay
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Drug Development
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CYP Induction Assay
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Bioanalytical Assays
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XenoTech offers non-regulated small molecule bioanalysis services through its Analytical Services group. Highlights of XenoTech's bioanalytical capabilities include:
- Protein precipitiation extraction (others as required)
- Matrices include plasma, serum, blood and urine
- Development of single or multiple analyte methods... Show more »

XenoTech offers non-regulated small molecule bioanalysis services through its Analytical Services group. Highlights of XenoTech's bioanalytical capabilities include:
- Protein precipitiation extraction (others as required)
- Matrices include plasma, serum, blood and urine
- Development of single or multiple analyte methods to support parent and metabolite(s) analysis or cassette analysis
- Method qualification (optional)
- Duplicate standard curves (bracketed samples)
- Flexible standard curve ranges up to 5000-fold (modify as needed)
- Sample analysis by LC-MS/MS
- Electronic data summary outlining analytical method and sample preparation, calibration curve and calculated sample concentrations
- Rapid turnaround times

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Bioanalytical Analysis LC/MS/MS
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CYP Phenotyping
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Analytical Chemistry Services
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Nuclear Receptor Assays
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Metabolite Generation
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In vivo Protein Binding Assays
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Protein Binding HPLC
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High Resolution Mass Spectrometry
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Solubility and Dissolution Testing
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NMR
Nuclear magnetic resonance spectroscopy
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Cell Products
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Manufacturing Services
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Chemical Stability Testing
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Forced Degradation Studies
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Custom Cell-Based Assays
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Cell Culture Consulting
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Assay Development Consulting
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Histology and Pathology Services
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Structure Determination
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Metabolite Profiling
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Immunophenotyping
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Lysosomal Trapping Assay
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Immunohistochemistry (IHC)
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Human Hepatocytes
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Assay Development
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Analytical Method Development
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In vivo Skin Irritation/Sensitization Testing
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Toxicology Services: In vitro toxicity testing - XenoTech utilizes the MatTek EpiDerm™ platform, a validated test system for the classification of chemicals for dermal irritation, according to the OECD Test Guideline 439. The EpiDerm™ platform is a 3D tissue culture model comprised of reconstructed human epidermal (RhE) cells... Show more »

Toxicology Services: In vitro toxicity testing - XenoTech utilizes the MatTek EpiDerm™ platform, a validated test system for the classification of chemicals for dermal irritation, according to the OECD Test Guideline 439. The EpiDerm™ platform is a 3D tissue culture model comprised of reconstructed human epidermal (RhE) cells differentiated into keratinocytes, which stimulate the physiological properties of the human skin. The assay is able to assess test chemicals with a wide variety of physical properties including solids, liquids, semi-solids or waxy.
Cell viability following chemical exposure is measured using the MTT assay. The test article is then classified according to the UN GHS (United Nations Globally Harmonized System of Classification and Labelling Chemicals) according to viability following chemical exposure.

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Cell and Tissue Culture
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Chemistry and Materials
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Specialty Mass Spectrometry Methods
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Product Development, Testing, and Packaging
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Engineering and Fabrication
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Natural Products
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Cardiovascular Animal Models
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Purification Services
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In vitro Bioavailability/Bioequivalence Studies
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Protein Services
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In vitro Disease Models
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Business Development, Marketing & Operations
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Synthetic Chemistry
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Immunostaining
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Compound Sourcing and Management
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Protein Expression Visualization
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In vivo Toxicity Testing
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Bioanalysis
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Biomolecular Interaction Analysis
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Biospecimens
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Tandem Mass Spectrometry Methods
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Drug Absorption Studies
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Experimental Design
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Omics
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Project and Process Management
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Animal Models of Disease
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Biomarkers
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Receptor Assays
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Biology
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Biochemistry & Molecular Biology
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Cell Culture Media and Reagents
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Computational Chemistry
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Drug Discovery & Development
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Transporter & Cell Uptake Assays
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Biochemical Assays
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Human Primary Cells
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Functional Human Tissue Assays
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Protein Conjugation
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Cell-Based Assays
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Metabolomics
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Lead Identification and Validation
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Pharmacology & Toxicology
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Radiochemistry
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Cells and Tissues
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Cell Death Assays
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Blood Banking and Transfusion Medicine
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Imaging & Spectroscopy
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Process Consulting
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Product Quality Control
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Immunoassays
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Chromatography
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Animal Models and Studies
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Physical Analysis Methods
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Pain/Neuropathy Animal Models
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Strength Analysis
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Antibody Services
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Human Biospecimens
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Formulation Services
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Cell Lines
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Safety Pharmacology
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Specialized Cell-Based Assays
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Spectroscopy
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Protein Characterization
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Pharmacology
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Pharmacology Services

Pharmacology Services

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2018-10-15 16:23:09 UTC

Net Promoter Score of 10 received for CYP Inhibition Assay.

Additional Ratings: satisfaction with deliverable: 10, satisfaction with timeliness: 10.
2017-05-24 18:27:14 UTC

Net Promoter Score of 10 received for Compound IC50 Assays.

Additional Ratings: satisfaction with deliverable: 10, satisfaction with timeliness: 10.
August 5, 2015

Positive review received for Compound IC50 Assays:

"It was great working with XenoTech to complete a project for one of our biopharma clients. They were easy to work with and very professional. The client was very satisfied with the quality of services. We would definitely recommend them to other clients in the future!"

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