Scripps Center for Metabolomics and Mass Spectrometry

The Center for Metabolomics and Mass Spectrometry provides routine analyses as well as specialty applications for Scripps Research and outside biotechnology communities with a wide variety of ESI and MALDI approaches as well as GC/MS. The Center has several instruments available, including MALDI TOF, ESI quads, ESI TOF, ESI QTOF and ESI ion traps. We analyze a wide variety of compounds including small molecules, peptides, proteins and oligonucleotides. Our routine analysis is a qualitative analysis, giving chromatogram traces, ms spectra for all major peaks, and a library search to help ascertain identity. If quantitative analysis is desired, standards of the compound(s) will need to be provided. **Recent Publications** - Montenegro-Burke J. R., Aisporna A. E., Benton H. P., Rinehart D., Fang M., Huan T., Warth B., Forsberg E., Abe B. T., Ivanisevic J., Wolan D. W. , Teyton L., Lairson L., and Siuzdak G. Data Streaming for Metabolomics: Accelerating Data Processing and Analysis from Days to Minutes *Analytical Chemistry* 2017 PMC5244434 - Warth B., Levin N., Rinehart D., Teijaro J., Benton H. P., Siuzdak G. Metabolizing Data in the Cloud *Trends in Biotechnology* 2017 - Montenegro-Burke J. R., Phommavongsay T., Aisporna A.E., Huan T., Rinehart D., Forsberg E., Thorgersen M. P., Adams M. W. W., Northen T. R., Robbins P.D., Niedernhofer L. J., Lairson L., Benton H. P., Siuzdak G. Smartphone Analytics: Mobilizing the Lab into the Cloud for Omic-Scale Analyses *Analytical Chemistry* 2016 - Johnson C., Ivanisevic J., Siuzdak G. Metabolomics: Beyond Biomarkers and Towards Mechanisms *Nature Reviews Molecular Cell Biology* 2016 - Kurihara K., Westenskow P., Gantner M., Usui Y., Schultz A., Bravo S., Aguilara E., Wittgrove C., SanGiovanni J., Friedlander M., Paris L., Chew E., Siuzdak G., Friedlander M. Hypoxia induced metabolic stress in RPE cells is sufficient to induce photoreceptor degeneration *eLife* 2016 PMC4848091 - Wang J., Westenskow P., Fang M., Friedlander M., Siuzdak G. Quantitative Metabolomics of Photoreceptor Degeneration and the Effects of Stem Cell Derived RPE Transplantation *Philosophical Transactions A* 2016 - Kurczy M., Forsberg E., Thorgersen M., Poole II F., Benton H.P., Ivanisevic J., Tran M., Wall J., Elias D., Adams M., Siuzdak G. Global Isotope Metabolomics Reveals Adaptive Strategies for Nitrogen Assimilation *ACS Chemical Biology* 2016 - Ivanisevic J., Stauch K., Petrascheck. M., Benton H.P., Epstein A., Fang M., Gorantla S., Tran M., Hoang L., Boska M., Gendelman H., Fox H., Siuzdak G. Metabolic Drift in the Aging Brain *Aging* 2016 PMC4931850 - Paris L., Johnson C., Aguilar E., Usui Y., Cho K., Hoang L., Feitelberg D., Benton H.P., Westenskow P., Kurihara T., Trombley J., Patti G., Ivanisevic J., Siuzdak G, Friedlander M. Global metabolomics reveals metabolic dysregulation in ischemic retinopathy *Metabolomics* 2016 PMC4651979