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Scintipharma, Inc.

Lexington, Kentucky, US

SCINTIPHARMA, Inc. is a privately held company focused on problem solving in the field of pharmaceutical dosage form development. The company's main objective is to provide services to the pharmaceutical industry for the optimization of drug delivery systems. The primary mission is improved delivery of currently marketed and potentially marketable therapeutic agents in the gastrointestinal tract as well as other routes such as nasal, ocular, inhalation, or rectal.

Some of the world's principal experts in pharmaceutical drug delivery are available for consultation. Scintipharma staff received their formal training from and continue to consult the innovating pioneer of gamma scintigraphy in pharmaceutical research. Pharmaceutical formulation and gamma scintigraphic studies have been performed for many of the pharmaceutical industries leading companies.

Recent Publications

SCINTIPHARMA, Inc. is a privately held company focused on problem solving in the field of pharmaceutical dosage form development. The company's main objective is to provide services to the pharmaceutical industry for the optimization of drug delivery systems. The primary mission is improved delivery of currently marketed and potentially marketable therapeutic agents in the gastrointestinal tract as well as other routes such as nasal, ocular, inhalation, or rectal.

Some of the world's principal experts in pharmaceutical drug delivery are available for consultation. Scintipharma staff received their formal training from and continue to consult the innovating pioneer of gamma scintigraphy in pharmaceutical research. Pharmaceutical formulation and gamma scintigraphic studies have been performed for many of the pharmaceutical industries leading companies.

Recent Publications

  • L. Kim, J. Martinez, K. Hodgson, G. Trager, J. Brandl, E. Sandefer, W. Doll, D. Liebowitz, S. Tucker. Systemic and Mucosal Immune Responses Following Oral Adenoviral Delivery of Influenza Vaccine to the Human Intestine by Radio Controlled Capsule. Nature.com Scientific Reports DOI: 10.1038/srep37295 (Nov 2016).
  • R.J. Rackley, T.E. Lawrence, P.J. Gupta, E.P. Sandefer, W.J. Doll, R.C. Page. The Paradox of Bioequivalence (BE) for Locally Acting Drugs in the GI Tract: Delayed Release (DR) Mesalamine (MESA) Test Tablet (T) versus an Asacol® Reference Tablet (R) and the Utility of Pharmacoscintigraphy to Fortify Proof of Equivalence. M1330 (2014), AAPS Annual Meeting San Diego, CA.
  • D.S. Krause, E.P Sandefer, R.C. Page, W.J. Doll, J.A. Dowell, C.A. Leister. Pharmacokinetic (PK) Evaluation of Investigational Delayed-Release (DR) Salmon Calcitonin Tablets (sCT 0.2mg): The Challenge of Demonstrating Bioequivalence (BE) of Short Half-Life DR Drugs and the Role of Gamma Scintgraphy in Initiate Intensive Blood Sampling Times Following Observed Real-Time Gastric Emptying (GE). M1334 (2014), AAPS Annual Meeting San Diego, CA.
  • J. Brown, C. Chien, P. Timmins, A. Dennis, L. Zhu, W. Doll, E. Sandefer, R. Nettles. Compartmental Absorption Modeling and Site of Absorption Studies to Determine Feasibility of an Extended Release Formulation of an HIV Attachment Inhibitor Phosphate Ester Prodrug. Journal of Pharmaceutical Sciences 102: 1742-1751 (2013).
  • R.L O=Conner-Semmes, E.P. Sandefer, E.K. Hussey. W. Tao, W.J. Doll, R.C. Page and R. Dobbins. Regional Gastrointestinal Delivery of Remogliflozin Etabonate in Humans. Biopharmaceutics & Drug Disposition 34: 79-86 (2013).
  • J.C. Ermer, M.B Haffey, W.J. Doll, P. Martin, E.P. Sandefer, K. Dennis, M. Corcoran, L. Trespidi, and R.C. Page. Pharmacokinetics of Lisdexamfetamine Dimesylate after Targeted Gastrointestinal Release or Oral Administration in Healthy Adults. Drug Metabolism and Disposition. 40:290-297 (February, 2012).
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Clinical Scintigraphy
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What is Gamma Scintigraphy?

Gamma scintigraphy is a technique whereby the transit of a dosage form through its intended site of delivery can be non-invasively imaged in vivo via the judicious introduction of an appropriate short lived gamma emitting radioisotope. The observed transit of the dosage form can then be correlated... Show more »

What is Gamma Scintigraphy?

Gamma scintigraphy is a technique whereby the transit of a dosage form through its intended site of delivery can be non-invasively imaged in vivo via the judicious introduction of an appropriate short lived gamma emitting radioisotope. The observed transit of the dosage form can then be correlated with the rate and extent of drug absorption. Information such as the site of disintegration or dispersion can also be obtained. Assistance in product development as well as testing of finished products for corporate sponsors are commonly performed.

  • Non-invasive
  • Human clinical or animal studies
  • Oral and other routes of administration such as nasal, ocular, or inhalation
  • Neutron activation and standard radiolabeling techniques
  • Site specific delivery in the GI tract using the InteliSite® Companion Capsule
  • Dosage form transit or site of release correlated with drug absorption
  • Regulatory compliance
  • Expert consultation
  • Experience and innovation
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