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SCIKON Innovation Inc.

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North Carolina, US

About SCIKON Innovation Inc.

Founded: 2009 Type: Privately Held Size: 11-50 employees

SciKon is interdisciplinary. We merge living entities with engineered structures. We are recognized for our unique ability to pioneer human and animal primary cell culture devices into predictive model biotools. Simply put, we provide both the cells and the engineered tool-boxes needed to generate different types of disease responses, all within controlled environments.

SciKon has extensive cell manufacture expertise with many healthy and unhealthy organ phenotypes, especially the liver.
SciKon Innovation works with many of the major pharmaceutical companies, CRO’s, government, and academic institutions. Our goal is to establish a long-term, collaborative relationship that provides optimal outcomes.

Our facilities are located in Research Triangle Park, NC in close proximity to GlaxoSmithKline, National Institute of Environmental Health Science, Biogen, Bayer, Duke University and University of North Carolina and many others.

Our Services (18)


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Drug Induced Phospholipidosis (PLD) Assay

Price on request
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Animal Hepatocytes

Price on request

Pekin Duck Hepatocyte Manufacture (Serology Normal and/or DHBV+)

  • Derived from Young Ducklings (3 – 5 days)
  • DHBV is an approved human model surrogate

Procurement Options

  • Arrange Your Timeline and Acquire Larger Quantity Cell Products
    • Schedule Orders (you specify delivery day and cell counts)
    • Fresh Hepatocytes, Serology Normal
    • Fresh Hepatocytes, Serology DHBV+
    • Receive FIVE Products at One Time:
        1. Fresh hepatocytes (Serology Normal)
        1. 0.5 ml Whole Blood (Serology Normal)
        1. Fresh Hepatocytes (DHBV+)
        1. 0.5 ml Whole blood (DHBV+)
        1. 100 ml cell culture media
  • Defer Delivery until SciKon’s Next Cell Manufacture Schedule (pre-orders required)
    • Reserve Orders (limited cells): First PO’s = first fill
    • Hepatocytes, Serology Normal
    • Hepatocytes, Serology DHBV+
    • Hepatocyte Cell Culture Media

Pekin Duck Alternative Organs (Serology Normal and/or DHBV+)

  • Derived from Young Ducklings (3 – 5 days)
  • Whole Blood, Heparinized
  • Organ Access: Kidney, Intestine, Pancreas, Lung, Heart, Other…

Hepatocyte Proficiency (General)

Our scientists have wide-ranging cell phenotype proficiency; human, animal, rodent, bird, fish


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3D Cell Culture Models

Price on request

Cells and Cell Culture Environments

  • 3D cultures; Spheroids; Gel Entrapment; Tissue Slices
  • We evaluate Culture Surface Formulas for cell adhesion (D7) or non-attachment (F7)
  • We have wide-ranging cell phenotype proficiency


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Cryopreservation

Price on request

Cell Freezing and Cell Thawing; both Equally Critical to Your Cell Efficacy

  • Advanced Cell Cryopreservation Techniques
  • Advanced Cell Thawing Techniques “KryoThaw Product Line”
  • We have wide-ranging cell phenotype proficiency


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In vitro Toxicity Testing

Price on request

SciKon is committed to delivering in vitro drug toxicity services in support of our clients’ drug development needs. Many of our development activities are focused in early drug discovery, lead selection/optimization, metabolism, bioactivation, and systems physiology. By leveraging advanced 2D & 3D plate-based benchtop techniques, SciKon can rapidly perform key assays (real-time and/or end-study) that allow you to identify potential issues with compounds that are being developed.

Two intrinsic examples: 1) SciKon’s resources include automated x,y,z high-throughput (HTP) imagers and readers for 3D culture evaluations with concurrent fluid flow analysis. 2) SciKon’s exclusive microfluidic SciFlow technology allows researchers to identify the difference between compound-related toxicity, metabolite-related toxicity, and concurrently delivers key cell bioactivation data in both HTP and data-centric outcomes (a montage assembly of data).

Metabolism Toxicity / Cytotoxicity

  • Exposure Time Course (multiple days)
  • Dose Response Curves (low -> high)
  • CellTiter Glo ATP Detection Assay
  • LDH, MTT, Live/Dead Assays

Hepatotoxicty / Cell Functions

  • Hepatocyte Cell Viability / Urea
  • Steatosis and Phospholipidosis
  • CYP / Enzyme Induction

Mitochondrial Toxicity

  • Mitochondrial Membrane Potential Assay
  • Metabolism (cell energy flux assay)
  • Hepatocyte (RST/OCR) Assay


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Human Tissue Procurement

Price on request
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Cells and Tissues

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Human Biospecimen Collection

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Drug Discovery & Development

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Drug Discovery & Development Services


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Pharmacology & Toxicology

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Pharmacology & Toxicology Services


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Toxicology

Price on request

Toxicology Services


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Biospecimen Management and Storage

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Biospecimen Management and Storage Services


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Cryostorage and Cryoprocessing

Price on request

Cryostorage and Cryoprocessing Services


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Cell and Tissue Culture

Price on request

Cell and Tissue Culture Services


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Mammalian Cell Culture

Price on request

Mammalian Cell Culture Services


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Animal Biospecimens

Price on request

Animal Biospecimens Services


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Biology

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Biospecimens

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Randy McClelland

Management

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