Jchxjcn6qpc3z8hajrlc sn

Schaffer-Nishimura Lab

ic No Reviews Yet
ic No Completed Orders
Ithaca, New York, US

About Schaffer-Nishimura Lab

Divison of: Cornell University

Our lab is interested in studying the contribution of multiple physiological systems to disease initiation and progression, with applications in neurodegenerative disease, cardiovascular disease, and cancer. We would like to understand how the vascular, immune, inflammatory systems and cells native to a tissue... Show more »

Our lab is interested in studying the contribution of multiple physiological systems to disease initiation and progression, with applications in neurodegenerative disease, cardiovascular disease, and cancer. We would like to understand how the vascular, immune, inflammatory systems and cells native to a tissue interact in these diseases. A major challenge in such work is that model systems such as cell culture or even organotypic tissue culture cannot fully recapitulate all the different cell types involved in disease, so in vivo studies are required. However, it is experimentally difficult to study and manipulate cell-level dynamics in live animals. Recently, we have worked to develop technologies such as improved imaging using multiphoton microscopy that work in whole animals and have sufficient spatial and temporal resolution to quantify cellular dynamics. We also now have tools, femtosecond laser ablation, to produce targeted disruption with cellular-scale precision.

Recent Publications

  • Ouzounov DG, Wang T, Wang M, Feng D, Horton NG, Cruz Hernández JC, Cheng Y, Reimer J, Tolias A, Nishimura N, Xu C. In vivo three-photon imaging of activity of GCaMP6-labeled neurons deep in intact mouse brain. Nature Methods (2017)
  • M. Koyama, F. Minale, J. Shum, N. Nishimura, C. B. Schaffer, and J. R. Fetcho. A circuit motif in the zebrafish hindbrain for a two alternative behavioral choice to turn left or right. eLife (2016)
  • G. D. Calvey, A. M. Katz, C. B. Schaffer, and L. Pollack. Mixing injector enables time-resolved crystallography with high hit rate at X-ray free electron lasers. Structural dynamics (2016)
  • Rakhilin N, Barth B, Choi J, Munoz N, Kulkarni S, LaVinka C, Dong X, Spencer M, Pasricha P, Nishimura N, Jones J, Small D, Cheng YT, Cao Y, Kan E, Shen X. Simultaneous Optical and Electrical In Vivo Analysis of the Enteric Nervous System. Nat Commun (2016)
  • F. J. Meyers, A. Mathur, C. N. Fuhrmann, T. C. O’Brien, I. Wefes, P. A. Labosky, D. S. Duncan, A. August, A. Feig, K. L. Gould, M. J. Friedlaner, C. B. Schaffer, A. Van Wart, R. Chalkley. The origin and implementation of the Broadening Experiences in Scientific Training programs: an NIH common fund initiative. FASEB Journal (2016)
  • W.C. Wayne, S. Chandrasekaran, M. J. Mitchell, M. F. Chan, R. E. Lee, C. B. Schaffer, M. R. King. TRAIL-coated leukocytes that prevent the bloodborne metastasis of prostate cancer,” Journal of Controlled Release (2016)
Show less

Our Services (7)


ic

Laser Scanning Confocal Microscopy

Price on request
Request a quote for more information about this service.

ic

Multiphoton Fluorescence Microscopy

Price on request
Request a quote for more information about this service.

ic

Fluorescence-Based Microscopy

Price on request
Request a quote for more information about this service.

ic

Confocal Microscopy

Price on request
Request a quote for more information about this service.

ic

Microscopy

Price on request
Request a quote for more information about this service.

ic

Optical Microscopy

Price on request
Request a quote for more information about this service.

ic

Imaging & Spectroscopy

Price on request
Request a quote for more information about this service.

Not finding what you're looking for?

Get info on this provider's capabilities without requesting a quote.
Missing Avatar

Amanda Bares

Graduate Research Assistant

Schaffer-Nishimura Lab has not received any reviews.

Schaffer-Nishimura Lab has not received any endorsements.