0supsunnthqgdjymu7ae samdi logo no bg

SAMDI Tech, Inc.

ic 10.0/10 Overall Rating No Reviews Yet
ic 7 Orders Completed
Chicago, Illinois, US

About SAMDI Tech, Inc.

SAMDI Tech is the industry leader in providing label-free solutions for drug discovery. We use our proprietary SAMDI technology, which combines high-density biochip arrays with MALDI mass spectrometry, for rapid and quantitative analysis of diverse analytes (peptides, small molecules, proteins,... Show more »

SAMDI Tech is the industry leader in providing label-free solutions for drug discovery. We use our proprietary SAMDI technology, which combines high-density biochip arrays with MALDI mass spectrometry, for rapid and quantitative analysis of diverse analytes (peptides, small molecules, proteins, oligonucleotides, among others) and biochemical targets. We routinely use 384 and 1536 feature biochips and our service offerings include assay development, high-throughput screening, hit confirmation, and dose response analysis.

Our approach eliminates high rates of false positives associated with using labels (such as antibodies, fluorophores, and radioactivity), and our team is dedicated to rapid data delivery to provide decision-making data fast.

Selected Publications

  • Identification of small molecule noncovalent binders utilizing SAMDI technology. VanderPorten EC, Scholle MD, Sherrill J, Tran JC, Liu Y. SLAS Discovery 2017, 22, 1211-1217.
  • Discovery of SIRT3 Inhibitors Using SAMDI Mass Spectrometry. K. Patel, J. Sherrill, M. Mrksich and M.D. Scholle. J. Biomol. Screen., 2015, 20, 842-848.
  • Acetyltransferase PCAF Regulates Crosstalk-Dependent Acetylation of Histone H3 by Distal Site Recognition. J.R. Kornacki, A.D. Stuparu and M. Mrksich. ACS Chemical Biology, 2015, 10, 157-164.
  • A High-Throughput Mass Spectrometry Assay Coupled with Redox Activity Testing Reduces Artifacts and False Positives in Lysine Demethylase Screening. Wigle TJ, Swinger KK, Campbell JE, Scholle MD, Sherrill J, Admirand EA, Boriack-Sjodin PA, Kuntz KW, Chesworth R, Moyer MP, Scott MP, Copeland RA. J Biomol Screen. 2015 Mar 9: 1-11.
  • Rapid Evaluation and Screening of Interfacial Reactions on Self-Assembled Monolayers. J. Li, P. S. Thiara and M. Mrksich, Langmuir, 2007, 23, 11826-11835.
  • Profiling the Selectivity of DNA Ligases in an Array Format with Mass Spectrometry. J. Kim and M. Mrksich, Nucleic Acids Research, 2010.
  • Functional Assays of Membrane-Bound Proteins with SAMDI-TOF Mass Spectrometry. V.L. Marin, T.H. Bayburt, S.G. Silgar and M. Mrksich, Angew. Chem. Int. Ed., 2007, 46(46), 8796-8798.
  • Discovery of Glycosyltransferases Using Carbohydrate Arrays and Mass Spectrometry. L. Ban, N. Pettit, L. Li, A.D. Stuparu, L. Cai, W. Chen, W. Guan, P.W. Wang and M. Mrksich. Nat. Chem. Biol., 2012, 8, 769-773.
  • Self-Assembled Monolayers for MALDI-TOF Mass Spectrometry for Immunoassays of Human Protein Antigens. S.M. Patrie and M. Mrksich, Anal. Chem., 2007, 79(15), 5878-5887.
  • Mass Spectroscopy of Self-Assembled Monolayers: A New Tool for Molecular Surface Science. M. Mrksich, ACS Nano, 2008, 2(1), 7-18.
Show less

Our Services (20)


ic

High Throughput Screening (HTS)

Price on request

We can transfer your existing or new assay into the SAMDI format for assay development and HTS.

SAMDI HTS

  • Screen your compound library or SAMDI Tech's diverse 1,000,000 molecule library against your target with SAMDI HTS.
  • Compound identity, rank ordering and Hill slopes in a convenient report format.
  • LC-MS of hit... Show more »

We can transfer your existing or new assay into the SAMDI format for assay development and HTS.

SAMDI HTS

  • Screen your compound library or SAMDI Tech's diverse 1,000,000 molecule library against your target with SAMDI HTS.
  • Compound identity, rank ordering and Hill slopes in a convenient report format.
  • LC-MS of hit compounds also available.

1,000,000 Small Molecule Libraries

  • Highly diverse set of compounds
  • Screen with single compounds or in pools of four or eight compounds
  • Library Statistics
Show less

ic

Assay Development

Price on request

SAMDI Tech offers a variety of high quality assay development experiments to characterize your enzyme of interest. We also provide the flexibility to tailor each assay to suit your needs.

  • Assay transfer to the SAMDI format
  • Km determination
  • [Enzyme] vs Velocity
  • IC50 determination
  • DMSO tolerance
  • Full 384 well plate uniformity with Z'-Factor
  • All multipoint with error bars!

SAMDI Tech offers a variety of high quality assay development experiments to characterize your enzyme of interest. We also provide the flexibility to tailor each assay to suit your needs.

  • Assay transfer to the SAMDI format
  • Km determination
  • [Enzyme] vs Velocity
  • IC50 determination
  • DMSO tolerance
  • Full 384 well plate uniformity with Z'-Factor
  • All multipoint with error bars!
Show less

ic

Biochemical Assays

Price on request
Request a quote for more information about this service.

ic

Hit Identification

Price on request
Request a quote for more information about this service.

ic

Peptide Arrays

Price on request

Explore the Possibilities

  • Discover new peptide substrates
  • Find optimal substrates for HTS drug discovery
  • Kinetic analyses on entire peptide arrays

We offer a variety of short peptide libraries and custom designed libraries to accommodate a wide range of biochemical activities.

Explore the Possibilities

  • Discover new peptide substrates
  • Find optimal substrates for HTS drug discovery
  • Kinetic analyses on entire peptide arrays

We offer a variety of short peptide libraries and custom designed libraries to accommodate a wide range of biochemical activities.

  • Acetylation
  • Methylation
  • Ubiquitination
  • Phosphorylation
  • Proteolysis
  • And many others.

SAMDI Profiler™ Software

Our custom data analysis software provides fast, accurate data tables and heat maps of biochemical activities.

Show less

ic

Drug Discovery

Price on request
Request a quote for more information about this service.

ic

Drug Discovery & Development

Price on request
Request a quote for more information about this service.

ic

Cell-Based Assays

Price on request
Request a quote for more information about this service.

ic

Cell-Based Compound Screening

Price on request
Request a quote for more information about this service.

ic

Project Management

Price on request
Request a quote for more information about this service.

ic

Biology

Price on request

Biology Services

Biology Services

Show less

ic

Synthetic Chemistry

Price on request
Request a quote for more information about this service.

ic

Peptide Synthesis

Price on request
Request a quote for more information about this service.

ic

Chemistry and Materials

Price on request
Request a quote for more information about this service.

ic

Biochemistry & Molecular Biology

Price on request

Biochemistry & Molecular Biology Services

Biochemistry & Molecular Biology Services

Show less

ic

Business Development, Marketing & Operations

Price on request

Business Development, Marketing & Operations Services

Business Development, Marketing & Operations Services

Show less

ic

Business Operations and Logistics Support

Price on request

Business Operations and Logistics Support Services

Business Operations and Logistics Support Services

Show less

ic

Omics

Price on request

Omics Services

Omics Services

Show less

ic

Proteomics

Price on request

Proteomics Services

Proteomics Services

Show less

ic

Protein Arrays

Price on request

Protein Arrays Services

Protein Arrays Services

Show less

Not finding what you're looking for?

Get info on this provider's capabilities without requesting a quote.

SAMDI Tech, Inc. has not received any reviews.

SAMDI Tech, Inc. has not received any endorsements.