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SAMDI Tech, Inc.

Chicago, Illinois, US

SAMDI Tech is an early-stage technology company based on the pioneering research from the laboratory of Professor Milan Mrksich. The Company offers unique assay capabilities that are commercially available through our contract assay services. The assay platform, SAMDI, combines mass spectrometry (MS) with high-density arrays for rapid and quantitative measurement of analytes in biochemical reactions. Our approach to screening enzyme activities eliminates the caveats of labeled methodologies that include: reducing rates of false positives and negatives, shortening assay development times, and screening in a high-throughput format. Our SAMDI assay services can help provide a better understanding of biological function and aid in the discovery of early stage modulators of enzymes involved in human disease.

Selected Publications

  • Discovery of SIRT3 Inhibitors Using SAMDI Mass Spectrometry. K. Patel, J. Sherrill,... Show more »

SAMDI Tech is an early-stage technology company based on the pioneering research from the laboratory of Professor Milan Mrksich. The Company offers unique assay capabilities that are commercially available through our contract assay services. The assay platform, SAMDI, combines mass spectrometry (MS) with high-density arrays for rapid and quantitative measurement of analytes in biochemical reactions. Our approach to screening enzyme activities eliminates the caveats of labeled methodologies that include: reducing rates of false positives and negatives, shortening assay development times, and screening in a high-throughput format. Our SAMDI assay services can help provide a better understanding of biological function and aid in the discovery of early stage modulators of enzymes involved in human disease.

Selected Publications

  • Discovery of SIRT3 Inhibitors Using SAMDI Mass Spectrometry. K. Patel, J. Sherrill, M. Mrksich and M.D. Scholle. J. Biomol. Screen., 2015, 20, 842-848.
  • Acetyltransferase PCAF Regulates Crosstalk-Dependent Acetylation of Histone H3 by Distal Site Recognition. J.R. Kornacki, A.D. Stuparu and M. Mrksich. ACS Chemical Biology, 2015, 10, 157-164.
  • A High-Throughput Mass Spectrometry Assay Coupled with Redox Activity Testing Reduces Artifacts and False Positives in Lysine Demethylase Screening. Wigle TJ, Swinger KK, Campbell JE, Scholle MD, Sherrill J, Admirand EA, Boriack-Sjodin PA, Kuntz KW, Chesworth R, Moyer MP, Scott MP, Copeland RA. J Biomol Screen. 2015 Mar 9: 1-11.
  • Rapid Evaluation and Screening of Interfacial Reactions on Self-Assembled Monolayers. J. Li, P. S. Thiara and M. Mrksich, Langmuir, 2007, 23, 11826-11835.
  • Profiling the Selectivity of DNA Ligases in an Array Format with Mass Spectrometry. J. Kim and M. Mrksich, Nucleic Acids Research, 2010.
  • Functional Assays of Membrane-Bound Proteins with SAMDI-TOF Mass Spectrometry. V.L. Marin, T.H. Bayburt, S.G. Silgar and M. Mrksich, Angew. Chem. Int. Ed., 2007, 46(46), 8796-8798.
  • Discovery of Glycosyltransferases Using Carbohydrate Arrays and Mass Spectrometry. L. Ban, N. Pettit, L. Li, A.D. Stuparu, L. Cai, W. Chen, W. Guan, P.W. Wang and M. Mrksich. Nat. Chem. Biol., 2012, 8, 769-773.
  • Self-Assembled Monolayers for MALDI-TOF Mass Spectrometry for Immunoassays of Human Protein Antigens. S.M. Patrie and M. Mrksich, Anal. Chem., 2007, 79(15), 5878-5887.
  • Mass Spectroscopy of Self-Assembled Monolayers: A New Tool for Molecular Surface Science. M. Mrksich, ACS Nano, 2008, 2(1), 7-18.
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SAMDI Tech, Inc. has not listed any services.

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High Throughput Screening (HTS)
Price on request

We can transfer your existing or new assay into the SAMDI format for assay development and HTS.

SAMDI HTS

  • Screen your compound library or SAMDI Tech's diverse 500,000 molecule library against your target with SAMDI HTS.
  • Compound identity, rank ordering and Hill slopes in a convenient report format.
  • LC-MS of hit... Show more »

We can transfer your existing or new assay into the SAMDI format for assay development and HTS.

SAMDI HTS

  • Screen your compound library or SAMDI Tech's diverse 500,000 molecule library against your target with SAMDI HTS.
  • Compound identity, rank ordering and Hill slopes in a convenient report format.
  • LC-MS of hit compounds also available.

Our 350,000 Small Molecule Library

  • Highly diverse set of compounds
  • Screen with single compounds or in pools of four or eight compounds
  • Library Statistics
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Peptide Arrays
Price on request

Explore the Possibilities

  • Discover new peptide substrates
  • Find optimal substrates for HTS drug discovery
  • Kinetic analyses on entire peptide arrays

We offer a variety of short peptide libraries and custom designed libraries to accommodate a wide range of biochemical activities.

Explore the Possibilities

  • Discover new peptide substrates
  • Find optimal substrates for HTS drug discovery
  • Kinetic analyses on entire peptide arrays

We offer a variety of short peptide libraries and custom designed libraries to accommodate a wide range of biochemical activities.

  • Acetylation
  • Methylation
  • Ubiquitination
  • Phosphorylation
  • Proteolysis
  • And many others.

SAMDI Profiler™ Software

Our custom data analysis software provides fast, accurate data tables and heat maps of biochemical activities.

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Assay Development
Price on request

SAMDI Tech offers a variety of high quality assay development experiments to characterize your enzyme of interest. We also provide the flexibility to tailor each assay to suit your needs.

  • Assay transfer to the SAMDI format
  • Km determination
  • [Enzyme] vs Velocity
  • IC50 determination
  • DMSO tolerance
  • Full 384 well... Show more »

SAMDI Tech offers a variety of high quality assay development experiments to characterize your enzyme of interest. We also provide the flexibility to tailor each assay to suit your needs.

  • Assay transfer to the SAMDI format
  • Km determination
  • [Enzyme] vs Velocity
  • IC50 determination
  • DMSO tolerance
  • Full 384 well plate uniformity with Z'-Factor
  • All multipoint with error bars!
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Experimental Design
Price on request
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Project Management, Consulting, & Support Services
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Chemistry and Materials
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Synthetic Chemistry
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Peptide Synthesis
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Hit Identification
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Drug Discovery & Development
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Drug Discovery
Price on request
Request a quote for more information about this service.
2018-02-26 12:36:22 -0800

Net Promoter Score of 10 received for Drug Discovery.

Additional Ratings: satisfaction with deliverable: 10, satisfaction with timeliness: 10.

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