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SAMDI Tech, Inc.

Chicago, Illinois, US

SAMDI Tech is the industry leader in providing label-free solutions for drug discovery. We use our proprietary SAMDI technology, which combines high-density biochip arrays with MALDI mass spectrometry, for rapid and quantitative analysis of diverse analytes (peptides, small molecules, proteins, oligonucleotides, among others) and biochemical targets. We routinely use 384 and 1536 feature biochips and our service offerings include assay development, high-throughput screening, hit confirmation, and dose response analysis.

Our approach eliminates high rates of false positives associated with using labels (such as antibodies, fluorophores, and radioactivity), and our team is dedicated to rapid data delivery to provide decision-making data fast.

Selected Publications

  • Identification of small molecule noncovalent binders utilizing SAMDI technology. VanderPorten EC, Scholle MD, Sherrill J, Tran JC, Liu Y.... Show more »

SAMDI Tech is the industry leader in providing label-free solutions for drug discovery. We use our proprietary SAMDI technology, which combines high-density biochip arrays with MALDI mass spectrometry, for rapid and quantitative analysis of diverse analytes (peptides, small molecules, proteins, oligonucleotides, among others) and biochemical targets. We routinely use 384 and 1536 feature biochips and our service offerings include assay development, high-throughput screening, hit confirmation, and dose response analysis.

Our approach eliminates high rates of false positives associated with using labels (such as antibodies, fluorophores, and radioactivity), and our team is dedicated to rapid data delivery to provide decision-making data fast.

Selected Publications

  • Identification of small molecule noncovalent binders utilizing SAMDI technology. VanderPorten EC, Scholle MD, Sherrill J, Tran JC, Liu Y. SLAS Discovery 2017, 22, 1211-1217.
  • Discovery of SIRT3 Inhibitors Using SAMDI Mass Spectrometry. K. Patel, J. Sherrill, M. Mrksich and M.D. Scholle. J. Biomol. Screen., 2015, 20, 842-848.
  • Acetyltransferase PCAF Regulates Crosstalk-Dependent Acetylation of Histone H3 by Distal Site Recognition. J.R. Kornacki, A.D. Stuparu and M. Mrksich. ACS Chemical Biology, 2015, 10, 157-164.
  • A High-Throughput Mass Spectrometry Assay Coupled with Redox Activity Testing Reduces Artifacts and False Positives in Lysine Demethylase Screening. Wigle TJ, Swinger KK, Campbell JE, Scholle MD, Sherrill J, Admirand EA, Boriack-Sjodin PA, Kuntz KW, Chesworth R, Moyer MP, Scott MP, Copeland RA. J Biomol Screen. 2015 Mar 9: 1-11.
  • Rapid Evaluation and Screening of Interfacial Reactions on Self-Assembled Monolayers. J. Li, P. S. Thiara and M. Mrksich, Langmuir, 2007, 23, 11826-11835.
  • Profiling the Selectivity of DNA Ligases in an Array Format with Mass Spectrometry. J. Kim and M. Mrksich, Nucleic Acids Research, 2010.
  • Functional Assays of Membrane-Bound Proteins with SAMDI-TOF Mass Spectrometry. V.L. Marin, T.H. Bayburt, S.G. Silgar and M. Mrksich, Angew. Chem. Int. Ed., 2007, 46(46), 8796-8798.
  • Discovery of Glycosyltransferases Using Carbohydrate Arrays and Mass Spectrometry. L. Ban, N. Pettit, L. Li, A.D. Stuparu, L. Cai, W. Chen, W. Guan, P.W. Wang and M. Mrksich. Nat. Chem. Biol., 2012, 8, 769-773.
  • Self-Assembled Monolayers for MALDI-TOF Mass Spectrometry for Immunoassays of Human Protein Antigens. S.M. Patrie and M. Mrksich, Anal. Chem., 2007, 79(15), 5878-5887.
  • Mass Spectroscopy of Self-Assembled Monolayers: A New Tool for Molecular Surface Science. M. Mrksich, ACS Nano, 2008, 2(1), 7-18.
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SAMDI Tech, Inc. has not listed any services.

High Throughput Screening (HTS)
Price on request

We can transfer your existing or new assay into the SAMDI format for assay development and HTS.

SAMDI HTS

  • Screen your compound library or SAMDI Tech's diverse 500,000 molecule library against your target with SAMDI HTS.
  • Compound identity, rank ordering and Hill slopes in a convenient report format.
  • LC-MS of hit... Show more »

We can transfer your existing or new assay into the SAMDI format for assay development and HTS.

SAMDI HTS

  • Screen your compound library or SAMDI Tech's diverse 500,000 molecule library against your target with SAMDI HTS.
  • Compound identity, rank ordering and Hill slopes in a convenient report format.
  • LC-MS of hit compounds also available.

Our 350,000 Small Molecule Library

  • Highly diverse set of compounds
  • Screen with single compounds or in pools of four or eight compounds
  • Library Statistics
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Assay Development
Price on request

SAMDI Tech offers a variety of high quality assay development experiments to characterize your enzyme of interest. We also provide the flexibility to tailor each assay to suit your needs.

  • Assay transfer to the SAMDI format
  • Km determination
  • [Enzyme] vs Velocity
  • IC50 determination
  • DMSO tolerance
  • Full 384 well... Show more »

SAMDI Tech offers a variety of high quality assay development experiments to characterize your enzyme of interest. We also provide the flexibility to tailor each assay to suit your needs.

  • Assay transfer to the SAMDI format
  • Km determination
  • [Enzyme] vs Velocity
  • IC50 determination
  • DMSO tolerance
  • Full 384 well plate uniformity with Z'-Factor
  • All multipoint with error bars!
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Biochemical Assays
Price on request
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Hit Identification
Price on request
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Peptide Arrays
Price on request

Explore the Possibilities

  • Discover new peptide substrates
  • Find optimal substrates for HTS drug discovery
  • Kinetic analyses on entire peptide arrays

We offer a variety of short peptide libraries and custom designed libraries to accommodate a wide range of biochemical activities.

Explore the Possibilities

  • Discover new peptide substrates
  • Find optimal substrates for HTS drug discovery
  • Kinetic analyses on entire peptide arrays

We offer a variety of short peptide libraries and custom designed libraries to accommodate a wide range of biochemical activities.

  • Acetylation
  • Methylation
  • Ubiquitination
  • Phosphorylation
  • Proteolysis
  • And many others.

SAMDI Profiler™ Software

Our custom data analysis software provides fast, accurate data tables and heat maps of biochemical activities.

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Drug Discovery
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Drug Discovery & Development
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Cell-Based Assays
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Cell-Based Compound Screening
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Experimental Design
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Project and Process Management
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Biology
Price on request

Biology Services

Biology Services

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Synthetic Chemistry
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Peptide Synthesis
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Chemistry and Materials
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Biochemistry & Molecular Biology
Price on request

Biochemistry & Molecular Biology Services

Biochemistry & Molecular Biology Services

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2018-06-05 02:51:29 +0900

Net Promoter Score of 10 received for Hit Identification.

2018-02-27 05:36:22 +0900

Net Promoter Score of 10 received for Drug Discovery.

Additional Ratings: satisfaction with deliverable: 10, satisfaction with timeliness: 10.

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