A global-leading custom peptide manufacturer. We provide the pharmaceutical, cosmetic, and entire life science research industries with the highest quality custom peptides available. Research to full commercialization production scale capacity. We also provide design services, peptide libraries, catalog peptides, and polylonal antibody packages round out our complete peptide services portfolio.
State-of-the-art manufacturing facilities & equipment, allowing both solid and solution phase custom peptide synthesis, powerful analytical tools, and countless years of laboratory experience are behind RS Synthesis. This undoubtedly ensures high quality, prompt delivery, and consistent results. Let us accelerate your research today!
lexible Processes and high-throughput synthesis equipment enable us to offer ultra-competitive pricing, quick delivery, and high yields. Peptide library services for both small and large libraries are easily synthesized. Popular libraries include:
Overlapping, Alanine Scan, Positional Scan, Random, Scrambled, Truncation, and Di-peptide Libraries. Perfect for:
We can also incorporate most typical peptide modifications in our peptide library services, such as unusual amino acids, D-amino acids, C-terminal amidation, N-terminal modification, and biotin, dye or fluorescence labeling on the N-terminal or lysine side chains.
Peptide Library Specifications
Flexible packaging solutions
Scanning Peptide Library Services
Alanine Scanning libraries are most common, although scanning libraries of other amino acids have been reported. In alanine scanning libraries, each amino acid in the peptide sequence is individually replaced by alanine. Alanine scans are useful for identifying essential residues within the peptide. When an essential residue is replaced with alanine, the corresponding peptide shows markedly reduced activity.
Truncation Peptide Library Services
In truncation peptide libraries, the peptide sequence is systematically shortened from the N-terminal or C-terminal. Truncation libraries are useful for identifying the minimum peptide length required for activity. Truncation libraries can be useful in studying the metabolic degradation of peptide drugs.
Scrambled Peptide Library Services
Scrambled peptide libraries are prepared through permutation of the original peptide sequence. Scrambled libraries can provide valuable information for sequence optimization.
Combinatorial Peptide Library Services
Combinatorial peptide libraries, in their broadest form, contain every possible peptide of a specific length; therefore, they are useful for drug discovery and research. Combinatorial libraries are prepared by systematically substituting every amino acid at each position in the sequence. Since the number of possible peptides can become astronomical, combinatorial libraries are often constrained by strictly limiting the number of amino acids used in creating the library or limiting the number of positions that are substituted. When only a few positions are randomized, the library is called a Positional Scanning Library.
Positional Scanning Peptide Library Services
In positional scanning peptide libraries, every amino acid is systematically substituted into a specified position in a peptide. Positional scanning libraries are highly constrained versions of combinatorial libraries. They are useful for sequence optimization.
Overlapping Peptide Library Services
Overlap peptide libraries are used in mapping linear epitopes. Overlap libraries are characterized by the fragment length and overlap number
RS Synthesis can provide cGMP peptide manufacturing according to FDA 21 CFR parts 210 & 211, following ICH Q7A Good Manufacturing Practices. FDA registered, dedicated facilities for API manufacturing, including both SOLID and SOLUTION phase synthesis, purification, lyophilization, and packaging are the foundation of the quality systems in place for GMP peptide production.
GLP services also available, if GMP peptide is not yet required, such as for animal tox studies. Class 300,000/100,000/10,000 clean rooms, and on-site water treatment facilities round out the comprehensive GMP Petpide and API manufacturing services offered. Site visits and audits welcomed, and facility layout diagrams can be provided upon request. Download our GMP/API Specification Check Sheet
5L to 350L+ Reaction Vessel Capacities available.
Custom Peptide Synthesis Services:
RS Synthesis provides high quality, custom peptide synthesis at all scales, from milligrams (mg) to multi-kilograms (kg).
A Certificate of Analysis, HPLC, and Mass spec data accompany each custom peptide synthesis order to confirm purity and identity. State-of-the-art equipment, validated processes, and raw materials ensure the highest quality peptide synthesis. Outstanding yields for quantity and purity are achieved using the latest Fmoc solid phase synthesis technologies, which allow for quick delivery. Countless years of peptide production experience are the foundation of RS Synthesis, allowing us to continually improve our peptide manufacturing effiiciency, reduce your costs, and ultimately accelerate YOUR research.
We also offer a full line of custom peptide modifications, including unusual amino acids, modified side chains, phosphorylation, conjugations, N and C-terminal modifications, and isotopic labeling. With an almost 100% synthesis success rate, even for modified peptides, you can count on consistent, repeatable results when using our custom peptides. Please see our dedicated page for a comprehensive listing of specific modifications and pricing.
Additional custom peptide synthesis services, such as peptide content reporting, aliquoting, salt removal, and specific counter-ion requirements (HCL, Acetate, TFA) can be provided. RS Synthesis maintains strict quality control adherence at industry leading prices. Custom peptide synthesis prices start as low as < $5/residue, for peptides under 30 amino acids. We also provide custom peptides over 30 amino acids, and have vast experience synthesizing long peptides, up to 75+ amino acids in length, with high purity. Typical delivery time is 2-3 weeks for normal purified peptides.
Biochemistry & Molecular Biology Services
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