1340905230000

Roswell Park Cancer Institute

Buffalo, New York, US

Welcome to Roswell Park Cancer Institute (RPCI), America's first cancer center founded in 1898 by Dr. Roswell Park. His revolutionary model of a “multidisciplinary approach” to cancer – with scientists and clinicians working in concert and in consult – has become the standard by which all modern-day comprehensive cancer centers are measured.
RPCI is among the first and only upstate New York facility to hold the National Cancer Institute designation of "comprehensive cancer center" and to serve as a member of the prestigious National Comprehensive Cancer Network. Many RPCI faculty serve on the NCCN panels that create the Clinical Practice Guidelines in OncologyTM – the internationally recognized standards for clinical policy in oncology, and the most comprehensive, most frequently updated clinical practice guidelines available in any area of medicine.
Over its long history, Roswell Park Cancer Institute... Show more »

Welcome to Roswell Park Cancer Institute (RPCI), America's first cancer center founded in 1898 by Dr. Roswell Park. His revolutionary model of a “multidisciplinary approach” to cancer – with scientists and clinicians working in concert and in consult – has become the standard by which all modern-day comprehensive cancer centers are measured.
RPCI is among the first and only upstate New York facility to hold the National Cancer Institute designation of "comprehensive cancer center" and to serve as a member of the prestigious National Comprehensive Cancer Network. Many RPCI faculty serve on the NCCN panels that create the Clinical Practice Guidelines in OncologyTM – the internationally recognized standards for clinical policy in oncology, and the most comprehensive, most frequently updated clinical practice guidelines available in any area of medicine.
Over its long history, Roswell Park Cancer Institute has made fundamental contributions to reducing the cancer burden and has successfully maintained an exemplary leadership role in setting the national standards for cancer care, research and education.

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Pathology Resource Network

Buffalo New York
Order Completed
100% Positive

The Pathology Resource Network (PRN) provides human specimens and laboratory services for basic and translational research to further the understanding of human cancers.

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Bioinformatics Shared Resource

Buffalo New York
No Reviews Available

The Bioinformatics Shared Resource supports the research needs of Roswell Park Cancer Institute (RPCI) investigators with respect to experimental design, data integration, as well as data analysis of clinical, laboratory, and population-based studies utilizing high-throughput... Show more »

The Bioinformatics Shared Resource supports the research needs of Roswell Park Cancer Institute (RPCI) investigators with respect to experimental design, data integration, as well as data analysis of clinical, laboratory, and population-based studies utilizing high-throughput bioinformatics technologies. The mission is to advance cancer research and cancer treatment by providing an array of bioinformatics shared research and services to the institute community through collaboration. Our expertise lies in developing and utilizing state-of-the-art bioinformatics algorithms to design, analyze and integrate various voluminous “-omics” data for a better understanding of the molecular mechanisms underlying human cancer initiation, progression and prognosis.

The Bioinformatics Shared Resource takes advantage of two major computing resources available.

First, each faculty and staff has a Dell Linux workstation.
The workstation is ideally for moderately compute-intensive bioinformatics projects.

Second, through collaboration with the Center for Computational Research at University at Buffalo, we have high-priority access to their Linux cluster with more than 2,000 processors.

This cluster is specifically designed for largely compute-intensive bioinformatics projects.

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The Center for Immunotherapy (CFI) Good Manufacturing Practices (GMP): Therapeutic Cell Production Facility is located on the 6th floor of the Gratwick Basic Science Building (GBSB) located on Elm & Carlton Streets. Consultation in the design, construction and operation of the... Show more »

The Center for Immunotherapy (CFI) Good Manufacturing Practices (GMP): Therapeutic Cell Production Facility is located on the 6th floor of the Gratwick Basic Science Building (GBSB) located on Elm & Carlton Streets. Consultation in the design, construction and operation of the RPCI CFI GMP was provided by the FDA during a Type C pre-facilities meeting.

The GMP cleanroom suite consists of a class 100,000 anteroom (gowning and storage) and class 10,000 cell processing room (manufacture of cell therapy products for Phase I and Phase II clinical trials). Additional space on the 6thfloor of GBSB is dedicated to provide office space, storage space and general secure areas equipped with filing cabinets and shelf space to provide storage capacity for records. Networked computers and printers for access to electronic databases are available. Conference rooms for staff meetings are available through joint departments, including the Department of Immunology, Department of Gynecologic Oncology and Department of Laboratory Medicine.

Occupying 628 ft2,the CFI GMP Facility cleanroom suite is fully equipped to provide extensive cell processing capabilities required by different investigator-initiated studies. GMP Facility personnel are responsible for maintaining the equipment in the CFI GMP cleanroom suite as required by the FDA.

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Genomics Shared Resource

Buffalo New York
Orders Completed
100% Positive

The GSR was founded in 1999 with the goal of affording investigators a full spectrum of services for parallel analyses of genomes and their expression.

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Immune Analysis Shared Resource

Buffalo New York
No Reviews Available

The Immune Analysis Facility (IAF), part of the Center for Immunotherapy at Roswell Park Cancer Institute, is a shared resource responsible for serial monitoring of immunologic functions in patients with cancer, those who are treated with biologic therapies, and those who... Show more »

The Immune Analysis Facility (IAF), part of the Center for Immunotherapy at Roswell Park Cancer Institute, is a shared resource responsible for serial monitoring of immunologic functions in patients with cancer, those who are treated with biologic therapies, and those who participate in clinical trials or research protocols at the RPCI. The development of immune monitoring assays is essential to determine the immune responses in patients receiving novel immune therapies and ultimately transitioning these therapies from the clinical trial phase to standard of care. The IAF makes available to its users a broad range of state-of-the-art immunologic assays, performed under a rigorous quality control program. In addition, as advances in immunobiology occur and new assays are requested by the users, the IAF performs pre-clinical evaluations of the assays and, when they become reliable and standardized, adds them to the available assay list. The ultimate goal of the facility is to continuously develop cutting-edge immune monitoring technology.

The IAF offers consultation regarding optimal immunologic assessment and assay development for innovative approaches to evaluate immune responses. We provide expert advice regarding the types of assays for immune monitoring and data interpretation tailored to fit the endpoints of each specific clinical trial.

The IAF maintains extensive quality control (QC) and quality assurance (QA) programs to ensure the validity of test results. We are currently participating in a worldwide immune monitoring consortium to standardize and validate immune assays and establish rigorous quality control standards. The IAF has established a fee-for-service schedule which gives priority to RPCI members. Interested investigators will be asked to provide a summary of their clinical trial design, which will be reviewed by the facility in order to design the appropriate methodology to successfully measure the endpoints of the study.

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Small Molecule Screening Core Facility

Buffalo New York
Order Completed

The Small Molecule Screening Core Facility (SMSC) at Roswell Park Cancer Institute offers high-throughput screening services using a broad range of non-radioactive cell based and biochemical assays at a competitive price. Our collection of more than 110,000 compounds can be used in... Show more »

The Small Molecule Screening Core Facility (SMSC) at Roswell Park Cancer Institute offers high-throughput screening services using a broad range of non-radioactive cell based and biochemical assays at a competitive price. Our collection of more than 110,000 compounds can be used in both 96- and 384-well format. Liquid handling and library delivery equipment allows a throughput rate of up to 16,000 data points per day.

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Clinical Data Network

Buffalo New York
No Reviews Available

The Clinical Data Network (CDN) is a developing shared resource for non-interventional studies. The primary focus of the CDN is to provide structured access to and use of real-time reliable clinical data for the advancement of non-interventional studies at Roswell Park Cancer... Show more »

The Clinical Data Network (CDN) is a developing shared resource for non-interventional studies. The primary focus of the CDN is to provide structured access to and use of real-time reliable clinical data for the advancement of non-interventional studies at Roswell Park Cancer Institute.

In addition to improving access to and use of data, the CDN Office, as a liaison with biobanks, facilitates the process for researchers to timely and accurately identify and determine the availability of required specimens. The CDN Office supports the data needs of investigators for Non Human Subject Research.

The CDN provides the leadership and the resources necessary to meet data management needs for each specific research project.


Instrumentation/Software

Concepts System: Used by researchers to improve the structuring of non-interventional research ideas prior to IRB protocol submission.

DaRTS (Data Request Tracking System): Used by all CDN members to identify & manage clinical data requests for research.

D2B2 (Database of Databases): Used as the official inventory of data sources to support the CDN.

GeneTegra (federated query system): Used by the CDN to connect multiple data sources and query them as one entity.

caTIES (Text Information Extraction System): Used by the CDN to extract information from free text Pathology reports and as a data source for GeneTegra.

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The Flow and Image Cytometry Resource

Buffalo New York
No Reviews Available

Located in the Roswell Park Cancer Institute Cancer Cell Center in Buffalo New York, this state-of-the-art facility provides advanced flow cytometric and morphology service at cellular and subcellular llevels of resolution. In conjunction with traditional diagnostic disciplines... Show more »

Located in the Roswell Park Cancer Institute Cancer Cell Center in Buffalo New York, this state-of-the-art facility provides advanced flow cytometric and morphology service at cellular and subcellular llevels of resolution. In conjunction with traditional diagnostic disciplines such as pathology and radiology, flow cytometry is dramatically increasing diagnostic accuracy and efficacy so that people can lead healthier lives through research and its transfer to clinical practice.

Advanced Diagnostic Flow Cytometry Services
Education and Consultation Services
Comprehensive Sample Processing, Data Acquisition and Data Analysis Services
Morphological Services at the Cellular and Sub Cellular Levels of Resolution
Luminex Cytokine, Chemokine and Growth Factor Quantification
Core Flow Cytometry Services for Investigator and Biotech Sponsored Clinical Trials

Maguire O, O'Loughlin K, Minderman H. J Immunol Methods. 2015 Aug;423:3-11. doi: 10.1016/j.jim.2015.03.018. Epub 2015 Apr 7. Simultaneous assessment of NF-κB/p65 phosphorylation and nuclear localization using imaging flow cytometry.

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Small Animal Bio-Imaging Resource

Buffalo New York
No Reviews Available
  • Provide the necessary intellectual and physical resources relating to non-invasive in vivo imaging in small animal models of cancer.
  • Develop novel preclinical imaging techniques that provide insight into various biological processes involved in disease and facilitate... Show more »
  • Provide the necessary intellectual and physical resources relating to non-invasive in vivo imaging in small animal models of cancer.
  • Develop novel preclinical imaging techniques that provide insight into various biological processes involved in disease and facilitate evaluation of experimental therapeutics.
  • Establish a technology platform that enables translation of imaging techniques evaluated in preclinical models to improve disease detection and monitoring of therapeutic response in the clinical setting.

Please note we are a dedicated research imaging facility and cannot image pets for veterinary services.

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Data Bank and BioRepository

Buffalo New York
No Reviews Available

The RPCI Data Bank and BioRepository (DBBR) prospectively collects and provides de-identified biospecimens and associated epidemiological and clinical data to investigators with IRB approved protocols. Newly diagnosed patients are consented for collection of blood tubes, completion... Show more »

The RPCI Data Bank and BioRepository (DBBR) prospectively collects and provides de-identified biospecimens and associated epidemiological and clinical data to investigators with IRB approved protocols. Newly diagnosed patients are consented for collection of blood tubes, completion of a risk factor questionnaire, and permission to link their samples to clinical data. DBBR samples and data can also be paired with tumor tissue from the Pathology Resource Network. Additionally, non-patients (family members and friends of patients and community members) with no personal history of cancer are asked to participate in the DBBR as healthy volunteers.

The DBBR strives to provide specimens that are rigorously collected, processed and stored so that the integrity of potential analytes will be consistent across all patients and controls. When consented, orders for phlebotomy are placed in the hospital electronic system, and labels for DBBR blood tubes are printed when participants register in phlebotomy. Tubes are drawn and sent to the DBBR laboratory through the pneumatic tube system, for processing into serum, plasma, red blood cells, buffy coat, and DNA.

Specimens are centrifuged and the supernatant is automatically aliquoted using a MAPI robot from Cryobiosystem (parent company is IMV International corp., L'Aigle, France). The robotic system aliquots serum, plasma, buffy coat and red blood cells into inert plastic straws (0.5 mL each), seals each end and labels each straw with a barcode identifier. The straws are kept in a liquid nitrogen storage system developed by Cryobiosystem. In addition to the straws, whole blood, clot and buffy coat are aliquoted in 0.5mL barcoded cryovials and stored at -80. The standard time from collection to freeze for DBBR blood samples is one hour. For more information, please visit https://www.roswellpark.edu/shared-resources/data-bank-and-biorepository

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Biostatistics Resource

Buffalo New York
No Reviews Available

The Biostatistics Resource ensures that biostatistical, bioinformatics and biomathematical support is readily available to basic, clinical and population-oriented RPCI collaborators. Services include exploratory data analysis; grant writing (statistical methods sections);... Show more »

The Biostatistics Resource ensures that biostatistical, bioinformatics and biomathematical support is readily available to basic, clinical and population-oriented RPCI collaborators. Services include exploratory data analysis; grant writing (statistical methods sections); hypothesis formulation; experimental design; fitting models to data; simulating data from models; developing customized data mining software and developing novel methods based on emerging technologies (.e.g. cutting edge microarray platforms, computer intensive statistical methods).

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Survey Research and Data Acquisition Resource

Buffalo New York
No Reviews Available

The Survey Research and Data Acquisition Resource (SRDAR) is an academic data collection center designated a core resource in It is a division of the Department of Health Behavior, in the Division of Cancer Prevention and Population Sciences and originated as an extension of Dr.... Show more »

The Survey Research and Data Acquisition Resource (SRDAR) is an academic data collection center designated a core resource in It is a division of the Department of Health Behavior, in the Division of Cancer Prevention and Population Sciences and originated as an extension of Dr. Andrew Hyland’s research program. SRDAR specializes in cohort and cross-sectional surveys on tobacco use, and because of its designation as a Core service within Roswell Park and its academic status, SRDAR typically provides the same quality or better service at a lower cost than for-profit firms

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shRNA Core

Buffalo New York
Orders Completed

The Roswell Park Cancer Institute/University at Buffalo shRNA Core shared resource serves as the focal point of RNAi expertise for the RPCI/UB research communities. The shRNA resource provides a centralized service that supports investigators interested in gene transfer using viral vector technologies.

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Hematologic Procurement Shared Resource

Buffalo New York
Orders Completed
100% Positive

The Roswell Park Hematologic Procurement Bank (formerly known as the Leukemia Tissue Bank and a part of the Pathology Network Shared Resource) provides researchers and investigators with appropriately procured and cryopreserved samples of bone marrow and peripheral blood cells,... Show more »

The Roswell Park Hematologic Procurement Bank (formerly known as the Leukemia Tissue Bank and a part of the Pathology Network Shared Resource) provides researchers and investigators with appropriately procured and cryopreserved samples of bone marrow and peripheral blood cells, DNA, RNA, and serum/plasma samples from patients with hematological malignancies treated at our institute.

Presently, the Bank contains over 100,000 cryopreserved marrow and blood samples from patients with hematological malignancies dating from the present back to 1991 linked to a clinical database. The majority of samples are from patients with acute leukemia. Approximately 70,300 samples from 1,550 individuals with acute myeloid leukemia (AML) and 11,700 samples from 260 patients with acute lymphocytic leukemia (ALL) are currently stored in this shared resource. Samples from patients with myeloid malignancies, chronic leukemias, lymphoproliferative diseases, multiple myeloma, and other hematological disorders are also available.

The Hematological Procurement Bank also contracts with Clinical Research Services to procure, process, and store correlative peripheral blood and other biological samples on patients with a variety of solid and hematological malignancies who are receiving investigational treatment on cancer clinical trials.

Recent Publications

  • Transfer RNA detection by small RNA deep sequencing and disease association with myelodysplastic syndromes. Guo Y, Bosompem A, Mohan S, Erdogan B, Ye F, Vickers KC, Sheng Q, Zhao S, Li CI, Su PF, Jagasia M, Strickland SA, Griffiths EA, Kim AS. BMC Genomics. 2015 Sep 24;16(1):727.
  • Lenalidomide induces ubiquitination and degradation of CK1α in del(5q) MDS. Krönke J, Fink EC, Hollenbach PW, MacBeth KJ, Hurst SN, Udeshi ND, Chamberlain PP, Mani DR, Man HW, Gandhi AK, Svinkina T, Schneider RK, McConkey M, Järås M, Griffiths E, Wetzler M, Bullinger L, Cathers BE, Carr SA, Chopra R, Ebert BL. Nature. 2015 Jul 9;523(7559):183-8.
  • Emadi A, Faramand R, Carter-Cooper B, Tolu S, Ford LA, Lapidus RG, Wetzler M, Wang ES, Etemadi A, Griffiths EA. Presence of isocitrate dehydrogenase (IDH) mutations may predict clinical response to hypomethylating agents in patients with acute myeloid leukemia. Am J Hematology, 2015 May; 90(5):E77-9. Epub 2015 Feb 27.
  • Pharmacological targeting of β-catenin in normal karyotype acute myeloid leukemia blasts. Griffiths EA, Golding MC, Srivastava P, Povinelli BJ, James SR, Ford LA, Wetzler M, Wang ES, Nemeth MJ. Haematologica. 2015 Feb;100(2):e49-52. Epub 2014 Nov 7.
  • Immunomodulatory action of SGI-110, a hypomethylating agent, in acute myeloid leukemia cells and xenografts. Srivastava P, Paluch BE, Matsuzaki J, James SR, Collamat-Lai G, Karbach J, Nemeth MJ, Taverna P, Karpf AR, Griffiths EA. Leuk Res. 2014 Nov;38(11):1332-41.
  • Low 25(OH) vitamin D3 levels are associated with adverse outcome in newly diagnosed, intensively treated adult acute myeloid leukemia. Lee HJ, Muindi JR, Tan W, Hu Q, Wang D, Liu S, Wilding GE, Ford LA, Sait SN, Block AW, Adjei AA, Barcos M, Griffiths EA, Thompson JE, Wang ES, Johnson CS, Trump DL, Wetzler M. Cancer. 2014 Feb 15;120(4):521-9.
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