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Robertson Microlit Laboratories

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Ledgewood, New Jersey, US

About Robertson Microlit Laboratories

Type: Privately Held Size: 11-50 employees

Robertson Microlit Laboratories is a full service analytical laboratory providing elemental analysis and chemical testing for the pharmaceutical, chemical, cosmetics and related industries for more than 30 years.

We at Robertson Microlit pride ourselves on providing industry leading analytical services and... Show more »

Robertson Microlit Laboratories is a full service analytical laboratory providing elemental analysis and chemical testing for the pharmaceutical, chemical, cosmetics and related industries for more than 30 years.

We at Robertson Microlit pride ourselves on providing industry leading analytical services and rapid turnaround times. Our corporate philosophy is committed to developing a partnership with all of our clients. We are an FDA inspected, GLP/GMP compliant laboratory located in Ledgewood, NJ.

You can rely on Robertson Microlit Laboratories to offer you expert services in:

  • Trace metals analysis
  • CHN, halogen and ion chromatography testing
  • Residual Solvents analyses
  • Spectroscopy and thermal analyses
  • Method Development and Validation Services
  • Karl Fischer analysis and other titrimetry/wet chemistry techniques
  • Customized analytical services and methods to meet your needs
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Our Services (36)


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Elemental Analysis

Price on request

Gas chromatography is a physical method of separation in which the components to be separated are distributed between two phases. Robertson Microlit offers a variety of Gas Chromatography (GC) services, including unknown solvent screening and residual solvent analysis. Headspace options are also available. Feel free to reach us... Show more »

Gas chromatography is a physical method of separation in which the components to be separated are distributed between two phases. Robertson Microlit offers a variety of Gas Chromatography (GC) services, including unknown solvent screening and residual solvent analysis. Headspace options are also available. Feel free to reach us for further information. Please note that all GC analysis requests should be communicated to us prior to submission to ensure that we are able to meet your specific requirements. When requesting GC analyses, please complete our GC-MS/GC-FID Request Form.

GC-FID
The most commonly used detector is the flame ionization detector (FID). Flame ionization detectors are widely used in gas chromatography because of their sensitivity to a wide range of components and ability to work over a wide range of concentrations. The FID detector is also quite robust and can measure organic substance concentration at very low and very high levels, with a linear response of 106.

USP <467> Residual Solvents
Residual solvents are typically determined using chromatographic techniques such as gas chromatography. There are many different solvents which may be used in pharmaceutical manufacturing. Residual solvents are separated into three classes based on risk assessment or their potential toxicity level. The objective of this general chapter is to provide acceptable amounts of residual solvents in pharmaceuticals for the safety of the patient.

GC-MS
Gas Chromatography-Mass Spectrometry (GC-MS) is capable of separating volatile and semi-volatile compounds in complex samples and is the method of choice for qualitatively and quantitatively evaluating samples containing a number of components. GC-MS has excellent linearity as well as an even lower limit of quantitation than that obtained by GC-FID and is capable of identifying unknown compounds that are present in a sample.

Unknown Scans by GC-MS
The actual identification of an unknown can be performed using GC-MS. Unknown scanning is a service offered for identification of unknown compounds by searching against a mass spectral database. A compound can not only be identified by its mass spectrum, but also by comparison of its retention time to that of a standard.

Headspace Analysis
Headspace gas chromatography is most suited for the analysis of the very light volatiles in samples that can be efficiently partitioned into the headspace gas volume from the liquid or solid matrix sample. The analysis of residual solvents in pharmaceutical products can benefit from this technique. Other common applications include industrial analyses of monomers in polymers and plastic, flavor compounds in beverages and food products, and fragrances in perfumes and cosmetics.

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Gas Chromatography (GC)

Gas Chromatography
Price on request

Gas chromatography is a physical method of separation in which the components to be separated are distributed between two phases. Robertson Microlit offers a variety of Gas Chromatography (GC) services, including unknown solvent screening and residual solvent analysis. Headspace options are also available. Feel free to reach us... Show more »

Gas chromatography is a physical method of separation in which the components to be separated are distributed between two phases. Robertson Microlit offers a variety of Gas Chromatography (GC) services, including unknown solvent screening and residual solvent analysis. Headspace options are also available. Feel free to reach us for further information. Please note that all GC analysis requests should be communicated to us prior to submission to ensure that we are able to meet your specific requirements. When requesting GC analyses, please complete our GC-MS/GC-FID Request Form.

GC-FID

The most commonly used detector is the flame ionization detector (FID). Flame ionization detectors are widely used in gas chromatography because of their sensitivity to a wide range of components and ability to work over a wide range of concentrations. The FID detector is also quite robust and can measure organic substance concentration at very low and very high levels, with a linear response of 106.

USP <467> Residual Solvents

Residual solvents are typically determined using chromatographic techniques such as gas chromatography. There are many different solvents which may be used in pharmaceutical manufacturing. Residual solvents are separated into three classes based on risk assessment or their potential toxicity level. The objective of this general chapter is to provide acceptable amounts of residual solvents in pharmaceuticals for the safety of the patient.

GC-MS

Gas Chromatography-Mass Spectrometry (GC-MS) is capable of separating volatile and semi-volatile compounds in complex samples and is the method of choice for qualitatively and quantitatively evaluating samples containing a number of components. GC-MS has excellent linearity as well as an even lower limit of quantitation than that obtained by GC-FID and is capable of identifying unknown compounds that are present in a sample.

Unknown Scans by GC-MS

The actual identification of an unknown can be performed using GC-MS. Unknown scanning is a service offered for identification of unknown compounds by searching against a mass spectral database. A compound can not only be identified by its mass spectrum, but also by comparison of its retention time to that of a standard.

Headspace Analysis

Headspace gas chromatography is most suited for the analysis of the very light volatiles in samples that can be efficiently partitioned into the headspace gas volume from the liquid or solid matrix sample. The analysis of residual solvents in pharmaceutical products can benefit from this technique. Other common applications include industrial analyses of monomers in polymers and plastic, flavor compounds in beverages and food products, and fragrances in perfumes and cosmetics.

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Ion Exchange Chromatography

Price on request

Ion Chromatography (IC), a hybrid method, is a preferred method for the determination of inorganic and organic ions. Direct aqueous dissolution provides for assay detection limits of ppm to the percent range. For compounds that require conversion of organically bound elements, the detection limit is 0.05% or lower. Proprietary... Show more »

Ion Chromatography (IC), a hybrid method, is a preferred method for the determination of inorganic and organic ions. Direct aqueous dissolution provides for assay detection limits of ppm to the percent range. For compounds that require conversion of organically bound elements, the detection limit is 0.05% or lower. Proprietary techniques and the use of Dionex Instrumentation make it possible to analyze ion concentrations from ppb to the percent range without the chemical interferences that are normally associated with titrimetric and photometric assays.

Robertson Microlit has recently updated its ion chromatography capabilities with the addition of the Thermo Scientific Dionex ICS-5000+ HPIC System. Thermo Scientific Dionex has led the industry for over 30 years, with instruments and solutions that represent state-of-the-art technological advancements and patented technologies. They’ve achieved best-in-class resolution, speed, and sensitivity optimized for ion chromatographic methods. This instrumentation ensures exceptional control and reproducibility for both isocratic and gradient separations, and provides fast, sensitive separations without sacrificing resolution. Whether using our general in-house method, or implementing customer-supplied methods and procedures, we have the capability to optimize peak resolution with a choice of isocratic and electrolytic gradient separations to achieve your most demanding analytical objectives.

Robertson Microlit has also updated its system to accommodate cations. Standard ions routinely analyzed at RML consist of SO4¯, Cl¯, Br¯, AcO¯, TFA ¯, I¯, PO4 ¯. Other ions are available but require a discussion with our chromatography specialist.

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HPLC

High Performance Liquid Chromatography
Price on request

High performance liquid chromatography (also referred to as high pressure liquid chromatography, HPLC, or simply LC) is one of several chromatographic separation techniques used to separate components, such as impurities or degradation products, which may be present in a particular sample. Separation of components is based on... Show more »

High performance liquid chromatography (also referred to as high pressure liquid chromatography, HPLC, or simply LC) is one of several chromatographic separation techniques used to separate components, such as impurities or degradation products, which may be present in a particular sample. Separation of components is based on their interactions with a liquid, or mobile phase, and a solid, stationary phase contained in a packed column. Because HPLC has the potential to provide reliable quantitative analyses of a main component and its related substances or impurities in a single run, it is a popular analytical technique commonly used in the pharmaceutical, food, nutritional supplements, and chemical industries.

Robertson Microlit has the capability of running normal and reverse phase isocratic or gradient methods utilizing multi-wavelength UV/Vis spectrophotometric or diode array detection (DAD).

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Trace Metal Analysis

Price on request

Metals analysis and trace metals testing are some of the expert services offered at Robertson Microlit. We offer multiple methods of perfoming these analyses, depending upon your needs and detection limits.

We have extensive, state-of-the-art capability to detect and accurately quantitate metal species in pharmaceutical or... Show more »

Metals analysis and trace metals testing are some of the expert services offered at Robertson Microlit. We offer multiple methods of perfoming these analyses, depending upon your needs and detection limits.

We have extensive, state-of-the-art capability to detect and accurately quantitate metal species in pharmaceutical or chemical compounds at percent, ppm, ppb, and in some cases, ppt levels, through the use of flame atomic absorption, atomic emission, and plasma-based instrumental techniques.

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ICP-MS

Inductively Coupled Plasma Mass Spectrometry
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Inductively Coupled Plasma, or ICP, is a high-temperature excitation source that desolvates, vaporizes, and atomizes samples in aerosol form, and then ionizes the resulting atoms. The excited analyte ions and atoms can then subsequently be detected by observing their emission lines (inductively coupled plasma optical emission... Show more »

Inductively Coupled Plasma, or ICP, is a high-temperature excitation source that desolvates, vaporizes, and atomizes samples in aerosol form, and then ionizes the resulting atoms. The excited analyte ions and atoms can then subsequently be detected by observing their emission lines (inductively coupled plasma optical emission spectrometry, or ICP-OES), or the excited or ground state ions can be determined using a mass detector (inductively coupled plasma mass spectrometry, or ICP-MS).Both ICP-OES and ICP-MS may be used for either single element or sequential/simultaneous multi-element qualitative or quantitative analysis.

We are currently using a Perkin Elmer Optima 7300DV ICP-OES, a Perkin Elmer NexION 300D ICP-MS, and we have acquired the latest in ICP-MS technology, an Agilent 7900 ICP-MS. With Agilent's 7900 ICP-MS, we are able to routinely measure samples containing up to 25% total dissolved solids (TDS) - 100 times higher than the traditional matrix limit for ICP-MS, and far beyond the capability of any other current system. The Agilent 7900 ICP-MS has a robust plasma and optional Ultra HIgh Matrix Introduction (UHMI) technology and the widest dynamic range. The new orthogonal detector system (ODS) delivers up to 11 orders of magnitude dynamic range from sub-ppt to percent-level concentrations, enabling us to measure trace elements and majors in the same run.

In addition, Robertson Microlit offers the ICP-MS multi-elemental scan, a service which provides a semi-quantitative determination of up to 71 elements in a single sample preparation. We also use our ICP-MS instrumentation for USP <232>/<233> Elemental Impurities . Validation and Method Development services are also available for metals analysis.

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AAS

Atomic Absorption Spectroscopy
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In Atomic Absorption Spectroscopy, or AA, a liquid sample is aspirated and atomized into a high-temperature flame. Light of a specific wavelength characteristic to the metal of interest, provided by a hollow cathode lamp, is passed through the flame containing the atomized sample. The corresponding metal atoms in the flame absorb... Show more »

In Atomic Absorption Spectroscopy, or AA, a liquid sample is aspirated and atomized into a high-temperature flame. Light of a specific wavelength characteristic to the metal of interest, provided by a hollow cathode lamp, is passed through the flame containing the atomized sample. The corresponding metal atoms in the flame absorb the light, resulting in a quantitative reduction of the light reaching the detector. This measured absorption can then be used to accurately determine the specific metal content of the sample solution.

Atomic Emission Spectroscopy, or AE, is similar to Atomic Absorption Spectroscopy as described above. However, no external light source is used. In Atomic Emission Spectroscopy, electrons of the atoms of interest are promoted to excited states in the flame and emit their characteristic radiation as they return to the ground state. The emission intensity at the characteristic wavelength is proportional to the concentration of the element in the sample.

Atomic Absorption and Atomic Emission may be used for quantitative and qualitative single-element determinations.

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Differential Scanning Calorimetry (DSC)

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Differential Scanning Calorimetry measures the amount of energy (heat) absorbed or released by a material as it is heated, cooled or held at a constant temperature. Solid and liquid samples can be analyzed with sample sizes between 1.0 mg. up to gram quantities. Used alone or in conjunction with other techniques, DSC can be used... Show more »

Differential Scanning Calorimetry measures the amount of energy (heat) absorbed or released by a material as it is heated, cooled or held at a constant temperature. Solid and liquid samples can be analyzed with sample sizes between 1.0 mg. up to gram quantities. Used alone or in conjunction with other techniques, DSC can be used for:

  • polymorph differentiation
  • eutectic purity
  • kinetic studies
  • thermal stability
  • thermal transitions
  • melting
  • crystallization
  • heat capacity
  • hydrate-solvate characterization
  • protein stability
  • formulation stability studies

DSC analyses can be performed using RML standard parameters, or with a client’s specified parameters.

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Thermogravimetric Analysis (TGA)

Thermogravimetric Analysis
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Thermogravimetric analysis, or TGA, examines the change in the mass of a substance as a function of temperature, time of heating, or both. This technique may be of more value and provide more meaningful information than a loss on drying determination, usually carried out at a fixed temperature for a fixed time at imprecise... Show more »

Thermogravimetric analysis, or TGA, examines the change in the mass of a substance as a function of temperature, time of heating, or both. This technique may be of more value and provide more meaningful information than a loss on drying determination, usually carried out at a fixed temperature for a fixed time at imprecise atmospheric conditions. TGA can, under most circumstances, distinguish surface-absorbed moisture or solvent from that occluded in a crystal formation or lattice, as well as losses due to thermally-induced degradation.

Measurements can be carried out in controlled atmospheres to reveal interactions with a drug substance, between drug substances, and between active substances and additives, excipients, or packaging materials.

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Melting Point Determination

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Melting Range or Melting Point is defined as those points of temperature within which, or the point at which, the first detectable liquid phase is detected to the temperature at which no solid phase is apparent. Factors influencing this phase transition include sample size, particle size, the efficiency of heat diffusion, and the... Show more »

Melting Range or Melting Point is defined as those points of temperature within which, or the point at which, the first detectable liquid phase is detected to the temperature at which no solid phase is apparent. Factors influencing this phase transition include sample size, particle size, the efficiency of heat diffusion, and the rate of heating. For some materials, the melting process may be accompanied by simultaneous decomposition, which may impair the precise determination of this property.

Robertson Microlit Laboratories can determine melting range, melting point, or decomposition temperature of submitted samples either visually, or instrumentally and precisely through the interpretation of an acquired thermogram.

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FT-IR

Fourier transform infrared spectroscopy
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Infrared spectra can be obtained for liquids and solids covering the 4000-400 cm-1 infrared region. Robertson Microlit offers an accurate, cost effective and efficient spectroscopy service using the Perkin Elmer Spectrum 400.

A variety of sample handling accessories allow nearly any type of solid sample to be analyzed. Liquids... Show more »

Infrared spectra can be obtained for liquids and solids covering the 4000-400 cm-1 infrared region. Robertson Microlit offers an accurate, cost effective and efficient spectroscopy service using the Perkin Elmer Spectrum 400.

A variety of sample handling accessories allow nearly any type of solid sample to be analyzed. Liquids are examined by either traditional IR techniques or with a Liquid Prism Cell. RML also has microscope capability. Graphical plots and spectral band labeling can be customized to individual requirements. Analysis data can also be stored on disk in J - CAMP format for further data manipulation. For an additional surcharge, spectral interpretation is available.

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NIR Spectroscopy

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Infrared (IR) absorption spectroscopy measures the interaction of electromagnetic radiation and the molecules, or atoms, of a chemical substance. Near-IR (or NIR) measures these interactions in the spectral range of 780 – 3000 nm. NIR is especially suitable for the qualitative determination of –OH and –NH groups, such as water in... Show more »

Infrared (IR) absorption spectroscopy measures the interaction of electromagnetic radiation and the molecules, or atoms, of a chemical substance. Near-IR (or NIR) measures these interactions in the spectral range of 780 – 3000 nm. NIR is especially suitable for the qualitative determination of –OH and –NH groups, such as water in alcohol, –OH in the presence of amines, alcohols in hydrocarbons, and primary and secondary amines in the presence of tertiary amines. Samples can be analyzed in powder form or by means of reflectance techniques with a minimum of preparation. NIR may also be used to confirm matrix modifications in pharmaceutical or similar preparations, and, with proper calibration, has the potential to be used for quantitative determinations.

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UV-VIS Spectroscopy

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UV/VIS analysis is useful in determining dosage strength, in quantifying isomeric purities and in assessing chemical reaction processes.

UV analysis at Robertson Microlit consists of a routine UV-Spectrum scan from 500-200 nm, which can be further expanded into the visible range if necessary. The wavelength range of our... Show more »

UV/VIS analysis is useful in determining dosage strength, in quantifying isomeric purities and in assessing chemical reaction processes.

UV analysis at Robertson Microlit consists of a routine UV-Spectrum scan from 500-200 nm, which can be further expanded into the visible range if necessary. The wavelength range of our instrumentation is 1100-190 nm.

Reports specify the respective nanometers for UV-maxima, shoulders and plateaus in absorption units (AU). If the molecular weight (MW) is provided, extinction coefficients (E) are calculated and included in the report; otherwise, values as (E1%1cm) are reported.

A standard solution of 0.5 mg compound in 50 ml spectro grade methanol is used for analysis; additional solvents are available.

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Optical Rotation

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Optical activity is the property of some substances, including certain active pharmaceutical ingredients, enabling the rotation of a beam of plane-polarized light. Polarimetry, the measurement of optical activity, is often the only convenient means for distinguishing optically active isomers from each other, and therefore provides... Show more »

Optical activity is the property of some substances, including certain active pharmaceutical ingredients, enabling the rotation of a beam of plane-polarized light. Polarimetry, the measurement of optical activity, is often the only convenient means for distinguishing optically active isomers from each other, and therefore provides an important methodology for the determination of identity and purity.

Robertson Microlit Laboratories can provide measurements of optical rotation for liquid substances, or specific rotation for solutions of solid substances at five discrete wavelengths under controlled temperature conditions. Typically, 10 - 20 mg of sample is required for this determination, depending upon your analytical requirements.

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Karl Fischer Titration

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Karl Fischer Coulometry quantitatively measures moisture Content (approximately 0.10%- 5%) in liquids or solids in the range of 10 micrograms to 10 mg. of water using 3 - 10 mg. of material.

Robertson Microlit utilizes Coulometric Titration, which affords greater sensitivity and requires smaller amounts of material than the... Show more »

Karl Fischer Coulometry quantitatively measures moisture Content (approximately 0.10%- 5%) in liquids or solids in the range of 10 micrograms to 10 mg. of water using 3 - 10 mg. of material.

Robertson Microlit utilizes Coulometric Titration, which affords greater sensitivity and requires smaller amounts of material than the Volumetric Titration method. We also perform Karl Fischer desorption analysis using an attached oven under nitrogen.

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USP Testing

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Robertson Microlit Laboratories routinely performs several USP monograph analyses:

USP <281> Residue on Ignition
USP <231> Heavy Metals*
USP <232>/<233> Elemental Impurities
USP <467> Residual Solvents
USP <191> Identity Testing

*Will become obsolete and replaced with USP <232>

Please note, we also have the... Show more »

Robertson Microlit Laboratories routinely performs several USP monograph analyses:

USP <281> Residue on Ignition
USP <231> Heavy Metals*
USP <232>/<233> Elemental Impurities
USP <467> Residual Solvents
USP <191> Identity Testing

*Will become obsolete and replaced with USP <232>

Please note, we also have the capabilities and expertise to perform many other USP analyses. Please contact us with your specific test method and requirements for details and a quote.

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Analytical Method Development

Price on request

We at Robertson Microlit Laboratories understand that analytical method development and validation are extremely important in the development of our clients’ products. Analytical methods must be validated to provide reliable data for regulatory submissions. With over 30 years of experience, our team routinely gives support to the... Show more »

We at Robertson Microlit Laboratories understand that analytical method development and validation are extremely important in the development of our clients’ products. Analytical methods must be validated to provide reliable data for regulatory submissions. With over 30 years of experience, our team routinely gives support to the development of these methods to ensure compliance with quality and safety standards. We have gained confidence with our clients by providing accurate and reproducible results. Our holistic approach provides processes for proven, well-developed methods which rapidly and accurately test samples. We are continuously updating and adding capabilities to suit the needs required by today’s fast paced and ever changing environment. To discuss these custom services or to request a quote, please feel free to contact us.

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Chemistry and Materials

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Engineering and Fabrication

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Product Development, Testing, and Packaging

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Product Development, Testing, and Packaging Services

Product Development, Testing, and Packaging Services

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Product Testing Services

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Product Testing Services

Product Testing Services

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Physical Analysis Methods

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Imaging & Spectroscopy

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Imaging & Spectroscopy Services

Imaging & Spectroscopy Services

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Spectroscopy

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Spectroscopy Services

Spectroscopy Services

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Spectrophotometry

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Spectrophotometry Services

Spectrophotometry Services

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Infrared Spectroscopy Services

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Infrared Spectroscopy Services

Infrared Spectroscopy Services

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Calorimetry

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Calorimetry Services

Calorimetry Services

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Mass Spectrometry

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Mass Spectrometry Services

Mass Spectrometry Services

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Other Mass Spectrometry Methods

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Other Mass Spectrometry Methods Services

Other Mass Spectrometry Methods Services

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Liquid Chromatography (LC)

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Liquid Chromatography Services

Liquid Chromatography Services

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Thermal Analysis Services

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Pyrolysis/Thermal Analysis

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Headspace Gas Chromatography

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Analytical Chemistry Services

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Chromatography

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Separation/Purification Services

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