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Revolve Biotechnologies, Inc.

Baltimore, Maryland, US

Revolve Biotechnologies is a life science company focused on engineering better biomolecules using novel directed evolution technologies.

Revolve offers custom DNA variant libraries and antibody discovery services. Our technology provides rapid access to comprehensive and expansive user-defined diversity, boosting the success rate of biopharmaceutical and enzyme optimization, protein variant discovery, and mutational mapping. Further applications include antibody/ADC/bispecific engineering, affinity maturation, and epitope mapping. The benefits of our novel patent-pending mutagenesis technology means a rapid delivery time at a highly cost-effective price.

The company’s IP portfolio was developed at and licensed from Johns Hopkins University. In addition to its internal protein pipeline, Revolve is currently offering a service for construction of custom DNA variant libraries with industry-leading performance and... Show more »

Revolve Biotechnologies is a life science company focused on engineering better biomolecules using novel directed evolution technologies.

Revolve offers custom DNA variant libraries and antibody discovery services. Our technology provides rapid access to comprehensive and expansive user-defined diversity, boosting the success rate of biopharmaceutical and enzyme optimization, protein variant discovery, and mutational mapping. Further applications include antibody/ADC/bispecific engineering, affinity maturation, and epitope mapping. The benefits of our novel patent-pending mutagenesis technology means a rapid delivery time at a highly cost-effective price.

The company’s IP portfolio was developed at and licensed from Johns Hopkins University. In addition to its internal protein pipeline, Revolve is currently offering a service for construction of custom DNA variant libraries with industry-leading performance and delivery time.

Selected Publications

  • Firnberg E, Labonte JW, Gray JJ, Ostermeier MA. A comprehensive, high-resolution map of a gene's fitness landscape, Molecular Biology and Evolution (2014)
  • Firnberg E, Ostermeier MA. PFunkel: efficient, expansive, user-defined mutagenesis, PLoS ONE (2012).
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Ribosome Display
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Phage Display Library Construction and Screening
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Protein Engineering
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Site-Directed Mutagenesis
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Antibody Discovery
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Drug Discovery & Development
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Site Saturation Mutagenesis
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Therapeutic Monoclonal Antibody (mAb) Development
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Antibody Services
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DNA Amplification
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Complementary Determining Region (CDR) Walking Mutagenesis
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ScFv Expression
Single Chain Variable Fragment Expression
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In vitro Monoclonal Antibody (mAb) Production
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Plasmid Monoclonal Antibody (mAb) Production
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Phospho Specific Monoclonal Antibody (mAb) Development
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Monoclonal Antibody (mAb) Production from Synthetic Peptides
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Complementary Determining Region (CDR) Grafting
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Custom Monoclonal Antibody (mAb) Production
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Directed Enzyme and Protein Evolution
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DNA Libraries
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Nucleic Acid Services
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Recombinant Antibody Production
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Phospho Antibody Production
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PCR
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Protein Purification and Quantification
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Antibody Affinity Maturation
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Random Mutagenesis
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DNA Library Screening
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Monoclonal Antibody (mAb) Production
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Protein Conjugation
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DNA
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Protein Services
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Mutagenesis
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Protein Expression
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Protein Expression Services

Protein Expression Services

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Alanine Scanning Mutagenesis
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