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Revolution Biosciences LLC

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Scituate, Massachusetts, US

About Revolution Biosciences LLC

Revolution Biosciences LLC is an early stage biopharmaceutical discovery company incorporated in Massachusetts in March 2015. Revolution Biosciences’ collaborative R&D discovery model leverages the power of chemical biology to discover and develop transformative medicines in partnership with the life... Show more »

Revolution Biosciences LLC is an early stage biopharmaceutical discovery company incorporated in Massachusetts in March 2015. Revolution Biosciences’ collaborative R&D discovery model leverages the power of chemical biology to discover and develop transformative medicines in partnership with the life science community. Revolution Biosciences enables life science companies’ access to cutting edge technologies through consulting agreements, collaborative partnerships and contract research. We develop new bioanalytical methods using Matrix Assisted Laser Desorption/Ionization Mass Spectrometry (MALDI-MS) to directly identify proteins, peptides and small molecules and their molecular interactions in all types of biological samples. Our small molecule drug discovery expertise and application of advanced proteomics technologies accelerates drug discovery research and our state of the art bioanalytical laboratory is equipped to handle bioanalytical studies from assay development through high throughput screening.

Revolution Biosciences is located at the Venture Development Center (VDC) at the University of Massachusetts in Boston in a secure, fully permitted laboratory for BSL-2 activities. Revolution Biosciences equipment resources include:

• Bruker AutoFlex II MALDI-TOF with reflector mode and enabled for Mass Imaging.
• Two TTP Labtech Mosquito Liquid Handlers (HTS & HV models)
• Tecan Safire plate reader
• Mettler Toledo AG285 balance
• Agilent Vcode barcode labeler with stacker
• Labconco XPert Filtered Balance Hood
• Thermo Multidrop Combi Liquid Dispenser
• Formulatrix Mantis Reagent Dispenser
• Cepheid SmartCycler Real-Time PCR instrument

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Diversity Certificates

Small business

Our Services (17)


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MALDI TOF MS

Matrix-assisted laser desorption ionization time-of-flight mass spectrometry
Starting at $25.00 per test

Measurement of small molecule, peptide and protein samples using MALDI-TOF MS, 4 test minimum.
(A test corresponds to one client sample analyzed using one MALDI Matrix)
Volume pricing available upon request.
Turnaround time: 1 week from sample receipt.

Measurement of small molecule, peptide and protein samples using MALDI-TOF MS, 4 test minimum.
(A test corresponds to one client sample analyzed using one MALDI Matrix)
Volume pricing available upon request.
Turnaround time: 1 week from sample receipt.

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MALDI Mass Spectrometry Methods

Price on request

We develop robust label-free assays for compound screening using MALDI mass spectrometry involving protein/peptide modification with the capacity to support Hit & Lead Optimization programs as well as primary screening. Our validated services are:

  • Label-Free Biochemical Screening
  • Covalent Labelling Assay Development

We develop robust label-free assays for compound screening using MALDI mass spectrometry involving protein/peptide modification with the capacity to support Hit & Lead Optimization programs as well as primary screening. Our validated services are:

  • Label-Free Biochemical Screening
  • Covalent Labelling Assay Development
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Differential Scanning Fluorimetry (DSF)

Differential Scanning Fluorimetry
Price on request

We develop robust Protein Thermal Shift assays using Differential Scanning Fluorimetry (DSF) with the capacity to support biophysical characterization in Hit & Lead Optimization programs as well as compound fragment screening.

We develop robust Protein Thermal Shift assays using Differential Scanning Fluorimetry (DSF) with the capacity to support biophysical characterization in Hit & Lead Optimization programs as well as compound fragment screening.

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High Content Screening

Price on request
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Drug Discovery Consulting

Price on request

Our major areas of expertise in medicinal chemistry and drug discovery:

  • Tardget identification & Validation
  • High Throughput Screening (HTS) including miniaturization and detection technologies
  • Hit & Optimization Chemistry
  • Biochemical and Biophysical Characterization
  • Cell Biology
  • High Content Analysis
  • Design... Show more »

Our major areas of expertise in medicinal chemistry and drug discovery:

  • Tardget identification & Validation
  • High Throughput Screening (HTS) including miniaturization and detection technologies
  • Hit & Optimization Chemistry
  • Biochemical and Biophysical Characterization
  • Cell Biology
  • High Content Analysis
  • Design and Build of Automation Solutions
  • Compound Management
  • Cancer Signal Transduction
  • Biomarker /translational research in solid tumors and hematologic malignancies
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Assay Development

Price on request
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Mass Spectrometry

Price on request
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Drug Discovery & Development

Price on request
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Spectroscopy

Price on request
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Chemistry and Materials

Price on request
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Cell-Based Screening Methods

Price on request
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Project Management

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Sequencing data in FASTQ

Price on request
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Analytical Chemistry Services

Price on request
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Drug Discovery

Price on request
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Cell-Based Assays

Price on request
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Imaging & Spectroscopy

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Brian Healey

President
FileType/PDF Created with Sketch.

AppNote-Covalent Labelling by MALDI-MS.pdf

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AppNote-Label-Free Biochemical Screening by MALDI-MS.pdf

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AppNote-ProteinThermalShift by DSF.pdf

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