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Revolution Biosciences LLC

1 Order Completed
Scituate, Massachusetts, US

About Revolution Biosciences LLC

Revolution Biosciences LLC is an early stage biopharmaceutical discovery company incorporated in Massachusetts in March 2015. Revolution Biosciences’ collaborative R&D discovery model leverages the power of chemical biology to discover and develop transformative medicines in partnership with the life... Show more »

Revolution Biosciences LLC is an early stage biopharmaceutical discovery company incorporated in Massachusetts in March 2015. Revolution Biosciences’ collaborative R&D discovery model leverages the power of chemical biology to discover and develop transformative medicines in partnership with the life science community. Revolution Biosciences enables life science companies’ access to cutting edge technologies through consulting agreements, collaborative partnerships and contract research. We develop new bioanalytical methods using Matrix Assisted Laser Desorption/Ionization Mass Spectrometry (MALDI-MS) to directly identify proteins, peptides and small molecules and their molecular interactions in all types of biological samples. Our small molecule drug discovery expertise and application of advanced proteomics technologies accelerates drug discovery research and our state of the art bioanalytical laboratory is equipped to handle bioanalytical studies from assay development through high throughput screening.

Revolution Biosciences is located at the Venture Development Center (VDC) at the University of Massachusetts in Boston in a secure, fully permitted laboratory for BSL-2 activities. Revolution Biosciences equipment resources include:

• Bruker AutoFlex II MALDI-TOF with reflector mode and enabled for Mass Imaging.
• Two TTP Labtech Mosquito Liquid Handlers (HTS & HV models)
• Tecan Safire plate reader
• Mettler Toledo AG285 balance
• Agilent Vcode barcode labeler with stacker
• Labconco XPert Filtered Balance Hood
• Thermo Multidrop Combi Liquid Dispenser
• Formulatrix Mantis Reagent Dispenser
• Cepheid SmartCycler Real-Time PCR instrument

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Diversity Certificates

Small business

Our Services (18)


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MALDI TOF MS

Matrix-assisted laser desorption ionization time-of-flight mass spectrometry
Starting at $25.00 per test

Measurement of small molecule, peptide and protein samples using MALDI-TOF MS, 4 test minimum.
(A test corresponds to one client sample analyzed using one MALDI Matrix)
Volume pricing available upon request.
Turnaround time: 1 week from sample receipt.

Measurement of small molecule, peptide and protein samples using MALDI-TOF MS, 4 test minimum.
(A test corresponds to one client sample analyzed using one MALDI Matrix)
Volume pricing available upon request.
Turnaround time: 1 week from sample receipt.

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MALDI Mass Spectrometry Methods

Price on request

We develop robust label-free assays for compound screening using MALDI mass spectrometry involving protein/peptide modification with the capacity to support Hit & Lead Optimization programs as well as primary screening. Our validated services are:

  • Label-Free Biochemical Screening
  • Covalent Labelling Assay Development

We develop robust label-free assays for compound screening using MALDI mass spectrometry involving protein/peptide modification with the capacity to support Hit & Lead Optimization programs as well as primary screening. Our validated services are:

  • Label-Free Biochemical Screening
  • Covalent Labelling Assay Development
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Protein Structure Determination

Price on request

Our internal structural biology expertise can help progress your drug development programs by providing... Show more »

Our internal structural biology expertise can help progress your drug development programs by providing critical structural insights that will guide development of your hit and lead molecules. 

Protein Engineering

Revolution Biosciences has expertise in protein engineering for yield, solubility, crystallization, and assay development.

  •  Molecular Biology: Revolution Biosciences has expertise in cloning and construct design for heterologous protein expression in prokaryotic and eukaryotic expression systems.
  •  Protein Expression and Purification: Revolution Biosciences has expertise in protein expression in, and purification from, E. coli, insect, and mammalian cells.
  •  Crystallization:  Revolution Biosciences has expertise in protein crystallization and has high throughput crystallization capabilities employing three Mosquito (TTP Labtech) liquid dispensing robots.

 Data collection

  • Revolution Biosciences has a proprietary user agreement for collection of x-ray diffraction data at the Brookhaven National Laboratory NSLS II. The 17-ID-1 AMX beamline at NSLS II is a 7x5 mm automated microfocus synchrotron beamline with crystal rastering and crystal vector design capabilities to optimize data collection from crystals with regional defects.

Structural Biology 

  • Revolution Biosciences has expertise in the determination of crystal structures by x-ray diffraction.
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Synchrotron protein crystallization Drug Discovery

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Drug Discovery Consulting

Price on request

Our major areas of expertise in medicinal chemistry and drug discovery:

  • Tardget identification & Validation
  • High Throughput Screening (HTS) including miniaturization and detection technologies
  • Hit & Optimization Chemistry
  • Biochemical and Biophysical Characterization
  • Cell Biology
  • High Content Analysis
  • Design... Show more »

Our major areas of expertise in medicinal chemistry and drug discovery:

  • Tardget identification & Validation
  • High Throughput Screening (HTS) including miniaturization and detection technologies
  • Hit & Optimization Chemistry
  • Biochemical and Biophysical Characterization
  • Cell Biology
  • High Content Analysis
  • Design and Build of Automation Solutions
  • Compound Management
  • Cancer Signal Transduction
  • Biomarker /translational research in solid tumors and hematologic malignancies
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Differential Scanning Fluorimetry (DSF)

Differential Scanning Fluorimetry
Price on request

We develop robust Protein Thermal Shift assays using Differential Scanning Fluorimetry (DSF) with the capacity to support biophysical characterization in Hit & Lead Optimization programs as well as compound fragment screening.

We develop robust Protein Thermal Shift assays using Differential Scanning Fluorimetry (DSF) with the capacity to support biophysical characterization in Hit & Lead Optimization programs as well as compound fragment screening.

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High Content Screening

Price on request
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Assay Development

Price on request
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Imaging & Spectroscopy

Price on request
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Cell-Based Assays

Price on request
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Drug Discovery

Price on request
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Analytical Chemistry Services

Price on request
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Biology

Price on request
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Project Management

Price on request
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Cell-Based Screening Methods

Price on request
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Chemistry and Materials

Price on request
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Spectroscopy

Price on request
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Drug Discovery & Development

Price on request
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Mass Spectrometry

Price on request
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Brian Healey

President

FileType/PDF Created with Sketch. AppNote-Covalent Labelling by MALDI-MS.pdf

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FileType/PDF Created with Sketch. AppNote-Label-Free Biochemical Screening by MALDI-MS.pdf

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FileType/PDF Created with Sketch. AppNote-ProteinThermalShift by DSF.pdf

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