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Reveal Biosciences

52 Orders Completed
San Diego, California, US

About Reveal Biosciences

Founded: 2012 Type: Privately Held Size: 1-10 employees

Reveal Biosciences is a San Diego-based contract research organization (CRO) that specializes in specializes in AI-powered histopathology services, including immunohistochemistry (IHC), immunofluorescence (IF), in situ hybridization (ISH), whole slide imaging, and... Show more »

Reveal Biosciences is a San Diego-based contract research organization (CRO) that specializes in specializes in AI-powered histopathology services, including immunohistochemistry (IHC), immunofluorescence (IF), in situ hybridization (ISH), whole slide imaging, and image analysis. Our proprietary deep-learning platform, ImageDx™, delivers pathologists and scientists a novel class of actionable, quantitative data to advance research and enhance patient care. Our integrated lab and computational teams work closely to ensure the highest-quality samples, images, and  data for your project. Contact us to find out how you can contain costs, meet timelines, and achieve your preclinical research goals.

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Our Services (78)


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Tumor Profiling

Price on request

From H&E stained tissue sections, we provide quantitation of percentage of tumor, stroma, necrosis, and inflammatory cells, as well as viable cell nuclei, using our ImageDx™ artificial intelligence platform. ImageDx uses sophisticated proprietary machine learning technology for reliable generation of quantitative data for your science.

From H&E stained tissue sections, we provide quantitation of percentage of tumor, stroma, necrosis, and inflammatory cells, as well as viable cell nuclei, using our ImageDx™ artificial intelligence platform. ImageDx uses sophisticated proprietary machine learning technology for reliable generation of quantitative data for your science.

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Leica BOND-III Human Mouse Rodents Hematoxylin Eosin Oncology Colorectal cancer Breast cancer Lung Cancer Ovarian Cancer Pancreatic cancer Machine learning whole slide imaging tissue section imaging FFPE tissue Human tissue Tumor tissue Biology Drug Discovery Show 20 more tags Show less

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Multiplex Immunohistochemistry (mIHC)

Price on request

Our multiplex IHC service includes staining of paraffin (FFPE) or frozen tissue sections. Assay development and optimization using colorimetric, fluorescent and multiplex approaches are available. Optimization of your choice of antibody and detection system is also available on request.
Our state-of-the-art Leica Bond... Show more »

Our multiplex IHC service includes staining of paraffin (FFPE) or frozen tissue sections. Assay development and optimization using colorimetric, fluorescent and multiplex approaches are available. Optimization of your choice of antibody and detection system is also available on request.
Our state-of-the-art Leica Bond immunostainer produces consistent quality high throughput immunohistochemistry (IHC). We have developed and validated a wide range of automated IHC protocols for rodent and human tissue. Ask us about our validated protocols.

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monoclonal antibodies antibodies Oncology multiplex immunohistochemistry Triple-stain Immunohistochemistry Dual-stain Immunohistochemistry FFPE tissue Biology Drug Discovery Toxicology PD-L1 cd8 CD3 CD4 CD31 CD68 FOXP3 PD1 Ki67 pan-cytokeratin Show 21 more tags Show less

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Tissue Cross Reactivity Studies

Price on request

We test and optimize the experimental antibody in a single tissue, then test for cross-reactivity in a set number of other tissues, depending on the customer's needs.

We test and optimize the experimental antibody in a single tissue, then test for cross-reactivity in a set number of other tissues, depending on the customer's needs.

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Data Analysis

Price on request

NAFLD/NASH Analysis

Co-developed with top liver pathologists, our NASH capabilities automate scoring in the cloud, with a focus on accuracy, reproducibility & scale. The NAFLD activity score includes assessments of micro & macro steatosis, lobular inflammation, and hepatocellular ballooning. The... Show more »

NAFLD/NASH Analysis

Co-developed with top liver pathologists, our NASH capabilities automate scoring in the cloud, with a focus on accuracy, reproducibility & scale. The NAFLD activity score includes assessments of micro & macro steatosis, lobular inflammation, and hepatocellular ballooning. The fibrosis description and score covers perisinusoidal / periportal fibrosis, bridging, and cirrhosis. Assays for iron deposition and Mallory bodies are also available.

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RNAscope Assay

Price on request

We offer high quality singleplex and multiplex in situ hybridization (ISH) to localize mRNA in your tissue samples, using the two leading ISH technologies RNascope (ACD) and ViewRNA (Thermo Fisher Scientific). Custom probes can be provided on request, please contact us to discuss your needs.
Tissue preparation including wax... Show more »

We offer high quality singleplex and multiplex in situ hybridization (ISH) to localize mRNA in your tissue samples, using the two leading ISH technologies RNascope (ACD) and ViewRNA (Thermo Fisher Scientific). Custom probes can be provided on request, please contact us to discuss your needs.
Tissue preparation including wax processing, embedding and RNAse-free sectioning (microtomy), or frozen section preparation (cryotomy) are also available on request.
In addition, we offer digital slide scanning and image analysis, resulting in quantitative ISH data.

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FISH Fluorescence in situ Hybridization mRNA Biology Drug Discovery

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Biomarker Assay Development

Price on request

Antibody selection and procurement services along with a full range of biomarker assay optimization levels for preclinical and clinical applications. Primary antibodies are tested on positive control tissue to determine optimal concentration and antigen retrieval conditions with a strong positive signal and low background. ... Show more »

Antibody selection and procurement services along with a full range of biomarker assay optimization levels for preclinical and clinical applications. Primary antibodies are tested on positive control tissue to determine optimal concentration and antigen retrieval conditions with a strong positive signal and low background. Immunohistochemistry and immunofluorescence available. Single-plex and multi-plex staining. Download "Reveal Biosciences Validated Biomarkers Feb 2018.pdf" in the resources for a list of our validated protocols.

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Antibody Testing

Price on request

Full range of antibody testing levels for preclinical and clinical histopathological applications. Primary antibodies are tested on positive control tissue to determine optimal concentration and antigen retrieval conditions with a strong positive signal and low background.

Full range of antibody testing levels for preclinical and clinical histopathological applications. Primary antibodies are tested on positive control tissue to determine optimal concentration and antigen retrieval conditions with a strong positive signal and low background.

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AlexaFluor Immunofluorescence immunohistochemistry histology IHC

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Imaging & Spectroscopy

Price on request
Request a quote for more information about this service.
Oncology Biology Drug Discovery

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Antibody Validation

Price on request

Full range of antibody optimization levels for preclinical and clinical histopathological applications. Primary antibodies are tested on positive control tissue to determine optimal concentration and antigen retrieval conditions with a strong positive signal and low background. See our white paper "Reveal Biosciences Antibody Validation" in the resources for more details.

Full range of antibody optimization levels for preclinical and clinical histopathological applications. Primary antibodies are tested on positive control tissue to determine optimal concentration and antigen retrieval conditions with a strong positive signal and low background. See our white paper "Reveal Biosciences Antibody Validation" in the resources for more details.

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Immunofluorescence immunohistochemistry histology IHC

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Antibody Optimization

Price on request

Full range of antibody optimization levels for preclinical and clinical histopathological applications. Primary antibodies are tested on positive control tissue to determine optimal concentration and antigen retrieval conditions with a strong positive signal and low background.

Full range of antibody optimization levels for preclinical and clinical histopathological applications. Primary antibodies are tested on positive control tissue to determine optimal concentration and antigen retrieval conditions with a strong positive signal and low background.

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Immunofluorescence immunohistochemistry histology IHC

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Antibody Screening

Price on request

Full range of antibody optimization levels for preclinical and clinical histopathological applications. Primary antibodies are tested on positive control tissue to determine optimal concentration and antigen retrieval conditions with a strong positive signal and low background.

Full range of antibody optimization levels for preclinical and clinical histopathological applications. Primary antibodies are tested on positive control tissue to determine optimal concentration and antigen retrieval conditions with a strong positive signal and low background.

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Immunofluorescence immunohistochemistry histology Drug Discovery

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Antibody Characterization

Price on request

Full range of antibody characterization levels for preclinical and clinical histopathological applications. Primary antibodies are tested on positive control tissue to determine optimal concentration and antigen retrieval conditions with a strong positive signal and low background.

Full range of antibody characterization levels for preclinical and clinical histopathological applications. Primary antibodies are tested on positive control tissue to determine optimal concentration and antigen retrieval conditions with a strong positive signal and low background.

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Immunofluorescence immunohistochemistry histology IHC

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Quantitative Histology

Price on request

Full service histology lab offering histological staining, immunohistochemistry, immunofluorescence, in situ hybridization with whole slide imaging and quantitative analysis

Full service histology lab offering histological staining, immunohistochemistry, immunofluorescence, in situ hybridization with whole slide imaging and quantitative analysis

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Leica BOND-III 3DHISTECH Pannoramic 250 Flash III Human Mouse Pig Rat Non-human Humanized Mouse monoclonal antibodies antibodies Oncology CNS/Neurology Non-Alcoholic Steatohepatitis (NASH) Immunofluorescence immunohistochemistry Machine learning FFPE tissue Biology Drug Discovery PD-L1 cd8 CD3 CD4 CD31 CD68 FOXP3 PD1 Ki67 pan-cytokeratin Show 29 more tags Show less

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Digital Pathology Software

Price on request

Our proprietary ImageDx software quickly and accurately analyzes images cell-by-cell for positivity and intensity to turn your tissue images into hard quantitative data. Request a quote today for more information.

Our proprietary ImageDx software quickly and accurately analyzes images cell-by-cell for positivity and intensity to turn your tissue images into hard quantitative data. Request a quote today for more information.

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Quantitative Image Analysis

Price on request

Our proprietary ImageDx software quickly and accurately analyzes images cell-by-cell for positivity and intensity to turn your tissue images into hard quantitative data. Request a quote today for more information.

Our proprietary ImageDx software quickly and accurately analyzes images cell-by-cell for positivity and intensity to turn your tissue images into hard quantitative data. Request a quote today for more information.

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Oncology CNS/Neurology Machine learning Deep Learning Artificial Intelligence Biology Drug Discovery Show 7 more tags Show less

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Biomarker Analysis

Price on request

Antibody selection and procurement services along with a full range of optimization levels for preclinical and clinical applications. Primary antibodies are tested on positive control tissue to determine optimal concentration and antigen retrieval conditions with a strong positive signal and low background. Immunohistochemistry... Show more »

Antibody selection and procurement services along with a full range of optimization levels for preclinical and clinical applications. Primary antibodies are tested on positive control tissue to determine optimal concentration and antigen retrieval conditions with a strong positive signal and low background. Immunohistochemistry and immunofluorescence available. Single-plex and multi-plex staining. Download "Reveal Biosciences Validated Biomarkers Feb 2018.pdf" in the resources for a list of our validated protocols.

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Leica BOND-III 3DHISTECH Pannoramic 250 Flash III monoclonal antibodies antibodies Oncology multiplex Immunofluorescence immunohistochemistry Dual-stain Immunohistochemistry Singlex FFPE tissue Biology Drug Discovery PD-L1 cd8 CD3 CD4 CD31 CD68 FOXP3 PD1 Ki67 pan-cytokeratin Show 23 more tags Show less

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Bright-Field Microscopy

Price on request
  • High resolution whole slide imaging in bright field and fluorescence​
  • Award-winning image quality
  • 20x (0.8 NA) and 40x (0.95 NA) magnification options; z-stacks available
  • Fast turn-around high throughput whole slide scanning
  • Comprehensive image QC process
    Our imaging suite includes whole slide scanning in both... Show more »
  • High resolution whole slide imaging in bright field and fluorescence​
  • Award-winning image quality
  • 20x (0.8 NA) and 40x (0.95 NA) magnification options; z-stacks available
  • Fast turn-around high throughput whole slide scanning
  • Comprehensive image QC process
    Our imaging suite includes whole slide scanning in both bright field and fluorescence using a range of slide scanning and imaging instruments from leading manufacturers including 3DHISTECH. Our comprehensive Quality Management Program includes a deep learning-based image quality application to automatically assess focus and image quality at scale.

Whole slide imaging for small or large-scale studies, including clinical trials.

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Leica BOND-III 3DHISTECH Pannoramic 250 Flash III 3DHISTECH Pannoramic SCAN II Oncology whole slide imaging tissue section imaging Biology Drug Discovery Show 8 more tags Show less

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Histology Control Slides

Price on request

High quality control slides for histological staining.

High quality control slides for histological staining.

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Leica BOND-III Oncology histology microscopy Biology Drug Discovery Show 6 more tags Show less

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Coverslipping

Price on request

Thin glass covering used to protect and preserve samples on slides. Service included in all histological staining, immunohistochemisty, immunofluorescence and in situ hybridization.

Thin glass covering used to protect and preserve samples on slides. Service included in all histological staining, immunohistochemisty, immunofluorescence and in situ hybridization.

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Leica BOND-III Oncology Biology Drug Discovery

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Cryoembedding

Price on request

Cryoprotecting and embedding of tissues for frozen sections with an astute level of control and predictability.

Cryoprotecting and embedding of tissues for frozen sections with an astute level of control and predictability.

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Cryosectioning

Price on request

OCT embedded frozen tissues are sectioned by our experienced histologists for histological staining or unstained slides

OCT embedded frozen tissues are sectioned by our experienced histologists for histological staining or unstained slides

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Leica BOND-III Microm HM 505 E Cryostat Oncology histology cryosectioning frozen sectioning cryotomy Biology Drug Discovery Show 9 more tags Show less

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Whole Slide Imaging/Digital Slide Scanning

Price on request

We offer bright field or fluorescent digital whole slide scanning using a 3D Histech Pannoramic SCAN scanner. High resolution images are provided with accompanying free software that allows image manipulation including zoom, rotation and channel selection.

We offer bright field or fluorescent digital whole slide scanning using a 3D Histech Pannoramic SCAN scanner. High resolution images are provided with accompanying free software that allows image manipulation including zoom, rotation and channel selection.

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Leica BOND-III 3DHISTECH Pannoramic SCAN II Human Mouse Rat Oncology Acute Lymphocytic Leukemia (ALL) microscopy Fluorescence whole slide imaging tissue section imaging FFPE tissue Human tissue Biology Drug Discovery Show 15 more tags Show less

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Fluorescence-Based Microscopy

Price on request

High resolution whole slide imaging in fluorescence​
Award-winning image quality
20x (0.8 NA) and 40x (0.95 NA) fluorescence magnification options
Up to 9-channel fluorescent channel scanning
Z stack up to 30 layers
Multi-layer scanning for perfect co-localization in FISH studies
Fast turn-around high throughput whole slide scanning
Comprehensive image QC process

High resolution whole slide imaging in fluorescence​
Award-winning image quality
20x (0.8 NA) and 40x (0.95 NA) fluorescence magnification options
Up to 9-channel fluorescent channel scanning
Z stack up to 30 layers
Multi-layer scanning for perfect co-localization in FISH studies
Fast turn-around high throughput whole slide scanning
Comprehensive image QC process

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Leica BOND-III 3DHISTECH Pannoramic SCAN II Oncology Immunofluorescence FISH IF Fluorescence in situ Hybridization Biology Drug Discovery Show 9 more tags Show less

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Formalin Fixation

Price on request

Tissue fixation in 10% Neutral Buffered Formalin (NBF) that ensures excellent preservation of tissue and cellular morphology for histological sections prior to processing and embedding.

Tissue fixation in 10% Neutral Buffered Formalin (NBF) that ensures excellent preservation of tissue and cellular morphology for histological sections prior to processing and embedding.

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Leica BOND-III Oncology Fresh Tissue Tumor tissue Biology Drug Discovery Show 6 more tags Show less

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Tissue Decalcification

Price on request

Formic Acid Tissue Decalcification
A weak acid used to decalcify samples for processing. Formic Acid is commonly used as it is a more gentle acid, and less likely to interfere with nuclear staining.

EDTA Tissue Decalcification
Ethylenediaminetetracetic acid (EDTA) decalcifying process; typically used for research... Show more »

Formic Acid Tissue Decalcification
A weak acid used to decalcify samples for processing. Formic Acid is commonly used as it is a more gentle acid, and less likely to interfere with nuclear staining.

EDTA Tissue Decalcification
Ethylenediaminetetracetic acid (EDTA) decalcifying process; typically used for research applications with very high quality morphology or particular molecular elements preservation requirements (IHC, FISH).

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Leica BOND-III Oncology Biology Drug Discovery

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H&E Staining

Hematoxylin and eosin staining
Price on request

Hematoxylin and eosin staining on both frozen and FFPE tissue sections.

Hematoxylin and eosin staining on both frozen and FFPE tissue sections.

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Leica BOND-III Human Mouse Rodents Hematoxylin Eosin Oncology Non-Alcoholic Steatohepatitis (NASH) FFPE tissue Biology Drug Discovery Toxicology Show 12 more tags Show less

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Histology and Pathology Services

Price on request

Slide preparation in either paraffin (FFPE) or Optimal Cutting Temperature (OCT, frozen sections). RNAse-free sections can be prepared on request. Histology services include:
-Tissue trimming
-Paraffin processing and embedding
-Microtomy and RNAse-free microtomy
-Cryotomy
-Decalcification of bone
-Hematoxylin & Eosin... Show more »

Slide preparation in either paraffin (FFPE) or Optimal Cutting Temperature (OCT, frozen sections). RNAse-free sections can be prepared on request. Histology services include:
-Tissue trimming
-Paraffin processing and embedding
-Microtomy and RNAse-free microtomy
-Cryotomy
-Decalcification of bone
-Hematoxylin & Eosin (H&E) stain
-Wide range of special stains
-Pathology review by a Board Certified DVM or MD pathologist

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Leica BOND-III Human Mouse Rodents Trichrome stain Hematoxylin Eosin Oncology Immunofluorescence immunohistochemistry histology IHC Machine learning cryoembedding cryosectioning tissue section imaging FFPE tissue Human tissue Tumor tissue Biology Drug Discovery PD-L1 cd8 CD3 CD4 CD31 CD68 FOXP3 PD1 Ki67 pan-cytokeratin Show 31 more tags Show less

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Digital Pathology Image Analysis

Price on request

Our proprietary ImageDx software quickly and accurately analyzes images cell-by-cell for positivity and intensity to turn your tissue images into hard quantitative data. Custom quantification available to meet your study goals.

Our proprietary ImageDx software quickly and accurately analyzes images cell-by-cell for positivity and intensity to turn your tissue images into hard quantitative data. Custom quantification available to meet your study goals.

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Histopathological Examination

Price on request

Pathology review by a Board Certified pathologist

Pathology review by a Board Certified pathologist

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Immunocytochemistry

Price on request

We offer immunohistochemistry and immunofluorescent staining services in fixed cells. Request a quote today for more information.

We offer immunohistochemistry and immunofluorescent staining services in fixed cells. Request a quote today for more information.

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Leica BOND-III 3DHISTECH Pannoramic SCAN II Oncology Biology Drug Discovery

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Immunofluorescence

Price on request

We offer high quality singleplex or multiplex immunofluorescent (IF) staining of your OCT or FFPE samples (tissue or fixed cells). Optimization of your antibody of interest is available on request. Contact us for more information on our IF services.

We offer high quality singleplex or multiplex immunofluorescent (IF) staining of your OCT or FFPE samples (tissue or fixed cells). Optimization of your antibody of interest is available on request. Contact us for more information on our IF services.

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Leica BOND-III 3DHISTECH Pannoramic 250 Flash III 3DHISTECH Pannoramic SCAN II Human Mouse Rodents monoclonal antibodies antibodies AlexaFluor Alexa Fluor 488 Alexa Fluor 546 Alexa Fluor 647 Oncology CNS/Neurology multiplex Immunofluorescence microscopy Singlex FFPE tissue Biology Drug Discovery PD-L1 cd8 CD3 CD4 CD31 CD68 FOXP3 PD1 Ki67 pan-cytokeratin Show 31 more tags Show less

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Immunohistochemistry (IHC)

Price on request

Our IHC service includes staining of paraffin (FFPE) or frozen tissue sections. Assay development and optimization using colorimetric, fluorescent and multiplex approaches are available. Optimization of your choice of antibody and detection system is also available on request.
Our state-of-the-art Leica Bond immunostainer... Show more »

Our IHC service includes staining of paraffin (FFPE) or frozen tissue sections. Assay development and optimization using colorimetric, fluorescent and multiplex approaches are available. Optimization of your choice of antibody and detection system is also available on request.
Our state-of-the-art Leica Bond immunostainer produces consistent quality high throughput immunohistochemistry (IHC). We have developed and validated a wide range of automated IHC protocols for rodent and human tissue. Ask us about our validated protocols.

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Leica BOND-III 3DHISTECH Pannoramic 250 Flash III Oncology CNS/Neurology Immuno-Oncology immunohistochemistry IHC Biology Drug Discovery Cytokines PD-L1 cd8 CD3 CD4 CD31 CD68 FOXP3 PD1 Ki67 pan-cytokeratin Show 20 more tags Show less

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In situ Hybridization (ISH)

In Situ Hybridization
Price on request

We offer high quality singleplex and multiplex in situ hybridization (ISH) to localize mRNA in your tissue samples, using the two leading ISH technologies ViewRNA (Thermo Fisher Scientific) and RNascope (ACD). Custom probes can be provided on request, please contact us to discuss your needs.
Tissue preparation including wax... Show more »

We offer high quality singleplex and multiplex in situ hybridization (ISH) to localize mRNA in your tissue samples, using the two leading ISH technologies ViewRNA (Thermo Fisher Scientific) and RNascope (ACD). Custom probes can be provided on request, please contact us to discuss your needs.
Tissue preparation including wax processing, embedding and RNAse-free sectioning (microtomy), or frozen section preparation (cryotomy) are also available on request.
In addition, we offer digital slide scanning and image analysis, resulting in quantitative ISH data.

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Leica BOND-III 3DHISTECH Pannoramic 250 Flash III Oncology CNS/Neurology FISH in situ hybridization ish mRNA Biology Drug Discovery Show 10 more tags Show less

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Mallory's Trichrome Staining

Price on request

Mallory's triple stain is composed of aniline blue, acid fuchsin, and orange G solution and is commonly used for distinguishing cellular from extracellular components.

Mallory's triple stain is composed of aniline blue, acid fuchsin, and orange G solution and is commonly used for distinguishing cellular from extracellular components.

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Leica BOND-III Trichrome stain histology Biology Drug Discovery

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Masson's Trichrome Staining

Price on request

This three-color staining protocol is used to distinguish cells from surrounding connective tissue; red reveals keratin and muscle fibers, blue- collagen and bone, dark pink- cytoplasm, and brown- cell nuclei. This staining is ideal for tissue fibrosis visualization.

This three-color staining protocol is used to distinguish cells from surrounding connective tissue; red reveals keratin and muscle fibers, blue- collagen and bone, dark pink- cytoplasm, and brown- cell nuclei. This staining is ideal for tissue fibrosis visualization.

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Leica BOND-III Human Mouse Rodents Trichrome stain Non-Alcoholic Steatohepatitis (NASH) Biology Drug Discovery Toxicology Show 9 more tags Show less

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Microscopy Image Analysis

Price on request

Our proprietary ImageDx software quickly and accurately analyzes images for marker positivity and intensity to turn your tissue images into hard quantitative data. Request a quote today for more information.

Our proprietary ImageDx software quickly and accurately analyzes images for marker positivity and intensity to turn your tissue images into hard quantitative data. Request a quote today for more information.

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Oncology CNS/Neurology Machine learning Biology Drug Discovery

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Cell Morphometry

Price on request

Morphometric analysis of a tissue slide; provides values referring to the metric dimensions of cells.

Morphometric analysis of a tissue slide; provides values referring to the metric dimensions of cells.

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Leica BOND-III Oncology Biology Drug Discovery

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Paraffin Embedding

Price on request

We offer paraffin-embedding of fixed and processed tissue samples and cells. Contact us for more information.

We offer paraffin-embedding of fixed and processed tissue samples and cells. Contact us for more information.

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FFPE tissue

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Periodic Acid-Schiff (PAS) Staining

Price on request

A staining method used for demonstration of polysaccharides and mucosubstances in tissues.

A staining method used for demonstration of polysaccharides and mucosubstances in tissues.

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Leica BOND-III Periodic Acid Schiff Oncology CNS/Neurology FFPE tissue Frozen Tissue Show 6 more tags Show less

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Paraffin Sectioning

Price on request

Human or animal paraffin embedded tissue sectioned using a microtome (microtomy) and prepared for staining and/or analysis.

Human or animal paraffin embedded tissue sectioned using a microtome (microtomy) and prepared for staining and/or analysis.

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Leica BOND-III Microm HM 340 E Microtome Oncology Biology Drug Discovery

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Veterinary Pathology

Price on request

Pathology review by a Board Certified DVM pathologist

Pathology review by a Board Certified DVM pathologist

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Leica BOND-III Mouse Rat Dog histology

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Special Slide Staining

Price on request

Various alternative staining techniques to detect, visualize, and evaluate particular tissue structures, elements or substances. We have more than 100 stains, including Masson’s Trichrome, Picrosirius Red, Oil Red O, Periodic Acid Schiff (PAS), Luxol Fast Blue (LFB), Nissl.

Various alternative staining techniques to detect, visualize, and evaluate particular tissue structures, elements or substances. We have more than 100 stains, including Masson’s Trichrome, Picrosirius Red, Oil Red O, Periodic Acid Schiff (PAS), Luxol Fast Blue (LFB), Nissl.

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Leica BOND-III Human Mouse Rodents Oil Red O Periodic Acid Schiff Masson's Trichrome Niss1 Picrosirius Red TUNEL Luxol Fast Blue Prussian Blue Fluorojade Oncology histology FFPE tissue Show 16 more tags Show less

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TUNEL Assay

Terminal deoxynucleotidyl transferase dUTP nick end labeling assay
Price on request

Automated TUNEL assay available for the detection of apoptotic cells in tissue sections. This assay can be performed on FFPE or frozen tissue sections from a range of species. Tissue preparation including wax processing, embedding and sectioning (microtomy), or frozen section preparation (cryotomy) also available on request. ... Show more »

Automated TUNEL assay available for the detection of apoptotic cells in tissue sections. This assay can be performed on FFPE or frozen tissue sections from a range of species. Tissue preparation including wax processing, embedding and sectioning (microtomy), or frozen section preparation (cryotomy) also available on request. Additionally, digital slide scanning and TUNEL quantification are available if needed.

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Leica BOND-III

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Tissue Microarrays

Price on request

A cost-effective approach to immunohistochemistry (IHC) on a range of high quality TMAs from multiple tissue types, delivering IHC data from a large number of patient samples. A cost-effective approach to immunohistochemistry (IHC) on a range of high quality TMAs from multiple tissue types, delivering IHC data from a large number... Show more »

A cost-effective approach to immunohistochemistry (IHC) on a range of high quality TMAs from multiple tissue types, delivering IHC data from a large number of patient samples. A cost-effective approach to immunohistochemistry (IHC) on a range of high quality TMAs from multiple tissue types, delivering IHC data from a large number of patient samples. Cancers of the bladder, breast, colon, endometrium, esophagus, kidney, liver, lung, brain, ovary, testis, pancreas, prostate, rectum, skin, stomach, thyroid and lymphoma available.

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Leica BOND-III Human Mouse Rat Melanoma Colorectal cancer Prostate Cancer Breast cancer Lung Cancer Ovarian Cancer Gastric Cancer Pancreatic cancer Liver cancer Bladder cancer Lymphoma Microarray Human tissue Show 17 more tags Show less

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Tissue Preparation

Price on request

Tissue trimming, tissue sectioning, tissue fixation, paraffin processing, embedding and staining for immunohistochemical (IHC), immunofluorescence (IF), or in situ hybridization (ISH) analysis.

Tissue trimming, tissue sectioning, tissue fixation, paraffin processing, embedding and staining for immunohistochemical (IHC), immunofluorescence (IF), or in situ hybridization (ISH) analysis.

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Leica BOND-III Microm HM 505 E Cryostat Microm HM 340 E Microtome tissue section imaging FFPE tissue

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Toluidine Blue Staining

Price on request

A basic thiazine metachromatic dye that selectively stains acidic tissue components; often used for staining tissues rich in DNA and RNA.

A basic thiazine metachromatic dye that selectively stains acidic tissue components; often used for staining tissues rich in DNA and RNA.

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Leica BOND-III

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Two-Photon Excitation Microscopy

Price on request

A fluorescence imaging technique that allows imaging of living tissue up to a very high depth of about one millimeter. The use of infrared light minimizes scattering in the tissue; two-photon excitation can be a superior alternative to confocal microscopy due to its deeper tissue penetration, efficient light detection, and reduced phototoxicity.

A fluorescence imaging technique that allows imaging of living tissue up to a very high depth of about one millimeter. The use of infrared light minimizes scattering in the tissue; two-photon excitation can be a superior alternative to confocal microscopy due to its deeper tissue penetration, efficient light detection, and reduced phototoxicity.

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Leica BOND-III 3DHISTECH Pannoramic SCAN II microscopy Fluorescence

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Widefield Fluorescence Microscopy

Price on request

Imaging and scanning of histopathological slides using widefield fluorescence microscopy.

Imaging and scanning of histopathological slides using widefield fluorescence microscopy.

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Leica BOND-III 3DHISTECH Pannoramic SCAN II Oncology histology microscopy Fluorescence FFPE tissue Biology Drug Discovery Show 9 more tags Show less

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Computational Modeling

Price on request

Our computational pathology team offers a range of quantitative options from traditional cell-by-cell machine learning-based analysis to artificial intelligence (AI) and deep learning-based applications. Accurate, reproducible, scalable data.

Our computational pathology team offers a range of quantitative options from traditional cell-by-cell machine learning-based analysis to artificial intelligence (AI) and deep learning-based applications. Accurate, reproducible, scalable data.

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Machine learning Deep Learning Artificial Intelligence Biology Drug Discovery

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Biospecimens

Price on request

High quality formalin-fixed paraffin embedded (FFPE) tissue microarrays cut fresh to order. Cancers of the bladder, breast, colon, endometrium, esophagus, kidney, liver, lung, brain, ovary, testis, pancreas, prostate, rectum, skin, stomach, thyroid and lymphoma, multi-tumor and normal tissue TMAs available.

High quality formalin-fixed paraffin embedded (FFPE) tissue microarrays cut fresh to order. Cancers of the bladder, breast, colon, endometrium, esophagus, kidney, liver, lung, brain, ovary, testis, pancreas, prostate, rectum, skin, stomach, thyroid and lymphoma, multi-tumor and normal tissue TMAs available.

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Human Mouse Oncology Respiratory Nephrology and Urology Hepatology Melanoma Colorectal cancer Prostate Cancer Breast cancer Lung Cancer Ovarian Cancer Gastric Cancer Pancreatic cancer Liver cancer Bladder cancer Lymphoma Esophageal cancer Microarray FFPE tissue Biology Drug Discovery Show 22 more tags Show less

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Tissue Fixation

Price on request

Our experienced scientists will ensure your tissue is fully fixed prior to processing.

Our experienced scientists will ensure your tissue is fully fixed prior to processing.

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Oncology Fresh Tissue Tumor tissue

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Biomarkers

Price on request

Hundreds of biomarkers optimized for single and multi-plex immunohistochemistry and immunofluorescence or we can optimize your marker of interest. Download "Reveal Biosciences Validated Biomarkers Feb 2018.pdf" in the resources for a list of our validated protocols.

Hundreds of biomarkers optimized for single and multi-plex immunohistochemistry and immunofluorescence or we can optimize your marker of interest. Download "Reveal Biosciences Validated Biomarkers Feb 2018.pdf" in the resources for a list of our validated protocols.

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Oncology Immunofluorescence immunohistochemistry IHC Biology Drug Discovery PD-L1 cd8 CD3 CD4 CD31 CD68 FOXP3 PD1 Ki67 pan-cytokeratin Show 16 more tags Show less

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Clinical Research

Price on request

Our full service histology laboratory offers fast turnaround, high quality reproducible results and a multi-step QC process.

Our full service histology laboratory offers fast turnaround, high quality reproducible results and a multi-step QC process.

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Oncology Biology Drug Discovery

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Clinical Laboratory Services

Price on request

Our full service histology laboratory offers fast turnaround, high quality reproducible results and a multi-step QC process.

Our full service histology laboratory offers fast turnaround, high quality reproducible results and a multi-step QC process.

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Oncology Biology Drug Discovery

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Tissue Embedding

Price on request

Our experienced scientists will orient and embed your tissue in paraffin or OCT compound (optimal cutting temperature compound) according to your specifications

Our experienced scientists will orient and embed your tissue in paraffin or OCT compound (optimal cutting temperature compound) according to your specifications

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Human Mouse Rodents Oncology CNS/Neurology FFPE tissue Show 6 more tags Show less

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Antibody Services

Price on request

Antibody selection and procurement services along with a full range of optimization levels for preclinical and clinical applications. Primary antibodies are tested on positive control tissue to determine optimal concentration and antigen retrieval conditions with a strong positive signal and low background.

Antibody selection and procurement services along with a full range of optimization levels for preclinical and clinical applications. Primary antibodies are tested on positive control tissue to determine optimal concentration and antigen retrieval conditions with a strong positive signal and low background.

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Leica BOND-III Human Rabbit Mouse Rat Oncology Biology Drug Discovery Show 8 more tags Show less

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Common Histochemical Stains

Price on request

Our histology lab offers H&E staining, Masson's Trichrome, PAS, Oil Red O, Nissl, Picrosirius red, TUNEL, Luxol Fast blue, Prussian blue, and Fluorojade. Ask us about other special stains.

Our histology lab offers H&E staining, Masson's Trichrome, PAS, Oil Red O, Nissl, Picrosirius red, TUNEL, Luxol Fast blue, Prussian blue, and Fluorojade. Ask us about other special stains.

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Human Rabbit Mouse Rat Dog Trichrome stain Iron hemotoxylin stain Hematoxylin Eosin Oil Red O Masson's Trichrome PAS Niss1 Picrosirius Red TUNEL Luxol Fast Blue Prussian Blue Flurojade Oncology Biology Drug Discovery Show 21 more tags Show less

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Clinical and Anatomic Pathology

Price on request

Pathological evaluation by board certified pathologist

Pathological evaluation by board certified pathologist

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Oncology Biology Drug Discovery

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Immunostaining

Price on request

We offer immunostaining of your OCT and FFPE samples. Assay development and optimization using colorimetric, fluorescent and multiplex approaches are available.
Our state-of-the-art Leica Bond immunostainer produces consistent quality high throughput immunohistochemistry (IHC). We have developed and validated a wide range of... Show more »

We offer immunostaining of your OCT and FFPE samples. Assay development and optimization using colorimetric, fluorescent and multiplex approaches are available.
Our state-of-the-art Leica Bond immunostainer produces consistent quality high throughput immunohistochemistry (IHC). We have developed and validated a wide range of automated IHC protocols for rodent and human tissue. Ask us about our validated protocols.

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Oncology immunohistochemistry IHC Biology Drug Discovery

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Protein Expression Visualization

Price on request

Visualization and quantitation of protein biomarkers in human or animal tissue using immunohistochemistry (IHC) or immunofluorescence (IF). Hundreds of protein biomarkers protocols available. Download "Reveal Biosciences Validated Biomarkers Feb 2018.pdf" in the resources for a list of our validated protocols.

Visualization and quantitation of protein biomarkers in human or animal tissue using immunohistochemistry (IHC) or immunofluorescence (IF). Hundreds of protein biomarkers protocols available. Download "Reveal Biosciences Validated Biomarkers Feb 2018.pdf" in the resources for a list of our validated protocols.

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Leica BOND-III Oncology immunohistochemistry IHC Biology Drug Discovery cd8 Show 7 more tags Show less

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Image Analysis

Price on request

Our proprietary ImageDx software quickly and accurately analyzes images cell-by-cell for marker positivity and intensity to turn your tissue images into hard quantitative data. Request a quote today for more information.

Our proprietary ImageDx software quickly and accurately analyzes images cell-by-cell for marker positivity and intensity to turn your tissue images into hard quantitative data. Request a quote today for more information.

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Oncology Machine learning Deep Learning Artificial Intelligence Biology Drug Discovery Show 6 more tags Show less

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Data Services

Price on request

Our computational pathology team offers a range of quantitative options from traditional cell-by-cell machine learning-based analysis to artificial intelligence (AI) and deep learning-based applications. Accurate, reproducible, scalable data.

Our computational pathology team offers a range of quantitative options from traditional cell-by-cell machine learning-based analysis to artificial intelligence (AI) and deep learning-based applications. Accurate, reproducible, scalable data.

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Oncology Machine learning Deep Learning Artificial Intelligence Biology Drug Discovery Show 6 more tags Show less

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Microscopy

Price on request

We offer bright field or fluorescent digital whole slide scanning using a 3D Histech Pannoramic SCAN scanner. High resolution images are provided with accompanying free software that allows image manipulation including zoom, rotation and channel selection.

We offer bright field or fluorescent digital whole slide scanning using a 3D Histech Pannoramic SCAN scanner. High resolution images are provided with accompanying free software that allows image manipulation including zoom, rotation and channel selection.

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microscopy whole slide imaging Biology Drug Discovery

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Histological Staining

Price on request

Our full service histology lab offers histochemical stains, immuhistochemistry and immunofluorescent staining.

Our full service histology lab offers histochemical stains, immuhistochemistry and immunofluorescent staining.

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Hematoxylin Eosin Oncology Immunofluorescence immunohistochemistry IHC FFPE tissue Biology Drug Discovery Show 9 more tags Show less

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Cell-Based Assays

Price on request

Processing and embedding of cell pellets. Histological staining, immunohistochemistry, immunofluorescence, in situ hybridization along with whole slide imaging and quantitative image analysis.

Processing and embedding of cell pellets. Histological staining, immunohistochemistry, immunofluorescence, in situ hybridization along with whole slide imaging and quantitative image analysis.

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3DHISTECH Pannoramic 250 Flash III Oncology Biology Drug Discovery

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Tissue Processing

Price on request

Fixed or frozen tissue processed for FFPE or OCT blocks. Experienced scientists ensure tissue is properly fixed prior to processing and embedding.

Fixed or frozen tissue processed for FFPE or OCT blocks. Experienced scientists ensure tissue is properly fixed prior to processing and embedding.

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Microm HM 505 E Cryostat Microm HM 340 E Microtome

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Cells and Tissues

Price on request

Procurement of cells and tissue samples to accompany your IHC, IF or ISH study. Reveal offers high quality formalin-fixed paraffin embedded (FFPE) tissue microarrays cut fresh to order.

Procurement of cells and tissue samples to accompany your IHC, IF or ISH study. Reveal offers high quality formalin-fixed paraffin embedded (FFPE) tissue microarrays cut fresh to order.

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Oncology Melanoma Colorectal cancer Prostate Cancer Breast cancer Lung Cancer Ovarian Cancer Gastric Cancer Pancreatic cancer Liver cancer Bladder cancer Lymphoma Microarray Human tissue Biology Drug Discovery Show 16 more tags Show less

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Bioanalysis

Price on request

Quantitative histology services including H&E, special stains, immunohistochemistry, immunofluorescence, and in situ hybridization with whole slide imaging and quantitative analysis

Quantitative histology services including H&E, special stains, immunohistochemistry, immunofluorescence, and in situ hybridization with whole slide imaging and quantitative analysis

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Leica BOND-III 3DHISTECH Pannoramic 250 Flash III Oncology Biology Drug Discovery

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Tissue Sectioning

Price on request

High quality sectioning of FFPE or frozen tissue by experienced histologists. Includes slide mounting.

High quality sectioning of FFPE or frozen tissue by experienced histologists. Includes slide mounting.

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Microm HM 505 E Cryostat Microm HM 340 E Microtome cryosectioning frozen sectioning FFPE tissue

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Transmitted Light Microscopy

Price on request
Request a quote for more information about this service.

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Drug Discovery & Development

Price on request

Drug Discovery & Development Services

Drug Discovery & Development Services

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Computational Pathology

Price on request

Our computational pathology team offers a range of quantitative options from traditional cell-by-cell machine learning-based analysis to AI and deep learning-based applications. Accurate, reproducible, scalable data.

Our computational pathology team offers a range of quantitative options from traditional cell-by-cell machine learning-based analysis to AI and deep learning-based applications. Accurate, reproducible, scalable data.

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Machine learning Deep Learning Artificial Intelligence Biology Drug Discovery

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Fluorescence in situ Hybridization (FISH)

Price on request

We offer high quality singleplex and multiplex fluorescence in situ hybridization (FISH) to localize mRNA in your tissue samples, using the two leading technologies ViewRNA (Thermo Fisher Scientific) and RNascope (ACD). Custom probes can be provided on request, please contact us to discuss your needs.
Tissue preparation... Show more »

We offer high quality singleplex and multiplex fluorescence in situ hybridization (FISH) to localize mRNA in your tissue samples, using the two leading technologies ViewRNA (Thermo Fisher Scientific) and RNascope (ACD). Custom probes can be provided on request, please contact us to discuss your needs.
Tissue preparation including wax processing, embedding and RNAse-free sectioning (microtomy), or frozen section preparation (cryotomy) are also available on request.
In addition, we offer digital slide scanning and image analysis, resulting in quantitative FISH data.

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FISH Fluorescence Fluorescence in situ Hybridization mRNA

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RNA Services

Price on request

We offer high quality singleplex and multiplex fluorescence in situ hybridization (FISH) to localize mRNA in your tissue samples, using the two leading technologies ViewRNA (Thermo Fisher Scientific) and RNascope (ACD). Custom probes can be provided on request, please contact us to discuss your needs.
Tissue preparation... Show more »

We offer high quality singleplex and multiplex fluorescence in situ hybridization (FISH) to localize mRNA in your tissue samples, using the two leading technologies ViewRNA (Thermo Fisher Scientific) and RNascope (ACD). Custom probes can be provided on request, please contact us to discuss your needs.
Tissue preparation including wax processing, embedding and RNAse-free sectioning (microtomy), or frozen section preparation (cryotomy) are also available on request.
In addition, we offer digital slide scanning and image analysis, resulting in quantitative FISH data.

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Pharmacology

Price on request

Pharmacology Services

Pharmacology Services

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Tumor Marker Testing

Price on request

Tumor Marker Testing Services

Tumor Marker Testing Services

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Antibody/Antigen Detection Based Testing

Price on request

Antibody/Antigen Detection Based Testing Services

Antibody/Antigen Detection Based Testing Services

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Clinical Chemistry

Price on request

Clinical Chemistry Services

Clinical Chemistry Services

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Get info on this provider's capabilities without requesting a quote.

FileType/PDF Created with Sketch. Reveal Bioscience Validated Biomarkers Feb 2018.pdf

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FileType/PDF Created with Sketch. Reveal Biosciences Antibody Validation.pdf

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FileType/PDF Created with Sketch. Reveal Biosciences Introduction.pdf

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  • Positive review for In situ Hybridization (ISH):

    March 2018

    "I worked with Reveal Biosciences twice and I will work with them again and again. Their services exceeded my expectations. My service requests are always followed by many questions, they always answered them promptly ( within 1-2 hrs), clearly and with professionalism. The service turn-out time is really fast and service cost is reasonable. Thank you Reveal Biosciences for facilitating my research ! Mariam Ba"

  • Positive review for Immunohistochemistry (IHC):

    March 2017

    "Reveal Biosciences performed a very thorough antibody validation for IHC. Even though, we did not find an optimal antibody for our purpose (in spite of an existing antibody validation paper out there), Reveal and Caroline worked very hard to test additional antibodies and were very flexible as the scope of work changed along the way. They were accommodating and professional all the way to completion of the project. We will definitely return back to do additional work with Reveal."

  • Positive review for Immunofluorescence:

    August 2013

    "We have worked with Claire on several occasions and have always been really impressed by her high quality work and excellent service."

  • Positive review for Immunohistochemistry (IHC):

    July 2013

    "Excellent - would highly recommend."

  • Positive review for Immunohistochemistry (IHC):

    April 2013

    "Excellent. Provided very high quality immunohistochemistry images. Communication and service level were excellent."

  • Positive review for Immunohistochemistry (IHC):

    September 2012

    "Excellent service and quick communications, just a pleasure to work with!"

Reveal Biosciences has not received any endorsements.