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Reveal Biosciences

59 Orders Completed
San Diego, California, US

About Reveal Biosciences

Founded: 2012 Type: Privately Held Size: 1-10 employees

**Discounts available for COVID-19-related research. Click 'Request More Info' button on this page to ask about offer details.**

Reveal Biosciences is a San Diego-based contract research organization (CRO) that specializes in specializes in AI-powered histopathology services, including...

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**Discounts available for COVID-19-related research. Click 'Request More Info' button on this page to ask about offer details.**

Reveal Biosciences is a San Diego-based contract research organization (CRO) that specializes in specializes in AI-powered histopathology services, including immunohistochemistry (IHC), immunofluorescence (IF), in situ hybridization (ISH), whole slide imaging, and image analysis. Our proprietary deep-learning platform, ImageDx™, delivers pathologists and scientists a novel class of actionable, quantitative data to advance research and enhance patient care. Our integrated lab and computational teams work closely to ensure the highest-quality samples, images, and  data for your project. Contact us to find out how you can contain costs, meet timelines, and achieve your preclinical research goals.

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Our Services (78)


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Tumor Profiling

Price on request

From H&E stained tissue sections, we provide quantitation of percentage of tumor, stroma, necrosis, and inflammatory cells, as well as viable cell nuclei, using our ImageDx™ artificial intelligence platform. ImageDx uses sophisticated proprietary machine learning technology for reliable generation of quantitative data for your science.

From H&E stained tissue sections, we provide quantitation of percentage of tumor, stroma, necrosis, and inflammatory cells, as well as viable cell nuclei, using our ImageDx™ artificial intelligence platform. ImageDx uses sophisticated proprietary machine learning technology for reliable generation of quantitative data for your science.

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Ovarian Cancer Breast cancer Pancreatic cancer Lung Cancer Colorectal cancer Leica BOND-III Drug Discovery Biology Machine learning tissue section imaging whole slide imaging Hematoxylin Eosin FFPE tissue Tumor tissue Human tissue Human Mouse Rodents Oncology Show 20 more tags Show less

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Multiplex Immunohistochemistry (mIHC)

Price on request

Our multiplex IHC service includes staining of paraffin (FFPE) or frozen tissue sections. Assay development and optimization using colorimetric, fluorescent and multiplex approaches are available. Optimization of your choice of antibody and detection system is also available on request.
Our state-of-the-art Leica Bond... Show more »

Our multiplex IHC service includes staining of paraffin (FFPE) or frozen tissue sections. Assay development and optimization using colorimetric, fluorescent and multiplex approaches are available. Optimization of your choice of antibody and detection system is also available on request.
Our state-of-the-art Leica Bond immunostainer produces consistent quality high throughput immunohistochemistry (IHC). We have developed and validated a wide range of automated IHC protocols for rodent and human tissue. Ask us about our validated protocols.

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Drug Discovery Biology multiplex immunohistochemistry Dual-stain Immunohistochemistry Triple-stain Immunohistochemistry antibodies monoclonal antibodies FFPE tissue Toxicology Oncology CD3 CD4 CD31 CD68 cd8 FOXP3 PD1 PD-L1 Ki67 pan-cytokeratin Show 21 more tags Show less

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Tissue Cross Reactivity Studies

Price on request

We test and optimize the experimental antibody in a single tissue, then test for cross-reactivity in a set number of other tissues, depending on the customer's needs.

We test and optimize the experimental antibody in a single tissue, then test for cross-reactivity in a set number of other tissues, depending on the customer's needs.

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Data Analysis

Price on request

NAFLD/NASH Analysis

Co-developed with top liver pathologists, our NASH capabilities automate scoring in the cloud, with a focus on accuracy, reproducibility & scale. The NAFLD activity score includes assessments of micro & macro steatosis, lobular inflammation, and hepatocellular ballooning. The... Show more »

NAFLD/NASH Analysis

Co-developed with top liver pathologists, our NASH capabilities automate scoring in the cloud, with a focus on accuracy, reproducibility & scale. The NAFLD activity score includes assessments of micro & macro steatosis, lobular inflammation, and hepatocellular ballooning. The fibrosis description and score covers perisinusoidal / periportal fibrosis, bridging, and cirrhosis. Assays for iron deposition and Mallory bodies are also available.

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RNAscope Assay

Price on request

We offer high quality singleplex and multiplex in situ hybridization (ISH) to localize mRNA in your tissue samples, using the two leading ISH technologies RNascope (ACD) and ViewRNA (Thermo Fisher Scientific). Custom probes can be provided on request, please contact us to discuss your needs.
Tissue preparation including wax... Show more »

We offer high quality singleplex and multiplex in situ hybridization (ISH) to localize mRNA in your tissue samples, using the two leading ISH technologies RNascope (ACD) and ViewRNA (Thermo Fisher Scientific). Custom probes can be provided on request, please contact us to discuss your needs.
Tissue preparation including wax processing, embedding and RNAse-free sectioning (microtomy), or frozen section preparation (cryotomy) are also available on request.
In addition, we offer digital slide scanning and image analysis, resulting in quantitative ISH data.

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mRNA Drug Discovery Biology Fluorescence in situ Hybridization FISH

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Biomarker Assay Development

Price on request

Antibody selection and procurement services along with a full range of biomarker assay optimization levels for preclinical and clinical applications. Primary antibodies are tested on positive control tissue to determine optimal concentration and antigen retrieval conditions with a strong positive signal and low background. ... Show more »

Antibody selection and procurement services along with a full range of biomarker assay optimization levels for preclinical and clinical applications. Primary antibodies are tested on positive control tissue to determine optimal concentration and antigen retrieval conditions with a strong positive signal and low background. Immunohistochemistry and immunofluorescence available. Single-plex and multi-plex staining. Download "Reveal Biosciences Validated Biomarkers Feb 2018.pdf" in the resources for a list of our validated protocols.

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Antibody Testing

Price on request

Full range of antibody testing levels for preclinical and clinical histopathological applications. Primary antibodies are tested on positive control tissue to determine optimal concentration and antigen retrieval conditions with a strong positive signal and low background.

Full range of antibody testing levels for preclinical and clinical histopathological applications. Primary antibodies are tested on positive control tissue to determine optimal concentration and antigen retrieval conditions with a strong positive signal and low background.

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histology immunohistochemistry IHC Immunofluorescence AlexaFluor

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Imaging & Spectroscopy

Price on request
Request a quote for more information about this service.
Oncology Drug Discovery Biology

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Antibody Validation

Price on request

Full range of antibody optimization levels for preclinical and clinical histopathological applications. Primary antibodies are tested on positive control tissue to determine optimal concentration and antigen retrieval conditions with a strong positive signal and low background. See our white paper "Reveal Biosciences Antibody Validation" in the resources for more details.

Full range of antibody optimization levels for preclinical and clinical histopathological applications. Primary antibodies are tested on positive control tissue to determine optimal concentration and antigen retrieval conditions with a strong positive signal and low background. See our white paper "Reveal Biosciences Antibody Validation" in the resources for more details.

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histology immunohistochemistry IHC Immunofluorescence

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Antibody Optimization

Price on request

Full range of antibody optimization levels for preclinical and clinical histopathological applications. Primary antibodies are tested on positive control tissue to determine optimal concentration and antigen retrieval conditions with a strong positive signal and low background.

Full range of antibody optimization levels for preclinical and clinical histopathological applications. Primary antibodies are tested on positive control tissue to determine optimal concentration and antigen retrieval conditions with a strong positive signal and low background.

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histology immunohistochemistry IHC Immunofluorescence

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Antibody Screening

Price on request

Full range of antibody optimization levels for preclinical and clinical histopathological applications. Primary antibodies are tested on positive control tissue to determine optimal concentration and antigen retrieval conditions with a strong positive signal and low background.

Full range of antibody optimization levels for preclinical and clinical histopathological applications. Primary antibodies are tested on positive control tissue to determine optimal concentration and antigen retrieval conditions with a strong positive signal and low background.

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Drug Discovery histology immunohistochemistry Immunofluorescence

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Antibody Characterization

Price on request

Full range of antibody characterization levels for preclinical and clinical histopathological applications. Primary antibodies are tested on positive control tissue to determine optimal concentration and antigen retrieval conditions with a strong positive signal and low background.

Full range of antibody characterization levels for preclinical and clinical histopathological applications. Primary antibodies are tested on positive control tissue to determine optimal concentration and antigen retrieval conditions with a strong positive signal and low background.

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histology immunohistochemistry IHC Immunofluorescence

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Quantitative Histology

Price on request

Full service histology lab offering histological staining, immunohistochemistry, immunofluorescence, in situ hybridization with whole slide imaging and quantitative analysis

Full service histology lab offering histological staining, immunohistochemistry, immunofluorescence, in situ hybridization with whole slide imaging and quantitative analysis

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Leica BOND-III Mouse Human Humanized Mouse Rat Pig Drug Discovery Biology immunohistochemistry Immunofluorescence Machine learning FFPE tissue Oncology CNS/Neurology antibodies monoclonal antibodies Non-Alcoholic Steatohepatitis (NASH) 3DHISTECH Pannoramic 250 Flash III CD3 CD4 cd8 CD31 CD68 FOXP3 PD1 PD-L1 Ki67 pan-cytokeratin Non-human Show 29 more tags Show less

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Digital Pathology Software

Price on request

Our proprietary ImageDx software quickly and accurately analyzes images cell-by-cell for positivity and intensity to turn your tissue images into hard quantitative data. Request a quote today for more information.

Our proprietary ImageDx software quickly and accurately analyzes images cell-by-cell for positivity and intensity to turn your tissue images into hard quantitative data. Request a quote today for more information.

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Drug Discovery Biology Machine learning Oncology Deep Learning Artificial Intelligence Show 6 more tags Show less

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Quantitative Image Analysis

Price on request

Our proprietary ImageDx software quickly and accurately analyzes images cell-by-cell for positivity and intensity to turn your tissue images into hard quantitative data. Request a quote today for more information.

Our proprietary ImageDx software quickly and accurately analyzes images cell-by-cell for positivity and intensity to turn your tissue images into hard quantitative data. Request a quote today for more information.

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Drug Discovery Biology Machine learning Oncology CNS/Neurology Deep Learning Artificial Intelligence Show 7 more tags Show less

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Biomarker Analysis

Price on request

Antibody selection and procurement services along with a full range of optimization levels for preclinical and clinical applications. Primary antibodies are tested on positive control tissue to determine optimal concentration and antigen retrieval conditions with a strong positive signal and low background. Immunohistochemistry... Show more »

Antibody selection and procurement services along with a full range of optimization levels for preclinical and clinical applications. Primary antibodies are tested on positive control tissue to determine optimal concentration and antigen retrieval conditions with a strong positive signal and low background. Immunohistochemistry and immunofluorescence available. Single-plex and multi-plex staining. Download "Reveal Biosciences Validated Biomarkers Feb 2018.pdf" in the resources for a list of our validated protocols.

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Leica BOND-III multiplex Singlex immunohistochemistry Immunofluorescence antibodies monoclonal antibodies FFPE tissue Dual-stain Immunohistochemistry Oncology 3DHISTECH Pannoramic 250 Flash III Biology Drug Discovery CD3 CD4 cd8 CD31 CD68 FOXP3 PD1 PD-L1 Ki67 pan-cytokeratin Show 23 more tags Show less

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Bright-Field Microscopy

Price on request
  • High resolution whole slide imaging in bright field and fluorescence​
  • Award-winning image quality
  • 20x (0.8 NA) and 40x (0.95 NA) magnification options; z-stacks available
  • Fast turn-around high throughput whole slide scanning
  • Comprehensive image QC process
    Our imaging suite includes whole slide scanning in both... Show more »
  • High resolution whole slide imaging in bright field and fluorescence​
  • Award-winning image quality
  • 20x (0.8 NA) and 40x (0.95 NA) magnification options; z-stacks available
  • Fast turn-around high throughput whole slide scanning
  • Comprehensive image QC process
    Our imaging suite includes whole slide scanning in both bright field and fluorescence using a range of slide scanning and imaging instruments from leading manufacturers including 3DHISTECH. Our comprehensive Quality Management Program includes a deep learning-based image quality application to automatically assess focus and image quality at scale.

Whole slide imaging for small or large-scale studies, including clinical trials.

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Leica BOND-III whole slide imaging tissue section imaging Oncology 3DHISTECH Pannoramic 250 Flash III 3DHISTECH Pannoramic SCAN II Biology Drug Discovery Show 8 more tags Show less

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Histology Control Slides

Price on request

High quality control slides for histological staining.

High quality control slides for histological staining.

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Leica BOND-III histology microscopy Oncology Biology Drug Discovery Show 6 more tags Show less

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Coverslipping

Price on request

Thin glass covering used to protect and preserve samples on slides. Service included in all histological staining, immunohistochemisty, immunofluorescence and in situ hybridization.

Thin glass covering used to protect and preserve samples on slides. Service included in all histological staining, immunohistochemisty, immunofluorescence and in situ hybridization.

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Oncology Leica BOND-III Biology Drug Discovery

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Cryoembedding

Price on request

Cryoprotecting and embedding of tissues for frozen sections with an astute level of control and predictability.

Cryoprotecting and embedding of tissues for frozen sections with an astute level of control and predictability.

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Cryosectioning

Price on request

OCT embedded frozen tissues are sectioned by our experienced histologists for histological staining or unstained slides

OCT embedded frozen tissues are sectioned by our experienced histologists for histological staining or unstained slides

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histology Drug Discovery Biology cryosectioning frozen sectioning Oncology Leica BOND-III Microm HM 505 E Cryostat cryotomy Show 9 more tags Show less

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Whole Slide Imaging/Digital Slide Scanning

Price on request

We offer bright field or fluorescent digital whole slide scanning using a 3D Histech Pannoramic SCAN scanner. High resolution images are provided with accompanying free software that allows image manipulation including zoom, rotation and channel selection.

We offer bright field or fluorescent digital whole slide scanning using a 3D Histech Pannoramic SCAN scanner. High resolution images are provided with accompanying free software that allows image manipulation including zoom, rotation and channel selection.

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Leica BOND-III whole slide imaging Acute Lymphocytic Leukemia (ALL) tissue section imaging Fluorescence FFPE tissue Human tissue Human Mouse Rat Oncology 3DHISTECH Pannoramic SCAN II Drug Discovery Biology microscopy Show 15 more tags Show less

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Fluorescence-Based Microscopy

Price on request

High resolution whole slide imaging in fluorescence​
Award-winning image quality
20x (0.8 NA) and 40x (0.95 NA) fluorescence magnification options
Up to 9-channel fluorescent channel scanning
Z stack up to 30 layers
Multi-layer scanning for perfect co-localization in FISH studies
Fast turn-around high throughput whole slide scanning
Comprehensive image QC process

High resolution whole slide imaging in fluorescence​
Award-winning image quality
20x (0.8 NA) and 40x (0.95 NA) fluorescence magnification options
Up to 9-channel fluorescent channel scanning
Z stack up to 30 layers
Multi-layer scanning for perfect co-localization in FISH studies
Fast turn-around high throughput whole slide scanning
Comprehensive image QC process

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Fluorescence in situ Hybridization FISH Oncology Leica BOND-III 3DHISTECH Pannoramic SCAN II Drug Discovery Biology Immunofluorescence IF Show 9 more tags Show less

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Formalin Fixation

Price on request

Tissue fixation in 10% Neutral Buffered Formalin (NBF) that ensures excellent preservation of tissue and cellular morphology for histological sections prior to processing and embedding.

Tissue fixation in 10% Neutral Buffered Formalin (NBF) that ensures excellent preservation of tissue and cellular morphology for histological sections prior to processing and embedding.

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Leica BOND-III Fresh Tissue Tumor tissue Oncology Drug Discovery Biology Show 6 more tags Show less

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Tissue Decalcification

Price on request

Formic Acid Tissue Decalcification
A weak acid used to decalcify samples for processing. Formic Acid is commonly used as it is a more gentle acid, and less likely to interfere with nuclear staining.

EDTA Tissue Decalcification
Ethylenediaminetetracetic acid (EDTA) decalcifying process; typically used for research... Show more »

Formic Acid Tissue Decalcification
A weak acid used to decalcify samples for processing. Formic Acid is commonly used as it is a more gentle acid, and less likely to interfere with nuclear staining.

EDTA Tissue Decalcification
Ethylenediaminetetracetic acid (EDTA) decalcifying process; typically used for research applications with very high quality morphology or particular molecular elements preservation requirements (IHC, FISH).

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Leica BOND-III Oncology Biology Drug Discovery

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H&E Staining

Hematoxylin and eosin staining
Price on request

Hematoxylin and eosin staining on both frozen and FFPE tissue sections.

Hematoxylin and eosin staining on both frozen and FFPE tissue sections.

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Leica BOND-III Drug Discovery Biology Hematoxylin Eosin FFPE tissue Human Rodents Mouse Oncology Non-Alcoholic Steatohepatitis (NASH) Toxicology Show 12 more tags Show less

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Histology and Pathology Services

Price on request

Slide preparation in either paraffin (FFPE) or Optimal Cutting Temperature (OCT, frozen sections). RNAse-free sections can be prepared on request. Histology services include:
-Tissue trimming
-Paraffin processing and embedding
-Microtomy and RNAse-free microtomy
-Cryotomy
-Decalcification of bone
-Hematoxylin & Eosin... Show more »

Slide preparation in either paraffin (FFPE) or Optimal Cutting Temperature (OCT, frozen sections). RNAse-free sections can be prepared on request. Histology services include:
-Tissue trimming
-Paraffin processing and embedding
-Microtomy and RNAse-free microtomy
-Cryotomy
-Decalcification of bone
-Hematoxylin & Eosin (H&E) stain
-Wide range of special stains
-Pathology review by a Board Certified DVM or MD pathologist

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Leica BOND-III Drug Discovery Biology cryoembedding cryosectioning Machine learning tissue section imaging immunohistochemistry Immunofluorescence IHC histology Hematoxylin Eosin Trichrome stain FFPE tissue Human tissue Tumor tissue Human Mouse Rodents Oncology CD3 CD4 cd8 CD31 CD68 FOXP3 PD1 PD-L1 Ki67 pan-cytokeratin Show 31 more tags Show less

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Digital Pathology Image Analysis

Price on request

Our proprietary ImageDx software quickly and accurately analyzes images cell-by-cell for positivity and intensity to turn your tissue images into hard quantitative data. Custom quantification available to meet your study goals.

Our proprietary ImageDx software quickly and accurately analyzes images cell-by-cell for positivity and intensity to turn your tissue images into hard quantitative data. Custom quantification available to meet your study goals.

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Histopathological Examination

Price on request

Pathology review by a Board Certified pathologist

Pathology review by a Board Certified pathologist

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Immunocytochemistry

Price on request

We offer immunohistochemistry and immunofluorescent staining services in fixed cells. Request a quote today for more information.

We offer immunohistochemistry and immunofluorescent staining services in fixed cells. Request a quote today for more information.

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Leica BOND-III Oncology 3DHISTECH Pannoramic SCAN II Drug Discovery Biology

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Immunofluorescence

Price on request

We offer high quality singleplex or multiplex immunofluorescent (IF) staining of your OCT or FFPE samples (tissue or fixed cells). Optimization of your antibody of interest is available on request. Contact us for more information on our IF services.

We offer high quality singleplex or multiplex immunofluorescent (IF) staining of your OCT or FFPE samples (tissue or fixed cells). Optimization of your antibody of interest is available on request. Contact us for more information on our IF services.

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Immunofluorescence Singlex multiplex microscopy antibodies monoclonal antibodies FFPE tissue AlexaFluor Leica BOND-III 3DHISTECH Pannoramic 250 Flash III Biology Drug Discovery CD3 CD4 cd8 CD31 CD68 FOXP3 PD1 PD-L1 Ki67 pan-cytokeratin Alexa Fluor 488 Alexa Fluor 546 Alexa Fluor 647 Mouse Rodents Human Oncology CNS/Neurology 3DHISTECH Pannoramic SCAN II Show 31 more tags Show less

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Immunohistochemistry (IHC)

Price on request

Our IHC service includes staining of paraffin (FFPE) or frozen tissue sections. Assay development and optimization using colorimetric, fluorescent and multiplex approaches are available. Optimization of your choice of antibody and detection system is also available on request.
Our state-of-the-art Leica Bond immunostainer... Show more »

Our IHC service includes staining of paraffin (FFPE) or frozen tissue sections. Assay development and optimization using colorimetric, fluorescent and multiplex approaches are available. Optimization of your choice of antibody and detection system is also available on request.
Our state-of-the-art Leica Bond immunostainer produces consistent quality high throughput immunohistochemistry (IHC). We have developed and validated a wide range of automated IHC protocols for rodent and human tissue. Ask us about our validated protocols.

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Leica BOND-III Cytokines Immuno-Oncology 3DHISTECH Pannoramic 250 Flash III Drug Discovery Biology immunohistochemistry IHC CD3 CD4 cd8 CD31 CD68 FOXP3 PD1 PD-L1 Ki67 pan-cytokeratin Oncology CNS/Neurology Show 20 more tags Show less

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In situ Hybridization (ISH)

In Situ Hybridization
Price on request

We offer high quality singleplex and multiplex in situ hybridization (ISH) to localize mRNA in your tissue samples, using the two leading ISH technologies ViewRNA (Thermo Fisher Scientific) and RNascope (ACD). Custom probes can be provided on request, please contact us to discuss your needs.
Tissue preparation including wax... Show more »

We offer high quality singleplex and multiplex in situ hybridization (ISH) to localize mRNA in your tissue samples, using the two leading ISH technologies ViewRNA (Thermo Fisher Scientific) and RNascope (ACD). Custom probes can be provided on request, please contact us to discuss your needs.
Tissue preparation including wax processing, embedding and RNAse-free sectioning (microtomy), or frozen section preparation (cryotomy) are also available on request.
In addition, we offer digital slide scanning and image analysis, resulting in quantitative ISH data.

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Drug Discovery Biology mRNA Oncology Leica BOND-III 3DHISTECH Pannoramic 250 Flash III in situ hybridization ish FISH CNS/Neurology Show 10 more tags Show less

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Mallory's Trichrome Staining

Price on request

Mallory's triple stain is composed of aniline blue, acid fuchsin, and orange G solution and is commonly used for distinguishing cellular from extracellular components.

Mallory's triple stain is composed of aniline blue, acid fuchsin, and orange G solution and is commonly used for distinguishing cellular from extracellular components.

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Leica BOND-III Drug Discovery Biology histology Trichrome stain

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Masson's Trichrome Staining

Price on request

This three-color staining protocol is used to distinguish cells from surrounding connective tissue; red reveals keratin and muscle fibers, blue- collagen and bone, dark pink- cytoplasm, and brown- cell nuclei. This staining is ideal for tissue fibrosis visualization.

This three-color staining protocol is used to distinguish cells from surrounding connective tissue; red reveals keratin and muscle fibers, blue- collagen and bone, dark pink- cytoplasm, and brown- cell nuclei. This staining is ideal for tissue fibrosis visualization.

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Leica BOND-III Drug Discovery Biology Trichrome stain Non-Alcoholic Steatohepatitis (NASH) Toxicology Human Mouse Rodents Show 9 more tags Show less

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Microscopy Image Analysis

Price on request

Our proprietary ImageDx software quickly and accurately analyzes images for marker positivity and intensity to turn your tissue images into hard quantitative data. Request a quote today for more information.

Our proprietary ImageDx software quickly and accurately analyzes images for marker positivity and intensity to turn your tissue images into hard quantitative data. Request a quote today for more information.

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Drug Discovery Biology Machine learning CNS/Neurology Oncology

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Cell Morphometry

Price on request

Morphometric analysis of a tissue slide; provides values referring to the metric dimensions of cells.

Morphometric analysis of a tissue slide; provides values referring to the metric dimensions of cells.

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Leica BOND-III Oncology Biology Drug Discovery

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Paraffin Embedding

Price on request

We offer paraffin-embedding of fixed and processed tissue samples and cells. Contact us for more information.

We offer paraffin-embedding of fixed and processed tissue samples and cells. Contact us for more information.

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FFPE tissue

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Periodic Acid-Schiff (PAS) Staining

Price on request

A staining method used for demonstration of polysaccharides and mucosubstances in tissues.

A staining method used for demonstration of polysaccharides and mucosubstances in tissues.

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Leica BOND-III Periodic Acid Schiff FFPE tissue Frozen Tissue Oncology CNS/Neurology Show 6 more tags Show less

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Paraffin Sectioning

Price on request

Human or animal paraffin embedded tissue sectioned using a microtome (microtomy) and prepared for staining and/or analysis.

Human or animal paraffin embedded tissue sectioned using a microtome (microtomy) and prepared for staining and/or analysis.

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Leica BOND-III Oncology Drug Discovery Biology Microm HM 340 E Microtome

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Veterinary Pathology

Price on request

Pathology review by a Board Certified DVM pathologist

Pathology review by a Board Certified DVM pathologist

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Leica BOND-III histology Mouse Dog Rat

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Special Slide Staining

Price on request

Various alternative staining techniques to detect, visualize, and evaluate particular tissue structures, elements or substances. We have more than 100 stains, including Masson’s Trichrome, Picrosirius Red, Oil Red O, Periodic Acid Schiff (PAS), Luxol Fast Blue (LFB), Nissl.

Various alternative staining techniques to detect, visualize, and evaluate particular tissue structures, elements or substances. We have more than 100 stains, including Masson’s Trichrome, Picrosirius Red, Oil Red O, Periodic Acid Schiff (PAS), Luxol Fast Blue (LFB), Nissl.

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Leica BOND-III histology Oil Red O Periodic Acid Schiff FFPE tissue Human Mouse Rodents Oncology Masson's Trichrome Niss1 Picrosirius Red TUNEL Luxol Fast Blue Prussian Blue Fluorojade Show 16 more tags Show less

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TUNEL Assay

Terminal deoxynucleotidyl transferase dUTP nick end labeling assay
Price on request

Automated TUNEL assay available for the detection of apoptotic cells in tissue sections. This assay can be performed on FFPE or frozen tissue sections from a range of species. Tissue preparation including wax processing, embedding and sectioning (microtomy), or frozen section preparation (cryotomy) also available on request. ... Show more »

Automated TUNEL assay available for the detection of apoptotic cells in tissue sections. This assay can be performed on FFPE or frozen tissue sections from a range of species. Tissue preparation including wax processing, embedding and sectioning (microtomy), or frozen section preparation (cryotomy) also available on request. Additionally, digital slide scanning and TUNEL quantification are available if needed.

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Leica BOND-III

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Tissue Microarrays

Price on request

A cost-effective approach to immunohistochemistry (IHC) on a range of high quality TMAs from multiple tissue types, delivering IHC data from a large number of patient samples. A cost-effective approach to immunohistochemistry (IHC) on a range of high quality TMAs from multiple tissue types, delivering IHC data from a large number... Show more »

A cost-effective approach to immunohistochemistry (IHC) on a range of high quality TMAs from multiple tissue types, delivering IHC data from a large number of patient samples. A cost-effective approach to immunohistochemistry (IHC) on a range of high quality TMAs from multiple tissue types, delivering IHC data from a large number of patient samples. Cancers of the bladder, breast, colon, endometrium, esophagus, kidney, liver, lung, brain, ovary, testis, pancreas, prostate, rectum, skin, stomach, thyroid and lymphoma available.

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Leica BOND-III Colorectal cancer Prostate Cancer Breast cancer Lung Cancer Ovarian Cancer Gastric Cancer Melanoma Pancreatic cancer Liver cancer Bladder cancer Lymphoma Human tissue Human Mouse Rat Microarray Show 17 more tags Show less

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Tissue Preparation

Price on request

Tissue trimming, tissue sectioning, tissue fixation, paraffin processing, embedding and staining for immunohistochemical (IHC), immunofluorescence (IF), or in situ hybridization (ISH) analysis.

Tissue trimming, tissue sectioning, tissue fixation, paraffin processing, embedding and staining for immunohistochemical (IHC), immunofluorescence (IF), or in situ hybridization (ISH) analysis.

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Leica BOND-III tissue section imaging FFPE tissue Microm HM 340 E Microtome Microm HM 505 E Cryostat

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Toluidine Blue Staining

Price on request

A basic thiazine metachromatic dye that selectively stains acidic tissue components; often used for staining tissues rich in DNA and RNA.

A basic thiazine metachromatic dye that selectively stains acidic tissue components; often used for staining tissues rich in DNA and RNA.

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Leica BOND-III

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Two-Photon Excitation Microscopy

Price on request

A fluorescence imaging technique that allows imaging of living tissue up to a very high depth of about one millimeter. The use of infrared light minimizes scattering in the tissue; two-photon excitation can be a superior alternative to confocal microscopy due to its deeper tissue penetration, efficient light detection, and reduced phototoxicity.

A fluorescence imaging technique that allows imaging of living tissue up to a very high depth of about one millimeter. The use of infrared light minimizes scattering in the tissue; two-photon excitation can be a superior alternative to confocal microscopy due to its deeper tissue penetration, efficient light detection, and reduced phototoxicity.

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Leica BOND-III microscopy Fluorescence 3DHISTECH Pannoramic SCAN II

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Widefield Fluorescence Microscopy

Price on request

Imaging and scanning of histopathological slides using widefield fluorescence microscopy.

Imaging and scanning of histopathological slides using widefield fluorescence microscopy.

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Leica BOND-III Drug Discovery Biology histology Fluorescence microscopy FFPE tissue Oncology 3DHISTECH Pannoramic SCAN II Show 9 more tags Show less

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Computational Modeling

Price on request

Our computational pathology team offers a range of quantitative options from traditional cell-by-cell machine learning-based analysis to artificial intelligence (AI) and deep learning-based applications. Accurate, reproducible, scalable data.

Our computational pathology team offers a range of quantitative options from traditional cell-by-cell machine learning-based analysis to artificial intelligence (AI) and deep learning-based applications. Accurate, reproducible, scalable data.

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Drug Discovery Biology Machine learning Deep Learning Artificial Intelligence

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Biospecimens

Price on request

High quality formalin-fixed paraffin embedded (FFPE) tissue microarrays cut fresh to order. Cancers of the bladder, breast, colon, endometrium, esophagus, kidney, liver, lung, brain, ovary, testis, pancreas, prostate, rectum, skin, stomach, thyroid and lymphoma, multi-tumor and normal tissue TMAs available.

High quality formalin-fixed paraffin embedded (FFPE) tissue microarrays cut fresh to order. Cancers of the bladder, breast, colon, endometrium, esophagus, kidney, liver, lung, brain, ovary, testis, pancreas, prostate, rectum, skin, stomach, thyroid and lymphoma, multi-tumor and normal tissue TMAs available.

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Bladder cancer Breast cancer Oncology Colorectal cancer Gastric Cancer Liver cancer Lung Cancer Melanoma Ovarian Cancer Pancreatic cancer Prostate Cancer Lymphoma Microarray Human Mouse Biology Drug Discovery FFPE tissue Esophageal cancer Nephrology and Urology Hepatology Respiratory Show 22 more tags Show less

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Tissue Fixation

Price on request

Our experienced scientists will ensure your tissue is fully fixed prior to processing.

Our experienced scientists will ensure your tissue is fully fixed prior to processing.

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Fresh Tissue Tumor tissue Oncology

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Biomarkers

Price on request

Hundreds of biomarkers optimized for single and multi-plex immunohistochemistry and immunofluorescence or we can optimize your marker of interest. Download "Reveal Biosciences Validated Biomarkers Feb 2018.pdf" in the resources for a list of our validated protocols.

Hundreds of biomarkers optimized for single and multi-plex immunohistochemistry and immunofluorescence or we can optimize your marker of interest. Download "Reveal Biosciences Validated Biomarkers Feb 2018.pdf" in the resources for a list of our validated protocols.

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immunohistochemistry IHC Immunofluorescence Oncology Biology Drug Discovery CD3 CD4 CD31 CD68 FOXP3 PD1 PD-L1 Ki67 pan-cytokeratin cd8 Show 16 more tags Show less

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Clinical Research

Price on request

Our full service histology laboratory offers fast turnaround, high quality reproducible results and a multi-step QC process.

Our full service histology laboratory offers fast turnaround, high quality reproducible results and a multi-step QC process.

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Oncology Drug Discovery Biology

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Clinical Laboratory Services

Price on request

Our full service histology laboratory offers fast turnaround, high quality reproducible results and a multi-step QC process.

Our full service histology laboratory offers fast turnaround, high quality reproducible results and a multi-step QC process.

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Oncology Biology Drug Discovery

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Tissue Embedding

Price on request

Our experienced scientists will orient and embed your tissue in paraffin or OCT compound (optimal cutting temperature compound) according to your specifications

Our experienced scientists will orient and embed your tissue in paraffin or OCT compound (optimal cutting temperature compound) according to your specifications

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FFPE tissue Mouse Human Rodents Oncology CNS/Neurology Show 6 more tags Show less

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Antibody Services

Price on request

Antibody selection and procurement services along with a full range of optimization levels for preclinical and clinical applications. Primary antibodies are tested on positive control tissue to determine optimal concentration and antigen retrieval conditions with a strong positive signal and low background.

Antibody selection and procurement services along with a full range of optimization levels for preclinical and clinical applications. Primary antibodies are tested on positive control tissue to determine optimal concentration and antigen retrieval conditions with a strong positive signal and low background.

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Leica BOND-III Mouse Human Rat Rabbit Oncology Biology Drug Discovery Show 8 more tags Show less

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Common Histochemical Stains

Price on request

Our histology lab offers H&E staining, Masson's Trichrome, PAS, Oil Red O, Nissl, Picrosirius red, TUNEL, Luxol Fast blue, Prussian blue, and Fluorojade. Ask us about other special stains.

Our histology lab offers H&E staining, Masson's Trichrome, PAS, Oil Red O, Nissl, Picrosirius red, TUNEL, Luxol Fast blue, Prussian blue, and Fluorojade. Ask us about other special stains.

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Trichrome stain Iron hemotoxylin stain Eosin Mouse Human Rat Rabbit Dog Oncology Drug Discovery Biology Masson's Trichrome PAS Oil Red O Niss1 Picrosirius Red TUNEL Luxol Fast Blue Prussian Blue Flurojade Hematoxylin Show 21 more tags Show less

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Clinical and Anatomic Pathology

Price on request

Pathological evaluation by board certified pathologist

Pathological evaluation by board certified pathologist

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Oncology Drug Discovery Biology

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Immunostaining

Price on request

We offer immunostaining of your OCT and FFPE samples. Assay development and optimization using colorimetric, fluorescent and multiplex approaches are available.
Our state-of-the-art Leica Bond immunostainer produces consistent quality high throughput immunohistochemistry (IHC). We have developed and validated a wide range of... Show more »

We offer immunostaining of your OCT and FFPE samples. Assay development and optimization using colorimetric, fluorescent and multiplex approaches are available.
Our state-of-the-art Leica Bond immunostainer produces consistent quality high throughput immunohistochemistry (IHC). We have developed and validated a wide range of automated IHC protocols for rodent and human tissue. Ask us about our validated protocols.

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immunohistochemistry IHC Oncology Drug Discovery Biology

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Protein Expression Visualization

Price on request

Visualization and quantitation of protein biomarkers in human or animal tissue using immunohistochemistry (IHC) or immunofluorescence (IF). Hundreds of protein biomarkers protocols available. Download "Reveal Biosciences Validated Biomarkers Feb 2018.pdf" in the resources for a list of our validated protocols.

Visualization and quantitation of protein biomarkers in human or animal tissue using immunohistochemistry (IHC) or immunofluorescence (IF). Hundreds of protein biomarkers protocols available. Download "Reveal Biosciences Validated Biomarkers Feb 2018.pdf" in the resources for a list of our validated protocols.

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Oncology Leica BOND-III Drug Discovery Biology immunohistochemistry IHC cd8 Show 7 more tags Show less

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Image Analysis

Price on request

Our proprietary ImageDx software quickly and accurately analyzes images cell-by-cell for marker positivity and intensity to turn your tissue images into hard quantitative data. Request a quote today for more information.

Our proprietary ImageDx software quickly and accurately analyzes images cell-by-cell for marker positivity and intensity to turn your tissue images into hard quantitative data. Request a quote today for more information.

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Machine learning Oncology Drug Discovery Biology Deep Learning Artificial Intelligence Show 6 more tags Show less

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Data Services

Price on request

Our computational pathology team offers a range of quantitative options from traditional cell-by-cell machine learning-based analysis to artificial intelligence (AI) and deep learning-based applications. Accurate, reproducible, scalable data.

Our computational pathology team offers a range of quantitative options from traditional cell-by-cell machine learning-based analysis to artificial intelligence (AI) and deep learning-based applications. Accurate, reproducible, scalable data.

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Machine learning Oncology Biology Drug Discovery Deep Learning Artificial Intelligence Show 6 more tags Show less

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Microscopy

Price on request

We offer bright field or fluorescent digital whole slide scanning using a 3D Histech Pannoramic SCAN scanner. High resolution images are provided with accompanying free software that allows image manipulation including zoom, rotation and channel selection.

We offer bright field or fluorescent digital whole slide scanning using a 3D Histech Pannoramic SCAN scanner. High resolution images are provided with accompanying free software that allows image manipulation including zoom, rotation and channel selection.

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Drug Discovery Biology whole slide imaging microscopy

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Histological Staining

Price on request

Our full service histology lab offers histochemical stains, immuhistochemistry and immunofluorescent staining.

Our full service histology lab offers histochemical stains, immuhistochemistry and immunofluorescent staining.

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Drug Discovery Biology immunohistochemistry Immunofluorescence IHC Oncology FFPE tissue Hematoxylin Eosin Show 9 more tags Show less

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Cell-Based Assays

Price on request

Processing and embedding of cell pellets. Histological staining, immunohistochemistry, immunofluorescence, in situ hybridization along with whole slide imaging and quantitative image analysis.

Processing and embedding of cell pellets. Histological staining, immunohistochemistry, immunofluorescence, in situ hybridization along with whole slide imaging and quantitative image analysis.

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Oncology 3DHISTECH Pannoramic 250 Flash III Biology Drug Discovery

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Tissue Processing

Price on request

Fixed or frozen tissue processed for FFPE or OCT blocks. Experienced scientists ensure tissue is properly fixed prior to processing and embedding.

Fixed or frozen tissue processed for FFPE or OCT blocks. Experienced scientists ensure tissue is properly fixed prior to processing and embedding.

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Microm HM 340 E Microtome Microm HM 505 E Cryostat

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Cells and Tissues

Price on request

Procurement of cells and tissue samples to accompany your IHC, IF or ISH study. Reveal offers high quality formalin-fixed paraffin embedded (FFPE) tissue microarrays cut fresh to order.

Procurement of cells and tissue samples to accompany your IHC, IF or ISH study. Reveal offers high quality formalin-fixed paraffin embedded (FFPE) tissue microarrays cut fresh to order.

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Colorectal cancer Breast cancer Lung Cancer Liver cancer Bladder cancer Oncology Gastric Cancer Melanoma Ovarian Cancer Pancreatic cancer Prostate Cancer Lymphoma Human tissue Microarray Biology Drug Discovery Show 16 more tags Show less

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Bioanalysis

Price on request

Quantitative histology services including H&E, special stains, immunohistochemistry, immunofluorescence, and in situ hybridization with whole slide imaging and quantitative analysis

Quantitative histology services including H&E, special stains, immunohistochemistry, immunofluorescence, and in situ hybridization with whole slide imaging and quantitative analysis

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Leica BOND-III Oncology 3DHISTECH Pannoramic 250 Flash III Biology Drug Discovery

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Tissue Sectioning

Price on request

High quality sectioning of FFPE or frozen tissue by experienced histologists. Includes slide mounting.

High quality sectioning of FFPE or frozen tissue by experienced histologists. Includes slide mounting.

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cryosectioning frozen sectioning FFPE tissue Microm HM 505 E Cryostat Microm HM 340 E Microtome

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Transmitted Light Microscopy

Price on request
Request a quote for more information about this service.

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Drug Discovery & Development

Price on request

Drug Discovery & Development Services

Drug Discovery & Development Services

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Computational Pathology

Price on request

Our computational pathology team offers a range of quantitative options from traditional cell-by-cell machine learning-based analysis to AI and deep learning-based applications. Accurate, reproducible, scalable data.

Our computational pathology team offers a range of quantitative options from traditional cell-by-cell machine learning-based analysis to AI and deep learning-based applications. Accurate, reproducible, scalable data.

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Biology Drug Discovery Machine learning Deep Learning Artificial Intelligence

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Fluorescence in situ Hybridization (FISH)

Price on request

We offer high quality singleplex and multiplex fluorescence in situ hybridization (FISH) to localize mRNA in your tissue samples, using the two leading technologies ViewRNA (Thermo Fisher Scientific) and RNascope (ACD). Custom probes can be provided on request, please contact us to discuss your needs.
Tissue preparation... Show more »

We offer high quality singleplex and multiplex fluorescence in situ hybridization (FISH) to localize mRNA in your tissue samples, using the two leading technologies ViewRNA (Thermo Fisher Scientific) and RNascope (ACD). Custom probes can be provided on request, please contact us to discuss your needs.
Tissue preparation including wax processing, embedding and RNAse-free sectioning (microtomy), or frozen section preparation (cryotomy) are also available on request.
In addition, we offer digital slide scanning and image analysis, resulting in quantitative FISH data.

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FISH Fluorescence in situ Hybridization Fluorescence mRNA

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RNA Services

Price on request

We offer high quality singleplex and multiplex fluorescence in situ hybridization (FISH) to localize mRNA in your tissue samples, using the two leading technologies ViewRNA (Thermo Fisher Scientific) and RNascope (ACD). Custom probes can be provided on request, please contact us to discuss your needs.
Tissue preparation... Show more »

We offer high quality singleplex and multiplex fluorescence in situ hybridization (FISH) to localize mRNA in your tissue samples, using the two leading technologies ViewRNA (Thermo Fisher Scientific) and RNascope (ACD). Custom probes can be provided on request, please contact us to discuss your needs.
Tissue preparation including wax processing, embedding and RNAse-free sectioning (microtomy), or frozen section preparation (cryotomy) are also available on request.
In addition, we offer digital slide scanning and image analysis, resulting in quantitative FISH data.

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Pharmacology

Price on request

Pharmacology Services

Pharmacology Services

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Tumor Marker Testing

Price on request

Tumor Marker Testing Services

Tumor Marker Testing Services

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Antibody/Antigen Detection Based Testing

Price on request

Antibody/Antigen Detection Based Testing Services

Antibody/Antigen Detection Based Testing Services

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Clinical Chemistry

Price on request

Clinical Chemistry Services

Clinical Chemistry Services

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AC

Assunta Carey

Product Specialist
CL
AL

Ami Lau

Director of Operations
MN

Mary Nguyen

Business Development Manager
ON

Oanh Nguyen

Scientist
MS

Marisa Sanchez

Application Scientist
DS

Daniel Schroen

Commercial Lead
JW

Jeremy Warner

Scientific Marketing Associate
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FileType/PDF Created with Sketch. Reveal Bioscience Validated Biomarkers Feb 2018.pdf

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FileType/PDF Created with Sketch. Reveal Biosciences Antibody Validation.pdf

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FileType/PDF Created with Sketch. Reveal Biosciences Introduction.pdf

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  • Positive review for In situ Hybridization (ISH):

    March 2018

    "I worked with Reveal Biosciences twice and I will work with them again and again. Their services exceeded my expectations. My service requests are always followed by many questions, they always answered them promptly ( within 1-2 hrs), clearly and with professionalism. The service turn-out time is really fast and service cost is reasonable. Thank you Reveal Biosciences for facilitating my research ! Mariam Ba"

  • Positive review for Immunohistochemistry (IHC):

    March 2017

    "Reveal Biosciences performed a very thorough antibody validation for IHC. Even though, we did not find an optimal antibody for our purpose (in spite of an existing antibody validation paper out there), Reveal and Caroline worked very hard to test additional antibodies and were very flexible as the scope of work changed along the way. They were accommodating and professional all the way to completion of the project. We will definitely return back to do additional work with Reveal."

  • Positive review for Immunofluorescence:

    July 2013

    "We have worked with Claire on several occasions and have always been really impressed by her high quality work and excellent service."

  • Positive review for Immunohistochemistry (IHC):

    July 2013

    "Excellent - would highly recommend."

  • Positive review for Immunohistochemistry (IHC):

    April 2013

    "Excellent. Provided very high quality immunohistochemistry images. Communication and service level were excellent."

  • Positive review for Immunohistochemistry (IHC):

    September 2012

    "Excellent service and quick communications, just a pleasure to work with!"

Reveal Biosciences has not received any endorsements.