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RetroVirox

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San Diego, California, US

About RetroVirox

RetroVirox is the only CRO exclusively focused on the antiviral field. RetroVirox has a large menu of validated antiviral services, including assays to evaluate small-molecule antivirals, antibodies and vaccines against many human viruses such as HIV, influenza, RSV, Dengue, Zika, CMV, rhinovirus, and other... Show more »

RetroVirox is the only CRO exclusively focused on the antiviral field. RetroVirox has a large menu of validated antiviral services, including assays to evaluate small-molecule antivirals, antibodies and vaccines against many human viruses such as HIV, influenza, RSV, Dengue, Zika, CMV, rhinovirus, and other infectious agents.

Since 2010, RetroVirox has also provided customized services to companies worldwide, including optimization and validation of novel antiviral assays, and tailored studies to understand the mechanism of action of antiviral agents. RetroVirox has also broad expertise in high throughput screening (HTS) for antiviral targets, and has successfully completed multiple HTS campaigns utilizing live infectious viruses.

The company is headquartered in San Diego, California

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Our Services (30)


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Antiviral Testing

Price on request

Antiviral services offered at RetroVirox include a full menu of in vitro antiviral assays against several important human pathogens (RSV, HIV, influenza, DENV, ZIKA, CMV, HBV, LCMV and HRV among others). The company can also determine the neutralizing activity of antibodies and sera against highly pathogenic viruses using HIV... Show more »

Antiviral services offered at RetroVirox include a full menu of in vitro antiviral assays against several important human pathogens (RSV, HIV, influenza, DENV, ZIKA, CMV, HBV, LCMV and HRV among others). The company can also determine the neutralizing activity of antibodies and sera against highly pathogenic viruses using HIV pseudovirions carrying heterologous proteins of Ebola virus, Lassa virus, Marburg virus, and avian influenza. Unlike other Contract Research Organizations (CRO), RetroVirox is specialized in offering biological services exclusively in the antiviral field. We work with virtual start-up companies lacking the appropriate facilities to perform antiviral studies, and with large Biotechnology and Pharmaceutical companies seeking CROs with unique expertise in the virology field.

We also offer a number of tailored antiviral assays to address the mechanism of action of novel antivirals. Development of novel antiviral assays against other viruses is also available on FTE basis and also fixed prices. With one of the largest collections of viral strains available (over 250 viral strains of 18 different viral species) RetroVirox can optimize assays and evaluate your molecules for activity against many commercially important human viruses. Evaluation of cytoxicity assays in uninfected stable cells or primary cells are also available when requested as part of antiviral services.

RetroVirox is 100% "IP and ownership-friendly", and does not request any ownership of intellectual property rights of any data, discoveries, or materials generated during any of its services.

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Viral Infectivity Assays

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Microneutralization Assay

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HIV-Infected Human Peripheral Blood Mononuclear Cells (PBMCs)

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Cell-Based Compound Screening

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Custom Cell-Based Assay Development

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Zika Screening

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Zika Antiviral Testing

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High Throughput Screening (HTS)

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NAb Assays

Neutralizing Antibody Assays
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Reverse Genetic Screening

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Vaccine Testing Services

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Cell Viability Assays

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Hemagglutination Assay

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Virus Production

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Drug Mechanism of Action Studies

Mechanism of Action Studies
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Viral Assays

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Viral Assays Services

Viral Assays Services

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Virology Services

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Virology Services

Virology Services

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Vaccines

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Vaccines Services

Vaccines Services

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Plaque Reduction Assays (PRA)

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In Vitro Combination Therapy Studies

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Drug Discovery & Development

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Drug Discovery & Development Services

Drug Discovery & Development Services

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Lead Identification and Validation

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Lead Identification and Validation Services

Lead Identification and Validation Services

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Hit Identification

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Hit Identification Services

Hit Identification Services

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Drug Target Identification

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Drug Discovery

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Drug Discovery Services

Drug Discovery Services

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Cell-Based Assays

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Cell-Based Assays Services

Cell-Based Assays Services

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Specialized Cell-Based Assays

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Specialized Cell-Based Assays Services

Specialized Cell-Based Assays Services

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Cell Viability & Proliferation Assays

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Cell Viability & Proliferation Assays Services

Cell Viability & Proliferation Assays Services

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Influenza Antiviral Panel

Price on request

The influenza panel is comprised of 20 different influenza A seasonal strains. Strains span from 1933 to 2012 season and include the H1N1 and H3N2 serotypes. The panel includes strains resistant to several neuraminidase inhibitors and also pandemic strains from the 2009 and 201 seasons.  This assay utilizes infected A549... Show more »

The influenza panel is comprised of 20 different influenza A seasonal strains. Strains span from 1933 to 2012 season and include the H1N1 and H3N2 serotypes. The panel includes strains resistant to several neuraminidase inhibitors and also pandemic strains from the 2009 and 201 seasons.  This assay utilizes infected A549 cells (human lung epithelial carcinoma cells) to evaluate the ability of test-items to block influenza replication. The assay detects the presence of intracellular viral antigens in influenza-infected cells. Immunodetection is performed with a proprietary cocktail of monoclonal antibodies (mAbs) designed to maximize the detection of different strains of Influenza A. The assay is optimized to evaluate inhibition of influenza replication and has been validated with known inhibitors of influenza replication (baloxavir, ribavirin and pimodivir).  Importantly, the cocktail excludes antibodies against the viral hemagglutinin (HA) protein, to avoid interference with test-items targeting the influenza HA protein. The assay can be used also to reveal the neutralization activity of influenza entry inhibitors, including antisera and monoclonal antibodies (mAbs)

Unlike other antiviral assays such as plaque reduction (PRA), which measures the number of plaques, or the focus forming assays (FFA), which measures foci or units of infected cells stained with fluorescent antibodies (FFU), this assay is faster, more robust and reproducible, superior in sensitivity, and also displays significantly lower variation than the more traditional assays. Additionally, many influenza strains are known to develop plaques or display foci in strain-dependent manners, with some strains known to poorly develop plaques. Our microneutralization assay has been optimized to generate a linear signal and can detect small variations in inhibition of viral replication. Another flaw observed with plaque-reduction based assays with some inhibitors is the appearance of plaques of diminished size without significantly altering the total number of plaques monitored.

 

TAT for the assay is 3 to 4 weeks, and up to 20 test-items can be evaluated per month (full dose response curves) with the entire panel. Test-items are assessed at 8 concentrations in duplicates.

If you are interested in more details please do not hesitate to contact us

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Juan Lama

CSO

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