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REPROCELL

Glasgow, GB

IMPROVING HUMAN HEALTH THROUGH BIOMEDICAL INNOVATION AND DISCOVERY

The ReproCELL Group is dedicated to providing researchers with single source bench-to-bedside solutions for the advancement of stem cell and human tissue research in drug discovery and regenerative medicine.

With facilities in the USA, Europe and Japan, our services are available to our clients world-wide.

The ReproCELL brands include:

REPROCELL
• Global provider of differentiated cell types; iPSC-derived hepatocytes, cardiomyocytes and neurons

BIOSERVE
• Biorepository and network of clinical sites for human tissue samples prospective collection
• Molecular services

STEMGENT
• RNA Reprogramming systems and services

ALVETEX
• 3D cell culture technology creating an in vivo-like cell environment

BIOPTA
• Predictive safety, efficacy and ADME assays in human and animal tissues for drug development

REPROCELL has not listed any services.

Genotyping Services
Price on request

MOLECULAR SERVICES: Genotyping Services

Our in-house expertise in assay design, oligonucleotide synthesis and SNP validation enable us to deliver accurate data, quickly and cost-effectively. We specialize in smaller to mid-size projects, providing intense customer service from assay design to data delivery and discussing your experiment results.

MOLECULAR SERVICES: Genotyping Services

Our in-house expertise in assay design, oligonucleotide synthesis and SNP validation enable us to deliver accurate data, quickly and cost-effectively. We specialize in smaller to mid-size projects, providing intense customer service from assay design to data delivery and discussing your experiment results.

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Life Technologies ViiA 7 Real-Time PCR System
MALDI-TOF-MS
real-time PCR
MALDI-TOF
RT-PCR
Reverse transcription polymerase chain reaction
Price on request

MOLECULAR SERVICES: Real-Time PCR

Real-time PCR measures amplification cycle-by-cycle enables quantitative measurements during the exponential phase of PCR. We now utilize latest in the family of real-time PCR instruments by Applied BioSystems – the ViiA7™.

MOLECULAR SERVICES: Real-Time PCR

Real-time PCR measures amplification cycle-by-cycle enables quantitative measurements during the exponential phase of PCR. We now utilize latest in the family of real-time PCR instruments by Applied BioSystems – the ViiA7™.

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Life Technologies ViiA 7 Real-Time PCR System
Mutation Detection
TaqMan
Genomic DNA Extraction
Price on request

MOLECULAR SERVICES: Genomic DNA Extraction

BioServe has 20 years of experience with genomic DNA isolation from nearly all biomaterials including whole blood, blood clots, buffy coats, PMBCs, nuclear pellets, serum, saliva, mouthwash, buccal swabs, cytobrushes, plant material, cultured cells, fresh and frozen tissues and... Show more »

MOLECULAR SERVICES: Genomic DNA Extraction

BioServe has 20 years of experience with genomic DNA isolation from nearly all biomaterials including whole blood, blood clots, buffy coats, PMBCs, nuclear pellets, serum, saliva, mouthwash, buccal swabs, cytobrushes, plant material, cultured cells, fresh and frozen tissues and paraffin embedded tissues. Quality of DNA is determined through electrophoresis.

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Human
Whole blood
FFPE tissue
Plant tissue
serum
saliva
Frozen Tissue
buccal swabs
real-time PCR
Cultured Cells
Fresh Tissue
PBMC's
Gel electrophoresis
RNA Extraction and Purification
Price on request

MOLECULAR SERVICES: RNA Extraction

BioServe has 20 years experience with RNA isolation from a variety of starting material. We have been successful in RNA extraction from whole blood, buffy coats, PAXgene tubes, lymphocytes, cultured cells, plant material, cartilage, fresh and frozen tissues and various bacteria. The quality of RNA isolated is determined using Agilent’s Bioanalyzer.

MOLECULAR SERVICES: RNA Extraction

BioServe has 20 years experience with RNA isolation from a variety of starting material. We have been successful in RNA extraction from whole blood, buffy coats, PAXgene tubes, lymphocytes, cultured cells, plant material, cartilage, fresh and frozen tissues and various bacteria. The quality of RNA isolated is determined using Agilent’s Bioanalyzer.

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Agilent Bioanalyzer
Whole blood
Bacteria
Plant tissue
Frozen Tissue
lymphocytes
Qiagen
Cultured Cells
Fresh Tissue
Buffy Coat
Cystic Fibrosis Gene Panel
Price on request

Cystic Fibrosis Genotyping Test (FDA Approved)

CLIA certified molecular diagnostic tests utilizing FDA approved GenMark Dx Tm platform. The Cystic Fibrosis Genotyping Test (FDA Approved) detects a panel of 23 recommended ACOG/ACMG mutations associated with cystic fibrosis

Cystic Fibrosis Genotyping Test (FDA Approved)

CLIA certified molecular diagnostic tests utilizing FDA approved GenMark Dx Tm platform. The Cystic Fibrosis Genotyping Test (FDA Approved) detects a panel of 23 recommended ACOG/ACMG mutations associated with cystic fibrosis

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Human
Cystic fibrosis
In Vitro Diagnostic
Warfarin Response (CYP2C9 and VKORC1) Genotyping
Price on request

Warfarin Sensitivity Test (FDA Approved) : This test detects three genetic markers known to play a critical role in metabolism of and sensitivity to warfarin: CYP450 2C9(*2 and 3) and VKORC1 (-1639G>A). CLIA certified molecular diagnostic tests utilizing FDA approved GenMark Dx Tm platform.

Warfarin Sensitivity Test (FDA Approved) : This test detects three genetic markers known to play a critical role in metabolism of and sensitivity to warfarin: CYP450 2C9(*2 and 3) and VKORC1 (-1639G>A). CLIA certified molecular diagnostic tests utilizing FDA approved GenMark Dx Tm platform.

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Human
CYP2C9
VKORC1
In Vitro Diagnostic
Thrombophilia Screening
Price on request

Thrombophilia Risk Test (FDA Approved) : This test detects all four inherited genetic risk factors of thrombophilia: FV, FII, MTHFR 677 and MTHFR 1298. CLIA certified molecular diagnostic tests utilizing FDA approved GenMark Dx Tm platform

Thrombophilia Risk Test (FDA Approved) : This test detects all four inherited genetic risk factors of thrombophilia: FV, FII, MTHFR 677 and MTHFR 1298. CLIA certified molecular diagnostic tests utilizing FDA approved GenMark Dx Tm platform

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Human
In Vitro Diagnostic
Respiratory Infection Gene Panel
Price on request

Respiratory Viral Panel (FDA Approved) : This panel is designed for simultaneous detection of 20 respiratory virus types and subtypes. CLIA certified molecular diagnostic tests utilizing FDA approved GenMark Dx Tm platform.

Respiratory Viral Panel (FDA Approved) : This panel is designed for simultaneous detection of 20 respiratory virus types and subtypes. CLIA certified molecular diagnostic tests utilizing FDA approved GenMark Dx Tm platform.

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Human
In Vitro Diagnostic
Clopidogrel Bioanalytical Assay
Price on request

Plavix Sensitivity Testing: This test is designed for detection and genotyping of the *2, *3, *4, *5, *6 ,*7, *8, *9, *10, *13 and *17 alleles of the cytochrome P450 2C19 gene locus. CLIA certified molecular diagnostic tests utilizing FDA approved GenMark Dx Tm platform.

Plavix Sensitivity Testing: This test is designed for detection and genotyping of the *2, *3, *4, *5, *6 ,*7, *8, *9, *10, *13 and *17 alleles of the cytochrome P450 2C19 gene locus. CLIA certified molecular diagnostic tests utilizing FDA approved GenMark Dx Tm platform.

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Human
Cardiovascular
CYP2C19
In Vitro Diagnostic
CYP Phenotyping
Price on request

Pain Management: This test is designed to test the variations in CYP 3A4 and CYP 3A5 that can help predict the effectiveness of the drugs involved in pain management. CLIA certified molecular diagnostic tests utilizing FDA approved GenMark Dx Tm platform.

Pain Management: This test is designed to test the variations in CYP 3A4 and CYP 3A5 that can help predict the effectiveness of the drugs involved in pain management. CLIA certified molecular diagnostic tests utilizing FDA approved GenMark Dx Tm platform.

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Human
Pain
CYP3A5
CYP3A4
In Vitro Diagnostic
Human Biospecimens
Price on request

Human Biorepository

BioServe’s Global BioRepository is one of the largest commercial human tissue banks in the world. With more than 600,000 human serum, DNA, RNA, and FFPE samples, from over 120,000 patients on four continents. BioServe also continues to establish procurement partnerships with speciality clinics around the... Show more »

Human Biorepository

BioServe’s Global BioRepository is one of the largest commercial human tissue banks in the world. With more than 600,000 human serum, DNA, RNA, and FFPE samples, from over 120,000 patients on four continents. BioServe also continues to establish procurement partnerships with speciality clinics around the United States in a number of indications/diseases for prospective sample collection.

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Human
Oncology
Arthritis
serum
RNA
DNA
Frozen Tissue
Diabetes
Cardiovascular
Nephrology and Urology
Asthma
FFPE
Autoimmune disease
Custom Collection
normal human controls
Inflammation
Stem Cell Reprogramming
Price on request

Exclusive provider of the Stemgent® StemRNA™ 3rd Gen reprogramming technology — the most rapid, robust, and clinically relevant integration-free method on the market, allowing REPROCELL to deliver iPSCs in around half the time of its competitors, even from refractory patient lines. Custom iPSC production services include:

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Exclusive provider of the Stemgent® StemRNA™ 3rd Gen reprogramming technology — the most rapid, robust, and clinically relevant integration-free method on the market, allowing REPROCELL to deliver iPSCs in around half the time of its competitors, even from refractory patient lines. Custom iPSC production services include:

• Fresh, normal or diseased tissue available through our custom collection network
• Establishment of patient-derived primary somatic cell lines as part of the standard service
• Reprogramming of multiple human and non-human cell types
• Cryopreserved patient-derived primary cells and iPSCs expanded and provided
• Milestone achievements for flexible project customization and fair value

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Regenerative Medicine
Whole blood
Urine
Drug Discovery
Rare Disease
Diseased human tissue
Karyotyping
Human skin fibroblasts
Patient Samples
Skin Punch Biopsy
normal human controls
Induced Pluripotent Stem Cell (iPSC) Differentiation
Price on request

We have extensive experience with differentiation of iPSCs into hepatocytes, cardiomyocytes and neuronal cells (mixed progenitors, dopaminergic, sensory). REPROCELL also has collaborations with key academic labs and ongoing projects related to several other differentiated cell types. This service can be used in conjunction with our iPSC Reprogramming Services.

We have extensive experience with differentiation of iPSCs into hepatocytes, cardiomyocytes and neuronal cells (mixed progenitors, dopaminergic, sensory). REPROCELL also has collaborations with key academic labs and ongoing projects related to several other differentiated cell types. This service can be used in conjunction with our iPSC Reprogramming Services.

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Human
Hepatocytes
Rare Disease
iPS cells
Mixed Neurons
Sensory Neurons
Dopaminergic neurons
Cardiomyocytes
In vitro Neural Models
Price on request

Novel Alvetex-based 3D assay for inhibition and recovery of Neurite Outgrowth. Using TERA-2 or ReproNeuro™ iPSC-derived Human Neurons (wild-type, Alzheimer's presinilin-2 patient and presinilin-1 mutant). Explore physiological and pathological ECM coatings (laminin, CSPGs), known pathway inhibitors and therapeutic lead compounds.

Novel Alvetex-based 3D assay for inhibition and recovery of Neurite Outgrowth. Using TERA-2 or ReproNeuro™ iPSC-derived Human Neurons (wild-type, Alzheimer's presinilin-2 patient and presinilin-1 mutant). Explore physiological and pathological ECM coatings (laminin, CSPGs), known pathway inhibitors and therapeutic lead compounds.

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Human
Neurodegenerative diseases
3D culture
Alzheimers Disease
neurite outgrowth
Functional Human Tissue Ion Channel Assays
Price on request

Human Mucosa (ileum, trachea) Ion Channel Activity Assays

This assay assesses whether a test compound causes a change in short circuit current across healthy human tracheal mucosa or healthy human gastrointestinal mucosa. Controls include isoprenaline, amiloride and cholera toxin.

Human Mucosa (ileum, trachea) Ion Channel Activity Assays

This assay assesses whether a test compound causes a change in short circuit current across healthy human tracheal mucosa or healthy human gastrointestinal mucosa. Controls include isoprenaline, amiloride and cholera toxin.

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Human
Drug Discovery
Gastroenterology
Respiratory
Toxicology
Healthy
Ussing Chambers
Functional Human Tissue Inflammation Assays
Price on request

Human Ex-vivo Culture Inflammation Assays

These assays assess the effect of test compounds on ex-vivo cultures of Human biopsies from skin, GI and lung tissue, from healthy and diseased patients. Diseased tissues that can be accessed include psoriasis, atopic dermatitis, asthma, COPD, Ulcerative Colitis and Crohn's... Show more »

Human Ex-vivo Culture Inflammation Assays

These assays assess the effect of test compounds on ex-vivo cultures of Human biopsies from skin, GI and lung tissue, from healthy and diseased patients. Diseased tissues that can be accessed include psoriasis, atopic dermatitis, asthma, COPD, Ulcerative Colitis and Crohn's Disease. Inflammation can also be induced via pre-treatment of healthy biopsies with LPS, TH-17 cocktail or TH-2 cocktail. Common endpoints are ELISA and gene expression.

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Human
Drug Discovery
ELISA
Psoriasis
Inflammatory Bowel Disease
Chronic obstructive pulmonary disease (COPD)
Dermatology
Gastroenterology
Respiratory
LPS
Asthma
Ulcerative colitis
Crohn's disease
Atopic dermatitis
Healthy
Ex-Vivo Cultures
Inflammation
Human Precision-Cut Lung Slice Assays
Price on request

This assays assesses the effect of test compounds on viability, cytokine release, as well as artery and airway diameter, in Human precision-cut lung slices. Treatments include LPS and isoprenaline.

This assays assesses the effect of test compounds on viability, cytokine release, as well as artery and airway diameter, in Human precision-cut lung slices. Treatments include LPS and isoprenaline.

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Human
Drug Discovery
Respiratory
Toxicology
Healthy
Ex-Vivo Cultures
Inflammation
Human Gastrointestinal Drug Absorption Assays
Price on request

This assay assesses the permeability of test articles across healthy human gastrointestinal mucosa. It is possible to assess permeability across multiple regions of the GI system, eg. stomach, jejunum, ileum, colon.

This assay assesses the permeability of test articles across healthy human gastrointestinal mucosa. It is possible to assess permeability across multiple regions of the GI system, eg. stomach, jejunum, ileum, colon.

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Human
Drug Discovery
ADME
Healthy
Ussing Chambers
Human Airway Bronchoconstriction Assays
Price on request

This assay assesses whether test compounds cause bronchoconstriction in human airways, using denuded secondary, tertiary or lower airways from healthy, asthma or COPD human donors. Controls include carbachol, histamine, acetylcholine, leukotriene D4, U46619.

This assay assesses whether test compounds cause bronchoconstriction in human airways, using denuded secondary, tertiary or lower airways from healthy, asthma or COPD human donors. Controls include carbachol, histamine, acetylcholine, leukotriene D4, U46619.

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Human
Chronic obstructive pulmonary disease (COPD)
Respiratory
Asthma
Healthy
Organ Baths
Wire Myographs
Human Airway Bronchodilation Assays
Price on request

This assay assesses whether test compounds cause bronchodilation in human airways, using denuded secondary, tertiary or lower airways from healthy, asthma or COPD human donors. Controls include isoprenaline, formoterol, salbutamol, salmeterol.

This assay assesses whether test compounds cause bronchodilation in human airways, using denuded secondary, tertiary or lower airways from healthy, asthma or COPD human donors. Controls include isoprenaline, formoterol, salbutamol, salmeterol.

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Human
Chronic obstructive pulmonary disease (COPD)
Respiratory
Asthma
Healthy
Organ Baths
Wire Myographs
Functional Human Tissue Contractility Assays
Price on request

Human Cardiac Muscle Contractility Assays

This assay assesses whether test compounds cause an increase in contractile force in electrically stimulated human atrial or ventricular muscle, from normal or failing hearts. Targets include 5-HT receptor, adrenoceptors, PDE3 receptor, acetylcholine receptor.

*Human Uterus... Show more »

Human Cardiac Muscle Contractility Assays

This assay assesses whether test compounds cause an increase in contractile force in electrically stimulated human atrial or ventricular muscle, from normal or failing hearts. Targets include 5-HT receptor, adrenoceptors, PDE3 receptor, acetylcholine receptor.

Human Uterus Contractility Assays

This assay assesses whether test articles cause an increase, or a decrease, in spontaneous contractile activity in isolated human uterine tissue. Controls include oxytocin, vasopressin, isoprenaline, isradipine and SNP.

Human Gastrointestinal (stomach, colon) Muscle Contractility Assays

This assay assesses whether test articles cause a change in contractile force on electrically stimulated human stomach or colon. Controls include galantamine, meptanizol and erythromycin.

Human Urinary (Ureter, Bladder, Urethra) Contractility Assays

This assay assesses whether test articles cause contraction in isolated human urethra, or cause relaxation in isolated human ureter or human bladder strips. Controls include epinephrine, isoprenaline and isoproterenol.

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Human
Drug Discovery
Cardiovascular
Women's Health
Gastroenterology
Nephrology and Urology
Toxicology
Organ Baths
Functional Human Tissue Vasoconstriction Assays
Price on request

This experiment assesses whether test articles cause vasoconstriction in human coronary arteries, sub-cutaneous resistance arteries or saphenous vein. Ask us for other vascular beds. Targets include receptors for angiotensin, 5-HT, opiods, vasopressin, oxytocin, phenylephrine and prostanoids

This experiment assesses whether test articles cause vasoconstriction in human coronary arteries, sub-cutaneous resistance arteries or saphenous vein. Ask us for other vascular beds. Targets include receptors for angiotensin, 5-HT, opiods, vasopressin, oxytocin, phenylephrine and prostanoids

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Human
Drug Discovery
Cardiovascular
Atherosclerosis
Toxicology
Healthy
Wire Myographs
Functional Human Tissue Vasodilation Assays
Price on request

The experiment assesses whether test articles cause vasodilatation in human chorionic plate arteries, skeletal muscle arteries or sub-cutaneous resistance arteries. Ask us for other vascular beds. Tragets include receptors for bradykinin, PDE3, PDE5, acetlycholine, SNP, vasopressin and oxytocin.

The experiment assesses whether test articles cause vasodilatation in human chorionic plate arteries, skeletal muscle arteries or sub-cutaneous resistance arteries. Ask us for other vascular beds. Tragets include receptors for bradykinin, PDE3, PDE5, acetlycholine, SNP, vasopressin and oxytocin.

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Human
Drug Discovery
Cardiovascular
Ischemia
Toxicology
Healthy
Preeclampsia
Wire Myographs
Biology
Price on request

Biology Services

Biology Services

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Custom Functional Human Tissue Assays
Price on request

REPROCELL has access to a range of human tissue and we are happy to discuss any assay formats that are not listed elsewhere on this page. Please be aware REPROCELL can also generate comparative pharmacology data using a variety of preclinical species. To discuss a customized assay, please contact us.

REPROCELL has access to a range of human tissue and we are happy to discuss any assay formats that are not listed elsewhere on this page. Please be aware REPROCELL can also generate comparative pharmacology data using a variety of preclinical species. To discuss a customized assay, please contact us.

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Guinea pig
ex-vivo
Mouse
Pig
Rat
Dog
Genomic DNA extraction
Drug Discovery
ELISA
histology
Diseased human tissue
Normal Human tissue
real-time PCR
Custom Assays
Toxicology
RNA Extraction
In Vitro ADME
Ussing Chambers
Organ Baths
Wire Myographs
2018-06-04 11:34:58 -1100

Net Promoter Score of 10 received for Functional Human Tissue Vasoconstriction Assays.

Additional Ratings: satisfaction with deliverable: 10, satisfaction with timeliness: 10.

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