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reMYND

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Leuven (Heverlee), BE

About reMYND

reMYND drives the development of disease-modifying treatments against protein misfolding disorders

reMYND NV, founded in 2002 as a spin-off from the University of Leuven, drives the development of disease-modifying treatments against Alzheimer’s, Parkinson’s, Diabetes and other orphan protein misfolding... Show more »

reMYND drives the development of disease-modifying treatments against protein misfolding disorders

reMYND NV, founded in 2002 as a spin-off from the University of Leuven, drives the development of disease-modifying treatments against Alzheimer’s, Parkinson’s, Diabetes and other orphan protein misfolding disorders. reMYND is organized along two independently managed business units, the Contract Research Organization (CRO) and the own Drug Discovery & Development unit:

Contract Research

The in-vivo Contract Research Organization (CRO) helps its clients assess the pharmacokinetics and -dynamics of their experimental treatments against Alzheimer's disease in reMYND’s proprietary Alzheimer mouse models. Its mission is to be a strategic partner for its clients and help them identify the most promising set-up to assess potential effects.

In vivo efficacy testing of experimental Alzheimer treatments in extensively validated transgenic mouse models

Given the extensive experience fully focused on Alzheimer's, reMYND’s CRO can contribute its expertise for every type of Alzheimer treatment in any form of application.

reMYND, a trusted research partner

reMYND’s Contract Research Organization (CRO) is a trusted research partner specialized in the pre-clinical in vivo testing of all experimental Alzheimer treatments. By contributing our extensive expertise and experience we are helping our clients in understanding as fast as possible the therapeutic in vivo effects of their lead preclinical Alzheimer therapies.

  • World-class CRO with clients in US, Europe and Japan, including the leading biotechs and a majority of the top 10 pharmaco’s
  • Research partner in the preclinical in-vivo testing of all types of Alzheimer treatments
    • testing of tau and Abeta directed approaches, as well as other hypotheses
    • small molecule and immunization strategies;
    • prophylactic and curative treatments;
    • pharmaceuticals and nutraceuticals;
  • Mastering all routes of administration (e.g., gavage, stereotactic injection in brain, ip, sc, iv)
  • Offering a set of proprietary unique and validated mouse models
    • based on the human clinical APP-London allele APP[V717I] either alone or in combination with the human clinical PS1[A246E] allele
    • based on the human clinical TAU[P301L] allele – featuring a progressive tauopathy model – extended to an APPxTAU model, combining both amyloid and tau pathology
    • now adding TAU[P301S] as a complementary tauopathy model
  • With a broad testing window for a whole portfolio of behavioral, immunohistochemical and biochemical read-outs, both in brain and csf
  • Committed to a short response time allowing rapid study start also with aged mice
  • High client satisfaction is our key driver, committing us to excel in communication, dedication and flexibility.

The CRO is serving 6 of the Top 10 pharmaco’s worldwide and its client-base covers the US, Europe and Japan. The CRO has provided in-vivo proof-of-concept data for several candidate drugs that reMYND’s clients have currently in clinical development.

Drug discovery

reMYND’s own Drug Discovery & Development unit focuses entirely on disease-modifying treatments with the aim to decelerate – or even reverse – cellular degeneration found in protein misfolding disorders, such as Alzheimer’s disease (AD), Parkinson’s disease (PD), type 2 diabetes mellitus (T2DM) and several orphan diseases.

As such, reMYND responds to a clear unmet medical need, as all marketed treatments and the majority of the products under development world-wide are aimed mainly to mitigate symptoms.
reMYND’s pipeline primarily consists of 4 disease-modifying programs counteracting tau-toxicity for AD, 2 programs for T2DM, and 2 counteracting synuclein-toxicity for PD, with recent additions in orphan diseases.

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Our Services (53)


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Biomarker Discovery

Price on request

A range of translatable biomarkers are offered in the context of our Alzheimer Disease mouse models, Tauopathy mouse models and other models of neurodegenerative diseases including:

EEG analysis
Neurofilament light (NfL) in the plasma
Tau and Ab42/40 in the CSF

A range of translatable biomarkers are offered in the context of our Alzheimer Disease mouse models, Tauopathy mouse models and other models of neurodegenerative diseases including:

EEG analysis
Neurofilament light (NfL) in the plasma
Tau and Ab42/40 in the CSF

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Animal Organ Harvesting

Price on request

We have experience with:

  • Brain
  • Heart
  • Liver
  • Kidney
  • Pancreas
  • Lungs
  • Spleen
  • Thymus
  • Sciatic nerve
  • Bones
  • Spinal cord
  • Adrenals
  • Adipose tissue
  • Specific muscle tissue

We have experience with:

  • Brain
  • Heart
  • Liver
  • Kidney
  • Pancreas
  • Lungs
  • Spleen
  • Thymus
  • Sciatic nerve
  • Bones
  • Spinal cord
  • Adrenals
  • Adipose tissue
  • Specific muscle tissue
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Animal Cerebrospinal Fluid Collection

Price on request

Collection of CSF during sacrifice to further analyse biomarkers.

Collection of CSF during sacrifice to further analyse biomarkers.

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Animal Stereotactic Surgery

Price on request

Most commonly used for the seeding of Tau fibrils and subsequent spreading. With an automatic stereotact, the position of the injection can be accurately determined and executed.

Most commonly used for the seeding of Tau fibrils and subsequent spreading. With an automatic stereotact, the position of the injection can be accurately determined and executed.

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Microscopy

Price on request
  • Plaque deposition or amyloid deposits, diffuse plaques (LOC or other antibodies), dense core plaques (Thioflavin S or Methoxy-X04 staining)
  • Hyperphosphorylation and aggregation of Tau can visualised using various antibodies targeting ptau epitopes (e.g. AT8, AT100, ...) or direct staining of neurofibrillary... Show more »
  • Plaque deposition or amyloid deposits, diffuse plaques (LOC or other antibodies), dense core plaques (Thioflavin S or Methoxy-X04 staining)
  • Hyperphosphorylation and aggregation of Tau can visualised using various antibodies targeting ptau epitopes (e.g. AT8, AT100, ...) or direct staining of neurofibrillary tangles
  • Neuroinflammation, microgliosis and microglia (e.g. CD11, CD45, CD68, ...), astrocytosis and astrocytes (GFAP)
  • Neuronal loss (anti-NeuN)
  • Custom stainings
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Immunofluorescence

Price on request

On request

On request

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Tissue Sectioning

Price on request

Brain tissue can be cut into coronal or sagittal slices using a (cooled) vibratome. Afterwards, immunohistochemistry (IHC) can be performed on the slices.

Dissection of mouse brain in:

Hippocampus
Cortex
Midbrain
Pons & medulla
Cerebellum
Striatum

Brain tissue can be cut into coronal or sagittal slices using a (cooled) vibratome. Afterwards, immunohistochemistry (IHC) can be performed on the slices.

Dissection of mouse brain in:

Hippocampus
Cortex
Midbrain
Pons & medulla
Cerebellum
Striatum

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Rotarod Performance Test

Price on request

To measure alleviating therapeutic effects of your Tauopathy compound in development on balance, motor coordination and motor planning.

To measure alleviating therapeutic effects of your Tauopathy compound in development on balance, motor coordination and motor planning.

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Morris Water Maze Assay

Price on request

The Morris Water Maze is a widely used behavioural test to assess spatial learning and long-term spatial memory in mice. We look at several parameters within the Morris Water Maze paradigm to assess therapeutic effects of your compound in development.

The Morris Water Maze is a widely used behavioural test to assess spatial learning and long-term spatial memory in mice. We look at several parameters within the Morris Water Maze paradigm to assess therapeutic effects of your compound in development.

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Animal Learning, Memory, and Behavior Tests

Price on request

Our behavioural/cognition assays include:

  • Open Field
  • Morris Water Maze

Motoric test include:

  • Beam Walk
  • Rotarod
  • Clasping scoring

Our behavioural/cognition assays include:

  • Open Field
  • Morris Water Maze

Motoric test include:

  • Beam Walk
  • Rotarod
  • Clasping scoring
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Animal Blood Collection

Price on request

We have extensive experience with several blood collecting methods, at the timepoints of your choosing, including collection according to pharmacokinetic and pharmacodynamic (PK and PD) schedules.

We have extensive experience with several blood collecting methods, at the timepoints of your choosing, including collection according to pharmacokinetic and pharmacodynamic (PK and PD) schedules.

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Animal Behavior Studies

Price on request

Our behavioural/cognition assays include:

  • Open Field
  • Morris Water Maze

Motoric test include:

  • Beam Walk
  • Rotarod
  • Clasping scoring

Our behavioural/cognition assays include:

  • Open Field
  • Morris Water Maze

Motoric test include:

  • Beam Walk
  • Rotarod
  • Clasping scoring
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Immunohistochemistry (IHC)

Price on request
  • Plaque deposition or amyloid deposits, diffuse plaques (LOC or other antibodies), dense core plaques (Thioflavin S or Methoxy-X04 staining)
  • Hyperphosphorylation and aggregation of Tau can visualised using various antibodies targeting ptau epitopes (e.g. AT8, AT100, ...) or direct staining of neurofibrillary... Show more »
  • Plaque deposition or amyloid deposits, diffuse plaques (LOC or other antibodies), dense core plaques (Thioflavin S or Methoxy-X04 staining)
  • Hyperphosphorylation and aggregation of Tau can visualised using various antibodies targeting ptau epitopes (e.g. AT8, AT100, ...) or direct staining of neurofibrillary tangles
  • Neuroinflammation, microgliosis and microglia (e.g. CD11, CD45, CD68, ...), astrocytosis and astrocytes (GFAP)
  • Neuronal loss (anti-NeuN)
  • Custom stainings
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Tauopathy Animal Models

Price on request

Our range of proprietary Tauopathy mouse models allows us to validate or screen your compound(s) in development for Tau-based approaches or approaches affecting Tau. Specifically, our models are:

  • Tau[P301L]
  • Tau[P301S]

In addition, we offer Tau transsynaptic seed and spread models.

Our range of proprietary Tauopathy mouse models allows us to validate or screen your compound(s) in development for Tau-based approaches or approaches affecting Tau. Specifically, our models are:

  • Tau[P301L]
  • Tau[P301S]

In addition, we offer Tau transsynaptic seed and spread models.

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Quantitative Histology

Price on request
  • Plaque deposition or amyloid deposits, diffuse plaques (LOC or other antibodies), dense core plaques (Thioflavin S or Methoxy-X04 staining)
  • Hyperphosphorylation and aggregation of Tau can visualised using various antibodies targeting ptau epitopes (e.g. AT8, AT100, ...) or direct staining of neurofibrillary... Show more »
  • Plaque deposition or amyloid deposits, diffuse plaques (LOC or other antibodies), dense core plaques (Thioflavin S or Methoxy-X04 staining)
  • Hyperphosphorylation and aggregation of Tau can visualised using various antibodies targeting ptau epitopes (e.g. AT8, AT100, ...) or direct staining of neurofibrillary tangles
  • Neuroinflammation, microgliosis and microglia (e.g. CD11, CD45, CD68, ...), astrocytosis and astrocytes (GFAP)
  • Neuronal loss (anti-NeuN)
  • Custom stainings
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Preclinical Histology

Price on request
  • Plaque deposition or amyloid deposits, diffuse plaques (LOC or other antibodies), dense core plaques (Thioflavin S or Methoxy-X04 staining)
  • Hyperphosphorylation and aggregation of Tau can visualised using various antibodies targeting ptau epitopes (e.g. AT8, AT100, ...) or direct staining of neurofibrillary... Show more »
  • Plaque deposition or amyloid deposits, diffuse plaques (LOC or other antibodies), dense core plaques (Thioflavin S or Methoxy-X04 staining)
  • Hyperphosphorylation and aggregation of Tau can visualised using various antibodies targeting ptau epitopes (e.g. AT8, AT100, ...) or direct staining of neurofibrillary tangles
  • Neuroinflammation, microgliosis and microglia (e.g. CD11, CD45, CD68, ...), astrocytosis and astrocytes (GFAP)
  • Neuronal loss (anti-NeuN)
  • Custom stainings
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Animal Motor Function and Activity Testing

Price on request

The motor function tests include:

  • Beam walk
  • Rotarod
  • Clasping scoring

The motor function tests include:

  • Beam walk
  • Rotarod
  • Clasping scoring
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Animal Cognition & Behavior Tests

Price on request

Our behavioural/cognition assays include:

  • Open Field
  • Morris Water Maze

Motoric test include:

  • Beam Walk
  • Rotarod
  • Clasping scoring

Our behavioural/cognition assays include:

  • Open Field
  • Morris Water Maze

Motoric test include:

  • Beam Walk
  • Rotarod
  • Clasping scoring
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Animal Electroencephalography (EEG)

Price on request

In collaboration with a subcontracter, we can extend the range of generated immunohistochemical, biochemical and behavioural data to electrophysiological data.

In collaboration with a subcontracter, we can extend the range of generated immunohistochemical, biochemical and behavioural data to electrophysiological data.

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In vivo Electrophysiology

Price on request

In collaboration with a subcontracter, we can extend the range of generated immunohistochemical, biochemical and behavioural data to electrophysiological data.

In collaboration with a subcontracter, we can extend the range of generated immunohistochemical, biochemical and behavioural data to electrophysiological data.

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Ex vivo Electrophysiology

Price on request

In collaboration with a subcontracter, we can extend the range of generated immunohistochemical, biochemical and behavioural data to electrophysiological data.

In collaboration with a subcontracter, we can extend the range of generated immunohistochemical, biochemical and behavioural data to electrophysiological data.

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Animal Surgery

Price on request

Stereotactic microinjection. Additional techniques on request.

Stereotactic microinjection. Additional techniques on request.

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Electrophysiology

Price on request

In collaboration with a subcontracter, we can extend the range of generated immunohistochemical, biochemical and behavioural data to electrophysiological data.

In collaboration with a subcontracter, we can extend the range of generated immunohistochemical, biochemical and behavioural data to electrophysiological data.

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Patch Clamp Recording

Price on request

In collaboration with a subcontracter, we can extend the range of generated immunohistochemical, biochemical and behavioural data to electrophysiological data.

In collaboration with a subcontracter, we can extend the range of generated immunohistochemical, biochemical and behavioural data to electrophysiological data.

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Project Management

Price on request

The general flow of a study is:

1) signing a NDA if necessary
2) discussing the envisioned study design with input from reMYND via e-mail and/or telephone
3) summary of the study design(s) in a quote(s)
4) summary of the study design in a study plan after signing of the quote
5) regular updates during... Show more »

The general flow of a study is:

1) signing a NDA if necessary
2) discussing the envisioned study design with input from reMYND via e-mail and/or telephone
3) summary of the study design(s) in a quote(s)
4) summary of the study design in a study plan after signing of the quote
5) regular updates during the study
6) finding of study summarized in a draft report
7) input from client to deliver the final report.

The payments are made according the several milestones

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In vivo PK/PD Studies

Price on request

reMYND has ample experience with collection of blood, serum, plasma, brain samples, CSF and organs at specific time points to enable pharmacokinetic and pharmacodynamic analysis (PK and PD).

reMYND has ample experience with collection of blood, serum, plasma, brain samples, CSF and organs at specific time points to enable pharmacokinetic and pharmacodynamic analysis (PK and PD).

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Assay Development

Price on request

In addition to the optimized SOPs, we are open to and experienced in implementing new assays to tailor the study design to your needs.

In addition to the optimized SOPs, we are open to and experienced in implementing new assays to tailor the study design to your needs.

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Biomarker Analysis

Price on request

A broad range of biomarker analysis are optimized offered in the context of our proprietary Alzheimer Disease mouse models, Tauopathy mouse models and other models of neurodegenerative diseases. We are open to and experienced in implementing new assays to report the evolution in the biomarker of your choosing.

A broad range of biomarker analysis are optimized offered in the context of our proprietary Alzheimer Disease mouse models, Tauopathy mouse models and other models of neurodegenerative diseases. We are open to and experienced in implementing new assays to report the evolution in the biomarker of your choosing.

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Tissue Embedding

Price on request

Brain tissue can be cut into coronal or sagittal slices using a (cooled) vibratome. Afterwards, immunohistochemistry (IHC) can be performed on the slices.

Brain tissue can be cut into coronal or sagittal slices using a (cooled) vibratome. Afterwards, immunohistochemistry (IHC) can be performed on the slices.

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Histological Staining

Price on request
  • Plaque deposition or amyloid deposits, diffuse plaques (LOC or other antibodies), dense core plaques (Thioflavin S or Methoxy-X04 staining)
  • Hyperphosphorylation and aggregation of Tau can visualised using various antibodies targeting ptau epitopes (e.g. AT8, AT100, ...) or direct staining of neurofibrillary... Show more »
  • Plaque deposition or amyloid deposits, diffuse plaques (LOC or other antibodies), dense core plaques (Thioflavin S or Methoxy-X04 staining)
  • Hyperphosphorylation and aggregation of Tau can visualised using various antibodies targeting ptau epitopes (e.g. AT8, AT100, ...) or direct staining of neurofibrillary tangles
  • Neuroinflammation, microgliosis and microglia (e.g. CD11, CD45, CD68, ...), astrocytosis and astrocytes (GFAP)
  • Neuronal loss (anti-NeuN)
  • Custom stainings
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Immunostaining

Price on request
  • Plaque deposition or amyloid deposits, diffuse plaques (LOC or other antibodies), dense core plaques (Thioflavin S or Methoxy-X04 staining)
  • Hyperphosphorylation and aggregation of Tau can visualised using various antibodies targeting ptau epitopes (e.g. AT8, AT100, ...) or direct staining of neurofibrillary... Show more »
  • Plaque deposition or amyloid deposits, diffuse plaques (LOC or other antibodies), dense core plaques (Thioflavin S or Methoxy-X04 staining)
  • Hyperphosphorylation and aggregation of Tau can visualised using various antibodies targeting ptau epitopes (e.g. AT8, AT100, ...) or direct staining of neurofibrillary tangles
  • Neuroinflammation, microgliosis and microglia (e.g. CD11, CD45, CD68, ...), astrocytosis and astrocytes (GFAP)
  • Neuronal loss (anti-NeuN)
  • Custom stainings
Show less

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Animal Motor Function Tests

Price on request

The motor function tests include:

  • Beam walk
  • Rotarod
  • Clasping scoring

The motor function tests include:

  • Beam walk
  • Rotarod
  • Clasping scoring
Show less

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Animal Model in vivo Analyses

Price on request
Request a quote for more information about this service.

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Neuroscience Animal Models

Price on request

Our range of proprietary Alzheimer Disease, Tauopathy mouse models and other models of neurodegenerative disease allows us to validate or screen your compound(s) in development for both Tau- and amyloid-based approaches, but also neuroinflammation- and protein homeostasis based approaches.
We can provide a transgenic mouse... Show more »

Our range of proprietary Alzheimer Disease, Tauopathy mouse models and other models of neurodegenerative disease allows us to validate or screen your compound(s) in development for both Tau- and amyloid-based approaches, but also neuroinflammation- and protein homeostasis based approaches.
We can provide a transgenic mouse model with both APP and MAPT/Tau mutations. Specifically, our transgenic models are:

  • APP(Lon)
  • APP(Lon)xPS1[A246E]
  • Tau[P301L]
  • Tau[P301S]
  • APP(Lon)xTau[P301S]

In addition, we offer Tau transsynaptic seed and spread models and have experience with crossbreeding of transgenic mouse lines.

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Cognition and Behavior Animal Models

Price on request

Our range of proprietary Alzheimer Disease, Tauopathy mouse models and other models of neurodegenerative disease allows us to validate or screen your compound(s) in development for both Tau- and amyloid-based approaches, but also neuroinflammation- and protein homeostasis based approaches.
We can provide a transgenic mouse... Show more »

Our range of proprietary Alzheimer Disease, Tauopathy mouse models and other models of neurodegenerative disease allows us to validate or screen your compound(s) in development for both Tau- and amyloid-based approaches, but also neuroinflammation- and protein homeostasis based approaches.
We can provide a transgenic mouse model with both APP and MAPT/Tau mutations. Specifically, our transgenic models are:

  • APP(Lon)
  • APP(Lon)xPS1[A246E]
  • Tau[P301L]
  • Tau[P301S]
  • APP(Lon)xTau[P301S]

In addition, we offer Tau transsynaptic seed and spread models and have experience with crossbreeding of transgenic mouse lines.

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Animal Model Housing and Maintenance

Price on request

All our mice are housed according to SPF (FELASA).

All our mice are housed according to SPF (FELASA).

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Genetically Engineered Mice

Price on request

In addition to our proprietary transgenic mouse models, we have experience with crossbreeding of transgenic mouse lines.

In addition to our proprietary transgenic mouse models, we have experience with crossbreeding of transgenic mouse lines.

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Western Blot

Price on request

Western blot quantification of Tau and pTau in the total, soluble and sarkosyl-insoluble fraction.

Ample experience with custom design western blot assays like receptor and phosphoreceptor quantification for pharmacodynamic evaluation.

Western blot quantification of Tau and pTau in the total, soluble and sarkosyl-insoluble fraction.

Ample experience with custom design western blot assays like receptor and phosphoreceptor quantification for pharmacodynamic evaluation.

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Transgenic Mouse Services

Price on request

In addition to our proprietary transgenic mouse models, we have experience with crossbreeding of transgenic mouse lines.

In addition to our proprietary transgenic mouse models, we have experience with crossbreeding of transgenic mouse lines.

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Bioanalysis

Price on request

reMYND has ample experience with collection of blood, serum, plasma, brain samples, CSF and organs at specififc time points to enable pharmacokinetic and pharmacodynamic analysis (PK and PD).

reMYND has ample experience with collection of blood, serum, plasma, brain samples, CSF and organs at specififc time points to enable pharmacokinetic and pharmacodynamic analysis (PK and PD).

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Mouse Models

Price on request

Our range of proprietary Alzheimer Disease, Tauopathy mouse models and other models of neurodegenerative disease allows us to validate or screen your compound(s) in development for both Tau- and amyloid-based approaches, but also neuroinflammation- and protein homeostasis based approaches.
We can provide a transgenic mouse... Show more »

Our range of proprietary Alzheimer Disease, Tauopathy mouse models and other models of neurodegenerative disease allows us to validate or screen your compound(s) in development for both Tau- and amyloid-based approaches, but also neuroinflammation- and protein homeostasis based approaches.
We can provide a transgenic mouse model with both APP and MAPT/Tau mutations. Specifically, our transgenic models are:

  • APP(Lon)
  • APP(Lon)xPS1[A246E]
  • Tau[P301L]
  • Tau[P301S]
  • APP(Lon)xTau[P301S]

In addition, we offer Tau transsynaptic seed and spread models and have experience with crossbreeding of transgenic mouse lines.

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Transgenic Animal Model Development

Price on request

In addition to our proprietary transgenic mouse models, we have experience with crossbreeding of transgenic mouse lines.

In addition to our proprietary transgenic mouse models, we have experience with crossbreeding of transgenic mouse lines.

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Pain/Neuropathy Animal Models

Price on request

Our range of proprietary Alzheimer Disease, Tauopathy mouse models and other models of neurodegenerative disease allows us to validate or screen your compound(s) in development for both Tau- and amyloid-based approaches, but also neuroinflammation- and protein homeostasis based approaches.
We can provide a transgenic mouse... Show more »

Our range of proprietary Alzheimer Disease, Tauopathy mouse models and other models of neurodegenerative disease allows us to validate or screen your compound(s) in development for both Tau- and amyloid-based approaches, but also neuroinflammation- and protein homeostasis based approaches.
We can provide a transgenic mouse model with both APP and MAPT/Tau mutations. Specifically, our transgenic models are:

  • APP(Lon)
  • APP(Lon)xPS1[A246E]
  • Tau[P301L]
  • Tau[P301S]
  • APP(Lon)xTau[P301S]

In addition, we offer Tau transsynaptic seed and spread models and have experience with crossbreeding of transgenic mouse lines.

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Cognitive, Behavioral, and Psychiatric Animal Models

Price on request

Our range of proprietary Alzheimer Disease, Tauopathy mouse models and other models of neurodegenerative disease allows us to validate or screen your compound(s) in development for both Tau- and amyloid-based approaches, but also neuroinflammation- and protein homeostasis based approaches.
We can provide a transgenic mouse... Show more »

Our range of proprietary Alzheimer Disease, Tauopathy mouse models and other models of neurodegenerative disease allows us to validate or screen your compound(s) in development for both Tau- and amyloid-based approaches, but also neuroinflammation- and protein homeostasis based approaches.
We can provide a transgenic mouse model with both APP and MAPT/Tau mutations. Specifically, our transgenic models are:

  • APP(Lon)
  • APP(Lon)xPS1[A246E]
  • Tau[P301L]
  • Tau[P301S]
  • APP(Lon)xTau[P301S]

In addition, we offer Tau transsynaptic seed and spread models and have experience with crossbreeding of transgenic mouse lines.

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ic

Biomarkers

Price on request

A broad range of biomarker analysis are optimized offered in the context of our proprietary Alzheimer Disease mouse models, Tauopathy mouse models and other models of neurodegenerative diseases. We are open to and experienced in implementing new assays to report the evolution in the biomarker of your choosing.

A broad range of biomarker analysis are optimized offered in the context of our proprietary Alzheimer Disease mouse models, Tauopathy mouse models and other models of neurodegenerative diseases. We are open to and experienced in implementing new assays to report the evolution in the biomarker of your choosing.

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In vivo Drug Efficacy Testing

Price on request

In order to validate or screen your compound(s) in development, we can provide a plethora of assays in proprietary Alzheimer Disease mouse models, Tauopathy mouse models and other models of deurodegenerative diseases. We have extensive experience with our transgenic mouse models and are open to discuss new assays to achieve a study design in line with your wishes.

In order to validate or screen your compound(s) in development, we can provide a plethora of assays in proprietary Alzheimer Disease mouse models, Tauopathy mouse models and other models of deurodegenerative diseases. We have extensive experience with our transgenic mouse models and are open to discuss new assays to achieve a study design in line with your wishes.

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Imaging & Spectroscopy

Price on request

On request

On request

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In vivo Pharmacology Studies

Price on request

In order to validate or screen your compound(s) in development, we can provide a plethora of assays in proprietary Alzheimer Disease mouse models, Tauopathy mouse models and other models of deurodegenerative diseases. We have extensive experience with our transgenic mouse models and are open to discuss new assays to achieve a study design in line with your wishes.

In order to validate or screen your compound(s) in development, we can provide a plethora of assays in proprietary Alzheimer Disease mouse models, Tauopathy mouse models and other models of deurodegenerative diseases. We have extensive experience with our transgenic mouse models and are open to discuss new assays to achieve a study design in line with your wishes.

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Drug Discovery & Development

Price on request

reMYND's Drug Discovery & Development focuses entirely on disease-modifying treatments with the aim to decelerate – or even stop – cellular degeneration in patients suffering protein misfolding disorders, such as Alzheimer's and Parkinson's disease. As such, reMYND responds to a clear unmet medical need, as all marketed treatments... Show more »

reMYND's Drug Discovery & Development focuses entirely on disease-modifying treatments with the aim to decelerate – or even stop – cellular degeneration in patients suffering protein misfolding disorders, such as Alzheimer's and Parkinson's disease. As such, reMYND responds to a clear unmet medical need, as all marketed treatments and the majority of the products under development world-wide are aimed to only mitigate symptoms in the respective disorders.

Alzheimer's disease

It is estimated that there are currently 26 million people worldwide with Alzheimer’s disease. This number is expected to reach 100 million by 2050. Existing therapies are all symptomatic, whereas most ongoing developments for 'causal' remedies aimed to inhibit neuronal degeneration have failed up to now.

Parkinson's disease

Parkinson’s disease is the most common motor disorder, typically affecting the aged (65+) population. About 0.1% to 0.2% of the western population is a Parkinson’s patient. It is expected that the number of patients suffering from Parkinson’s disease will double in the next ten years, reflecting the aging of the population in the western world. With the exception of cell transplants and gene therapy programs there are have been no breakthroughs in the field since the seventies.

Diabetes mellitus type 2

Diabetes mellitus type 2 is a chronic metabolic disorder resulting from a failure to manage glucose levels in the blood appropriately. The 2008 prevalence of diabetes mellitus in the seven major markets was 8.5% (about 10 times higher than the 0.9% prevalence of Alzheimer’s disease, and 40 times higher than Parkinson’s). The major increase however will happen in Asia and the Rest-of-World, resulting in an estimated global number of diabetics of 380 million people worldwide in 2025, an increase of over 50% in less than 20 years.

Other protein misfolding disorders

reMYND’s technology platform is amenable to address numerous other, highly delibiting protein-misfolding disorders, such as Huntington’s disease or Amyotrophic Lateral Sclerosis, to discover and develop drug candidates. A further diversification of our product pipeline comprising other protein misfolding disorders is anticipated in the near future.

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Animal Models of Disease

Price on request

Our range of proprietary Alzheimer Disease, Tauopathy mouse models and other models of neurodegenerative disease allows us to validate or screen your compound(s) in development for both Tau- and amyloid-based approaches, but also neuroinflammation- and protein homeostasis based approaches.
We can provide a transgenic mouse... Show more »

Our range of proprietary Alzheimer Disease, Tauopathy mouse models and other models of neurodegenerative disease allows us to validate or screen your compound(s) in development for both Tau- and amyloid-based approaches, but also neuroinflammation- and protein homeostasis based approaches.
We can provide a transgenic mouse model with both APP and MAPT/Tau mutations. Specifically, our transgenic models are:

  • APP(Lon)
  • APP(Lon)xPS1[A246E]
  • Tau[P301L]
  • Tau[P301S]
  • APP(Lon)xTau[P301S]

In addition, we offer Tau transsynaptic seed and spread models and have experience with crossbreeding of transgenic mouse lines.

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Animal Models and Studies

Price on request

In order to validate or screen your compound(s) in development, we can provide a plethora of assays in proprietary Alzheimer Disease mouse models, Tauopathy mouse models and other models of neurodegenerative diseases. We have extensive experience with our transgenic mouse models and are open to discuss new assays to achieve a study design in line with your wishes.

In order to validate or screen your compound(s) in development, we can provide a plethora of assays in proprietary Alzheimer Disease mouse models, Tauopathy mouse models and other models of neurodegenerative diseases. We have extensive experience with our transgenic mouse models and are open to discuss new assays to achieve a study design in line with your wishes.

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CNS/Neurology Animal Models

Price on request

Our range of proprietary Alzheimer Disease, Tauopathy mouse models and other models of neurodegenerative disease allows us to validate or screen your compound(s) in development for both Tau- and amyloid-based approaches, but also neuroinflammation- and protein homeostasis based approaches.
We can provide a transgenic mouse... Show more »

Our range of proprietary Alzheimer Disease, Tauopathy mouse models and other models of neurodegenerative disease allows us to validate or screen your compound(s) in development for both Tau- and amyloid-based approaches, but also neuroinflammation- and protein homeostasis based approaches.
We can provide a transgenic mouse model with both APP and MAPT/Tau mutations. Specifically, our transgenic models are:

  • APP(Lon)
  • APP(Lon)xPS1[A246E]
  • Tau[P301L]
  • Tau[P301S]
  • APP(Lon)xTau[P301S]

In addition, we offer Tau transsynaptic seed and spread models and have experience with crossbreeding of transgenic mouse lines.

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Alzheimer's Disease Animal Models

Price on request
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