To53czmtseor89ebwiyq reaction

Reaction Biology Corp.

ic 9.0/10 Overall Rating No Reviews Yet
ic 17 Orders Completed
Malvern, Pennsylvania, US

About Reaction Biology Corp.

Reaction Biology Corporation is an industry leader and innovator specializing in assay services for early-stage drug discovery. Founded in 2001, Reaction Biology offers a wide range of services, including robust assay technologies for kinase and epigenetic biochemical and cell-based high throughput screening... Show more »

Reaction Biology Corporation is an industry leader and innovator specializing in assay services for early-stage drug discovery. Founded in 2001, Reaction Biology offers a wide range of services, including robust assay technologies for kinase and epigenetic biochemical and cell-based high throughput screening (HTS) and selectivity compound profiling. We also offer relevant HTS assay reagents, including highly purified and characterized epigenetic proteins. On average, several million HTS and profiling reactions are performed per year. Over 600 companies worldwide, including pharmaceutical, biotech, academic, and nonprofit laboratories, utilize our biochemical and cellular assay services and purchase epigenetic proteins.

Recent Publications:

  • Joseph J. Ferry, Robert F. Smith, Natalie Denney, Colin P. Walsh, Lauren McCauley, Jie Qian, Haiching Ma, Kurumi Y. Horiuchi, and Konrad T. Howitz. Development and Use of Assay Conditions Suited to Screening for and Profiling of SET-Domain-Targeted Inhibitors of the MLL/SET1 Family of Lysine Methyltransferases. ASSAY and Drug Development Technologies vol.13 no.4 (May 2014), 221-234.
  • Kurumi Y. Horiuchi, Mia M. Eason, Joseph J. Ferry, Jamie L. Planck, Colin P. Walsh, Konrad T. Howitz and Haiching Ma. Assay Development for Histone Methyltransferases. ASSAY and Drug Development Technologies vol.11 no.4 (May 2013), 227-236.
  • Jianghong Wu, Yuren Wang, Shuguang Liang, Haiching Ma. Cytoprotective Effort of Selective Small-Molecule Caspase Inhibitors against Staurosporine-induced Apoptosis. Drug Design, Development and Therapy 2014:8 583–600.
  • Mark E. McDonnell, Haiyan Bian, Jay Wrobel, Garry R. Smith, Shuguang Liang, Haiching Ma, Allen B. Reitz.
    Anilino-monoindolylmaleimides as potent and selective JAK3 inhibitors. Bioorganic & Medicinal Chemistry Letters 24 (2014) 1116–1121.
Show less

Diversity Certificates

Small business

Our Services (115)


ic

Microscale Thermophoresis

Price on request

MST ASSAY

MST assays measure the interactions directly in solution without the need of immobilization to a surface (immobilization-free technology). MST uses a small amount of samples and allows for quick assay development and affinity determination (KD) of interactions. It can be used to detect binding between any kind... Show more »

MST ASSAY

MST assays measure the interactions directly in solution without the need of immobilization to a surface (immobilization-free technology). MST uses a small amount of samples and allows for quick assay development and affinity determination (KD) of interactions. It can be used to detect binding between any kind of biomolecules including proteins, DNA, RNA, peptides, small molecules, fragments and ions, with quick measurement times and low sample consumption. The detection range of MST on Binding affinity is between pM to mM range.

Show less
Monolith NT.115 pico

ic

NAD(P)H:Quinone Oxidoreductase (NQO) Assays

Price on request

Reaction Biology offers NQO1 for profiling services.

Reaction Biology offers NQO1 for profiling services.

Show less

ic

Apoptosis Assays

Price on request

Reaction Biology offers cIAP-1, cIAP-2, XIAP for profiling services.

Reaction Biology offers cIAP-1, cIAP-2, XIAP for profiling services.

Show less

ic

BCL-2 Assays

B-Cell Lymphoma-2 Assays
Price on request

Reaction Biology offers Bcl-2 and BCL-xL for HTS and profiling services.

Reaction Biology offers Bcl-2 and BCL-xL for HTS and profiling services.

Show less

ic

CYP Inhibition Assay

Price on request

Reaction Biology offers CYP 1A2, CYP 2C19, CYP 2C9, CYP 2D6, and CYP 3A4 for HTS and profiling.

Reaction Biology offers CYP 1A2, CYP 2C19, CYP 2C9, CYP 2D6, and CYP 3A4 for HTS and profiling.

Show less

ic

Bromodomain Assays

Price on request

Reaction Biology offers bromodomain HTS and profiling services. RBC also offers other reader domain proteins as assay targets, such as chromodomains, MBTs, multiple domains, PHDs, SRAs, and tudor domains. Assays available include AlphaScreen, Thermal Shift, and ITC. All bromodomain proteins are produced by Reaction Biology and are also available for purchase.

Reaction Biology offers bromodomain HTS and profiling services. RBC also offers other reader domain proteins as assay targets, such as chromodomains, MBTs, multiple domains, PHDs, SRAs, and tudor domains. Assays available include AlphaScreen, Thermal Shift, and ITC. All bromodomain proteins are produced by Reaction Biology and are also available for purchase.

Show less

ic

Cell Invasion Assays

Price on request
Request a quote for more information about this service.

ic

Cell Proliferation Assays

Price on request
Request a quote for more information about this service.

ic

Custom Cell-Based Assay Development

Price on request
Request a quote for more information about this service.

ic

Cell Viability Assays

Price on request
Request a quote for more information about this service.

ic

Custom Protein Production

Price on request
Request a quote for more information about this service.

ic

Deubiquitinase (DUB) Assays

Price on request

Reaction Biology offers A20, Ataxin3, BAP1, NEDP1, SENP1, UCHL1, UCHL3, USP2, USP5, USP8, USP10, and USP14 for profiling services.

Reaction Biology offers A20, Ataxin3, BAP1, NEDP1, SENP1, UCHL1, UCHL3, USP2, USP5, USP8, USP10, and USP14 for profiling services.

Show less

ic

Assay Development

Price on request
Request a quote for more information about this service.

ic

Drug Mechanism of Action Studies

Mechanism of Action Studies
Price on request
Request a quote for more information about this service.

ic

Drug Target Validation

Price on request
Request a quote for more information about this service.

ic

Fibroblast Growth Factor Receptor (FGFR) Assays

Price on request
Request a quote for more information about this service.

ic

Epigenetic Studies

Price on request
Request a quote for more information about this service.

ic

Anaplastic Lymphoma Kinase (ALK) Assays

Price on request
Request a quote for more information about this service.

ic

Histone Acetyltransferase (HAT) Assays

Histone Acetyltransferase Assays
Price on request

Reaction Biology offers HAT profiling services for early drug discovery. Available targets are CBP, KAT5, MYST2, MYST4, p300, hGCN5 and pCAF.

Reaction Biology offers HAT profiling services for early drug discovery. Available targets are CBP, KAT5, MYST2, MYST4, p300, hGCN5 and pCAF.

Show less

ic

VEGF Signaling Assays

Vascular Endothelial Growth Factor Assays
Price on request
Request a quote for more information about this service.

ic

Heat Shock Protein Assays

Price on request

Reaction Biology offers HSP90a and HSP90b for HTS and profiling.

Reaction Biology offers HSP90a and HSP90b for HTS and profiling.

Show less

ic

Human Epidermal Growth Factor Receptor (HER/EGFR) Assays

Price on request
Request a quote for more information about this service.

ic

hERG Channel Inhibition Assay

Price on request
Request a quote for more information about this service.

ic

Mitogen/Extracellular signal-regulated Kinase (MEK) Assays

Price on request
Request a quote for more information about this service.

ic

High Throughput Screening (HTS)

Price on request
Request a quote for more information about this service.

ic

Histone Deacetylase (HDAC) Assays

Price on request

Reaction Biology offers HDAC HTS and profiling services for early drug discovery. HDACs 1-11 are available as targets.

Reaction Biology offers HDAC HTS and profiling services for early drug discovery. HDACs 1-11 are available as targets.

Show less

ic

Checkpoint Kinase-1 (ChK-1) Assays

Price on request
Request a quote for more information about this service.

ic

Isocitrate Dehydrogenase (IDH) Assays

Isocitrate Dehydrogenase Assay
Price on request

Reaction Biology offers IDH1 R132C, IDH1 R132H, IDH1 WT, IDH2 R140Q, IDH2 R172Q, and IDH2 WT for profiling services.

Reaction Biology offers IDH1 R132C, IDH1 R132H, IDH1 WT, IDH2 R140Q, IDH2 R172Q, and IDH2 WT for profiling services.

Show less

ic

BRAF Mutation Analysis

Price on request
Request a quote for more information about this service.

ic

Isothermal Titration Calorimetry (ITC)

Price on request
Request a quote for more information about this service.

ic

Kinase Assays

Price on request

Reaction Biology offers radioisotope based HTS and profiling for 631 wild type, mutant, and atypical kinases. One free control compound is included in every assay and in your report.

Reaction Biology offers radioisotope based HTS and profiling for 631 wild type, mutant, and atypical kinases. One free control compound is included in every assay and in your report.

Show less

ic

Raf Activity Assays

Price on request
Request a quote for more information about this service.

ic

Lipid Kinase Assays

Price on request

Reaction Biology offers profiling for 17 lipid kinases. One free control compound is included in every assay and in your report.

Reaction Biology offers profiling for 17 lipid kinases. One free control compound is included in every assay and in your report.

Show less

ic

Colony Stimulating Factor 1 Receptor (CSF-1R) Assays

Price on request
Request a quote for more information about this service.

ic

Extracellular Signal Regulated Kinase Assays

Price on request
Request a quote for more information about this service.

ic

Lysine Specific Demethylase-1 (LSD-1) Assays

Price on request

Reaction Biology offers LSD1, as well as several other demethylase assays for profiling.

Reaction Biology offers LSD1, as well as several other demethylase assays for profiling.

Show less

ic

Kallikrein (KLK)-Related Serine Protease Assays

Price on request
Request a quote for more information about this service.

ic

Mammalian Two-Hybrid (MTH) Assays

Price on request
Request a quote for more information about this service.

ic

RNA Methylation Assays

Price on request
Request a quote for more information about this service.

ic

Methyltransferase Assays

Price on request

Reaction Biology offers the only 'Gold Standard' radioisotope based HMT assay service available for both profiling and low cost HTS. With over 30 HMTs available, RBC is able to offer the largest collection of HMTs for assay services and for purchase.

Reaction Biology offers the only 'Gold Standard' radioisotope based HMT assay service available for both profiling and low cost HTS. With over 30 HMTs available, RBC is able to offer the largest collection of HMTs for assay services and for purchase.

Show less

ic

PARP Cleavage Assay

Poly-(ADP-Ribose) Polymerase Cleavage Assay
Price on request

Reaction Biology has several PARP assays available for HTS and profiling services, including PARP1, PARP2, and PARP5B.

Reaction Biology has several PARP assays available for HTS and profiling services, including PARP1, PARP2, and PARP5B.

Show less

ic

Phosphatase Assays

Price on request

Reaction Biology offers several phosphatase assays for HTS and profiling services. Targets include DUSP22_MKPX, PP1A, PP1B, PP2Aalpha, PTPN1_PTP1B, PTPN11_SHP2, PTPN12_PTP-PEST, PTPN2_TC-PTP, PTPN6-SHP1, PTPN7_LC-PTP, and PTPRC_CD45

Reaction Biology offers several phosphatase assays for HTS and profiling services. Targets include DUSP22_MKPX, PP1A, PP1B, PP2Aalpha, PTPN1_PTP1B, PTPN11_SHP2, PTPN12_PTP-PEST, PTPN2_TC-PTP, PTPN6-SHP1, PTPN7_LC-PTP, and PTPRC_CD45

Show less

ic

Phosphodiesterase (PDE) Assays

Price on request

Reaction Biology offers PDE HTS and profiling for early drug discovery. Targets include PDE10A, PDE1A, PDE2A, PDE3A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE7A, PDE8A, and PDE9A.

Reaction Biology offers PDE HTS and profiling for early drug discovery. Targets include PDE10A, PDE1A, PDE2A, PDE3A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE7A, PDE8A, and PDE9A.

Show less

ic

Protease Assays

Price on request

Reaction Biology offers more than 60 targets for protease profiling.

Reaction Biology offers more than 60 targets for protease profiling.

Show less

ic

Time Dependent Study

Price on request
Request a quote for more information about this service.

ic

Phosphorylation Analysis

Price on request
Request a quote for more information about this service.

ic

Sirtuin Assays

Price on request

Reaction Biology offers Sirtuin HTS and profiling services for early drug discovery. SIRT1, SIRT2, SIRT3, and SIRT5 are available as targets.

Reaction Biology offers Sirtuin HTS and profiling services for early drug discovery. SIRT1, SIRT2, SIRT3, and SIRT5 are available as targets.

Show less

ic

Ligand Binding Assays

Price on request
Request a quote for more information about this service.

ic

Surface Plasmon Resonance (SPR)

Price on request
Request a quote for more information about this service.

ic

ATP Binding Assays

Price on request
Request a quote for more information about this service.

ic

Thermal Shift Assay (TSA)

Price on request
Request a quote for more information about this service.

ic

Cell Viability & Proliferation Assays

Price on request
Request a quote for more information about this service.

ic

Enzyme Assays

Price on request
Request a quote for more information about this service.

ic

Stem Cell Differentiation

Price on request
Request a quote for more information about this service.

ic

Pharmacology & Toxicology

Price on request
Request a quote for more information about this service.

ic

Human Primary Cell Isolation

Price on request
Request a quote for more information about this service.

ic

Calorimetry

Price on request
Request a quote for more information about this service.

ic

Cellular Health & Metabolism Assays

Price on request
Request a quote for more information about this service.

ic

Sequencing data in FASTQ

Price on request
Request a quote for more information about this service.

ic

Phosphorylase Assays

Price on request
Request a quote for more information about this service.

ic

DNA Services

Price on request
Request a quote for more information about this service.

ic

In vitro Cardiotoxicity Screening

Price on request
Request a quote for more information about this service.

ic

Physical Analysis Methods

Price on request
Request a quote for more information about this service.

ic

Phosphospecific Antibodies

Price on request
Request a quote for more information about this service.

ic

Cell Invasion & Migration Assays

Price on request
Request a quote for more information about this service.

ic

Potassium Channel Assays

Price on request
Request a quote for more information about this service.

ic

Medicinal Chemistry

Price on request
Request a quote for more information about this service.

ic

Acetyltransferase Assays

Price on request
Request a quote for more information about this service.

ic

Hit Identification

Price on request
Request a quote for more information about this service.

ic

Biochemical Assays

Price on request
Request a quote for more information about this service.

ic

Biomolecular Interaction Analysis

Price on request
Request a quote for more information about this service.

ic

Drug Discovery

Price on request
Request a quote for more information about this service.

ic

Drug Target Identification

Price on request
Request a quote for more information about this service.

ic

Hydrolase Assays

Price on request
Request a quote for more information about this service.

ic

Biochemistry & Molecular Biology

Price on request
Request a quote for more information about this service.

ic

CYP Induction Assay

Price on request
Request a quote for more information about this service.

ic

Transferase Assays

Price on request
Request a quote for more information about this service.

ic

Cell Death Assays

Price on request
Request a quote for more information about this service.

ic

Compound Profiling

Price on request
Request a quote for more information about this service.

ic

ADME/DMPK Studies

Drug Metabolism and Pharmacokinetics
Price on request
Request a quote for more information about this service.

ic

Oxidoreductase Assays

Price on request
Request a quote for more information about this service.

ic

DNA Methylation Analysis

Price on request
Request a quote for more information about this service.

ic

Protein Production

Price on request
Request a quote for more information about this service.

ic

Protein-Protein Interaction Analysis

Price on request
Request a quote for more information about this service.

ic

Immunoassays

Price on request
Request a quote for more information about this service.

ic

Nucleic Acid Services

Price on request
Request a quote for more information about this service.

ic

Drug Discovery & Development

Price on request
Request a quote for more information about this service.

ic

Cell-Based Assays

Price on request
Request a quote for more information about this service.

ic

Protein Characterization

Price on request
Request a quote for more information about this service.

ic

Biomarker Discovery

Price on request
Request a quote for more information about this service.

ic

Specialized Cell-Based Assays

Price on request
Request a quote for more information about this service.

ic

Cell-Based Compound Screening

Price on request
Request a quote for more information about this service.

ic

Protein Services

Price on request
Request a quote for more information about this service.

ic

Project Management

Price on request
Request a quote for more information about this service.

ic

Mammalian Cell Culture

Price on request
Request a quote for more information about this service.

ic

Cell Signaling Analyses

Price on request
Request a quote for more information about this service.

ic

Clinical Molecular Diagnostics

Price on request
Request a quote for more information about this service.

ic

Peptide Synthesis

Price on request
Request a quote for more information about this service.

ic

Thermal Analysis Services

Price on request

Thermal Analysis Services

Thermal Analysis Services

Show less

ic

Biomarkers

Price on request
Request a quote for more information about this service.

ic

Antibody Services

Price on request
Request a quote for more information about this service.

ic

RNA Services

Price on request
Request a quote for more information about this service.

ic

Human Primary Cells

Price on request
Request a quote for more information about this service.

ic

Cells and Tissues

Price on request
Request a quote for more information about this service.

ic

Receptor Assays

Price on request
Request a quote for more information about this service.

ic

Clinical Laboratory Services

Price on request
Request a quote for more information about this service.

ic

Biospecimens

Price on request
Request a quote for more information about this service.

ic

Clinical Research

Price on request
Request a quote for more information about this service.

ic

Genetic Marker Screening Services

Price on request
Request a quote for more information about this service.

ic

Bioanalysis

Price on request
Request a quote for more information about this service.

ic

In vitro Ion Channel Assays

Price on request
Request a quote for more information about this service.

ic

Synthetic Chemistry

Price on request
Request a quote for more information about this service.

ic

Human Biospecimens

Price on request
Request a quote for more information about this service.

ic

Chemistry and Materials

Price on request
Request a quote for more information about this service.

ic

Lead Identification and Validation

Price on request
Request a quote for more information about this service.

Not finding what you're looking for?

Get info on this provider's capabilities without requesting a quote.
FileType/PDF Created with Sketch.

FAQsRBC.pdf

Reaction Biology Corp. has not received any reviews.

Reaction Biology Corp. has not received any endorsements.