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Chief Science Officer
To53czmtseor89ebwiyq reaction

Reaction Biology Corp.

Malvern, Pennsylvania, US

Reaction Biology Corporation is an industry leader and innovator specializing in assay services for early-stage drug discovery. Founded in 2001, Reaction Biology offers a wide range of services, including robust assay technologies for kinase and epigenetic biochemical and cell-based high throughput screening (HTS) and selectivity compound profiling. We also offer relevant HTS assay reagents, including highly purified and characterized epigenetic proteins. On average, several million HTS and profiling reactions are performed per year. Over 600 companies worldwide, including pharmaceutical, biotech, academic, and nonprofit laboratories, utilize our biochemical and cellular assay services and purchase epigenetic proteins.

Recent Publications:

  • Joseph J. Ferry, Robert F. Smith, Natalie Denney, Colin P. Walsh, Lauren McCauley, Jie Qian, Haiching Ma, Kurumi Y. Horiuchi, and Konrad T. Howitz. Development and Use... Show more »

Reaction Biology Corporation is an industry leader and innovator specializing in assay services for early-stage drug discovery. Founded in 2001, Reaction Biology offers a wide range of services, including robust assay technologies for kinase and epigenetic biochemical and cell-based high throughput screening (HTS) and selectivity compound profiling. We also offer relevant HTS assay reagents, including highly purified and characterized epigenetic proteins. On average, several million HTS and profiling reactions are performed per year. Over 600 companies worldwide, including pharmaceutical, biotech, academic, and nonprofit laboratories, utilize our biochemical and cellular assay services and purchase epigenetic proteins.

Recent Publications:

  • Joseph J. Ferry, Robert F. Smith, Natalie Denney, Colin P. Walsh, Lauren McCauley, Jie Qian, Haiching Ma, Kurumi Y. Horiuchi, and Konrad T. Howitz. Development and Use of Assay Conditions Suited to Screening for and Profiling of SET-Domain-Targeted Inhibitors of the MLL/SET1 Family of Lysine Methyltransferases. ASSAY and Drug Development Technologies vol.13 no.4 (May 2014), 221-234.
  • Kurumi Y. Horiuchi, Mia M. Eason, Joseph J. Ferry, Jamie L. Planck, Colin P. Walsh, Konrad T. Howitz and Haiching Ma. Assay Development for Histone Methyltransferases. ASSAY and Drug Development Technologies vol.11 no.4 (May 2013), 227-236.
  • Jianghong Wu, Yuren Wang, Shuguang Liang, Haiching Ma. Cytoprotective Effort of Selective Small-Molecule Caspase Inhibitors against Staurosporine-induced Apoptosis. Drug Design, Development and Therapy 2014:8 583–600.
  • Mark E. McDonnell, Haiyan Bian, Jay Wrobel, Garry R. Smith, Shuguang Liang, Haiching Ma, Allen B. Reitz.
    Anilino-monoindolylmaleimides as potent and selective JAK3 inhibitors. Bioorganic & Medicinal Chemistry Letters 24 (2014) 1116–1121.
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NAD(P)H:Quinone Oxidoreductase (NQO) Assays
Price on request

Reaction Biology offers NQO1 for profiling services.

Reaction Biology offers NQO1 for profiling services.

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Apoptosis Assays
Price on request

Reaction Biology offers cIAP-1, cIAP-2, XIAP for profiling services.

Reaction Biology offers cIAP-1, cIAP-2, XIAP for profiling services.

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BCL-2 Assays
B-Cell Lymphoma-2 Assays
Price on request

Reaction Biology offers Bcl-2 and BCL-xL for HTS and profiling services.

Reaction Biology offers Bcl-2 and BCL-xL for HTS and profiling services.

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CYP Inhibition Assay
Price on request

Reaction Biology offers CYP 1A2, CYP 2C19, CYP 2C9, CYP 2D6, and CYP 3A4 for HTS and profiling.

Reaction Biology offers CYP 1A2, CYP 2C19, CYP 2C9, CYP 2D6, and CYP 3A4 for HTS and profiling.

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Bromodomain Assays
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Reaction Biology offers bromodomain HTS and profiling services. RBC also offers other reader domain proteins as assay targets, such as chromodomains, MBTs, multiple domains, PHDs, SRAs, and tudor domains. Assays available include AlphaScreen, Thermal Shift, and ITC. All bromodomain proteins are produced by Reaction Biology and are also available for purchase.

Reaction Biology offers bromodomain HTS and profiling services. RBC also offers other reader domain proteins as assay targets, such as chromodomains, MBTs, multiple domains, PHDs, SRAs, and tudor domains. Assays available include AlphaScreen, Thermal Shift, and ITC. All bromodomain proteins are produced by Reaction Biology and are also available for purchase.

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Cell Invasion Assays
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Cell Proliferation Assays
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Custom Cell-Based Assays
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Cell Viability Assays
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Custom Protein Production
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Deubiquitinase (DUB) Assays
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Reaction Biology offers A20, Ataxin3, BAP1, NEDP1, SENP1, UCHL1, UCHL3, USP2, USP5, USP8, USP10, and USP14 for profiling services.

Reaction Biology offers A20, Ataxin3, BAP1, NEDP1, SENP1, UCHL1, UCHL3, USP2, USP5, USP8, USP10, and USP14 for profiling services.

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Drug Mechanism of Action Studies
Mechanism of Action Studies
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Epigenetic Studies
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Histone Acetyltransferase (HAT) Assays
Histone Acetyltransferase Assays
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Reaction Biology offers HAT profiling services for early drug discovery. Available targets are CBP, KAT5, MYST2, MYST4, p300, hGCN5 and pCAF.

Reaction Biology offers HAT profiling services for early drug discovery. Available targets are CBP, KAT5, MYST2, MYST4, p300, hGCN5 and pCAF.

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Heat Shock Protein Assays
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Reaction Biology offers HSP90a and HSP90b for HTS and profiling.

Reaction Biology offers HSP90a and HSP90b for HTS and profiling.

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hERG Channel Inhibition Assay
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High Throughput Screening (HTS)
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Histone Deacetylase (HDAC) Assays
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Reaction Biology offers HDAC HTS and profiling services for early drug discovery. HDACs 1-11 are available as targets.

Reaction Biology offers HDAC HTS and profiling services for early drug discovery. HDACs 1-11 are available as targets.

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Isocitrate Dehydrogenase (IDH) Assays
Isocitrate Dehydrogenase Assay
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Reaction Biology offers IDH1 R132C, IDH1 R132H, IDH1 WT, IDH2 R140Q, IDH2 R172Q, and IDH2 WT for profiling services.

Reaction Biology offers IDH1 R132C, IDH1 R132H, IDH1 WT, IDH2 R140Q, IDH2 R172Q, and IDH2 WT for profiling services.

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Isothermal Titration Calorimetry (ITC)
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Kinase Assays
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Reaction Biology offers radioisotope based HTS and profiling for 599 wild type, mutant, and atypical kinases. One free control compound is included in every assay and in your report.

Reaction Biology offers radioisotope based HTS and profiling for 599 wild type, mutant, and atypical kinases. One free control compound is included in every assay and in your report.

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Lipid Kinase Assays
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Reaction Biology offers profiling for 17 lipid kinases. One free control compound is included in every assay and in your report.

Reaction Biology offers profiling for 17 lipid kinases. One free control compound is included in every assay and in your report.

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Lysine Specific Demethylase-1 (LSD-1) Assays
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Reaction Biology offers LSD1, as well as several other demethylase assays for profiling.

Reaction Biology offers LSD1, as well as several other demethylase assays for profiling.

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Mammalian Two-Hybrid (MTH) Assays
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Methyltransferase Assays
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Reaction Biology offers the only 'Gold Standard' radioisotope based HMT assay service available for both profiling and low cost HTS. With over 30 HMTs available, RBC is able to offer the largest collection of HMTs for assay services and for purchase.

Reaction Biology offers the only 'Gold Standard' radioisotope based HMT assay service available for both profiling and low cost HTS. With over 30 HMTs available, RBC is able to offer the largest collection of HMTs for assay services and for purchase.

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PARP Cleavage Assay
Poly-(ADP-Ribose) Polymerase Cleavage Assay
Price on request

Reaction Biology has several PARP assays available for HTS and profiling services, including PARP1, PARP2, and PARP5B.

Reaction Biology has several PARP assays available for HTS and profiling services, including PARP1, PARP2, and PARP5B.

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Phosphatase Assays
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Reaction Biology offers several phosphatase assays for HTS and profiling services. Targets include DUSP22_MKPX, PP1A, PP1B, PP2Aalpha, PTPN1_PTP1B, PTPN11_SHP2, PTPN12_PTP-PEST, PTPN2_TC-PTP, PTPN6-SHP1, PTPN7_LC-PTP, and PTPRC_CD45

Reaction Biology offers several phosphatase assays for HTS and profiling services. Targets include DUSP22_MKPX, PP1A, PP1B, PP2Aalpha, PTPN1_PTP1B, PTPN11_SHP2, PTPN12_PTP-PEST, PTPN2_TC-PTP, PTPN6-SHP1, PTPN7_LC-PTP, and PTPRC_CD45

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Phosphodiesterase (PDE) Assays
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Reaction Biology offers PDE HTS and profiling for early drug discovery. Targets include PDE10A, PDE1A, PDE2A, PDE3A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE7A, PDE8A, and PDE9A.

Reaction Biology offers PDE HTS and profiling for early drug discovery. Targets include PDE10A, PDE1A, PDE2A, PDE3A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE7A, PDE8A, and PDE9A.

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Protease Assays
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Reaction Biology offers more than 60 targets for protease profiling.

Reaction Biology offers more than 60 targets for protease profiling.

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Phosphorylation Analysis
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Sirtuin Assays
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Reaction Biology offers Sirtuin HTS and profiling services for early drug discovery. SIRT1, SIRT2, SIRT3, and SIRT5 are available as targets.

Reaction Biology offers Sirtuin HTS and profiling services for early drug discovery. SIRT1, SIRT2, SIRT3, and SIRT5 are available as targets.

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Surface Plasmon Resonance (SPR)
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Thermal Shift Assay (TSA)
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Cell Viability & Proliferation Assays
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Enzyme Assays
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Pharmacology & Toxicology
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Calorimetry
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Cellular Health & Metabolism Assays
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Biology
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DNA Services
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In vitro Cardiotoxicity Screening
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Physical Analysis Methods
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Cell Invasion & Migration Assays
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Medicinal Chemistry
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Hit Identification
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Biochemical Assays
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Biomolecular Interaction Analysis
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Drug Discovery
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Hydrolase Assays
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Biochemistry & Molecular Biology
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Transferase Assays
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Cell Death Assays
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ADME/DMPK Studies
Drug Metabolism and Pharmacokinetics
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Oxidoreductase Assays
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Protein Expression
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Protein-Protein Interaction Analysis
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Immunoassays
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Nucleic Acid Services
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Drug Discovery & Development
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Cell-Based Assays
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Protein Characterization Services
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Specialized Cell-Based Assays
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Protein Services
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2018-08-14 07:24:36 -0400

Net Promoter Score of 8 received for Methyltransferase Assays.

Additional Ratings: satisfaction with deliverable: 8, satisfaction with timeliness: 8.
2018-04-17 11:36:51 -0400

Net Promoter Score of 9 received for Histone Deacetylase (HDAC) Assays.

Additional Ratings: satisfaction with deliverable: 9, satisfaction with timeliness: 9.
2017-10-25 15:52:33 -0400

Net Promoter Score of 8 received for Methyltransferase Assays.

Additional Ratings: satisfaction with deliverable: 8, satisfaction with timeliness: 9.
2017-10-25 14:35:48 -0400

Net Promoter Score of 7 received for Histone Deacetylase (HDAC) Assays.

Additional Ratings: satisfaction with deliverable: 7, satisfaction with timeliness: 9.
2017-08-16 17:50:14 -0400

Net Promoter Score of 10 received for Kinase Assays.

Additional Ratings: satisfaction with deliverable: 9, satisfaction with timeliness: 9.
2017-05-30 14:08:04 -0400

Net Promoter Score of 10 received for Kinase Assays.

Additional Ratings: satisfaction with deliverable: 9, satisfaction with timeliness: 9.

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