16 Orders Completed
100% Positive

Tags:

Small business

Resources:

Lab Members:

Missing Avatar
Chief Science Officer
To53czmtseor89ebwiyq reaction

Reaction Biology Corp.

Malvern, Pennsylvania, US

Reaction Biology Corporation is an industry leader and innovator specializing in assay services for early-stage drug discovery. Founded in 2001, Reaction Biology offers a wide range of services, including robust assay technologies for kinase and epigenetic biochemical and cell-based high throughput screening (HTS) and selectivity compound profiling. We also offer relevant HTS assay reagents, including highly purified and characterized epigenetic proteins. On average, several million HTS and profiling reactions are performed per year. Over 600 companies worldwide, including pharmaceutical, biotech, academic, and nonprofit laboratories, utilize our biochemical and cellular assay services and purchase epigenetic proteins.

Recent Publications:

  • Joseph J. Ferry, Robert F. Smith, Natalie Denney, Colin P. Walsh, Lauren McCauley, Jie Qian, Haiching Ma, Kurumi Y. Horiuchi, and Konrad T. Howitz. Development and Use... Show more »

Reaction Biology Corporation is an industry leader and innovator specializing in assay services for early-stage drug discovery. Founded in 2001, Reaction Biology offers a wide range of services, including robust assay technologies for kinase and epigenetic biochemical and cell-based high throughput screening (HTS) and selectivity compound profiling. We also offer relevant HTS assay reagents, including highly purified and characterized epigenetic proteins. On average, several million HTS and profiling reactions are performed per year. Over 600 companies worldwide, including pharmaceutical, biotech, academic, and nonprofit laboratories, utilize our biochemical and cellular assay services and purchase epigenetic proteins.

Recent Publications:

  • Joseph J. Ferry, Robert F. Smith, Natalie Denney, Colin P. Walsh, Lauren McCauley, Jie Qian, Haiching Ma, Kurumi Y. Horiuchi, and Konrad T. Howitz. Development and Use of Assay Conditions Suited to Screening for and Profiling of SET-Domain-Targeted Inhibitors of the MLL/SET1 Family of Lysine Methyltransferases. ASSAY and Drug Development Technologies vol.13 no.4 (May 2014), 221-234.
  • Kurumi Y. Horiuchi, Mia M. Eason, Joseph J. Ferry, Jamie L. Planck, Colin P. Walsh, Konrad T. Howitz and Haiching Ma. Assay Development for Histone Methyltransferases. ASSAY and Drug Development Technologies vol.11 no.4 (May 2013), 227-236.
  • Jianghong Wu, Yuren Wang, Shuguang Liang, Haiching Ma. Cytoprotective Effort of Selective Small-Molecule Caspase Inhibitors against Staurosporine-induced Apoptosis. Drug Design, Development and Therapy 2014:8 583–600.
  • Mark E. McDonnell, Haiyan Bian, Jay Wrobel, Garry R. Smith, Shuguang Liang, Haiching Ma, Allen B. Reitz.
    Anilino-monoindolylmaleimides as potent and selective JAK3 inhibitors. Bioorganic & Medicinal Chemistry Letters 24 (2014) 1116–1121.
« Show less

Reaction Biology Corp. has not listed any services.

Microscale Thermophoresis
Price on request

MST ASSAY

MST assays measure the interactions directly in solution without the need of immobilization to a surface (immobilization-free technology). MST uses a small amount of samples and allows for quick assay development and affinity determination (KD) of interactions. It can be used to detect binding between any kind... Show more »

MST ASSAY

MST assays measure the interactions directly in solution without the need of immobilization to a surface (immobilization-free technology). MST uses a small amount of samples and allows for quick assay development and affinity determination (KD) of interactions. It can be used to detect binding between any kind of biomolecules including proteins, DNA, RNA, peptides, small molecules, fragments and ions, with quick measurement times and low sample consumption. The detection range of MST on Binding affinity is between pM to mM range.

« Show less
Monolith NT.115 pico
NAD(P)H:Quinone Oxidoreductase (NQO) Assays
Price on request

Reaction Biology offers NQO1 for profiling services.

Reaction Biology offers NQO1 for profiling services.

« Show less
Apoptosis Assays
Price on request

Reaction Biology offers cIAP-1, cIAP-2, XIAP for profiling services.

Reaction Biology offers cIAP-1, cIAP-2, XIAP for profiling services.

« Show less
BCL-2 Assays
B-Cell Lymphoma-2 Assays
Price on request

Reaction Biology offers Bcl-2 and BCL-xL for HTS and profiling services.

Reaction Biology offers Bcl-2 and BCL-xL for HTS and profiling services.

« Show less
CYP Inhibition Assay
Price on request

Reaction Biology offers CYP 1A2, CYP 2C19, CYP 2C9, CYP 2D6, and CYP 3A4 for HTS and profiling.

Reaction Biology offers CYP 1A2, CYP 2C19, CYP 2C9, CYP 2D6, and CYP 3A4 for HTS and profiling.

« Show less
Bromodomain Assays
Price on request

Reaction Biology offers bromodomain HTS and profiling services. RBC also offers other reader domain proteins as assay targets, such as chromodomains, MBTs, multiple domains, PHDs, SRAs, and tudor domains. Assays available include AlphaScreen, Thermal Shift, and ITC. All bromodomain proteins are produced by Reaction Biology and are also available for purchase.

Reaction Biology offers bromodomain HTS and profiling services. RBC also offers other reader domain proteins as assay targets, such as chromodomains, MBTs, multiple domains, PHDs, SRAs, and tudor domains. Assays available include AlphaScreen, Thermal Shift, and ITC. All bromodomain proteins are produced by Reaction Biology and are also available for purchase.

« Show less
Cell Invasion Assays
Price on request
Request a quote for more information about this service.
Cell Proliferation Assays
Price on request
Request a quote for more information about this service.
Custom Cell-Based Assays
Price on request
Request a quote for more information about this service.
Cell Viability Assays
Price on request
Request a quote for more information about this service.
Custom Protein Production
Price on request
Request a quote for more information about this service.
Deubiquitinase (DUB) Assays
Price on request

Reaction Biology offers A20, Ataxin3, BAP1, NEDP1, SENP1, UCHL1, UCHL3, USP2, USP5, USP8, USP10, and USP14 for profiling services.

Reaction Biology offers A20, Ataxin3, BAP1, NEDP1, SENP1, UCHL1, UCHL3, USP2, USP5, USP8, USP10, and USP14 for profiling services.

« Show less
Assay Development
Price on request
Request a quote for more information about this service.
Drug Mechanism of Action Studies
Mechanism of Action Studies
Price on request
Request a quote for more information about this service.
Drug Target Validation
Price on request
Request a quote for more information about this service.
Epigenetic Studies
Price on request
Request a quote for more information about this service.
Fibroblast Growth Factor Receptor (FGFR) Assays
Price on request
Request a quote for more information about this service.
Histone Acetyltransferase (HAT) Assays
Histone Acetyltransferase Assays
Price on request

Reaction Biology offers HAT profiling services for early drug discovery. Available targets are CBP, KAT5, MYST2, MYST4, p300, hGCN5 and pCAF.

Reaction Biology offers HAT profiling services for early drug discovery. Available targets are CBP, KAT5, MYST2, MYST4, p300, hGCN5 and pCAF.

« Show less
Anaplastic Lymphoma Kinase (ALK) Assays
Price on request
Request a quote for more information about this service.
Heat Shock Protein Assays
Price on request

Reaction Biology offers HSP90a and HSP90b for HTS and profiling.

Reaction Biology offers HSP90a and HSP90b for HTS and profiling.

« Show less
VEGF Signaling Assays
Vascular Endothelial Growth Factor Assays
Price on request
Request a quote for more information about this service.
hERG Channel Inhibition Assay
Price on request
Request a quote for more information about this service.
Human Epidermal Growth Factor Receptor (HER/EGFR) Assays
Price on request
Request a quote for more information about this service.
High Throughput Screening (HTS)
Price on request
Request a quote for more information about this service.
Mitogen/Extracellular signal-regulated Kinase (MEK) Assays
Price on request
Request a quote for more information about this service.
Histone Deacetylase (HDAC) Assays
Price on request

Reaction Biology offers HDAC HTS and profiling services for early drug discovery. HDACs 1-11 are available as targets.

Reaction Biology offers HDAC HTS and profiling services for early drug discovery. HDACs 1-11 are available as targets.

« Show less
Isocitrate Dehydrogenase (IDH) Assays
Isocitrate Dehydrogenase Assay
Price on request

Reaction Biology offers IDH1 R132C, IDH1 R132H, IDH1 WT, IDH2 R140Q, IDH2 R172Q, and IDH2 WT for profiling services.

Reaction Biology offers IDH1 R132C, IDH1 R132H, IDH1 WT, IDH2 R140Q, IDH2 R172Q, and IDH2 WT for profiling services.

« Show less
Checkpoint Kinase-1 (ChK-1) Assays
Price on request
Request a quote for more information about this service.
Isothermal Titration Calorimetry (ITC)
Price on request
Request a quote for more information about this service.
BRAF Mutation Analysis
Price on request
Request a quote for more information about this service.
Kinase Assays
Price on request

Reaction Biology offers radioisotope based HTS and profiling for 631 wild type, mutant, and atypical kinases. One free control compound is included in every assay and in your report.

Reaction Biology offers radioisotope based HTS and profiling for 631 wild type, mutant, and atypical kinases. One free control compound is included in every assay and in your report.

« Show less
Raf Activity Assays
Price on request
Request a quote for more information about this service.
Lipid Kinase Assays
Price on request

Reaction Biology offers profiling for 17 lipid kinases. One free control compound is included in every assay and in your report.

Reaction Biology offers profiling for 17 lipid kinases. One free control compound is included in every assay and in your report.

« Show less
Colony Stimulating Factor 1 Receptor (CSF-1R) Assays
Price on request
Request a quote for more information about this service.
Lysine Specific Demethylase-1 (LSD-1) Assays
Price on request

Reaction Biology offers LSD1, as well as several other demethylase assays for profiling.

Reaction Biology offers LSD1, as well as several other demethylase assays for profiling.

« Show less
Extracellular Signal Regulated Kinase Assays
Price on request
Request a quote for more information about this service.
Mammalian Two-Hybrid (MTH) Assays
Price on request
Request a quote for more information about this service.
Kallikrein (KLK)-Related Serine Protease Assays
Price on request
Request a quote for more information about this service.
Methyltransferase Assays
Price on request

Reaction Biology offers the only 'Gold Standard' radioisotope based HMT assay service available for both profiling and low cost HTS. With over 30 HMTs available, RBC is able to offer the largest collection of HMTs for assay services and for purchase.

Reaction Biology offers the only 'Gold Standard' radioisotope based HMT assay service available for both profiling and low cost HTS. With over 30 HMTs available, RBC is able to offer the largest collection of HMTs for assay services and for purchase.

« Show less
RNA Methylation Assays
Price on request
Request a quote for more information about this service.
PARP Cleavage Assay
Poly-(ADP-Ribose) Polymerase Cleavage Assay
Price on request

Reaction Biology has several PARP assays available for HTS and profiling services, including PARP1, PARP2, and PARP5B.

Reaction Biology has several PARP assays available for HTS and profiling services, including PARP1, PARP2, and PARP5B.

« Show less
Phosphatase Assays
Price on request

Reaction Biology offers several phosphatase assays for HTS and profiling services. Targets include DUSP22_MKPX, PP1A, PP1B, PP2Aalpha, PTPN1_PTP1B, PTPN11_SHP2, PTPN12_PTP-PEST, PTPN2_TC-PTP, PTPN6-SHP1, PTPN7_LC-PTP, and PTPRC_CD45

Reaction Biology offers several phosphatase assays for HTS and profiling services. Targets include DUSP22_MKPX, PP1A, PP1B, PP2Aalpha, PTPN1_PTP1B, PTPN11_SHP2, PTPN12_PTP-PEST, PTPN2_TC-PTP, PTPN6-SHP1, PTPN7_LC-PTP, and PTPRC_CD45

« Show less
Phosphodiesterase (PDE) Assays
Price on request

Reaction Biology offers PDE HTS and profiling for early drug discovery. Targets include PDE10A, PDE1A, PDE2A, PDE3A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE7A, PDE8A, and PDE9A.

Reaction Biology offers PDE HTS and profiling for early drug discovery. Targets include PDE10A, PDE1A, PDE2A, PDE3A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE7A, PDE8A, and PDE9A.

« Show less
Protease Assays
Price on request

Reaction Biology offers more than 60 targets for protease profiling.

Reaction Biology offers more than 60 targets for protease profiling.

« Show less
Phosphorylation Analysis
Price on request
Request a quote for more information about this service.
Time Dependent Study
Price on request
Request a quote for more information about this service.
Sirtuin Assays
Price on request

Reaction Biology offers Sirtuin HTS and profiling services for early drug discovery. SIRT1, SIRT2, SIRT3, and SIRT5 are available as targets.

Reaction Biology offers Sirtuin HTS and profiling services for early drug discovery. SIRT1, SIRT2, SIRT3, and SIRT5 are available as targets.

« Show less
Surface Plasmon Resonance (SPR)
Price on request
Request a quote for more information about this service.
Ligand Binding Assays
Price on request
Request a quote for more information about this service.
Thermal Shift Assay (TSA)
Price on request
Request a quote for more information about this service.
ATP Binding Assays
Price on request
Request a quote for more information about this service.
Cell Viability & Proliferation Assays
Price on request
Request a quote for more information about this service.
Enzyme Assays
Price on request
Request a quote for more information about this service.
Pharmacology & Toxicology
Price on request
Request a quote for more information about this service.
Stem Cell Differentiation
Price on request
Request a quote for more information about this service.
Calorimetry
Price on request
Request a quote for more information about this service.
Human Primary Cell Isolation
Price on request
Request a quote for more information about this service.
Cellular Health & Metabolism Assays
Price on request
Request a quote for more information about this service.
Biology
Price on request
Request a quote for more information about this service.
DNA Services
Price on request
Request a quote for more information about this service.
Phosphorylase Assays
Price on request
Request a quote for more information about this service.
In vitro Cardiotoxicity Screening
Price on request
Request a quote for more information about this service.
Physical Analysis Methods
Price on request
Request a quote for more information about this service.
Cell Invasion & Migration Assays
Price on request
Request a quote for more information about this service.
Phosphospecific Antibodies
Price on request
Request a quote for more information about this service.
Medicinal Chemistry
Price on request
Request a quote for more information about this service.
Potassium Channel Assays
Price on request
Request a quote for more information about this service.
Hit Identification
Price on request
Request a quote for more information about this service.
Acetyltransferase Assays
Price on request
Request a quote for more information about this service.
Biochemical Assays
Price on request
Request a quote for more information about this service.
Biomolecular Interaction Analysis
Price on request
Request a quote for more information about this service.
Drug Discovery
Price on request
Request a quote for more information about this service.
Hydrolase Assays
Price on request
Request a quote for more information about this service.
Drug Target Identification
Price on request
Request a quote for more information about this service.
Biochemistry & Molecular Biology
Price on request
Request a quote for more information about this service.
Transferase Assays
Price on request
Request a quote for more information about this service.
CYP Induction Assay
Price on request
Request a quote for more information about this service.
Cell Death Assays
Price on request
Request a quote for more information about this service.
ADME/DMPK Studies
Drug Metabolism and Pharmacokinetics
Price on request
Request a quote for more information about this service.
Compound Profiling
Price on request
Request a quote for more information about this service.
Oxidoreductase Assays
Price on request
Request a quote for more information about this service.
Protein Production
Price on request
Request a quote for more information about this service.
DNA Methylation Analysis
Price on request
Request a quote for more information about this service.
Protein-Protein Interaction Analysis
Price on request
Request a quote for more information about this service.
Immunoassays
Price on request
Request a quote for more information about this service.
Nucleic Acid Services
Price on request
Request a quote for more information about this service.
Drug Discovery & Development
Price on request
Request a quote for more information about this service.
Cell-Based Assays
Price on request
Request a quote for more information about this service.
Protein Characterization
Price on request
Request a quote for more information about this service.
Specialized Cell-Based Assays
Price on request
Request a quote for more information about this service.
Biomarker Discovery
Price on request
Request a quote for more information about this service.
Protein Services
Price on request
Request a quote for more information about this service.
Cell-Based Compound Screening
Price on request
Request a quote for more information about this service.
Experimental Design
Price on request
Request a quote for more information about this service.
Project and Process Management
Price on request
Request a quote for more information about this service.
Clinical Research
Price on request
Request a quote for more information about this service.
Cells and Tissues
Price on request
Request a quote for more information about this service.
Biospecimens
Price on request
Request a quote for more information about this service.
Mammalian Cell Culture
Price on request
Request a quote for more information about this service.
Thermal Analysis Services
Price on request

Thermal Analysis Services

Thermal Analysis Services

« Show less
Chemistry and Materials
Price on request
Request a quote for more information about this service.
Synthetic Chemistry
Price on request
Request a quote for more information about this service.
Lead Identification and Validation
Price on request
Request a quote for more information about this service.
Clinical Molecular Diagnostics
Price on request
Request a quote for more information about this service.
Clinical Laboratory Services
Price on request
Request a quote for more information about this service.
RNA Services
Price on request
Request a quote for more information about this service.
Human Primary Cells
Price on request
Request a quote for more information about this service.
In vitro Ion Channel Assays
Price on request
Request a quote for more information about this service.
Bioanalysis
Price on request
Request a quote for more information about this service.
Antibody Services
Price on request
Request a quote for more information about this service.
Biomarkers
Price on request
Request a quote for more information about this service.
Receptor Assays
Price on request
Request a quote for more information about this service.
Human Biospecimens
Price on request
Request a quote for more information about this service.
Peptide Synthesis
Price on request
Request a quote for more information about this service.
Cell Signaling Analyses
Price on request
Request a quote for more information about this service.
Genetic Marker Screening Services
Price on request
Request a quote for more information about this service.
2018-09-04 17:59:10 -0700

Net Promoter Score of 10 received for Surface Plasmon Resonance (SPR).

Additional Ratings: satisfaction with deliverable: 10, satisfaction with timeliness: 10.
2018-08-14 04:24:36 -0700

Net Promoter Score of 8 received for Methyltransferase Assays.

Additional Ratings: satisfaction with deliverable: 8, satisfaction with timeliness: 8.
2018-04-17 08:36:51 -0700

Net Promoter Score of 9 received for Histone Deacetylase (HDAC) Assays.

Additional Ratings: satisfaction with deliverable: 9, satisfaction with timeliness: 9.
2017-10-25 12:52:33 -0700

Net Promoter Score of 8 received for Methyltransferase Assays.

Additional Ratings: satisfaction with deliverable: 8, satisfaction with timeliness: 9.
2017-10-25 11:35:48 -0700

Net Promoter Score of 7 received for Histone Deacetylase (HDAC) Assays.

Additional Ratings: satisfaction with deliverable: 7, satisfaction with timeliness: 9.
2017-08-16 14:50:14 -0700

Net Promoter Score of 10 received for Kinase Assays.

Additional Ratings: satisfaction with deliverable: 9, satisfaction with timeliness: 9.
2017-05-30 11:08:04 -0700

Net Promoter Score of 10 received for Kinase Assays.

Additional Ratings: satisfaction with deliverable: 9, satisfaction with timeliness: 9.

Be the first to endorse Reaction Biology Corp.

Endorse this lab