Reaction Biology Corp.
About Reaction Biology Corp.
Reaction Biology Corporation is an industry leader and innovator specializing in assay services for early-stage drug discovery. Founded in 2001, Reaction Biology offers a wide range of services, including robust assay technologies for kinase and epigenetic biochemical and cell-based high throughput screening... Show more »
Reaction Biology Corporation is an industry leader and innovator specializing in assay services for early-stage drug discovery. Founded in 2001, Reaction Biology offers a wide range of services, including robust assay technologies for kinase and epigenetic biochemical and cell-based high throughput screening (HTS) and selectivity compound profiling. We also offer relevant HTS assay reagents, including highly purified and characterized epigenetic proteins. On average, several million HTS and profiling reactions are performed per year. Over 600 companies worldwide, including pharmaceutical, biotech, academic, and nonprofit laboratories, utilize our biochemical and cellular assay services and purchase epigenetic proteins.
Recent Publications:
- Joseph J. Ferry, Robert F. Smith, Natalie Denney, Colin P. Walsh, Lauren McCauley, Jie Qian, Haiching Ma, Kurumi Y. Horiuchi, and Konrad T. Howitz. Development and Use of Assay Conditions Suited to Screening for and Profiling of SET-Domain-Targeted Inhibitors of the MLL/SET1 Family of Lysine Methyltransferases. ASSAY and Drug Development Technologies vol.13 no.4 (May 2014), 221-234.
- Kurumi Y. Horiuchi, Mia M. Eason, Joseph J. Ferry, Jamie L. Planck, Colin P. Walsh, Konrad T. Howitz and Haiching Ma. Assay Development for Histone Methyltransferases. ASSAY and Drug Development Technologies vol.11 no.4 (May 2013), 227-236.
- Jianghong Wu, Yuren Wang, Shuguang Liang, Haiching Ma. Cytoprotective Effort of Selective Small-Molecule Caspase Inhibitors against Staurosporine-induced Apoptosis. Drug Design, Development and Therapy 2014:8 583–600.
- Mark E. McDonnell, Haiyan Bian, Jay Wrobel, Garry R. Smith, Shuguang Liang, Haiching Ma, Allen B. Reitz.
Anilino-monoindolylmaleimides as potent and selective JAK3 inhibitors. Bioorganic & Medicinal Chemistry Letters 24 (2014) 1116–1121.
Diversity Certificates
Our Services (115)
Microscale Thermophoresis
MST ASSAY
MST assays measure the interactions directly in solution without the need of immobilization to a surface (immobilization-free technology). MST uses a small amount of samples and allows for quick assay development and affinity determination (KD) of interactions. It can be used to detect binding between any kind... Show more »
MST ASSAY
MST assays measure the interactions directly in solution without the need of immobilization to a surface (immobilization-free technology). MST uses a small amount of samples and allows for quick assay development and affinity determination (KD) of interactions. It can be used to detect binding between any kind of biomolecules including proteins, DNA, RNA, peptides, small molecules, fragments and ions, with quick measurement times and low sample consumption. The detection range of MST on Binding affinity is between pM to mM range.
NAD(P)H:Quinone Oxidoreductase (NQO) Assays
Reaction Biology offers NQO1 for profiling services.
Reaction Biology offers NQO1 for profiling services.
Apoptosis Assays
Reaction Biology offers cIAP-1, cIAP-2, XIAP for profiling services.
Reaction Biology offers cIAP-1, cIAP-2, XIAP for profiling services.
BCL-2 Assays
B-Cell Lymphoma-2 Assays
Reaction Biology offers Bcl-2 and BCL-xL for HTS and profiling services.
Reaction Biology offers Bcl-2 and BCL-xL for HTS and profiling services.
CYP Inhibition Assay
Reaction Biology offers CYP 1A2, CYP 2C19, CYP 2C9, CYP 2D6, and CYP 3A4 for HTS and profiling.
Reaction Biology offers CYP 1A2, CYP 2C19, CYP 2C9, CYP 2D6, and CYP 3A4 for HTS and profiling.
Bromodomain Assays
Reaction Biology offers bromodomain HTS and profiling services. RBC also offers other reader domain proteins as assay targets, such as chromodomains, MBTs, multiple domains, PHDs, SRAs, and tudor domains. Assays available include AlphaScreen, Thermal Shift, and ITC. All bromodomain proteins are produced by Reaction Biology and are also available for purchase.
Reaction Biology offers bromodomain HTS and profiling services. RBC also offers other reader domain proteins as assay targets, such as chromodomains, MBTs, multiple domains, PHDs, SRAs, and tudor domains. Assays available include AlphaScreen, Thermal Shift, and ITC. All bromodomain proteins are produced by Reaction Biology and are also available for purchase.
Cell Invasion Assays
Cell Proliferation Assays
Custom Cell-Based Assay Development
Cell Viability Assays
Custom Protein Production
Deubiquitinase (DUB) Assays
Reaction Biology offers A20, Ataxin3, BAP1, NEDP1, SENP1, UCHL1, UCHL3, USP2, USP5, USP8, USP10, and USP14 for profiling services.
Reaction Biology offers A20, Ataxin3, BAP1, NEDP1, SENP1, UCHL1, UCHL3, USP2, USP5, USP8, USP10, and USP14 for profiling services.
Assay Development
Drug Mechanism of Action Studies
Mechanism of Action Studies
Drug Target Validation
Fibroblast Growth Factor Receptor (FGFR) Assays
Epigenetic Studies
Anaplastic Lymphoma Kinase (ALK) Assays
Histone Acetyltransferase (HAT) Assays
Histone Acetyltransferase Assays
Reaction Biology offers HAT profiling services for early drug discovery. Available targets are CBP, KAT5, MYST2, MYST4, p300, hGCN5 and pCAF.
Reaction Biology offers HAT profiling services for early drug discovery. Available targets are CBP, KAT5, MYST2, MYST4, p300, hGCN5 and pCAF.
VEGF Signaling Assays
Vascular Endothelial Growth Factor Assays
Heat Shock Protein Assays
Reaction Biology offers HSP90a and HSP90b for HTS and profiling.
Reaction Biology offers HSP90a and HSP90b for HTS and profiling.
Human Epidermal Growth Factor Receptor (HER/EGFR) Assays
hERG Channel Inhibition Assay
Mitogen/Extracellular signal-regulated Kinase (MEK) Assays
High Throughput Screening (HTS)
Histone Deacetylase (HDAC) Assays
Reaction Biology offers HDAC HTS and profiling services for early drug discovery. HDACs 1-11 are available as targets.
Reaction Biology offers HDAC HTS and profiling services for early drug discovery. HDACs 1-11 are available as targets.
Checkpoint Kinase-1 (ChK-1) Assays
Isocitrate Dehydrogenase (IDH) Assays
Isocitrate Dehydrogenase Assay
Reaction Biology offers IDH1 R132C, IDH1 R132H, IDH1 WT, IDH2 R140Q, IDH2 R172Q, and IDH2 WT for profiling services.
Reaction Biology offers IDH1 R132C, IDH1 R132H, IDH1 WT, IDH2 R140Q, IDH2 R172Q, and IDH2 WT for profiling services.
BRAF Mutation Analysis
Isothermal Titration Calorimetry (ITC)
Kinase Assays
Reaction Biology offers radioisotope based HTS and profiling for 631 wild type, mutant, and atypical kinases. One free control compound is included in every assay and in your report.
Reaction Biology offers radioisotope based HTS and profiling for 631 wild type, mutant, and atypical kinases. One free control compound is included in every assay and in your report.
Raf Activity Assays
Lipid Kinase Assays
Reaction Biology offers profiling for 17 lipid kinases. One free control compound is included in every assay and in your report.
Reaction Biology offers profiling for 17 lipid kinases. One free control compound is included in every assay and in your report.
Colony Stimulating Factor 1 Receptor (CSF-1R) Assays
Extracellular Signal Regulated Kinase Assays
Lysine Specific Demethylase-1 (LSD-1) Assays
Reaction Biology offers LSD1, as well as several other demethylase assays for profiling.
Reaction Biology offers LSD1, as well as several other demethylase assays for profiling.
Kallikrein (KLK)-Related Serine Protease Assays
Mammalian Two-Hybrid (MTH) Assays
RNA Methylation Assays
Methyltransferase Assays
Reaction Biology offers the only 'Gold Standard' radioisotope based HMT assay service available for both profiling and low cost HTS. With over 30 HMTs available, RBC is able to offer the largest collection of HMTs for assay services and for purchase.
Reaction Biology offers the only 'Gold Standard' radioisotope based HMT assay service available for both profiling and low cost HTS. With over 30 HMTs available, RBC is able to offer the largest collection of HMTs for assay services and for purchase.
PARP Cleavage Assay
Poly-(ADP-Ribose) Polymerase Cleavage Assay
Reaction Biology has several PARP assays available for HTS and profiling services, including PARP1, PARP2, and PARP5B.
Reaction Biology has several PARP assays available for HTS and profiling services, including PARP1, PARP2, and PARP5B.
Phosphatase Assays
Reaction Biology offers several phosphatase assays for HTS and profiling services. Targets include DUSP22_MKPX, PP1A, PP1B, PP2Aalpha, PTPN1_PTP1B, PTPN11_SHP2, PTPN12_PTP-PEST, PTPN2_TC-PTP, PTPN6-SHP1, PTPN7_LC-PTP, and PTPRC_CD45
Reaction Biology offers several phosphatase assays for HTS and profiling services. Targets include DUSP22_MKPX, PP1A, PP1B, PP2Aalpha, PTPN1_PTP1B, PTPN11_SHP2, PTPN12_PTP-PEST, PTPN2_TC-PTP, PTPN6-SHP1, PTPN7_LC-PTP, and PTPRC_CD45
Phosphodiesterase (PDE) Assays
Reaction Biology offers PDE HTS and profiling for early drug discovery. Targets include PDE10A, PDE1A, PDE2A, PDE3A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE7A, PDE8A, and PDE9A.
Reaction Biology offers PDE HTS and profiling for early drug discovery. Targets include PDE10A, PDE1A, PDE2A, PDE3A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE7A, PDE8A, and PDE9A.
Protease Assays
Reaction Biology offers more than 60 targets for protease profiling.
Reaction Biology offers more than 60 targets for protease profiling.
Time Dependent Study
Phosphorylation Analysis
Sirtuin Assays
Reaction Biology offers Sirtuin HTS and profiling services for early drug discovery. SIRT1, SIRT2, SIRT3, and SIRT5 are available as targets.
Reaction Biology offers Sirtuin HTS and profiling services for early drug discovery. SIRT1, SIRT2, SIRT3, and SIRT5 are available as targets.
Ligand Binding Assays
Surface Plasmon Resonance (SPR)
ATP Binding Assays
Thermal Shift Assay (TSA)
Cell Viability & Proliferation Assays
Enzyme Assays
Stem Cell Differentiation
Pharmacology & Toxicology
Human Primary Cell Isolation
Calorimetry
Cellular Health & Metabolism Assays
Sequencing data in FASTQ
Phosphorylase Assays
DNA Services
In vitro Cardiotoxicity Screening
Physical Analysis Methods
Phosphospecific Antibodies
Cell Invasion & Migration Assays
Potassium Channel Assays
Medicinal Chemistry
Acetyltransferase Assays
Hit Identification
Biochemical Assays
Biomolecular Interaction Analysis
Drug Discovery
Drug Target Identification
Hydrolase Assays
Biochemistry & Molecular Biology
CYP Induction Assay
Transferase Assays
Cell Death Assays
Compound Profiling
ADME/DMPK Studies
Drug Metabolism and Pharmacokinetics
Oxidoreductase Assays
DNA Methylation Analysis
Protein Production
Protein-Protein Interaction Analysis
Immunoassays
Nucleic Acid Services
Drug Discovery & Development
Cell-Based Assays
Protein Characterization
Biomarker Discovery
Specialized Cell-Based Assays
Cell-Based Compound Screening
Protein Services
Project Management
Mammalian Cell Culture
Cell Signaling Analyses
Clinical Molecular Diagnostics
Peptide Synthesis
Thermal Analysis Services
Thermal Analysis Services
Thermal Analysis Services
Biomarkers
Antibody Services
RNA Services
Human Primary Cells
Cells and Tissues
Receptor Assays
Clinical Laboratory Services
Biospecimens
Clinical Research
Genetic Marker Screening Services
Bioanalysis
In vitro Ion Channel Assays
Synthetic Chemistry
Human Biospecimens
Chemistry and Materials
Lead Identification and Validation
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