Reaction Biology Corporation is an industry leader and innovator specializing in assay services for early-stage drug discovery. Founded in 2001, Reaction Biology offers a wide range of services, including robust assay technologies for kinase and epigenetic biochemical and cell-based high throughput screening (HTS) and selectivity compound profiling. We also offer relevant HTS assay reagents, including highly purified and characterized epigenetic proteins. On average, several million HTS and profiling reactions are performed per year. Over 600 companies worldwide, including pharmaceutical, biotech, academic, and nonprofit laboratories, utilize our biochemical and cellular assay services and purchase epigenetic proteins.
MST assays measure the interactions directly in solution without the need of immobilization to a surface (immobilization-free technology). MST uses a small amount of samples and allows for quick assay development and affinity determination (KD) of interactions. It can be used to detect binding between any kind of biomolecules including proteins, DNA, RNA, peptides, small molecules, fragments and ions, with quick measurement times and low sample consumption. The detection range of MST on Binding affinity is between pM to mM range.
Reaction Biology offers NQO1 for profiling services.
Reaction Biology offers cIAP-1, cIAP-2, XIAP for profiling services.
Reaction Biology offers Bcl-2 and BCL-xL for HTS and profiling services.
Reaction Biology offers CYP 1A2, CYP 2C19, CYP 2C9, CYP 2D6, and CYP 3A4 for HTS and profiling.
Reaction Biology offers bromodomain HTS and profiling services. RBC also offers other reader domain proteins as assay targets, such as chromodomains, MBTs, multiple domains, PHDs, SRAs, and tudor domains. Assays available include AlphaScreen, Thermal Shift, and ITC. All bromodomain proteins are produced by Reaction Biology and are also available for purchase.
Reaction Biology offers A20, Ataxin3, BAP1, NEDP1, SENP1, UCHL1, UCHL3, USP2, USP5, USP8, USP10, and USP14 for profiling services.
Reaction Biology offers HAT profiling services for early drug discovery. Available targets are CBP, KAT5, MYST2, MYST4, p300, hGCN5 and pCAF.
Reaction Biology offers HSP90a and HSP90b for HTS and profiling.
Reaction Biology offers HDAC HTS and profiling services for early drug discovery. HDACs 1-11 are available as targets.
Reaction Biology offers IDH1 R132C, IDH1 R132H, IDH1 WT, IDH2 R140Q, IDH2 R172Q, and IDH2 WT for profiling services.
Reaction Biology offers radioisotope based HTS and profiling for 631 wild type, mutant, and atypical kinases. One free control compound is included in every assay and in your report.
Reaction Biology offers profiling for 17 lipid kinases. One free control compound is included in every assay and in your report.
Reaction Biology offers LSD1, as well as several other demethylase assays for profiling.
Reaction Biology offers the only 'Gold Standard' radioisotope based HMT assay service available for both profiling and low cost HTS. With over 30 HMTs available, RBC is able to offer the largest collection of HMTs for assay services and for purchase.
Reaction Biology has several PARP assays available for HTS and profiling services, including PARP1, PARP2, and PARP5B.
Reaction Biology offers several phosphatase assays for HTS and profiling services. Targets include DUSP22_MKPX, PP1A, PP1B, PP2Aalpha, PTPN1_PTP1B, PTPN11_SHP2, PTPN12_PTP-PEST, PTPN2_TC-PTP, PTPN6-SHP1, PTPN7_LC-PTP, and PTPRC_CD45
Reaction Biology offers PDE HTS and profiling for early drug discovery. Targets include PDE10A, PDE1A, PDE2A, PDE3A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE7A, PDE8A, and PDE9A.
Reaction Biology offers more than 60 targets for protease profiling.
Reaction Biology offers Sirtuin HTS and profiling services for early drug discovery. SIRT1, SIRT2, SIRT3, and SIRT5 are available as targets.
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