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Ranomics

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Toronto, Ontario, CA

About Ranomics

Ranomics was founded on one core principle: to improve understanding of human genetics for the betterment of patient health and wellness. Our core strength is to create, test and access genetic changes cost-effectively and quickly.

We specialize in conducting multi-site saturation mutagenesis, to help create... Show more »

Ranomics was founded on one core principle: to improve understanding of human genetics for the betterment of patient health and wellness. Our core strength is to create, test and access genetic changes cost-effectively and quickly.

We specialize in conducting multi-site saturation mutagenesis, to help create libraries of single gene mutations at any targeted codon in your target gene. Our process generates much more diversity in gene libraries compared to single-site saturation mutagenesis or targeted single-site mutagenesis. Most importantly it is also cheaper and faster than other mutagenesis processes. Ranomics also offer custom functional studies services on any targeted gene. Using our mutagenesis process we create comprehensive variant libraries and develop assays to test how the variants effects the function of the gene.

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Our Services (32)


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Metabolic Engineering

Price on request
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Antibody Optimization

Price on request

Use Ranomics' multi-site saturation mutagenesis for your antibody optimization work today. Using our proprietary pipeline, Ranomics can generate precise scanning or combinatorial variant libraries for your antibody of interest. All combinatorial variant libraries are tuneable to carry any number of average mutations per molecule... Show more »

Use Ranomics' multi-site saturation mutagenesis for your antibody optimization work today. Using our proprietary pipeline, Ranomics can generate precise scanning or combinatorial variant libraries for your antibody of interest. All combinatorial variant libraries are tuneable to carry any number of average mutations per molecule in the library.

Ranomics will even screen your antibody library using phage display technology and provide you with antibody sequences with highest affinity to your antigen. Get results in as fast as 8-10 weeks.

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Antibody Screening

Starting at $45.00 per amino acid

Multisite saturation mutagenesis (VariantFind) is a proprietary method developed by Ranomics to create comprehensive variant libraries. Each molecule in the variant library will carry variant(s) leading to a single missense mutation.

VariantFind is a powerful platform for antibody optimization where projects can include... Show more »

Multisite saturation mutagenesis (VariantFind) is a proprietary method developed by Ranomics to create comprehensive variant libraries. Each molecule in the variant library will carry variant(s) leading to a single missense mutation.

VariantFind is a powerful platform for antibody optimization where projects can include increasing affinity, specificity and activity or creating new functions as well as other features of antibodies

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Drug Target Validation

Starting at $45.00 per amino acid

Multisite saturation mutagenesis (VariantFind) is a proprietary method developed by Ranomics to create comprehensive variant libraries. Comprehensive variant libraries can be built for any putative drug target and screened for binding or loss-of-binding to small molecule inhibitors in human cell lines.

This technique not only... Show more »

Multisite saturation mutagenesis (VariantFind) is a proprietary method developed by Ranomics to create comprehensive variant libraries. Comprehensive variant libraries can be built for any putative drug target and screened for binding or loss-of-binding to small molecule inhibitors in human cell lines.

This technique not only allows users to make precise mutations to validate drug target binding, but can also help uses map out the protein-drug binding interaction surface.

VariantFind is a powerful platform for drug target validation where projects include validating drug hits from chemogenomic library phenotypic screens.

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Phage Display Library Construction and Screening

Price on request

Ranomics can make any phage display library you need using our proprietary multi-site saturation mutagenesis libraries. Get flexible scanning or combinatorial antibody libraries cloned into your phage display vector and we will screen them for you. Get results for your highest affinity antibodies in as fast as 8 weeks.

Ranomics can make any phage display library you need using our proprietary multi-site saturation mutagenesis libraries. Get flexible scanning or combinatorial antibody libraries cloned into your phage display vector and we will screen them for you. Get results for your highest affinity antibodies in as fast as 8 weeks.

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Protein Engineering/Directed Evolution

Starting at $45.00 per amino acid

Multisite saturation mutagenesis (VariantFind) is a proprietary method developed by Ranomics to create comprehensive variant libraries. Each molecule in the variant library can carry single or multiple variant, as tailored to the users experimental needs.

Ranomics provides comprehensive DNA variant libraries in as little as 3... Show more »

Multisite saturation mutagenesis (VariantFind) is a proprietary method developed by Ranomics to create comprehensive variant libraries. Each molecule in the variant library can carry single or multiple variant, as tailored to the users experimental needs.

Ranomics provides comprehensive DNA variant libraries in as little as 3 weeks, which can be used in any downstream high-throughput functional screen.

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Epitope Mapping

Price on request

Using Ranomic's proprietary mutagenesis technique, Ranomics can generate a scanning mutagenesis library of your antibody or antigen in as little as 3 weeks. When combined with phage display screening technology and next generation sequencing readouts, Ranomics can help you map your antibody binding epitopes.

Using Ranomic's proprietary mutagenesis technique, Ranomics can generate a scanning mutagenesis library of your antibody or antigen in as little as 3 weeks. When combined with phage display screening technology and next generation sequencing readouts, Ranomics can help you map your antibody binding epitopes.

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Mutant Library Construction

Price on request

Ranomics provides its partners with a standalone gene mutagenesis service. Our one-of-a-kind process creates DNA variant libraries for any targeted region in your gene or an entire gene.

Our mutagenesis service consists of a series of multiplexed PCR reactions using targeted mutagenesis oligonucleotides that we designed using... Show more »

Ranomics provides its partners with a standalone gene mutagenesis service. Our one-of-a-kind process creates DNA variant libraries for any targeted region in your gene or an entire gene.

Our mutagenesis service consists of a series of multiplexed PCR reactions using targeted mutagenesis oligonucleotides that we designed using in-house software. The end product is a library of DNA constructs where each single DNA molecule will carry a single missense mutation

Our production process is flexible and scalable. There is no limit on target length and GC% composition. Additionally, we provide greater diversity compared to single-site saturation mutagenesis or targeted single site mutagenesis.

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DNA Library Preparation

Price on request

Ranomics provides its partners with a standalone gene mutagenesis service. Our one-of-a-kind process creates DNA variant libraries for any targeted region in your gene or an entire gene.

Our mutagenesis service consists of a series of multiplexed PCR reactions using targeted mutagenesis oligonucleotides that we designed using... Show more »

Ranomics provides its partners with a standalone gene mutagenesis service. Our one-of-a-kind process creates DNA variant libraries for any targeted region in your gene or an entire gene.

Our mutagenesis service consists of a series of multiplexed PCR reactions using targeted mutagenesis oligonucleotides that we designed using in-house software. The end product is a library of DNA constructs where each single DNA molecule will carry a single missense mutation

Our production process is flexible and scalable. There is no limit on target length and GC% composition. Additionally, we provide greater diversity compared to single-site saturation mutagenesis or targeted single site mutagenesis.

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DNA Libraries

Starting at $45.00 per amino acid

Multisite saturation mutagenesis (VariantFind) is a proprietary method developed by Ranomics to create comprehensive variant libraries. Each molecule in the variant library will carry variant(s) leading to a single missense mutation. Our mutagenesis service consists of a series of multiplexed PCR reactions using targeted... Show more »

Multisite saturation mutagenesis (VariantFind) is a proprietary method developed by Ranomics to create comprehensive variant libraries. Each molecule in the variant library will carry variant(s) leading to a single missense mutation. Our mutagenesis service consists of a series of multiplexed PCR reactions using targeted mutagenesis oligonucleotides that we designed using in-house software. The end product is a library of DNA constructs where each single DNA molecule will carry a single missense mutation. We also provide a 96 well plate deliverable, where each well contains a single mutation.

VariantFind is well suited for scanning, single and combinatorial libraries.

Our production process is flexible and scalable. There is no limit on target length and GC% composition. Additionally, we provide greater diversity compared to single-site saturation mutagenesis or targeted single-site mutagenesis.

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Multi-Site Saturation Mutagenesis

Starting at $45.00 per amino acid

Multisite saturation mutagenesis (VariantFind) is a proprietary method developed by Ranomics to create comprehensive variant libraries. Each molecule in the variant library will carry variant(s) leading to a single missense mutation. Our mutagenesis service consists of a series of multiplexed PCR reactions using targeted... Show more »

Multisite saturation mutagenesis (VariantFind) is a proprietary method developed by Ranomics to create comprehensive variant libraries. Each molecule in the variant library will carry variant(s) leading to a single missense mutation. Our mutagenesis service consists of a series of multiplexed PCR reactions using targeted mutagenesis oligonucleotides that we designed using in-house software. The end product is a library of DNA constructs where each single DNA molecule will carry a single missense mutation. We also provide a 96 well plate deliverable, where each well contains a single mutation.

VariantFind is well suited for scanning, single and combinatorial libraries.

Our production process is flexible and scalable. There is no limit on target length and GC% composition. Additionally, we provide greater diversity compared to single-site saturation mutagenesis or targeted single-site mutagenesis.

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Data Management

Price on request

The Ranomics knowledgebase is a cloud-based catalog of information on the functional impact of missense variants in cancer genes. See whether your variant of interest is functional or non-functional with our simple search interface, or upload a VCF to automatically append functional evidence to the variants in your list.

The Ranomics knowledgebase is a cloud-based catalog of information on the functional impact of missense variants in cancer genes. See whether your variant of interest is functional or non-functional with our simple search interface, or upload a VCF to automatically append functional evidence to the variants in your list.

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Functional Genomic Screening

Price on request

Let Ranomics design and execute functional assays for your gene of choice. Ranomics specializes
in designing, optimizing and conducting cellular functional assays to study variants in genes. This
service is offered on its own or can be easily combined with our multi-site saturation mutagenesis
platform to generate, screen, and... Show more »

Let Ranomics design and execute functional assays for your gene of choice. Ranomics specializes
in designing, optimizing and conducting cellular functional assays to study variants in genes. This
service is offered on its own or can be easily combined with our multi-site saturation mutagenesis
platform to generate, screen, and determine the functional impact of thousands of nucleotide mutations in
high throughput.

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Site Saturation Mutagenesis

Price on request

Ranomics provides its partners with a standalone gene mutagenesis service. Our one-of-a-kind process creates DNA variant libraries for any targeted region in your gene or an entire gene.

Our mutagenesis service consists of a series of multiplexed PCR reactions using targeted mutagenesis oligonucleotides that we designed using... Show more »

Ranomics provides its partners with a standalone gene mutagenesis service. Our one-of-a-kind process creates DNA variant libraries for any targeted region in your gene or an entire gene.

Our mutagenesis service consists of a series of multiplexed PCR reactions using targeted mutagenesis oligonucleotides that we designed using in-house software. The end product is a library of DNA constructs where each single DNA molecule will carry a single missense mutation

Our production process is flexible and scalable. There is no limit on target length and GC% composition. Additionally, we provide greater diversity compared to single-site saturation mutagenesis or targeted single site mutagenesis.

Ranomics offers per-mutation and custom pricing for its mutagenesis services.

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Oncology

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Therapeutic Monoclonal Antibody (mAb) Development

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Site-Directed Mutagenesis

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Computational Modeling

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Drug Discovery

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Biology

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Nucleic Acid Services

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Drug Discovery & Development

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Mutagenesis

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Antibody Services

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Lead Identification and Validation

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Data Services

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In vitro Genetic Screening

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Protein Services

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Genetic Engineering

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Biochemistry & Molecular Biology

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DNA Services

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Microbiology

Price on request

Microbiology Services

Microbiology Services

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Microbial Fermentation and Bioprocessing

Price on request

Microbial Fermentation and Bioprocessing Services

Microbial Fermentation and Bioprocessing Services

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Jonathan Stein

SVP of Commercial Development

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