Ranomics

Multisite saturation mutagenesis (VariantFind) is a proprietary method developed by Ranomics to create comprehensive variant libraries. Each molecule in the variant library will carry variant(s) leading to a single missense mutation.

VariantFind is a powerful platform for antibody optimization where projects can include increasing affinity, specificity and activity or creating new functions as well as other features of antibodies

Multisite saturation mutagenesis (VariantFind) is a proprietary method developed by Ranomics to create comprehensive variant libraries. Comprehensive variant libraries can be built for any putative drug target and screened for binding or loss-of-binding to small molecule inhibitors in human cell lines.

This technique not only allows users to make precise mutations to validate drug target binding, but can also help uses map out the protein-drug binding interaction surface.

VariantFind is a powerful platform for drug target validation where projects include validating drug hits from chemogenomic library phenotypic screens.

Ranomics can make any phage display library you need using our proprietary multi-site saturation mutagenesis libraries. Get flexible scanning or combinatorial antibody libraries cloned into your phage display vector and we will screen them for you. Get results for your highest affinity antibodies in as fast as 8 weeks.

Multisite saturation mutagenesis (VariantFind) is a proprietary method developed by Ranomics to create comprehensive variant libraries. Each molecule in the variant library can carry single or multiple variant, as tailored to the users experimental needs.

Ranomics provides comprehensive DNA variant libraries in as little as 3 weeks, which can be used in any downstream high-throughput functional screen.

Using Ranomic's proprietary mutagenesis technique, Ranomics can generate a scanning mutagenesis library of your antibody or antigen in as little as 3 weeks. When combined with phage display screening technology and next generation sequencing readouts, Ranomics can help you map your antibody binding epitopes.

Ranomics provides its partners with a standalone gene mutagenesis service. Our one-of-a-kind process creates DNA variant libraries for any targeted region in your gene or an entire gene.

Our mutagenesis service consists of a series of multiplexed PCR reactions using targeted mutagenesis oligonucleotides that we designed using in-house software. The end product is a library of DNA constructs where each single DNA molecule will carry a single missense mutation

Our production process is flexible and scalable. There is no limit on target length and GC% composition. Additionally, we provide greater diversity compared to single-site saturation mutagenesis or targeted single site mutagenesis.

Ranomics provides its partners with a standalone gene mutagenesis service. Our one-of-a-kind process creates DNA variant libraries for any targeted region in your gene or an entire gene.

Our mutagenesis service consists of a series of multiplexed PCR reactions using targeted mutagenesis oligonucleotides that we designed using in-house software. The end product is a library of DNA constructs where each single DNA molecule will carry a single missense mutation

Our production process is flexible and scalable. There is no limit on target length and GC% composition. Additionally, we provide greater diversity compared to single-site saturation mutagenesis or targeted single site mutagenesis.

Multisite saturation mutagenesis (VariantFind) is a proprietary method developed by Ranomics to create comprehensive variant libraries. Each molecule in the variant library will carry variant(s) leading to a single missense mutation. Our mutagenesis service consists of a series of multiplexed PCR reactions using targeted mutagenesis oligonucleotides that we designed using in-house software. The end product is a library of DNA constructs where each single DNA molecule will carry a single missense mutation. We also provide a 96 well plate deliverable, where each well contains a single mutation.

VariantFind is well suited for scanning, single and combinatorial libraries.

Our production process is flexible and scalable. There is no limit on target length and GC% composition. Additionally, we provide greater diversity compared to single-site saturation mutagenesis or targeted single-site mutagenesis.

Multisite saturation mutagenesis (VariantFind) is a proprietary method developed by Ranomics to create comprehensive variant libraries. Each molecule in the variant library will carry variant(s) leading to a single missense mutation. Our mutagenesis service consists of a series of multiplexed PCR reactions using targeted mutagenesis oligonucleotides that we designed using in-house software. The end product is a library of DNA constructs where each single DNA molecule will carry a single missense mutation. We also provide a 96 well plate deliverable, where each well contains a single mutation.

VariantFind is well suited for scanning, single and combinatorial libraries.

Our production process is flexible and scalable. There is no limit on target length and GC% composition. Additionally, we provide greater diversity compared to single-site saturation mutagenesis or targeted single-site mutagenesis.

The Ranomics knowledgebase is a cloud-based catalog of information on the functional impact of missense variants in cancer genes. See whether your variant of interest is functional or non-functional with our simple search interface, or upload a VCF to automatically append functional evidence to the variants in your list.

Let Ranomics design and execute functional assays for your gene of choice. Ranomics specializes
in designing, optimizing and conducting cellular functional assays to study variants in genes. This
service is offered on its own or can be easily combined with our multi-site saturation mutagenesis
platform to generate, screen, and determine the functional impact of thousands of nucleotide mutations in
high throughput.

Ranomics provides its partners with a standalone gene mutagenesis service. Our one-of-a-kind process creates DNA variant libraries for any targeted region in your gene or an entire gene.

Our mutagenesis service consists of a series of multiplexed PCR reactions using targeted mutagenesis oligonucleotides that we designed using in-house software. The end product is a library of DNA constructs where each single DNA molecule will carry a single missense mutation

Our production process is flexible and scalable. There is no limit on target length and GC% composition. Additionally, we provide greater diversity compared to single-site saturation mutagenesis or targeted single site mutagenesis.

Ranomics offers per-mutation and custom pricing for its mutagenesis services.