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R&D Systems

Minneapolis, Minnesota, US

When your work demands unique reagents or scientific support, turn to the decades of product development legacy at R&D Systems:

• Recombinant protein development
• Monoclonal and polyclonal antibody development
• Hybridoma to recombinant antibody conversion and engineering
• ELISA development and optimization
• Luminex assay development
• Bioactivity testing
• Biomarker assay validation, pre-clinical, and clinical sample testing services

Since 1976, R&D Systems has been a developer and manufacturer of high-quality reagents for the bio-scientific industry. As the world leader in research immunoassay development, our gold-standard Quantikine® ELISAs are built using recombinant proteins and panels of antibodies that are developed and manufactured in-house. Our products are produced in North America, under a stringent Quality Management System in our ISO-certified, FDA-regulated facility.

Together... Show more »

When your work demands unique reagents or scientific support, turn to the decades of product development legacy at R&D Systems:

• Recombinant protein development
• Monoclonal and polyclonal antibody development
• Hybridoma to recombinant antibody conversion and engineering
• ELISA development and optimization
• Luminex assay development
• Bioactivity testing
• Biomarker assay validation, pre-clinical, and clinical sample testing services

Since 1976, R&D Systems has been a developer and manufacturer of high-quality reagents for the bio-scientific industry. As the world leader in research immunoassay development, our gold-standard Quantikine® ELISAs are built using recombinant proteins and panels of antibodies that are developed and manufactured in-house. Our products are produced in North America, under a stringent Quality Management System in our ISO-certified, FDA-regulated facility.

Together with a dedicated project manager, our expert scientists, quality assurance team, and world-class technical support we will deliver solutions exactly tailored to bring you success faster and more economically.

Selected Recent Publications

Molecular Modeling and Functional Analysis of Exome Sequencing-Derived Variants of Unknown Significance Identifies a Novel Constitutively Active FGFR2 Mutant in Cholangiocarcinoma.
Egan et al., accepted in Journal of Clinical Oncology (2017).

Phenotyping CD4+ hTh2 Cells by Flow Cytometry: Simultaneous Detection of Transcription Factors, Secreted Cytokines, and Surface Markers.
Goetz et al., Signal Transduction Immunohistochemistry (2017) 1554:175.

Structural insight into allosteric modulation of protease-activated receptor 2.
Cheng et al., Nature (2017) 545: 7652.

Non-reducing end labeling of heparan sulfate via click chemistry and a high throughput ELISA assay for heparanase.
Wu et al., Glycobiology (2017) 27: 518.

Automated High-Content Screening of γ-H2AX Expression in HeLa Cells
Hopp et al., Signal Transduction Immunohistochemistry (2017) 1554:273.

Piecing it together: Unraveling the elusive structure-function relationship in single-pass membrane receptors.
Valley et al., Biochim Biophys Acta (2017).

Probing sialoglycans on fetal bovine fetuin with azido-sugars using glycosyltransferases.
Wu et al., Glycobiology (2016) 26: 329.

Development of Bipotent Cardiac/Skeletal Myogenic Progenitors from MESP1+ Mesoderm.
Chan et al., (2016) Stem Cell Reports 6: 26.

Comparative Multi-Donor Study of IFNγ Secretion and Expression by Human PBMCs Using ELISPOT Side-by-Side with ELISA and Flow Cytometry Assays.
Hagen et al., Cells (2015) 4:84.

A Liquid Chromatography-Mass Spectrometry-based Approach to Characterize the Substrate Specificity of Mammalian Heparanase.
Mao et al., The Journal of Biological Chemistry (2014) 289: 34141.

Immunohistochemistry with the anti-BRAF V600E (VE1) antibody: Impact of pre-analytical conditions and concordance with DNA sequencing in colorectal and papillary thyroid carcinoma.
Dvorak et al., Pathology (2014) 46:6.

Induction and Analysis of Epithelial to Mesenchymal Transition.
Tang et al., JOVE (2013) 78.

Development of a new mouse/human FoxP3 antibody using rabbit recombinant antibody technology (IRC4P.477).
Goetz et al., (2014) J. Immunology 192:60.

Stability and function of regulatory T cells is maintained by a neuropilin-1–semaphorin-4a axis.
Delgoffe et al., (2013) Nature 501:252.

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R&D Systems has not listed any services.

Clinical Biomarkers
Price on request
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Recombinant Protein Expression
Price on request

Apply the experience of the scientists behind the industry’s best proteins to your research.

History: Since 1985, R&D Systems has produced gold-standard proteins to meet the strictest development and purification standards.

Expertise: Our scientists have developed methods to express and purify some of the most... Show more »

Apply the experience of the scientists behind the industry’s best proteins to your research.

History: Since 1985, R&D Systems has produced gold-standard proteins to meet the strictest development and purification standards.

Expertise: Our scientists have developed methods to express and purify some of the most challenging proteins with the highest bioactivities on the market.

Delivery: We will produce exactly what you need and provide a test sample. If it meets your requirements, we will scale up production to meet your research and development needs.

Available Services

• Recombinant protein expression and purification (with typical high purity, high bioactivity, and low endotoxin levels)
• In vitro protein modification and processing
• Biotinylation
• PEGylation
• Fluorescent probe labeling
• Incorporation of non-standard chemical labels
• Point mutations
• Animal Component-Free Process, Animal-Free™, & GMP-grade
• Formulation to your requirements
• Hundreds of unique, non-catalog items available

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Human
Mouse
Rat
Transient expression
CHO
HEK
GMP
Cytokines
stable transfection
NS0
Insect
E coli
Nonhuman Primate
Monoclonal Antibody (mAb) Production
Price on request

When specificity, long-term consistency, and supply are critical, trust the experts.

History: R&D Systems manufactures more than 12,500 primary antibodies, against over 3,600 target analytes, across 19 different species.

Expertise: Using in-house immunogens and proprietary technologies, R&D Systems generates the... Show more »

When specificity, long-term consistency, and supply are critical, trust the experts.

History: R&D Systems manufactures more than 12,500 primary antibodies, against over 3,600 target analytes, across 19 different species.

Expertise: Using in-house immunogens and proprietary technologies, R&D Systems generates the antibodies that define the industry leading Quantikine® ELISA kits.

Delivery: We tailor immunogen and immunization protocols to generate antibodies with high specificity and outstanding performance in your desired application. If your provided test sample meets your requirements, we will scale up production to meet your research and development needs.

Antibody Services

• Polyclonal and monoclonal antibody development
• Rabbit recombinant monoclonal antibody development
• Hybridoma to recombinant antibody conversion
• Polyclonal to recombinant antibody conversion
• Large-scale production, affinity-based purification
• Conjugation to fluorophores, HRP, and biotin
• Access to our hybridoma panels containing thousands of non-catalog sister clones
• Monoclonal production of client-supplied hybridomas

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Rabbit
Mouse
Rat
Polyclonal
monoclonal
purity
specificity
Recombinant Antibody Production
Price on request

Immortalized Antibody Supply.

For applications requiring large amounts of consistent antibody, R&D Systems hybridoma and B-cell to recombinant antibody conversion service produces a dependable supply of custom engineered monoclonal antibody. R&D Systems proprietary processes guarantee yields that provide the gram... Show more »

Immortalized Antibody Supply.

For applications requiring large amounts of consistent antibody, R&D Systems hybridoma and B-cell to recombinant antibody conversion service produces a dependable supply of custom engineered monoclonal antibody. R&D Systems proprietary processes guarantee yields that provide the gram quantities required for the development of diagnostic and therapeutic reagents.

Why R&D Systems Recombinant Antibody Conversion?

• R&D Systems antibodies support the industry-leading Quantikine® ELISAs
• Ability to scale up to gram quantity production
• A cost-effective and time-saving solution for superior antibodies
• The sequence and cell line(s) can be held by a third party to guarantee supply
• Consistent quality and performance over time

Available Engineering Services

• Modification of the species, isotype, hinge, and Fc region
• Generation of active truncated forms
• Improved yield without any change in affinity

The Process

  1. Customer provides:
    a) Cell line expressing antibody or full-length antibody sequence.
    b) Antigen for testing the recombinant antibody using direct ELISA.
    c) Small aliquot of purified antibody.

  2. Conversion, small scale expression of recombinant antibody, and comparison to the original hybridoma-derived antibody by R&D Systems.

  3. Provision of data report and sample for customer's evaluation.

  4. Exclusive supply of purified antibody.

  5. Sequence and cell line(s) placed with third party for storage and security.

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recombinant conversion
hybridoma
comparison testing
engineering
Fc removal
antibody cleavage
Fab
Fab'2
HEK-293 cells
Antibody Screening
Price on request

Panels of Non-Catalog Antibodies.

For every monoclonal antibody in our catalog, we have a panel of non-catalog antibodies available.
You can test these antibody panels in your application to find the antibody that produces optimal results.

Screen Antibody Panels to Identify Antibody Matched Pairs

The antibody matched... Show more »

Panels of Non-Catalog Antibodies.

For every monoclonal antibody in our catalog, we have a panel of non-catalog antibodies available.
You can test these antibody panels in your application to find the antibody that produces optimal results.

Screen Antibody Panels to Identify Antibody Matched Pairs

The antibody matched pair you are looking for could be hiding in our selection of antibody panels.
Maximize your chances of successful antibody pairing by ordering our available antibody panels.

Consistent Antibody Supply

• Each antibody panel is produced in-house at R&D Systems, so we can meet your long-term supply needs.
• No 3rd party suppliers, which means no additional supply/licensing complications.
• All antibody panels are positive in direct ELISA for the analyte of interest.
• Convert any of our monoclonal antibodies to recombinant antibodies, and immortalize your antibody supply.
• Explore other antibody projects: antibody engineering, conjugation services, and more.

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antibody panels
panels
fusion panels
sister clones
non-catalog antibody clones
Polyclonal Antibody Development
Price on request

When specificity, long-term consistency, and supply are critical, trust the experts.

History: R&D Systems manufactures more than 12,500 primary antibodies, against over 3,600 target analytes, across 19 different species.

Expertise: Using in-house immunogens and proprietary technologies, R&D Systems generates the... Show more »

When specificity, long-term consistency, and supply are critical, trust the experts.

History: R&D Systems manufactures more than 12,500 primary antibodies, against over 3,600 target analytes, across 19 different species.

Expertise: Using in-house immunogens and proprietary technologies, R&D Systems generates the antibodies that define the industry leading Quantikine® ELISA kits.

Delivery: We tailor immunogen and immunization protocols to generate antibodies with high specificity and outstanding performance in your desired application. If your provided test sample meets your requirements, we will scale up production to meet your research and development needs.

Antibody Services

• Polyclonal and monoclonal antibody development
• Rabbit recombinant monoclonal antibody development
• Hybridoma to recombinant antibody conversion
• Polyclonal to recombinant antibody conversion
• Large-scale production, affinity-based purification
• Conjugation to fluorophores, HRP, and biotin
• Access to our hybridoma panels containing thousands of non-catalog sister clones
• Monoclonal production of client-supplied hybridomas

« Show less
rabbit
purity
specificity
Luminex Multiplex Assays
Price on request

Accelerate biomarker discovery, validation, and detection with unique analyte panels.

History

With the largest immediately available retail analyte selection and an active development pipeline of new targets, R&D Systems has developed a reputation for delivering high quality and customized content for Luminex®... Show more »

Accelerate biomarker discovery, validation, and detection with unique analyte panels.

History

With the largest immediately available retail analyte selection and an active development pipeline of new targets, R&D Systems has developed a reputation for delivering high quality and customized content for Luminex® assays.

Expertise

Building on the legacy of immunoassay development, our scientists can often translate Quantikine® ELISA reagents to the Luminex® platform and can optimize assay performance using decades of immunoassay experience.

Delivery

Utilizing our massive in-house collection of antibodies and proteins reduces development time, saves you money, and puts custom multiplex panels that detect your specific analytes of interest in your hands faster.

Available Services

• Unique analyte development
• Optimized panel configurations
• Sample type validation
• Evaluation of externally sourced antibodies
• Panel assembly to minimize required sample volume

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multiplex
Luminex
pair-testing
analyte development
luminex
ELISA Kits
Price on request

Harness the unique experience and expertise of the R&D Systems Quantikine® ELISA team.

History: R&D Systems unrivaled reputation for quality has made Quantikine® ELISA Kits the gold standard and most referenced, ready-to-use ELISAs in the industry.

Expertise: Our scientists have developed hundreds of unique... Show more »

Harness the unique experience and expertise of the R&D Systems Quantikine® ELISA team.

History: R&D Systems unrivaled reputation for quality has made Quantikine® ELISA Kits the gold standard and most referenced, ready-to-use ELISAs in the industry.

Expertise: Our scientists have developed hundreds of unique diluents and have decades of experience optimizing conditions to detect a range of analytes.

Delivery: Throughout the iterative immunoassay development process, our expert scientists and project management team will provide data reports and recommendations for assay improvements. As projects evolve, we have quality management systems and regulatory affairs in place to support every need, from basic discovery research, preclinical and clinical research through companion diagnostic applications.

Available Services

• Antibody matched pair screening
• Assay development and optimization
• Complete ELISA kit manufacturing
• Precision automated microplate coating
• Translation to automated platforms
• Facilitate the transition from RUO to IVD

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assay development
ELISA
pair-testing
assay optimization
Quantikine
Biomarker Analysis
Price on request

Accelerate biomarker discovery, validation, and detection with unique analyte panels.

History: R&D Systems have over 20 years of experience designing, testing, and optimizing immunoassay kits to ensure the highest level of performance in analyte quantification. Support your preclinical and clinical studies with the same... Show more »

Accelerate biomarker discovery, validation, and detection with unique analyte panels.

History: R&D Systems have over 20 years of experience designing, testing, and optimizing immunoassay kits to ensure the highest level of performance in analyte quantification. Support your preclinical and clinical studies with the same team that built your assay of choice.

Expertise: Scientists within the Biomarker Testing Service, a specialized division of R&D Systems, are specifically trained, operate under strict SOPs consistent with applicable GLP, and have full access to all R&D Systems products, technologies, and development expertise.

Delivery: Entrusting our expert personnel with your study samples ensures accurate results that are returned in a timely, efficient, and customized manner under our proven quality management systems.

Our Dedicated Team Specializes in the Following Sample Testing Services

Biomarker testing utilizing state-of-the-art platforms:
• ELISA, Luminex®, Simple Plex™, Proteome Profiler™ Arrays, ELISpot, and Simple Western™
• Sample stability evaluation
• Sample management
• Sample collection and shipping kits
• Sample type validation

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ELISA
Luminex
GLP
Quantikine
Simple Plex
Arrays
sample management
sample collection
sample validation
strict SOPs
ISO-9001
Quality Management System
Data Report
Product Testing Services
Price on request

Take advantage of over 900 established bioassays to measure bioactivity.

History: With more than 4,000 bioactive proteins developed and tested, and over 3,000 small molecules available to modulate responses, no other company matches the bioassay experience of Bio-Techne.

Expertise: We have more than 900 established bioassays... Show more »

Take advantage of over 900 established bioassays to measure bioactivity.

History: With more than 4,000 bioactive proteins developed and tested, and over 3,000 small molecules available to modulate responses, no other company matches the bioassay experience of Bio-Techne.

Expertise: We have more than 900 established bioassays available to test proteins, small molecules, and antibodies. Our scientists in Bioassay Services will consult with you to select and optimize an assay to deliver relevant results.

Delivery: Raw data are provided, along with a professionally formatted report and a detailed summary of the bioassay protocol employed.

Bioassays Include, but are not limited to

• Proliferation Assays
• Cytotoxicity/Survival/Apoptosis
• Cellular Differentiation
• Reporter Assays
• Cytokine Induction
• Chemotaxis
• Cell Adhesion
• Signal Transduction
• Neuronal Assays
• Ligand/Receptor Binding

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Cytotoxicity
bioactivity testing
activity testing
bioassay
proliferation
differentiation
chemotaxis
adhesion
ligand
receptor
Clinical Research
Price on request
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Clinical Laboratory Services
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Clinical Chemistry
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Antibody/Antigen Detection Based Testing
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Biology
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Biochemistry & Molecular Biology
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Protein Production
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Protein Quantification
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Antibody Services
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Therapeutic Monoclonal Antibody (mAb) Development
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Product Development, Testing, and Packaging
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Pharmacology & Toxicology
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Bioanalysis
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Biomarkers
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