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Quintara Discovery

6 Orders Completed
South San Francisco, California, US

About Quintara Discovery

Quintara Discovery is a San Francisco Bay Area CRO, which supports over 150 biotech, pharma, and academic organizations in the pre-clinical space for both large and small molecule discovery and development. Our talented, industry-experienced scientists are excited to work with you on in vitro ADME and bioanalysis (LC-MS) for small molecules, and dedicated assay development and compound screening for large molecule therapeutics. We have accumulated extensive knowledge and insight in designing high-fidelity assays, obtaining and analyzing critical data, and prioritizing compounds for advancement. All experiments are performed by our driven and detail-oriented team who is available for real-time communication, discussion and consultation. Our strong focus on lab operation, automation, instrumentation and project management enables an industry-leading turn-around delivery time with excellent quality, and we stand behind all of our scientific results. With a customer-centric focus, Quintara looks forward to developing a relationship with you and to becoming your trusted partner in drug discovery and development.

Our Advantages:

Quality Service: Core competency, extensive QC, Detail-oriented
Operation Efficiency: Streamlined Process from Compound Management to Data Reporting; Flexible Platform
Experience: Know-how, Trouble-shooting, Experimental design
Customer Centric: Understand the importance of Data Quality, Analysis, and Turn-around time
Sense of community: Local to the SF Bay Area, Integration into client’s team, Real-time communication

Please reach out through this platform and stop by at our next open house. We look forward to meeting you in person and to developing a strong working relationship.

Our Services (45)


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Reaction Phenotyping

Price on request
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CYP Induction Assay

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Multiplex PK Assays

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Assay Development

Price on request

We provide services in de novo assay development and in established, custom-fit assay development. We look forward to supporting you in achieving your company's drug discovery and development goals. Please give us an idea of what you would like to accomplish and we will deliver trustworthy results within a fast turnaround time.


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Bioanalytical Assays

Price on request

We offer a wide range of bioanalytical services and are happy to tailor them to your needs.
-Non-GLP bioanalysis for PK, TK, and BA studies
-Formulations support including solubility, stability, and quantification
-Purity and impurity determinations
-Fit for purpose analytical and bioanalytical analysis
-Comprehensive method development and validation
-Small molecules, peptides, ADC-warheads, xenobiotics, and biomarkers
-Customized data reporting including PK and TK reports
-In vitro and in vivo metabolite profiling and identification

Bioanalysis is performed in different matrices including:
-Plasma, whole blood, urine, feces, and bile
-Liver, lung, kidney, heart, brain, intestine, and colon
-Tumor, cell lysate, vitreous fluid, and bronchial lavage fluid

Dedicated instrumentation and laboratory service support:
-AB SCIEX API5000, API4000, 4000 Q Trap Mass Spec
-Shimadzu Nexera MP UHPLC system, Agilent HPLC 1200
-Sciclone 3000, Agilent Bravo, Biomek 2000 liquid handling systems

AB Sciex QTRAP Agilent 1200 Shimadzu UHPLC MS/MS Detector Sciclone 3000 Agilent Bravo Biomek Liquid Handling Robot Plasma Blood Stool Brain Tumor tissue Biofluids Show 12 more tags Show less

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Biochemical Compound Screening

Price on request

We provide services and expert knowledge for assay development and integration into the client's screening paradigm and drug discovery programs.

-Custom-fit established assays and de novo assay development
-Screening compounds for inhibition or activation of target activity
-Biomarker detection assays in disease models with cultured cells and/or PBMC and whole blood samples
-Complex kinetic and mechanism of action studies
-Excellent assay performance with Z' > 0.8

Custom Assays De Novo Assay Development Biopharmaceuticals/Biologics

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Drug Absorption Studies

Price on request

For Lead Optimization and DDI.

MDCK, Caco-2, and other cell lines.


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CYP Inhibition Assay

Price on request

CYP450 Interactions (Drug-drug interactions)

a. CYP Inhibition Assays (All major isoforms)
-Single-substrate or cocktail formats
-LC-MS/MS or RapidFire-MS/MS detection

b. Time-Dependent Inhibition - IC50 shift

c. Time-Dependent Inhibition - k(inact) / Ki

LC-MS/MS

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ELISA

Enzyme-linked immunosorbent assay
Price on request

Fully customizable qualification and validation to support your drug discovery and development needs.

Time Line: 5 - 10 day turnaround time dependent on the details of the request

Standard sample requirements: pg-ng/mL in buffer, serum, plasma, or tissue. This is highly dependent on each specific antibody/antigen but we are happy to help.

Capabilities and Advantages:

• High throughput analysis in 384-well or 96-well format, with the capacity to screen >100 plates per day
• Optimized for: Sensitivity and precision, Upper and lower limits of detection, Matrix and dilution effects, Considerations for free/bound forms, and Liquid handling and automation
• Capable of analyzing samples in multiple matrices such as serum, plasma and tissues
• PK analysis of large molecules is performed with WinNonlin modeling
• Extensive quality control
• Real-time communication

Instrumentation: Agilent Bravo, Biotek ELx405 HT, Thermo Multidrop Combi & WellMate, Envision multilabel plate reader, and Spectramax

Quintara Discovery has provided ELISA assay support for various protein and antibody programs with successful IND and BLA filings!

We look forward to supporting your research efforts and helping you to achieve your project goals.


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IND-Enabling Studies

Price on request

CYP450 Interactions (Drug/Drug Interactions)

a. CYP450 Ki Determinations

b. Reaction Phenotyping

  • HLM with specific inhibitors (5 isoforms)
  • Enzymes: 150-enzyme panel

c. CYP 450 Induction

  • 1A2, 3A4, and 2B6 with positive controls
  • Readouts: enzyme activity and mRNA level


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In vitro ADME/DMPK Studies

Price on request

Metabolic stability, CYP450 interactions, transporter interactions, solubility, permeability and much more.


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Drug Transporter Assays

Price on request

For Lead Optimization and DDI.

MDCK, Caco-2, and other cell lines.


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Metabolite Identification

Price on request

(IND-Enabling & Lead Optimization)
a. Microsomal/Hepatocyte incubation
b. Analysis by Q-TRAP
c. Identification of unique and disproportionate metabolites
d. Soft spot identification to direct the next round of synthesis
e. Selection of appropriate pre-clinical tox models


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Metabolomics

Price on request

-Tumor metabolism pathways; i.e. IDH (wt and mutant protein); measuring 2 HG, glucose, glutamate, etc.
-Cancer immunomodulatory pathways: i.e. IDO; measuring tryptophan, kynurenine, etc.
-Epigenetic pathways: i.e. SIRT1 and methyltransferases; measuring peptides and modified peptides

Unique chemical fingerprints are associated with specific cellular processes and their responses to modulation of drug candidates. Quintara Discovery has developed multiple assays to monitor metabolites in tumor metabolism, immunomoduation, and other pathways, providing a powerful too for investigating drug actions and cellular responses.

Oncology Epigenetics Drug Discovery

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In vitro Metabolic Stability Assays

Price on request

Lead Optimization
a. Microsomal Stability: human/monkey/dog/rat/mouse, etc.
b. S9 Stability: human/monkey/dog/rat/mouse
c. Hepatocyte Stability: human/monkey/dog/rat/mouse
d. Plasma/Blood Stability
e. Buffer Stability (PBS, SIF, SGF, etc)


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In vivo Protein Binding Assays

Price on request

(IND-Enabling & Lead Optimization)
a. Plasma Protein Binding
b. Blood-to-Plasma Ratio
c. Tissue Protein Binding


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Protein Characterization

Price on request

We provide de novo assays for protein characterizations, such as impurity analysis by ELISA, free thiol determination, ADC linker cleavage, binding measurements, and drug release in lysosomes, cells, or plasma.


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Target Gene Expression Analysis

Price on request

We provide RNA isolation and gene expression analysis of cultured cells, primary cells, and animal tissues. RT-qPCR experiments and analysis are performed using ABI 7300 and 7500 with targets normalized to a known housekeeping gene.

Neurodegenerative diseases Antibiotic Development ABI 7500 ABI 7300 Primary Cells Oncology Show 6 more tags Show less

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Physicochemical Testing

Price on request

(IND-Enabling & Lead Optimization)
a. Log D
b. pKa
c. Kinetic Solubility
d. Thermodynamic Solubility
e. Chemical Stability in Buffers (PBS, SIF, SGF)


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Cell-Based Compound Screening

Price on request

We provide services and expert knowledge for assay development and integration into the client's screening paradigm and drug discovery programs.

-Custom-fit established assays and de novo assay development
-Screening compounds for inhibition or activation of target activity
-Biomarker detection assays in disease models with cultured cells and/or PBMC and whole blood samples
-Complex kinetic and mechanism of action studies
-Excellent assay performance with Z' > 0.8

Cellular Compound Screening De Novo Assay Development Custom Assays Biopharmaceuticals/Biologics

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MS-MS

Tandem Mass Spectrometry
Price on request

Label-free technology using RapidFire-MS/MS detection provides a HT platform for investigating biomolecular interactions and complex signaling pathways without interference or quenching effects of labels. The RapidFie format allows for the study of multiple pathways simultaneously, making assay development less tedious and data more easily comparable.

Acute Lymphocytic Leukemia (ALL)

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Biomolecular Interaction Analysis

Price on request
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Hit Identification

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Protein Quantification

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Pharmacology & Toxicology

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Nucleic Acid Services

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Tandem Mass Spectrometry Methods

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Analytical Chemistry Services

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Protein Services

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Bioanalysis

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Spectroscopy

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Project Management

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Biology

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Imaging & Spectroscopy

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Omics

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Drug Discovery

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ADME/DMPK Studies

Drug Metabolism and Pharmacokinetics
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Mass Spectrometry

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Biochemistry & Molecular Biology

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Chemistry and Materials

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In vitro Bioavailability/Bioequivalence Studies

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RNA Services

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Drug Discovery & Development

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Regulatory Affairs Services

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Pharmacology

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Pharmacology Services


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AC

Alex Chuang

Lab Manager

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