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QuarryBio, LLC

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Tallahassee, Florida, US

About QuarryBio, LLC

QuarryBio’s mission is to provide high resolution protein analysis for routine applications in biologic drug discovery, development, and manufacturing. Our unique mass spectrometry based covalent labeling method uses diethypyrocarbonate (DEPC) to identify epitopes and paratopes as well as changes in protein... Show more »

QuarryBio’s mission is to provide high resolution protein analysis for routine applications in biologic drug discovery, development, and manufacturing. Our unique mass spectrometry based covalent labeling method uses diethypyrocarbonate (DEPC) to identify epitopes and paratopes as well as changes in protein higher order structure (HOS). The chemical specificity and stability of the DEPC label allows for a simpler experimental design and workflow when compared to hydrogen deuterium exchange and hydroxyl radical labeling mass spectrometry. In addition, our proprietary data analysis software allows for rapid parallel processing of multiple samples, providing rapid turn-around of results in a simple to read format. These innovations have allowed QuarryBio to provide high resolution epitope/paratope mapping and HOS analysis at a fraction of the cost associated with other high resolution technologies, opening the door for routine applications once thought to be out of the realm of possibility for high resolution analyses.

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Our Services (9)


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Epitope Mapping

Price on request

QuarryBio will perform covalent labeling studies for your proteins in our own lab.

  • Samples of client proteins are sent to QuarryBio, where we perform the covalent labeling study and analyze the resulting mass spec data using our proprietary data analysis software.
  • Our proprietary data analysis software enables rapid... Show more »

QuarryBio will perform covalent labeling studies for your proteins in our own lab.

  • Samples of client proteins are sent to QuarryBio, where we perform the covalent labeling study and analyze the resulting mass spec data using our proprietary data analysis software.
  • Our proprietary data analysis software enables rapid generation of easy-to-read and actionable results, identifying specific regions and residues where DEPC labeling was impacted by the study conditions.
  • Results are summarized and delivered to the client.

Most studies are performed in 2 stages. To minimize upfront costs, stage 1 conditions must be successfully completed before starting stage 2:

  • Stage 1 ensures that the proteins can be adequately labeled by DEPC, and that there is no structural impact from DEPC labeling. Digestion conditions are also explored and optimized.
  • Stage 2 includes the actual performance of the DEPC labeling study, including subjecting samples to any binding interactions or stressed conditions.

Sample needs may vary depending on the nature of the proteins being studied, and the details of the study to be performed. However, most studies require less than a mg of each protein.

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Post-Translational Modification Analysis

Price on request

QuarryBio will perform covalent labeling studies for your proteins in our own lab.

  • Samples of client proteins are sent to QuarryBio, where we perform the covalent labeling study and analyze the resulting mass spec data using our proprietary data analysis software.
  • Our proprietary data analysis software enables rapid... Show more »

QuarryBio will perform covalent labeling studies for your proteins in our own lab.

  • Samples of client proteins are sent to QuarryBio, where we perform the covalent labeling study and analyze the resulting mass spec data using our proprietary data analysis software.
  • Our proprietary data analysis software enables rapid generation of easy-to-read and actionable results, identifying specific regions and residues where DEPC labeling was impacted by the study conditions.
  • Results are summarized and delivered to the client.

Most studies are performed in 2 stages. To minimize upfront costs, stage 1 conditions must be successfully completed before starting stage 2:

  • Stage 1 ensures that the proteins can be adequately labeled by DEPC, and that there is no structural impact from DEPC labeling. Digestion conditions are also explored and optimized.
  • Stage 2 includes the actual performance of the DEPC labeling study, including subjecting samples to any binding interactions or stressed conditions.

Sample needs may vary depending on the nature of the proteins being studied, and the details of the study to be performed. However, most studies require less than a mg of each protein.

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ic

Protein Higher-Order Structure Analysis

Price on request

QuarryBio will perform covalent labeling studies for your proteins in our own lab.

  • Samples of client proteins are sent to QuarryBio, where we perform the covalent labeling study and analyze the resulting mass spec data using our proprietary data analysis software.
  • Our proprietary data analysis software enables rapid... Show more »

QuarryBio will perform covalent labeling studies for your proteins in our own lab.

  • Samples of client proteins are sent to QuarryBio, where we perform the covalent labeling study and analyze the resulting mass spec data using our proprietary data analysis software.
  • Our proprietary data analysis software enables rapid generation of easy-to-read and actionable results, identifying specific regions and residues where DEPC labeling was impacted by the study conditions.
  • Results are summarized and delivered to the client.

Most studies are performed in 2 stages. To minimize upfront costs, stage 1 conditions must be successfully completed before starting stage 2:

  • Stage 1 ensures that the proteins can be adequately labeled by DEPC, and that there is no structural impact from DEPC labeling. Digestion conditions are also explored and optimized.
  • Stage 2 includes the actual performance of the DEPC labeling study, including subjecting samples to any binding interactions or stressed conditions.

Sample needs may vary depending on the nature of the proteins being studied, and the details of the study to be performed. However, most studies require less than a mg of each protein.

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Protein Characterization

Price on request

Protein Characterization Services

Protein Characterization Services

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Structural Biology

Price on request

Structural Biology Services

Structural Biology Services

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Antibody Services

Price on request

Antibody Services

Antibody Services

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Protein Services

Price on request

Protein Services

Protein Services

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Biochemistry & Molecular Biology

Price on request

Biochemistry & Molecular Biology Services

Biochemistry & Molecular Biology Services

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Biology

Price on request

Biology Services

Biology Services

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