QTest Labs offers DMPK, pharmacology, and evaluation of therapeutics in mammals. QTest Labs is a CRO that specializes in efficacy, cardiovascular safety, and risk assessment of a pharmaceutical or medical device. Our aim is to minimize lead-time and cardiovascular risk, while increasing mechanistic understanding of the test article or device. We bring state-of-the-art science and technology to establish both drug safety and efficacy in a cost effective, expeditious manner, linking discovery, and pre-clinical trials to make drugs and devices safer for tomorrow. The response of a test article/device is mediated by it's complex interactions with different physiological systems. QTest thoroughly explores these interactions providing a clear and complete understanding of your products affects and liabilities. We utilize a series of models to expand the range of cardiovascular information that can be assessed on test articles. These models also ensure that studies are more comprehensive and economical. Understand your product completely! While others design limited studies based solely on regulatory guidelines and a fixed set of assessment tools, QTest Labs understands that truly predictive efficacy and safety testing must go beyond these constraints. By combining our unique, patent-pending paradigm, world renowned group of scientists, and state-of-the-art facilities, QTest Labs is positioned to offer clients services customized to meet their knowledge needs in a way that no others can. We deliver seamless, cost-effective and accurate results, establishing the safety and efficacy of your test article. ...helping you better understand your product Our Scientists include DVM cardiologists, a board certified anesthesiologist specializing in pain, and a biomedical engineer, who have worked for years in cardiovascular physiology, pharmacology, and toxicology and have over 750 publications in peer-reviewed journals. Two board-certified veterinary cardiologists, with experience in drug development and testing, supervise experiments and data analysis. A certified quality assurance officer audits all data for critical studies. Experiments are conducted according to excellent laboratory practices by personnel experienced in cardiovascular physiology (including electrophysiology) and pharmacology. We bring state-of-the-art science and technology to establish both drug safety and efficacy in a cost effective, expeditious manner.
Disease Models are utilized because therapies are seldom given to healthy patients and underlying pathophysiology can modulate clinical responses (heart failure, arrhythmia, ischemia, hypertension, diabetes, etc).
Permissive to torsade de pointes
More realistic modeling of targeted patient populations
May be evaluated with conscious and/or Langendorff preparations
Validated acquisition and analysis systems
QTest Labs provides expert consultation to both sponsors and regulatory agencies aiming to enhance or facilitate their understanding of the efficacy, safety, and mechanisms of action for a test article or device. QTest's state-of-the-art methodologies and vast physiological expertise help to interpret and clarify existing data sets as well as to offer both mechanistic knowledge and recommendations that simplify and define the development process.
Unrivaled clarity in data analysis
(Langendorff Isolated Perfused Heart) are utilized because metabolites and off-target responses (autonomic, vascular) can mask the direct cardiac effects of a test article in vivo.
Informative and economical
High sensitivity and specificity
Explores electrophysiological and mechanical parameters
Quantifies coronary vascular resistance
Millisecond accuracy for measuring QT and QT instability
In Vivo Assays (conscious, telemetered, anesthetized) are utilized because, in vivo different physiological states, metabolites, autonomic baroreceptor function, and vascular responses can modulate the effects and liabilities of a test article or device.
Quality repeat sampling focused on all important cardiac parameters
Integrity of autonomic nervous system and metabolism
No obfuscation by anesthetics
Measures vascular and cardiac parameters and baroreceptor function
Evaluates inotropy, lusitropy, and vascular properties
Studies reperfusion arrhythmias
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