4tbxs7gquutqi47rosni qps logo general use

QPS Austria GmbH

3 Orders Completed
Grambach, AT

About QPS Austria GmbH

Divison of: QPS Holdings, LLC

QPS Austria, part of the QPS group, is a full-service contract research organization (CRO). The company performs preclinical as well as clinical research. QPS Austria Neuropharmacology is well known as a leading CRO for CNS drug development. The availability of the most predictive disease models and... Show more »

QPS Austria, part of the QPS group, is a full-service contract research organization (CRO). The company performs preclinical as well as clinical research. QPS Austria Neuropharmacology is well known as a leading CRO for CNS drug development. The availability of the most predictive disease models and unparalleled experience with studies performed for biopharmaceutical companies of all sizes turn QPS into the first choice for most research needs. Validated transgenic and non-transgenic in vitro and in vivo models cover most targets of AD, PD, HD and other neurodegenerative diseases.

The clinical research team ensures an efficient development process from First-in-Man (Phase I) up to and including Post-Marketing-Surveillance-Studies (Phase IV). Our customers benefit from the competent teams at QPS Austria, the use of innovative technology as well as scientific and clinical expertise together with a worldwide network.

Recent Publications

  • Hepatic and neuronal phenotype of NPC1−/− mice. Santiago-Mujica E, Flunkert S, Rabl R, Neddens J, Loeffler T, Hutter-Paier B. Heliyon. 2019 Mar 14;5(3):e01293. doi: 10.1016/j.heliyon.2019.e01293
  • Phosphorylation of different tau sites during progression of Alzheimer’s disease. Neddens J, Temmel M, Flunkert S, Kerschbaumer B, Hoeller C, Loeffler T, Niederkofler V, Daum G, Attems J, Hutter-Paier B. Acta Neuropathol Commun. 2018 Jun 29;6(1):52. doi: 10.1186/s40478-018-0557-6.
  • mTh1 driven expression of hTDP-43 results in typical ALS/FTLD neuropathological symptoms. Scherz B, Rabl R, Flunkert S, Rohler S, Neddens J, Taub N, Temmel M, Panzenboeck U, Niederkofler V, Zimmermann R, Hutter-Paier B. PLOS ONE. 2018 May 22;13(5):e0197674. doi: 10.1371/journal.pone.0197674.
  • SEN1500, a novel oral amyloid-β aggregation inhibitor, attenuates brain pathology in a mouse model of Alzheimer’s disease. Brunner D, Flunkert S, Neddens J, Duller S, Scopes DIC, Treherne JM, Hutter-Paier B. Neurosci Lett. 2017 Sep 13. pii: S0304-3940(17)30770-X. doi: 10.1016/j.neulet.2017.09.028.
Show less

Certifications & Qualifications

AAALAC GLP

Diversity Certificates

Small business

Our Services (105)


ic

Biomarker Assay Development

Price on request

QPS Austria’s expertise lies within the field of neurodegenerative diseases. We provide a state of the art research environment (AAALAC certified) for testing and evaluating new potential treatment approaches. Besides offering a broad spectrum of transgenic models and applications, we offer the establishment of new and... Show more »

QPS Austria’s expertise lies within the field of neurodegenerative diseases. We provide a state of the art research environment (AAALAC certified) for testing and evaluating new potential treatment approaches. Besides offering a broad spectrum of transgenic models and applications, we offer the establishment of new and customized assays that suit your special needs.

Research Fields

  • Alzheimer's Disease
  • Parkinson's Disease
  • Tauopathies
  • Orphan Diseases
  • Lysosomal Storage Diseases
  • Psychiatric Diseases
  • Inflammation

Applications

  • Gene & Protein Expression
  • Enzyme Activity Assays
  • Customized Cloning
  • Cytokine Profile
  • Lipid Profile
  • A4 Assay
Show less
Alzheimers Disease Parkinson's disease (PD) Amyotrophic Lateral Sclerosis (ALS) CNS/Neurology Rare Disease Orphan Diseases Neurodegeneration Gaucher Alport Niemann-Pick Cytokines TAU Synuclein Amyloid SOD1 TDP43 Neurofilament Light Chain (NF-L) Show 17 more tags Show less

ic

Animal Biobanking

Price on request

QPS Austria’s well characterized and validated in vivo and in vitro models are useful tools to push your CNS drug discovery research forward. We are happy to support your research activities with sample material from our biobank composed of various specimen derived from our in-house in vivo and in vitro... Show more »

QPS Austria’s well characterized and validated in vivo and in vitro models are useful tools to push your CNS drug discovery research forward. We are happy to support your research activities with sample material from our biobank composed of various specimen derived from our in-house in vivo and in vitro models.

Various transgenic and non-transgenic in vivo models are readily available on various age groups as well as brain tissue, CSF and plasma samples derived from these animals. In vitro systems e.g. cellular lysates of primary hippocampal neurons and manifold overexpressing cell lines are rapidly available upon request.

Show less
Mouse Mice CNS/Neurology Alzheimers Disease Parkinson's disease (PD) FFPE tissue Blood Frozen Tissue Brain Plasma CSF APP TAU Synuclein Aggregation Show 15 more tags Show less

ic

In vivo Drug Efficacy Testing

Price on request

As a leading CRO for CNS drug development, QPS Austria is the premier provider for services with transgenic animals. The enterprise gained experience in generating, characterizing and maintaining transgenic disease models and using them for drug testing projects for more than 15 years.

The mouse and rat models... Show more »

As a leading CRO for CNS drug development, QPS Austria is the premier provider for services with transgenic animals. The enterprise gained experience in generating, characterizing and maintaining transgenic disease models and using them for drug testing projects for more than 15 years.

The mouse and rat models available for drug development in Alzheimer’s Disease (AD), Parkinson’s Disease (PD), Huntington’s Disease (HD), Niemann-Pick Disease, Amyotrophic Lateral Sclerosis (ALS) , Autism Spectrum Disorder (ASD), Schizophrenia, Frontotemporal Lobar Degeneration (FTLD), and other neurodegenerative diseases allow the quantitative evaluation of compound interactions with amyloid, tau, inflammation related markers, mitochondrial deficiency and other pathologies.

Show less

ic

In vivo PK/PD Studies

Price on request

As a leading CRO for CNS drug development, QPS Austria is the premier provider for services with transgenic animals. The enterprise gained experience in generating, characterizing and maintaining transgenic disease models and using them for drug testing projects for more than 15 years.

The mouse and rat models... Show more »

As a leading CRO for CNS drug development, QPS Austria is the premier provider for services with transgenic animals. The enterprise gained experience in generating, characterizing and maintaining transgenic disease models and using them for drug testing projects for more than 15 years.

The mouse and rat models available for drug development in Alzheimer’s Disease (AD), Parkinson’s Disease (PD), Huntington’s Disease (HD), Niemann-Pick Disease, Amyotrophic Lateral Sclerosis (ALS) , Autism Spectrum Disorder (ASD), Schizophrenia, Frontotemporal Lobar Degeneration (FTLD), and other neurodegenerative diseases allow the quantitative evaluation of compound interactions with amyloid, tau, inflammation related markers, mitochondrial deficiency and other pathologies.

Show less
Mouse Rat PK/PD PK pharmacokinetics pharmacodynamics in vivo pharmacology models Show 7 more tags Show less

ic

In vitro Inflammation Models

Price on request

Chronic neuroinflammation includes not only long-standing activation of microglia and subsequent sustained release of inflammatory mediators, but also the resulting increased oxidative and nitrosative stress.

LPS-stimulated organotypic hippocampal slices provide an optimal tool to investigate the impact of developmental... Show more »

Chronic neuroinflammation includes not only long-standing activation of microglia and subsequent sustained release of inflammatory mediators, but also the resulting increased oxidative and nitrosative stress.

LPS-stimulated organotypic hippocampal slices provide an optimal tool to investigate the impact of developmental compounds on inflammasome activation in vitro.
By maintaining the three-dimensional structure and interplay of different cell types of the postnatal brain, this system closely resembles the in vivo situation while offering several advantages for early screenings:

  • Take supernatant samples anytime
  • Test new compounds without the challenge of BBB permeability
  • Semi high through-put
  • Dexamethasone can serve as reference compound
Show less
Neuroinflammation Murine Microglia Organotypic Brain Slices Hippocampal Slices Cytokines caspase Inflammasome NLRP3 IL-1ß Show 9 more tags Show less

ic

Animal Models and Studies

Price on request

QPS offers mouse and rat models for drug development in Alzheimer’s Disease (AD), Parkinson’s Disease (PD), Huntington’s Disease (HD), Niemann-Pick Disease, Amyotrophic Lateral Sclerosis (ALS) , Autism Spectrum Disorder (ASD), Schizophrenia, Frontotemporal Lobar Degeneration (FTLD), and other neurodegenerative... Show more »

QPS offers mouse and rat models for drug development in Alzheimer’s Disease (AD), Parkinson’s Disease (PD), Huntington’s Disease (HD), Niemann-Pick Disease, Amyotrophic Lateral Sclerosis (ALS) , Autism Spectrum Disorder (ASD), Schizophrenia, Frontotemporal Lobar Degeneration (FTLD), and other neurodegenerative diseases.


The fully AAALAC accredited Animal Facility provides all in vivo services from mouse and rat breeding to delivering study reports that contain all experimental procedures and their outcome. Animals are housed under SPF conditions in IVC systems with periodic health monitoring. Our approach is based on a sequence of procedural building blocks that allow customization of any service request according to your specific needs. You have the option to select any entry point and exit point in our workflow.

Show less
Mice rats CNS/Neurology Aging Neurodegenerative diseases Parkinson's disease (PD) Dementia Rare Disease psychiatric disorders Orphan Diseases Niemann-Pick Frontotemporal Lobar Degeneration Neuroscience neurobehavioral screening behavioral assay Show 15 more tags Show less

ic

CNS/Neurology Animal Models

Price on request

QPS offers mouse and rat models for drug development in Alzheimer’s Disease (AD), Parkinson’s Disease (PD), Huntington’s Disease (HD), Niemann-Pick Disease, Amyotrophic Lateral Sclerosis (ALS) , Autism Spectrum Disorder (ASD), Schizophrenia, Frontotemporal Lobar Degeneration (FTLD), and other neurodegenerative... Show more »

QPS offers mouse and rat models for drug development in Alzheimer’s Disease (AD), Parkinson’s Disease (PD), Huntington’s Disease (HD), Niemann-Pick Disease, Amyotrophic Lateral Sclerosis (ALS) , Autism Spectrum Disorder (ASD), Schizophrenia, Frontotemporal Lobar Degeneration (FTLD), and other neurodegenerative diseases.


The fully AAALAC accredited Animal Facility provides all in vivo services from mouse and rat breeding to delivering study reports that contain all experimental procedures and their outcome. Animals are housed under SPF conditions in IVC systems with periodic health monitoring. Our approach is based on a sequence of procedural building blocks that allow customization of any service request according to your specific needs. You have the option to select any entry point and exit point in our workflow.

Show less
Mouse Rat rats 6-OHDA lesion model in rats Transgenic CNS/Neurology Aging Neurodegeneration Huntington's Disease Anxiety Alzheimers Disease Multiple sclerosis (MS) Parkinson's disease (PD) Autism Amyotrophic Lateral Sclerosis (ALS) Aging Rare Disease psychiatric disorders cognition Lysosomal Storage Disorders Orphan Diseases MPTP- induced parkinson model lentivirus Mouse LPS sprague dawley rat Rat Model Research models and services catheter rat breeding mouse breeding AAV testing animal model development transgenic animal model Biology Drug Discovery Pharmacology Toxicology Neuroscience APP TAU Show 40 more tags Show less

ic

Animal Behavior Studies

Price on request

QPS Neuropharmacology provides a wide range of behavioral tests for various indications. Most tests are evaluated using rater-independent digital animal tracking systems.

  • General Health & Activity Levels
    • Cylinder Test
    • Glucose Tolerance Test
    • Irwin Test
    • Nest Building... Show more »

QPS Neuropharmacology provides a wide range of behavioral tests for various indications. Most tests are evaluated using rater-independent digital animal tracking systems.

  • General Health & Activity Levels
    • Cylinder Test
    • Glucose Tolerance Test
    • Irwin Test
    • Nest Building Test
    • Open Field Test
  • Cognitive Tests
    • Barnes Maze Test
    • Contextual Fear Conditioning Test
    • Morris Water Maze Test
    • Novel Object Recognition Test
    • Passive and Active Avoidance Test
    • Two Choice Swim Test
    • Y-Maze Test
  • Motor Ability Tests
    • Beam Walk and Challenging Beam Walk Test
    • Grip Strength
    • Pasta Gnawing Test
    • Pole Test
    • Rota Rod Test
    • Wire Hanging Test
  • Anxiety & Depression Tests
    • Elevated Plus Maze
    • Forced Swim Test
    • Marble Burying Test
    • Novelty-Induced Hypophagia (NIH) Test
  • Social Behavior Tests
    • Autogrooming Test
    • The Reeperbahn Test
    • Three Chamber Social Test
  • Lateral Lesion Tests
    • Corner Turn Test
    • Corridor Test
    • Rotation Test

Can’t find what you are looking for? We are constantly establishing new tests and would be glad to develop tests according to your requirements.

Show less
Anxiety Depression Alzheimers Disease Parkinson's disease (PD) Amyotrophic Lateral Sclerosis (ALS) Aging Lysosomal Storage Disorders Orphan Diseases Forced swim test Elevated plus maze Open field Marble burying test Barnes maze rotarod Morris water maze Novel object recognition health Monitoring cognitive decline Animal Movement Analysis cognition and memory Pasta Gnawing Show 21 more tags Show less

ic

Alzheimer's Disease Animal Models

Price on request

QPS offers a variety of transgenic animal models for drug development in Alzheimer’s Disease (AD).

APP Transgenic Mouse Models

  • APPsl
  • APPsl x hQC
  • ApoB-100
  • ApoB x APP
  • 5xFAD
  • TBA2.1
  • Tg4-42... Show more »

QPS offers a variety of transgenic animal models for drug development in Alzheimer’s Disease (AD).

APP Transgenic Mouse Models

  • APPsl
  • APPsl x hQC
  • ApoB-100
  • ApoB x APP
  • 5xFAD
  • TBA2.1
  • Tg4-42 (TBA83)
  • Tg2576

TAU Transgenic Mouse Models

  • TMHT
  • hTau
  • PS19

Scopolamine Treated Mice

Show less
Neurodegenerative diseases Alzheimers Disease CNS/Neurology Neuroinflammation Neurodegeneration Seeding Tau Seeding tau propagation APP TAU Aggregation Amyloid Show 12 more tags Show less

ic

Parkinsons Disease Animal Models

Price on request

QPS Neuropharmacology offers a variety of transgenic and lesioned rodent models for drug development in Parkinson’s disease (PD).

Alpha-Synuclein Transgenic Mouse Models

  • D-Line
  • Line 61
  • Models by MJFF

Lesion Models:

QPS Neuropharmacology offers a variety of transgenic and lesioned rodent models for drug development in Parkinson’s disease (PD).

Alpha-Synuclein Transgenic Mouse Models

  • D-Line
  • Line 61
  • Models by MJFF

Lesion Models:

  • MPTP Mouse Model
  • 6-OHDA Lesion Model

Can’t find what you are looking for? We are constantly searching for new animal models and would be glad to characterize them for your drug development.

Show less
Movement Disorder Neurodegenerative diseases Parkinson's disease (PD) Neurodegeneration MPTP-induced Parkinson's disease model 6-OHDA unilateral 6-OHDA lesion MPTP Lesion model Animal Movement Analysis Synuclein LRRK2 Parkin Show 12 more tags Show less

ic

Inflammation Animal Models

Price on request

Neuroinflammation is a common feature of different neurodegenerative diseases, such as Alzheimer’s disease, Parkinson’s disease, Frontotemporal dementia, Amyotrophic lateral sclerosis and several others. Recent research suggests that targeting neuroinflammation might present a valid method to treat neurodegenerative... Show more »

Neuroinflammation is a common feature of different neurodegenerative diseases, such as Alzheimer’s disease, Parkinson’s disease, Frontotemporal dementia, Amyotrophic lateral sclerosis and several others. Recent research suggests that targeting neuroinflammation might present a valid method to treat neurodegenerative diseases. In order to model neuroinflammation independent from other disease-relevant pathologies, wildtype mice can be peripherally injected with lipopolysaccharide (LPS).

Show less
Neuroinflammation Mouse LPS Cytokines IL-1ß

ic

Neuronal Assays

Price on request

During development, neurons become assembled into functional networks by growing out axons and dendrites (collectively neurite outgrowth) that connect synaptically to other neurons. Strikingly, neurons retain their capacity for growth and synapse formation in the adult brain. Only those neurons that manage to establish adequate... Show more »

During development, neurons become assembled into functional networks by growing out axons and dendrites (collectively neurite outgrowth) that connect synaptically to other neurons. Strikingly, neurons retain their capacity for growth and synapse formation in the adult brain. Only those neurons that manage to establish adequate contacts with neighbor cells escape cell death. To stimulate and accelerate neurite outgrowth is thus important for restoring neuronal function after injury or from neurodegenerative diseases. A promising strategy for drugs targeted against neurodegenerative disorders such as Alzheimer’s and Parkinson’s disease is promoting the regeneration of neurons. Thus, new therapies are focusing on identifying new molecules that affect neurite outgrowth. For this purpose, QPS Austria provides cell culture models to assess the neurotrophic effects of your developmental compounds.

Show less
Neuroscience

ic

Cell and Tissue Culture

Price on request

QPS Austria provides in vitro research services with numerous standardized cell culture systems including transgenic and non-transgenic cell lines, glial cells, primary chicken and rat peripheral and central nervous system neurons of different developmental stages and organotypic brain slices. New models are developed and... Show more »

QPS Austria provides in vitro research services with numerous standardized cell culture systems including transgenic and non-transgenic cell lines, glial cells, primary chicken and rat peripheral and central nervous system neurons of different developmental stages and organotypic brain slices. New models are developed and validated on request.

In our cell culture systems we mimic disease related lesions for Alzheimer’s Disease, Parkinson’s Disease, Huntington’s Disease, Ischemia and other neuro-degenerative events. In addition, we perform assays for drug safety and have several systems available to test secretase modulators and inhibitors.

Send us a request to develop a straightforward strategy to support your development program.

Show less
Human Chicken Mouse Rat CNS/Neurology Neurodegenerative diseases Alzheimers Disease Parkinson's disease (PD) Neuroblastoma Amyotrophic Lateral Sclerosis (ALS) Neuroinflammation Neurodegeneration Primary Cells Cell Culture Supernate Cell lines Primary Neurons Microglia Mouse Embryonic Fibroblasts (MEFs) Astrocytes iPSC Induced Pluripotent Stem Cells Show 21 more tags Show less

ic

Primary Cell Culture

Price on request

QPS Austria offers functional screening of test compounds in a variety of cell culture models including primary neurons from different species. We provide custom tailored cell culture Primary Rat and Mouse Neurons

  • Hippocampal neurons
  • Cortical neurons
  • Dopaminergic neurons from the... Show more »

QPS Austria offers functional screening of test compounds in a variety of cell culture models including primary neurons from different species. We provide custom tailored cell culture Primary Rat and Mouse Neurons

  • Hippocampal neurons
  • Cortical neurons
  • Dopaminergic neurons from the ventral mesencephalon

Postnatal Mouse neurons

  • Cerebellar granule cells

Rat and Murine Glial Cultures

  • Astrocytes
  • Microglia

Embryonic Chicken Neurons

  • Mesencephalic neurons
  • Telencephalic neurons
Show less
Chicken Mouse Rat CNS/Neurology Neurodegenerative diseases Neuroinflammation Primary Neurons Microglia Mouse Embryonic Fibroblasts (MEFs) Astrocytes Cerebellar granule cells Show 11 more tags Show less

ic

Induced Pluripotent Stem Cell (iPSC) Culture

Price on request

QPS Austria offers functional screening of test compounds in a variety of cell culture models including Induced Pluripotent Stem Cells (iPSC).

QPS Austria offers functional screening of test compounds in a variety of cell culture models including Induced Pluripotent Stem Cells (iPSC).

Show less

ic

Cell Lines

Price on request

QPS Austria offers functional screening of test compounds in a variety of cell lines. We provide custom tailored cell culture systems and would be happy to establish or generate novel transgenic cell lines for you.

  • Human or rat neuroblastoma cell lines
  • Human fibroblasts from patients
  • Transgenic... Show more »

QPS Austria offers functional screening of test compounds in a variety of cell lines. We provide custom tailored cell culture systems and would be happy to establish or generate novel transgenic cell lines for you.

  • Human or rat neuroblastoma cell lines
  • Human fibroblasts from patients
  • Transgenic cell lines overexpressing APP, TAU or TDP43
  • and many more
Show less
Human Mouse Rat Alzheimers Disease Parkinson's disease (PD) Amyotrophic Lateral Sclerosis (ALS) CNS/Neurology Cell culture Cell-based assays Cell line engineering Cellular Compound Screening Cell Viability Assays Cell Proliferation Assays cell line generation immortalized cell lines Stable Cell Line Generating Cell Lines Cell Line Characterization Cell Line testing Show 19 more tags Show less

ic

Biochemistry & Molecular Biology

Price on request

QPS Austria’s department of Translational Medicine offers a selection of molecular biological methods for the investigation of various diseases. The unit supports in vitro and in vivo studies performed at QPS Austria. However with the same techniques routine sample analyses from external preclinical or clinical studies is... Show more »

QPS Austria’s department of Translational Medicine offers a selection of molecular biological methods for the investigation of various diseases. The unit supports in vitro and in vivo studies performed at QPS Austria. However with the same techniques routine sample analyses from external preclinical or clinical studies is performed. Using the same methods for cell culture, animal and human samples brings your compound faster forward.

Besides standard techniques for protein quantification and enzyme activity assessment, with colorimetric, fluorescence or luminescence detection, like:

  • Western blotting
  • ELISA
  • Enzymatic assays (e.g. Monoamine Oxidase, Acetyl/Butylcholinesterase activity)

We also offer protein analysis with all kits from the MSD platform (Mesoscale Discovery). By using this multiplex electrochemiluminescence immunosorbent assay technique, low sample volumes can be used to obtain several readouts within one measurement.

If you are interested in gene expression and mRNA analysis, we can also investigate your samples with:

  • Quantitative real-time PCR/gene expression analysis for any gene of interest
  • Standard PCR for any gene of interest

Furthermore, customized assays can be set up and validated, cloning and transfection of cell lines can be performed.

 

Show less
ELISA western blot Western blotting Protein Profiling ELISA Protein Analysis RNA Extraction qRT-PCR Protein Services Protein Expression PCR analysis Meso Scale Discovery MSD protein phosphorylation PCR/Taqman genotyping mRNA Protein Aggregation Serum Blood Plasma cell culture supernatant CSF tissue lysates biomarker Biochemical Assays Show 24 more tags Show less

ic

Immunohistochemistry (IHC)

Price on request

Staining Techniques and Applications

We routinely perform both fluorescent and chromogenic immunostainings. Additionally, we are happy to establish and optimize customized staining protocols for your specific needs.

Our Expertise Includes:

Staining Techniques and Applications

We routinely perform both fluorescent and chromogenic immunostainings. Additionally, we are happy to establish and optimize customized staining protocols for your specific needs.

Our Expertise Includes:

  • Hundreds of established staining protocols
  • Antibody testing and optimization
  • Target validation of viral infections
  • Target validation in transgenic models
  • Compound detection

Multichannel Immunofluorescence

  • 4-channel immunofluorescence plus DAPI labeling of nuclei
  • Numerous validated antibody combinations for mouse, rat and human tissue
Show less
Triple-stain Immunohistochemistry Dual-stain Immunohistochemistry antibody validation immunofluorescence labelling

ic

Special Slide Staining

Price on request

We routinely perform both fluorescent and chromogenic immunostainings as well as general histological stainings and stainings for special applications. Additionally, we are happy to establish and optimize customized staining protocols for your specific needs. Our Expertise Includes:

We routinely perform both fluorescent and chromogenic immunostainings as well as general histological stainings and stainings for special applications. Additionally, we are happy to establish and optimize customized staining protocols for your specific needs. Our Expertise Includes:

  • Hundreds of established staining protocols
  • Antibody testing and optimization
  • Target validation of viral infections
  • Target validation in transgenic models
  • Compound detection

Multichannel Immunofluorescence

  • 3-channel immunofluorescence plus DAPI labeling of nuclei
  • Numerous validated antibody combinations for mouse, rat and human tissue

General stainings

  • Hematoxylin & Eosin (H&E) Staining
  • Cresyl Violet Staining
  • Crystal Violet Staining
  • Luxol Fast Blue Staining
  • Prussian Blue Staining
  • Periodic Acid-Schiff (PAS) Staining
  • Jones' Staining

Protein Aggregation

  • Thioflavin S Staining
  • Campbell Switzer Staining
  • Gallya’s Staining
  • Congo Red Staining

Lipid Staining

  • Congo Red Staining
  • BODIPY 493/503

Silver stainings

  • Campbell Switzer Staining
  • Gallya’s Staining
  • Golgi Cox Staining

Fluorescence stainings

  • Fluoro Jade C
  • BODIPY 493/503 (Fluoreszenz)
  • Thioflavin S Staining

Cyclus Analysis

  • Shorr Staining

 

 

Show less

ic

Animal Learning, Memory, and Behavior Tests

Price on request

QPS Neuropharmacology provides a wide range of cognitive tests. Most tests are evaluated using rater-independent digital animal tracking systems.

  • Barnes Maze Test
  • Contextual Fear Conditioning Test
  • Morris Water Maze Test
  • Novel Object Recognition Test
  • Passive and Active Avoidance... Show more »

QPS Neuropharmacology provides a wide range of cognitive tests. Most tests are evaluated using rater-independent digital animal tracking systems.

  • Barnes Maze Test
  • Contextual Fear Conditioning Test
  • Morris Water Maze Test
  • Novel Object Recognition Test
  • Passive and Active Avoidance Test
  • Two Choice Swim Test
  • Y-Maze Test

Can’t find what you are looking for? We are constantly establishing new tests and would be glad to develop tests according to your requirements.

Show less
Rat Mice Alzheimers Disease Dementia cognition Barnes maze Morris water maze Novel object recognition passive avoidance Contextual Fear Conditioning Two Choice Swim Test Y-Maze Show 12 more tags Show less

ic

Object Recognition Test

Price on request

This two trial test is used to assess memory for interactions with novel objects. Rodents tend to spend more time interacting with a new object rather than with an already known object. Acquisition: after habituation to the test chamber on the first day, the animal is placed in the box and allowed to explore two identical objects... Show more »

This two trial test is used to assess memory for interactions with novel objects. Rodents tend to spend more time interacting with a new object rather than with an already known object. Acquisition: after habituation to the test chamber on the first day, the animal is placed in the box and allowed to explore two identical objects for a set period of time on the second day. Retention: on the third day, the animal is returned to the box where one of the familiar objects has been replaced with a novel object. The time exploring the novel object (relative to the time spent exploring the familiar object) is used as a measure of memory.

Show less

ic

Morris Water Maze Assay

Price on request

The Morris water maze is widely used to study spatial memory and learning. Animals are placed in a pool of water, and have to swim to a hidden escape platform. Each mouse has to perform three trials on each of four consecutive days. After the last trial on day 4, mice have to fulfill a probe trial. During the probe trial, the... Show more »

The Morris water maze is widely used to study spatial memory and learning. Animals are placed in a pool of water, and have to swim to a hidden escape platform. Each mouse has to perform three trials on each of four consecutive days. After the last trial on day 4, mice have to fulfill a probe trial. During the probe trial, the platform is removed from the pool and the number of crossings over the former target position is recorded together with the abidance in this quadrant.

Show less

ic

Barnes Maze Test

Price on request

The Barnes maze is a standard behavioral tool to investigate spatial learning and cognition in rodents.

The test consists of a circular arena with equally distributed holes on its periphery with one hole serving as target zone that is equipped with the animal’s home cage. The animal can use proximal or distal visual cues to... Show more »

The Barnes maze is a standard behavioral tool to investigate spatial learning and cognition in rodents.

The test consists of a circular arena with equally distributed holes on its periphery with one hole serving as target zone that is equipped with the animal’s home cage. The animal can use proximal or distal visual cues to locate and remember the target zone. Automated recordings of consecutive trials provide details on the rodent’s navigation in the arena and thus delivers information about their learning and memory performance.

Show less

ic

Animal Fear Conditioning Studies

Price on request

This test allows the simultaneous assessment of associative learning by simple cues and/or learning by complex stimuli such as context.

Animals are trained and tested on 2 consecutive days. On the training day animals are placed in a chamber and receive a conditioned stimuli / unconditioned stimuli package (tone/foot... Show more »

This test allows the simultaneous assessment of associative learning by simple cues and/or learning by complex stimuli such as context.

Animals are trained and tested on 2 consecutive days. On the training day animals are placed in a chamber and receive a conditioned stimuli / unconditioned stimuli package (tone/foot shock). Contextual memory is tested 24 hours after training. To do so the animal is placed into the same chamber as during the training and freezing behavior is automatically recorded. Cued memory is scored one hour after the contextual test in a novel, modified chamber where the animal receives the auditory cued stimulus and freezing behavior is again automatically recorded.

The time spent freezing during the contextual test and tone-dependent test are defined as index of fear-related learning and memory. Cued and contextual fear conditioning is a task that measures the ability of the animal to learn and remember an association between an aversive experience and environmental cues. All parameters of the test are measured automatically with a tracking system.

Show less
Neurodegenerative diseases cognition behavioral assay

ic

Animal Motor Function and Activity Testing

Price on request

Several customized behavioral tests are offered to phenotype mouse and rat models and evaluate effects of compounds in different in vivo models. New behavioral tests are continuously developed and validated. 

  • Beam Walk and Challenging Beam Walk Test
  • Grip Strength
  • Pasta Gnawing Test
  • Pole Test
  • RotaRod Test
  • Wire Hanging Test

Several customized behavioral tests are offered to phenotype mouse and rat models and evaluate effects of compounds in different in vivo models. New behavioral tests are continuously developed and validated. 

  • Beam Walk and Challenging Beam Walk Test
  • Grip Strength
  • Pasta Gnawing Test
  • Pole Test
  • RotaRod Test
  • Wire Hanging Test
Show less
Movement Disorder Huntington's Disease Parkinson's disease (PD) Amyotrophic Lateral Sclerosis (ALS) rotarod Beam walk Grip strength Wire hanging test Pole test Show 9 more tags Show less

ic

Rotarod Performance Test

Price on request

The Rota Rod apparatus is used to measure motor coordination and balance. The time the animal is able to stay on an accelerating rod is measured automatically.

The Rota Rod apparatus is used to measure motor coordination and balance. The time the animal is able to stay on an accelerating rod is measured automatically.

Show less
Movement Disorder Parkinson's disease (PD) Amyotrophic Lateral Sclerosis (ALS) Niemann-Pick

ic

Animal Anxiety and Depression Tests

Price on request

Several customized behavioral tests are offered to phenotype mouse and rat models and evaluate effects of compounds in different in vivo models. 

  • Elevated Plus Maze
  • Forced Swim Test
  • Marble Burying Test
  • Novelty-Induced Hypophagia (NIH) Test

Can’t find what you are... Show more »

Several customized behavioral tests are offered to phenotype mouse and rat models and evaluate effects of compounds in different in vivo models. 

  • Elevated Plus Maze
  • Forced Swim Test
  • Marble Burying Test
  • Novelty-Induced Hypophagia (NIH) Test

Can’t find what you are looking for? We are constantly establishing new behavioral tests and would be glad to develop new tests according to your requirements.

Show less
Anxiety Depression Schizophrenia Autism psychiatric disorders Forced swim test Elevated plus maze Marble burying test Novelty-Induced Hypophagia (NIH) Test Show 9 more tags Show less

ic

Forced Swim Test

Price on request

The Forced Swim Test is based on the assumption that animals try to escape from an aversive stimulus. The test is used to measure the effect of antidepressant drugs or the genotype on the emotional status of animals.

Animals are placed in a transparent Plexiglas cylinder filled with water during test session. The animal’s... Show more »

The Forced Swim Test is based on the assumption that animals try to escape from an aversive stimulus. The test is used to measure the effect of antidepressant drugs or the genotype on the emotional status of animals.

Animals are placed in a transparent Plexiglas cylinder filled with water during test session. The animal’s behavior is recorded and the duration of immobility as well as struggling and swimming is measured. Increased immobility (floating) is interpreted as a behavioral correlate of negative mood, representing a kind of depression in the animal.

Show less

ic

Elevated Plus Maze Animal Anxiety Test

Price on request

The Elevated Plus Maze (EPM) is currently one of the most frequenty used tests to study anxiety in small rodents.

The test is based on the aversion of rodents to open spaces and height. The EPM apparatus is elevated from the floor. The equipment is a four arm maze with two opposing open arms (lighted arms, without walls) and... Show more »

The Elevated Plus Maze (EPM) is currently one of the most frequenty used tests to study anxiety in small rodents.

The test is based on the aversion of rodents to open spaces and height. The EPM apparatus is elevated from the floor. The equipment is a four arm maze with two opposing open arms (lighted arms, without walls) and two opposing closed arms (sheltered arms, with walls). On the test day, the animal is placed in the center area facing the open arm. The behavior during the test session is recorded, and behavioral parameters such as time spent in the open and in the closed arms, number of visits in the open and closed arms as well as latency to enter the open arm are calculated automatically.

Show less

ic

Animal Social Behavior Test Panel

Price on request

Several customized behavioral tests are offered to phenotype mouse and rat models and evaluate effects of compounds in different in vivo models. Most tests are evaluated using rater-independent digital animal tracking systems.

  • Three Chamber Social Test
  • Autogrooming Test
    The Reeperbahn... Show more »

Several customized behavioral tests are offered to phenotype mouse and rat models and evaluate effects of compounds in different in vivo models. Most tests are evaluated using rater-independent digital animal tracking systems.

  • Three Chamber Social Test
  • Autogrooming Test
    The Reeperbahn Test

Can’t find what you are looking for? We are constantly establishing new tests and would be glad to develop tests according to your requirements!

Show less
Anxiety Depression Autism psychiatric disorders Autogrooming

ic

In vitro Neurodegeneration Models

Price on request

QPS Austria offers functional screening of test compounds in a variety of cell culture models including primary neurons from different species as well as cell lines.

  • Primary Cells
  • Cell Lines
  • Transgenic Cell Lines
  • Organotypic Brain Slices

We provide custom tailored cell... Show more »

QPS Austria offers functional screening of test compounds in a variety of cell culture models including primary neurons from different species as well as cell lines.

  • Primary Cells
  • Cell Lines
  • Transgenic Cell Lines
  • Organotypic Brain Slices

We provide custom tailored cell culture systems and would be happy to establish new primary cell culture systems or generate novel transgenic cell lines for you.

Show less
Alzheimers Disease Parkinson's disease (PD) Amyotrophic Lateral Sclerosis (ALS) Neuroinflammation Neurodegeneration Cell culture immortalized cell lines Stable Cell Line microglia Primary Neurons Mouse Embryonic Fibroblasts (MEFs) Astrocytes Primary Show 13 more tags Show less

ic

Cell Line Generation

Price on request

We provide custom tailored cell culture systems and would be happy to establish new primary cell culture systems or generate novel transgenic cell lines for you.

We provide custom tailored cell culture systems and would be happy to establish new primary cell culture systems or generate novel transgenic cell lines for you.

Show less
stable transfection immortalized cell lines silencing

ic

In vitro Excitotoxicity Models

Price on request

Excitotoxicity is the pathological process by which neurons are damaged and killed by excessive stimulation by neurotransmitters such as glutamate. QPS Austria offers several cellular models comprising primary neurons or transgenic and non-transgenic cell lines to mimic disease related conditions. Cellular models offer the... Show more »

Excitotoxicity is the pathological process by which neurons are damaged and killed by excessive stimulation by neurotransmitters such as glutamate. QPS Austria offers several cellular models comprising primary neurons or transgenic and non-transgenic cell lines to mimic disease related conditions. Cellular models offer the advantage of a controlled environment useful for exploring single pathogenic mechanisms and the proteins involved. Our models are fast and cost-efficient. Customized models are generated gladly on request.

 

Show less

ic

Cell Line Characterization

Price on request
Request a quote for more information about this service.

ic

Mouse Embryonic Fibroblast Generation

Price on request
Request a quote for more information about this service.

ic

Neurogenesis

Price on request

The balance between neurogenesis and cell death plays a critical role not only in the embryonic brain development but also in the maintenance of the adult brain. Alterations in these processes are seen in many neurodegenerative diseases. The hippocampus, a brain area critical for learning and memory, is especially vulnerable to... Show more »

The balance between neurogenesis and cell death plays a critical role not only in the embryonic brain development but also in the maintenance of the adult brain. Alterations in these processes are seen in many neurodegenerative diseases. The hippocampus, a brain area critical for learning and memory, is especially vulnerable to damage at early stages of Alzheimer’s disease (AD). Emerging evidence has indicated that compromised neurogenesis in the adult hippocampus represents an early critical event in the course of AD. For this purpose, QPS Austria provides a cell culture model to assess effects of your developmental compound on neurogenesis of hippocampal neurons.

Show less

ic

Synaptogenesis Studies

Price on request

Synapse formation but especially the synaptic maintenance (synaptogenesis) is critical for neuronal health and disease. Loss of synaptic maintenance is not only restricted to AD. Defects in synaptic maintenance most likely also contribute to the synaptic vulnerability in other neurodegenerative disorders as Huntington’s,... Show more »

Synapse formation but especially the synaptic maintenance (synaptogenesis) is critical for neuronal health and disease. Loss of synaptic maintenance is not only restricted to AD. Defects in synaptic maintenance most likely also contribute to the synaptic vulnerability in other neurodegenerative disorders as Huntington’s, Parkinson’s or Niemann Pick disease. A therapeutic strategy that favors synaptic maintenance may be a beneficial target for many neurodegenerative diseases. For this purpose, QPS Austria provides a cell culture model to assess effects of your developmental compound on synaptogenesis primary hippocampal neurons.

Show less

ic

Functional & Cell Type Specific Assays

Price on request

Cell lines and primary neurons can be exposed to different toxins and examined for mitochondrial activity, oxidatixe stress, cell viability, apoptosis and lipid metabolism.

  • TMRM and Mitotracker assay for mitochondrial activity
  • YO-PRO-1 Iodide for apoptosis
  • Colorimetric assays such as TBARS assay... Show more »

Cell lines and primary neurons can be exposed to different toxins and examined for mitochondrial activity, oxidatixe stress, cell viability, apoptosis and lipid metabolism.

  • TMRM and Mitotracker assay for mitochondrial activity
  • YO-PRO-1 Iodide for apoptosis
  • Colorimetric assays such as TBARS assay for oxidative stress

Can’t find what you are looking for? We are constantly establishing new methods and would be glad to develop new assays according to your requirements.

Show less
Pathway analysis Mitochondrial assay cellular pathway

ic

Cytotoxicity Assays

Price on request

Cell lines and primary neurons can be exposed to different toxins and examined for cell viability and apoptosis.

  • LDH assay
  • MTT assay
  • YO-PRO™-1 Iodide assay
  • Caspase assay
  • Propidium Iodide (PI) assay

Can’t find what you are looking for? We are constantly... Show more »

Cell lines and primary neurons can be exposed to different toxins and examined for cell viability and apoptosis.

  • LDH assay
  • MTT assay
  • YO-PRO™-1 Iodide assay
  • Caspase assay
  • Propidium Iodide (PI) assay

Can’t find what you are looking for? We are constantly establishing new methods and would be glad to develop assays according to your requirements.

Show less
viability testing MTT And MTS Assays Cell Viability Assays In Vitro Viability And Toxicity Assay Apoptosis assay caspase Show 6 more tags Show less

ic

Mitochondrial Toxicity Studies

Price on request

A reduction in mitochondrial activity has been strongly linked with various neurodegenerative diseases. Moreover, several mutations have been characterized that induce age-related mitochondrial malfunction. QPS Austria provides cell culture models that address the effect of compounds on mitochondrial activity and mitochondria... Show more »

A reduction in mitochondrial activity has been strongly linked with various neurodegenerative diseases. Moreover, several mutations have been characterized that induce age-related mitochondrial malfunction. QPS Austria provides cell culture models that address the effect of compounds on mitochondrial activity and mitochondria related cell death in vitro.

Cell lines and primary neurons can be exposed to different toxins and examined for mitochondrial activity and mitochondrial membrane depolarization.

  • Mitochondrial Activity (MitoTracker)
  • TMRM assay
Show less

ic

Animal Model Housing and Maintenance

Price on request

As a leading CRO for CNS drug development, QPS Austria is the premier provider for services with transgenic animals. The enterprise gained experience in generating, characterizing and maintaining transgenic disease models and using them for drug testing projects for more than 15 years.

The fully AAALAC accredited... Show more »

As a leading CRO for CNS drug development, QPS Austria is the premier provider for services with transgenic animals. The enterprise gained experience in generating, characterizing and maintaining transgenic disease models and using them for drug testing projects for more than 15 years.

The fully AAALAC accredited Animal Facility provides all in vivo services from mouse and rat breeding to delivering study reports that contain all experimental procedures and their outcome. Animals are housed under SPF conditions in IVC systems with periodic health monitoring. Our approach is based on a sequence of procedural building blocks that allow customization of any service request according to your specific needs. You have the option to select any entry point and exit point in our workflow.

Take advantage of the large assortment of rodent strains available at QPS Neuropharmacology, provide your own animals or arrange an external shipment to the QPS animal facility. Beside breeding we also offer aging of animals, treatments, implantations, in vivo tissue collection, behavioral tests and tissue sampling. In order to maximize the information gained per tissue sample, we also offer histological and biochemical analyses of parts of the same animal through the QPS TLM and Histology department. 

We provide fast in-house processing by experienced and well-trained staff, and work with highly reliable shipping companies to guarantee safe transfer of your valuable animals and samples.

We are happy to receive any inquiry to elaborate the most efficient way, including behavioral, immunohistochemical, biochemical and molecular biological techniques, for the support of your drug development approach.

Show less
Alzheimers Disease Parkinson's disease (PD) Amyotrophic Lateral Sclerosis (ALS) Lysosomal Storage Disorders Orphan Diseases

ic

Rodent Breeding

Price on request

Just discuss your needs with us, and we take care of your mice and rat breeding needs. Ship your own rodent model to us or decide for one of our life stock rodent models. Upon request we breed as many rodents as needed for your experiments. Once breeding is completed animals can be aged in house as long as demanded. Afterwards,... Show more »

Just discuss your needs with us, and we take care of your mice and rat breeding needs. Ship your own rodent model to us or decide for one of our life stock rodent models. Upon request we breed as many rodents as needed for your experiments. Once breeding is completed animals can be aged in house as long as demanded. Afterwards, animals can either be shipped to you or can be used in-house for studies according to your study needs.

Animal breeding and maintenance is performed by our trained animal keepers. Health monitoring is continuously performed by our in-house veterinarian.

Show less

ic

Animal Surgery

Price on request

Our expertise covers a wide range of surgery techniques in mice and rats that include the following (but are not limited to them):

  • Implantation of osmotic pumps
  • Catheterization
  • Stereotactic injections into hippocampus, cortex, ventricle, striatum or almost any other brain region to... Show more »

Our expertise covers a wide range of surgery techniques in mice and rats that include the following (but are not limited to them):

  • Implantation of osmotic pumps
  • Catheterization
  • Stereotactic injections into hippocampus, cortex, ventricle, striatum or almost any other brain region to inject:
    • Drugs
    • Test items
    • Toxins
    • Viruses (Biosafety level 2)
Show less
Mouse Rat lentivirus osmotic minipump catheterizations catheter Stereotactic Injections adenovirus Show 8 more tags Show less

ic

Animal Blood Collection

Price on request

We routinely perform in vivo blood sampling in mice and rats.

  • Vena mandibularis bleeding
  • Tail vein bleeding
  • Heart puncture (terminal)
  • Tail vein bleeding for immediate glucose measurements

Can’t find what you are looking for? We are constantly establishing new methods... Show more »

We routinely perform in vivo blood sampling in mice and rats.

  • Vena mandibularis bleeding
  • Tail vein bleeding
  • Heart puncture (terminal)
  • Tail vein bleeding for immediate glucose measurements

Can’t find what you are looking for? We are constantly establishing new methods and would be glad to develop new methods according to your requirements.

Show less
Mouse Rat Blood

ic

Transgenic Mouse Services

Price on request

QPS Neuropharmacology is experienced in generating, characterizing and maintaining of transgenic disease models and using them for drug testing projects for more than 15 years. 

The mouse and rat models available for drug development in Alzheimer’s Disease (AD), Parkinson’s Disease (PD),... Show more »

QPS Neuropharmacology is experienced in generating, characterizing and maintaining of transgenic disease models and using them for drug testing projects for more than 15 years. 

The mouse and rat models available for drug development in Alzheimer’s Disease (AD), Parkinson’s Disease (PD), Huntington’s Disease (HD), Niemann-Pick Disease, Gaucher Disease, Amyotrophic Lateral Sclerosis (ALS) , Autism Spectrum Disorder (ASD), Schizophrenia, Frontotemporal Lobar Degeneration (FTLD), and other neurodegenerative diseases allow the quantitative evaluation of compound interactions with amyloid, tau, inflammation related markers, mitochondrial deficiency and other pathologies.

We are happy to receive any inquiry to elaborate the most efficient way, including behavioral, immunohistochemical, biochemical and molecular biological techniques, for the support of your drug development approach.

Our biobank can provide samples (brain tissue, CSF, etc.) of our animal models for analyses in your laboratory.

Show less
Mouse Rat Neurodegenerative diseases Alzheimers Disease Amyotrophic Lateral Sclerosis (ALS) Rare Disease Lysosomal Storage Disorders Orphan Diseases Mucopolysaccharidosis Gaucher Niemann-Pick Show 11 more tags Show less

ic

Genotyping and Gene Expression Assays

Price on request
Request a quote for more information about this service.

ic

Mouse Phenotyping

Price on request

Several customized behavioral tests are offered to phenotype mouse and rat models and evaluate effects of compounds in different in vivo models. 

New behavioral tests are continuously developed and validated.

Several customized behavioral tests are offered to phenotype mouse and rat models and evaluate effects of compounds in different in vivo models. 

New behavioral tests are continuously developed and validated.

Show less

ic

Neurodegeneration Animal Models

Price on request

QPS Neuropharmacology is experienced in generating, characterizing and maintaining of transgenic disease models and using them for drug testing projects for more than 15 years.

The mouse and rat models available for drug development in Alzheimer’s Disease (AD), Parkinson’s Disease (PD), Huntington’s... Show more »

QPS Neuropharmacology is experienced in generating, characterizing and maintaining of transgenic disease models and using them for drug testing projects for more than 15 years.

The mouse and rat models available for drug development in Alzheimer’s Disease (AD), Parkinson’s Disease (PD), Huntington’s Disease (HD), Niemann-Pick Disease, Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Lobar Degeneration (FTLD), allow the quantitative evaluation of compound interactions with amyloid, tau, inflammation related markers, mitochondrial deficiency and other pathologies.

Show less

ic

Cognition and Behavior Animal Models

Price on request

QPS Neuropharmacology is experienced in generating, characterizing and maintaining of transgenic disease models and using them for drug testing projects for more than 15 years.

The mouse and rat models available for drug development in Alzheimer’s Disease (AD), Frontotemporal Lobar Degeneration (FTLD) and other... Show more »

QPS Neuropharmacology is experienced in generating, characterizing and maintaining of transgenic disease models and using them for drug testing projects for more than 15 years.

The mouse and rat models available for drug development in Alzheimer’s Disease (AD), Frontotemporal Lobar Degeneration (FTLD) and other neurodegenerative diseases allow the quantitative evaluation of compound interactions with amyloid, tau, inflammation related markers, mitochondrial deficiency and other pathologies.

We are happy to receive any inquiry to elaborate the most efficient way, including behavioral, immunohistochemical, biochemical and molecular biological techniques, for the support of your drug development approach.

Show less
Alzheimers Disease Dementia cognition Frontotemporal Lobar Degeneration Open field Morris water maze Novel object recognition passive avoidance Contextual Fear Conditioning Two Choice Swim Test Y-Maze Neuroinflammation TAU Amyloid Show 14 more tags Show less

ic

Lesion-Induced CNS Animal Models

Price on request

QPS Austria offers lesion induced animal models for drug efficacy testing.

  • MPTP Mouse Model for Parkinson's Diseases
  • 6-OHDA Lesion Model for Parkinson's Diseases

Can’t find what you are looking for? We are constantly establishing new CNS animal models and would be glad to develop an animal model according to your requirements.

QPS Austria offers lesion induced animal models for drug efficacy testing.

  • MPTP Mouse Model for Parkinson's Diseases
  • 6-OHDA Lesion Model for Parkinson's Diseases

Can’t find what you are looking for? We are constantly establishing new CNS animal models and would be glad to develop an animal model according to your requirements.

Show less
Parkinson's disease (PD) MPTP- induced parkinson model 6-OHDA MPTP Lesion model

ic

Multiple Sclerosis Animal Models

Price on request

The cuprizone mouse model captures several aspects of MS pathology like demyelination / remyelination, cognitive decline, altered activity and motor deficits. The cuprizone model is the most frequently used model among the toxin-induced MS models, which include lysolecithin and ethidium bromide, and is used to study mechanisms... Show more »

The cuprizone mouse model captures several aspects of MS pathology like demyelination / remyelination, cognitive decline, altered activity and motor deficits. The cuprizone model is the most frequently used model among the toxin-induced MS models, which include lysolecithin and ethidium bromide, and is used to study mechanisms of oligodendrocyte turnover, gliosis as well as motor capabilities. This animal model is thus be suitable to assess certain aspects of MS pathology and to test pharmaceutical compounds.

Show less
Multiple sclerosis (MS) cuprizone myelination Myelin Basic Protein

ic

Tissue Embedding

Price on request

Just discuss your needs with us, and we take care of dissecting the target tissue, accurate trimming of the tissue block, fixation and embedding of your tissue samples. Highly standardized default procedures are established, but alternatives can be used upon request. We are experienced working... Show more »

Just discuss your needs with us, and we take care of dissecting the target tissue, accurate trimming of the tissue block, fixation and embedding of your tissue samples. Highly standardized default procedures are established, but alternatives can be used upon request. We are experienced working RNase-free.

Fixation

  • Standard: 4% paraformaldehyde
  • Alternatives: Glutaraldehyde, zinc, picric acid
  • Buffers: PBS, cacodylate, sulfide

Embedding

  • Standard: OCT or paraffin (Sakura, Tissue-Tek TEC)
  • Alternative: Plastic
Show less

ic

Paraffin Embedding

Price on request

Just discuss your needs with us, and we take care of dissecting the target tissue, accurate trimming of the tissue block, fixation and embedding of your tissue samples. Highly standardized default procedures are established, but alternatives can be used upon request. We are experienced working RNase-free.

Fixation

-... Show more »

Just discuss your needs with us, and we take care of dissecting the target tissue, accurate trimming of the tissue block, fixation and embedding of your tissue samples. Highly standardized default procedures are established, but alternatives can be used upon request. We are experienced working RNase-free.

Fixation

  • Standard: 4% paraformaldehyde
  • Alternatives: Glutaraldehyde, zinc, picric acid
  • Buffers: PBS, cacodylate, sulfide

Embedding

  • Standard: OCT or paraffin (Sakura, Tissue-Tek TEC)
  • Alternative: Plastic
Show less

ic

Tissue Sectioning

Price on request

Our expertise covers a wide range of sectioning techniques and tissue collection strategies. We process your samples according to the specific requirements of your project.

Sectioning

  • Sliding microtome (Leica, SM2000R)
  • Cryotome (Leica, CM1950S and CM3050S)
  • Vibrating blade microtome (Leica, VT1000S)
  • Choose any... Show more »

Our expertise covers a wide range of sectioning techniques and tissue collection strategies. We process your samples according to the specific requirements of your project.

Sectioning

  • Sliding microtome (Leica, SM2000R)
  • Cryotome (Leica, CM1950S and CM3050S)
  • Vibrating blade microtome (Leica, VT1000S)
  • Choose any orientation and specify the section thickness

Collecting

  • Specify your collection scheme
  • Systematic uniform random sampling available
    (For explanation see: http://www.stereology.info/sampling/)
  • Free floating sections
  • Sections mounted on slides
  • Choose slides according to your needs
Show less

ic

Immunofluorescence

Price on request

We routinely perform both fluorescent immunostainings as well as general histological stainings. We have established protocols for more than hundred stainings.

Additionally, we are happy to establish and optimize customized staining protocols for your specific needs. Our expertise also includes

We routinely perform both fluorescent immunostainings as well as general histological stainings. We have established protocols for more than hundred stainings.

Additionally, we are happy to establish and optimize customized staining protocols for your specific needs. Our expertise also includes

  • Antibody testing and optimization
  • Target validation of viral infections
  • Target validation in transgenic models
  • Compound detection

Examples for established staining protocols:

  • Neuronal markers (beta-III tubulin, neurofilament, MAP2, tyrosine hydroxylase)‏ 
  • Glial markers (GFAP, CD11b)‏ 
  • Disease related markers (Tau, phosphorylated Tau, signaling molecules, synuclein)‏ -
  • Synaptic proteins (synaptophysin)‏
Show less
CNS/Neurology immunohistochemistry histology Triple-stain Immunohistochemistry Fluorescence in situ Hybridization antibody validation Histology assessment immunofluorescence labelling Show 8 more tags Show less

ic

H&E Staining

Hematoxylin and eosin staining
Price on request

We routinely perform both fluorescent and chromogenic immunostainings as well as general histological stainings and stainings for special applications.

Additionally, we are happy to establish and optimize customized staining protocols for your specific needs.

We routinely perform both fluorescent and chromogenic immunostainings as well as general histological stainings and stainings for special applications.

Additionally, we are happy to establish and optimize customized staining protocols for your specific needs.

Show less

ic

Image Analysis

Price on request

We use sophisticated macro-based software solutions to automatically analyze different features of brain morphology and pathology, e.g. numerical densities of cell somata or axonal fibers, synaptic density, dendritic arborization, area and volume of brain areas or plaques. We are pleased to develop new quantification methods, as... Show more »

We use sophisticated macro-based software solutions to automatically analyze different features of brain morphology and pathology, e.g. numerical densities of cell somata or axonal fibers, synaptic density, dendritic arborization, area and volume of brain areas or plaques. We are pleased to develop new quantification methods, as well as to assess used (feasibility analysis) or ameliorate existing methods (proof of measurement).

Identification and Detection of Labeled Structures

  • Accuracy of detected labeled structures through:
    • Validation of antibodies on knockout tissue whenever possible
    • Appropriate imaging controls
  • Determination and consistent usage of thresholding and filtering parameters throughout the whole study

Analysis of Region and Object Features

We routinely offer a wide variety of automatically generated outcome measures. These include:

  • Total immuno-reactive area
  • Sum or mean fluorescence intensity of immuno-reactive particles
  • Number, size, density and shape of labeled particles
  • Size exclusions and binning of objects
  • Exact morphometric delineation of regions of interest for volume estimation
  • And many more
Show less

ic

Biology

Price on request

QPS Austria’s department of Translational Medicine offers a selection of molecular biological methods for the investigation of various diseases. The unit supports in vitro and in vivo studies performed at QPS Austria. However with the same techniques routine sample analyses from external preclinical or clinical studies is... Show more »

QPS Austria’s department of Translational Medicine offers a selection of molecular biological methods for the investigation of various diseases. The unit supports in vitro and in vivo studies performed at QPS Austria. However with the same techniques routine sample analyses from external preclinical or clinical studies is performed. Using the same methods for cell culture, animal and human samples brings your compound faster forward.

Show less
PCR ELISA western blot Cell-based assays protein quantification RNA Extraction qRT-PCR Protein Services Meso Scale Discovery DNA Isolation protein phosphorylation Protein Aggregation Cytokines TAU Amyloid SOD1 TDP43 Show 17 more tags Show less

ic

Tissue Processing

Price on request

Tissue samples are routinely prepared and fractionized according to established methods.

  • Brain tissue e.g. processed to soluble or insoluble fractions
  • Extraction and purification of DNA/RNA/protein

Tissue samples are routinely prepared and fractionized according to established methods.

  • Brain tissue e.g. processed to soluble or insoluble fractions
  • Extraction and purification of DNA/RNA/protein
Show less

ic

Protein Services

Price on request

Besides standard techniques for protein quantification and enzyme activity assessment, with colorimetric, fluorescence or luminescence detection, like:

  • Western blotting
  • ELISA
  • Enzymatic assays (e.g. Monoamine Oxidase, Acetyl/Butylcholinesterase activity

We also offer protein analysis... Show more »

Besides standard techniques for protein quantification and enzyme activity assessment, with colorimetric, fluorescence or luminescence detection, like:

  • Western blotting
  • ELISA
  • Enzymatic assays (e.g. Monoamine Oxidase, Acetyl/Butylcholinesterase activity

We also offer protein analysis with all kits from the MSD platform (Mesoscale Discovery). By using this multiplex electrochemiluminescence immunosorbent assay technique, low sample volumes can be used to obtain several readouts within one measurement.

  • Inflammation marker/cytokines (TNF-a, IFN-γ, IL,….)
  • Abeta 38, 40, 42
  • (p-)Tau,
  • Synuclein
  • and many more

Additionally also the areas of oxidative stress and lipid metabolism can be investigated in house:

  • Colorimetric assays such as TBARS assay for oxidative stress
  • Assessment of total cholesterol levels in plasma and tissues

Can’t find what you are looking for? We are constantly establishing new methods and would be glad to develop assays according to your requirements.

Show less
ELISA Western blotting quantitative western blot Meso Scale Discovery Blood Frozen Tissue Plasma Tissue Tissue Homogenate CSF Rodent Tissue Show 11 more tags Show less

ic

Protein Quantification

Price on request
Request a quote for more information about this service.

ic

Western Blot

Price on request
  • Synaptic proteins (glutamate receptor 1, NMDA receptors, synaptophysin, drebrin) e.g. from matured hippocampal neurons
  • Tau and phospho-Tau isoforms
  • Abeta peptide profile, Abeta aggregation assays
  • Cell signaling molecules
  • TDP43
  • Synuclein
  • Synaptic proteins (glutamate receptor 1, NMDA receptors, synaptophysin, drebrin) e.g. from matured hippocampal neurons
  • Tau and phospho-Tau isoforms
  • Abeta peptide profile, Abeta aggregation assays
  • Cell signaling molecules
  • TDP43
  • Synuclein
Show less

ic

ELISA

Enzyme-linked immunosorbent assay
Price on request
  • Abeta1-38, Abeta1-40, Abeta1-42, sAPP-alpha, sAPP-beta
  • Tau and phospho Tau profile
  • Signal transduction molecules
  • Inflammation markers (e.g. Prostaglandin E2)
  • Cytokine Profile
  • Abeta1-38, Abeta1-40, Abeta1-42, sAPP-alpha, sAPP-beta
  • Tau and phospho Tau profile
  • Signal transduction molecules
  • Inflammation markers (e.g. Prostaglandin E2)
  • Cytokine Profile
Show less

ic

qRT-PCR

Quantitative reverse transcription polymerase chain reaction
Price on request

If you are interested in gene expression and mRNA analysis, we can investigate your samples with:

  • Quantitative real-time PCR/gene expression analysis for any gene of interest
  • Standard PCR for any gene of interest

Furthermore, customized assays can be set up and validated.

If you are interested in gene expression and mRNA analysis, we can investigate your samples with:

  • Quantitative real-time PCR/gene expression analysis for any gene of interest
  • Standard PCR for any gene of interest

Furthermore, customized assays can be set up and validated.

Show less
Real time qPCR RT-PCR Quantitative Polymerase Chain Reaction mRNA

ic

LC-MS/MS

Liquid chromatography tandem mass spectrometry
Price on request
Request a quote for more information about this service.

ic

Statistical Analysis

Price on request

Statistical Data Analysis

  • Professional statistical data analysis (unbiased and representative) performed by our team of scientists and biostatisticians
  • Conscientious quality checks of measurements and results


Reporting of Experiments and... Show more »

Statistical Data Analysis

  • Professional statistical data analysis (unbiased and representative) performed by our team of scientists and biostatisticians
  • Conscientious quality checks of measurements and results


Reporting of Experiments and Results

At the end of each study our customers receive a full study report including all experimental procedures, qualitative and quantitative assessment of the results, as well a comprehensive statistical analysis. Constant updates throughout the study are provided if desired.

Show less
Data Report Biostatistics Data analysis Data analysis workflow

ic

Cells and Tissues

Price on request

QPS Austria provides in vitro research services with numerous standardized cell culture systems including transgenic and non-transgenic cell lines, glial cells, primary chicken and rat peripheral and central nervous system neurons of different developmental stages and organotypic brain slices. New models are developed and... Show more »

QPS Austria provides in vitro research services with numerous standardized cell culture systems including transgenic and non-transgenic cell lines, glial cells, primary chicken and rat peripheral and central nervous system neurons of different developmental stages and organotypic brain slices. New models are developed and validated on request.

QPS Austria’s department of Translational Medicine offers a selection of molecular biological methods for the investigation of various diseases. The unit supports in vitro and in vivo studies performed at QPS Austria. However with the same techniques routine sample analyses from external preclinical or clinical studies is performed. Using the same methods for cell culture, animal and human samples brings your compound faster forward.

Show less

ic

Genetic Engineering

Price on request

We provide custom tailored cell culture systems and would be happy to generate novel transgenic cell lines for you.

We are experienced in performing in vitro and in vivo assays using lentivirus (LV) or adeno-associated virus (AAV).

We provide custom tailored cell culture systems and would be happy to generate novel transgenic cell lines for you.

We are experienced in performing in vitro and in vivo assays using lentivirus (LV) or adeno-associated virus (AAV).

Show less

ic

In vitro Neurotoxicity Testing

Price on request

QPS Austria provides in vitro research services with numerous standardized cell culture systems including transgenic and non-transgenic cell lines, glial cells, primary chicken and rat peripheral and central nervous system neurons of different developmental stages and organotypic brain slices. New models are developed and... Show more »

QPS Austria provides in vitro research services with numerous standardized cell culture systems including transgenic and non-transgenic cell lines, glial cells, primary chicken and rat peripheral and central nervous system neurons of different developmental stages and organotypic brain slices. New models are developed and validated on request.

In our cell culture systems we mimic disease related lesions for Alzheimer’s Disease, Parkinson’s Disease, Huntington’s Disease, Ischemia and other neuro-degenerative events. In addition, we perform assays for drug safety and have several systems available to test secretase modulators and inhibitors.

Send us a request to develop a straightforward strategy to support your development program.

Show less
Oxidative Stress Neurodegenerative diseases Ischemia CNS/Neurology Neuroinflammation

ic

Cell-Based Assays

Price on request

ell lines and primary neurons can be exposed to different toxins and examined for mitochondrial activity, oxidatixe stress, cell viability and apoptosis

  • TMRM and Mitotracker assay for mitochondrial activity
  • YO-PRO-1 Iodide for apoptosis
  • Colorimetric assays such as TBARS assay for oxidative stress

ell lines and primary neurons can be exposed to different toxins and examined for mitochondrial activity, oxidatixe stress, cell viability and apoptosis

  • TMRM and Mitotracker assay for mitochondrial activity
  • YO-PRO-1 Iodide for apoptosis
  • Colorimetric assays such as TBARS assay for oxidative stress
Show less

ic

Mitochondrial Stress Tests

Price on request

A reduction in mitochondrial activity has been strongly linked with various neurodegenerative diseases. Moreover, several mutations have been characterized that induce age-related mitochondrial malfunction. QPS Austria provides cell culture models that address the effect of compounds on mitochondrial activity and mitochondria... Show more »

A reduction in mitochondrial activity has been strongly linked with various neurodegenerative diseases. Moreover, several mutations have been characterized that induce age-related mitochondrial malfunction. QPS Austria provides cell culture models that address the effect of compounds on mitochondrial activity and mitochondria related cell death in vitro.

Cell lines and primary neurons can be exposed to different toxins and examined for mitochondrial activity and mitochondrial membrane depolarization.

  • Mitochondrial Activity (MitoTracker)
  • TMRM assay
Show less
Mitochondrial assay CNS/Neurology

ic

Apoptosis Assays

Price on request

Cell lines and primary neurons can be exposed to different toxins and examined for apoptosis.

  • YO-PRO™-1 Iodide assay
  • Caspase assay

Can’t find what you are looking for? We are constantly establishing new methods and would be glad to develop assays according to your requirements.

Cell lines and primary neurons can be exposed to different toxins and examined for apoptosis.

  • YO-PRO™-1 Iodide assay
  • Caspase assay

Can’t find what you are looking for? We are constantly establishing new methods and would be glad to develop assays according to your requirements.

Show less

ic

Necrosis Assays

Price on request

Cell lines and primary neurons can be exposed to different toxins and examined for necrosis.

  • LDH assay
  • Propidium Iodide (PI) assay

Can’t find what you are looking for? We are constantly establishing new methods and would be glad to develop assays according to your requirements.

Cell lines and primary neurons can be exposed to different toxins and examined for necrosis.

  • LDH assay
  • Propidium Iodide (PI) assay

Can’t find what you are looking for? We are constantly establishing new methods and would be glad to develop assays according to your requirements.

Show less

ic

LDH Release Assay

Lactate Dehydrogenase Release Assay
Price on request

Cell lines and primary neurons can be exposed to different toxins and examined for cytotoxicity using the LDH assay. Lactate dehydrogenase (LDH) is a stable cytoplasmatic enzyme present in all cells. It is rapidly releasedinto the cell culture supernatant upon damage of the plasma membrane.

Cell lines and primary neurons can be exposed to different toxins and examined for cytotoxicity using the LDH assay. Lactate dehydrogenase (LDH) is a stable cytoplasmatic enzyme present in all cells. It is rapidly releasedinto the cell culture supernatant upon damage of the plasma membrane.

Show less

ic

MTT and MTS Assays

Price on request

Cell lines and primary neurons can be exposed to different toxins and examined for cell viability using the MTT assay. The MTT-assay is based on the metabolicreduction of MTT, a substance with yellow color, to a blue formazan product by mitochondrialdehydrogenases. Only viable cells are able to catalyze this reaction.

 

Cell lines and primary neurons can be exposed to different toxins and examined for cell viability using the MTT assay. The MTT-assay is based on the metabolicreduction of MTT, a substance with yellow color, to a blue formazan product by mitochondrialdehydrogenases. Only viable cells are able to catalyze this reaction.

 

Show less

ic

Animal Models of Disease

Price on request

QPS Neuropharmacology is experienced in generating, characterizing and maintaining of transgenic disease models and using them for drug testing projects for more than 15 years. 

The mouse and rat models available for drug development in Alzheimer’s Disease (AD), Parkinson’s Disease (PD),... Show more »

QPS Neuropharmacology is experienced in generating, characterizing and maintaining of transgenic disease models and using them for drug testing projects for more than 15 years. 

The mouse and rat models available for drug development in Alzheimer’s Disease (AD), Parkinson’s Disease (PD), Huntington’s Disease (HD), Niemann-Pick Disease, Gaucher Disease, Amyotrophic Lateral Sclerosis (ALS) , Autism Spectrum Disorder (ASD), Schizophrenia, Frontotemporal Lobar Degeneration (FTLD), and other neurodegenerative diseases allow the quantitative evaluation of compound interactions with amyloid, tau, inflammation related markers, mitochondrial deficiency and other pathologies.

We are happy to receive any inquiry to elaborate the most efficient way, including behavioral, immunohistochemical, biochemical and molecular biological techniques, for the support of your drug development approach.

Our biobank can provide samples (brain tissue, CSF, etc.) of our animal models for analyses in your laboratory.

Show less
Movement Disorder Huntington's Disease Depression Alzheimers Disease Multiple sclerosis (MS) Schizophrenia Parkinson's disease (PD) Dementia Autism Amyotrophic Lateral Sclerosis (ALS) psychiatric disorders cognition Lysosomal Storage Disorders Neurodegeneration Mucopolysaccharidosis Gaucher Alport Niemann-Pick Neuroscience Show 19 more tags Show less

ic

Rodent Models

Price on request
Request a quote for more information about this service.

ic

Rat Models

Price on request
Request a quote for more information about this service.

ic

Mouse Models

Price on request
Request a quote for more information about this service.

ic

Cognitive, Behavioral, and Psychiatric Animal Models

Price on request

QPS offers mouse and rat models for drug development in Alzheimer’s Disease (AD), Autism Spectrum Disorder (ASD), Schizophrenia, Frontotemporal Lobar Degeneration (FTLD), and other neurodegenerative diseases.

The fully AAALAC accredited Animal Facility provides all in vivo services from mouse and rat breeding to... Show more »

QPS offers mouse and rat models for drug development in Alzheimer’s Disease (AD), Autism Spectrum Disorder (ASD), Schizophrenia, Frontotemporal Lobar Degeneration (FTLD), and other neurodegenerative diseases.

The fully AAALAC accredited Animal Facility provides all in vivo services from mouse and rat breeding to delivering study reports that contain all experimental procedures and their outcome. Animals are housed under SPF conditions in IVC systems with periodic health monitoring. Our approach is based on a sequence of procedural building blocks that allow customization of any service request according to your specific needs. You have the option to select any entry point and exit point in our workflow.

Show less

ic

Animal Model in vivo Analyses

Price on request

QPS Neuropharmacology provides a wide range of behavioral tests for various indications. Most tests are evaluated using rater-independent digital animal tracking systems.

  • General Health & Activity Levels
  • Cognitive Tests
  • Motor Ability Tests
  • Anxiety & Depression... Show more »

QPS Neuropharmacology provides a wide range of behavioral tests for various indications. Most tests are evaluated using rater-independent digital animal tracking systems.

  • General Health & Activity Levels
  • Cognitive Tests
  • Motor Ability Tests
  • Anxiety & Depression Tests
  • Social Behavior Tests
  • Lateral Lesion Tests

Can’t find what you are looking for? We are constantly establishing new tests and would be glad to develop tests according to your requirements.

Show less
health Monitoring animal monitoring Animal Movement Analysis cognition and memory transgenic animal model survival analysis Show 6 more tags Show less

ic

Animal Cognition & Behavior Tests

Price on request

QPS Neuropharmacology provides a wide range of cognitive tests. Most tests are evaluated using rater-independent digital animal tracking systems.

  • Barnes Maze Test
  • Contextual Fear Conditioning Test
  • Morris Water Maze Test
  • Novel Object Recognition Test
  • Passive and Active Avoidance... Show more »

QPS Neuropharmacology provides a wide range of cognitive tests. Most tests are evaluated using rater-independent digital animal tracking systems.

  • Barnes Maze Test
  • Contextual Fear Conditioning Test
  • Morris Water Maze Test
  • Novel Object Recognition Test
  • Passive and Active Avoidance Test
  • Two Choice Swim Test
  • Y-Maze Test

Can’t find what you are looking for? We are constantly establishing new tests and would be glad to develop tests according to your requirements.

Show less
Mouse Rat Mice rats Neurodegenerative diseases Alzheimers Disease Dementia cognition Neurodegeneration Morris water maze Novel object recognition passive avoidance Contextual Fear Conditioning Two Choice Swim Test Y-Maze Show 15 more tags Show less

ic

Animal Motor Function Tests

Price on request

Several customized behavioral tests are offered to phenotype mouse and rat models and evaluate effects of compounds in different in vivo models. New behavioral tests are continuously developed and validated. 

  • Beam Walk and Challenging Beam Walk Test
  • Grip Strength
  • Pasta Gnawing Test
  • Pole Test
  • RotaRod Test
  • Wire Hanging Test

Several customized behavioral tests are offered to phenotype mouse and rat models and evaluate effects of compounds in different in vivo models. New behavioral tests are continuously developed and validated. 

  • Beam Walk and Challenging Beam Walk Test
  • Grip Strength
  • Pasta Gnawing Test
  • Pole Test
  • RotaRod Test
  • Wire Hanging Test
Show less
Movement Disorder Huntington's Disease Parkinson's disease (PD) Amyotrophic Lateral Sclerosis (ALS) Niemann-Pick rotarod Pasta Gnawing Beam walk Grip strength Wire hanging test Show 10 more tags Show less

ic

Animal Social Domain Tests

Price on request

QPS Neuropharmacology provides a wide range of  social domain tests for various indications. Most tests are evaluated using rater-independent digital animal tracking systems.

  • Three Chamber Social Test
  • Autogrooming Test
  • The Reeperbahn Test

Can’t find what you... Show more »

QPS Neuropharmacology provides a wide range of  social domain tests for various indications. Most tests are evaluated using rater-independent digital animal tracking systems.

  • Three Chamber Social Test
  • Autogrooming Test
  • The Reeperbahn Test

Can’t find what you are looking for? We are constantly establishing new tests and would be glad to develop tests according to your requirements!

Show less

ic

Animal Social Behavior Tests

Price on request

QPS Neuropharmacology provides a wide range of  social behavior tests for various indications. Most tests are evaluated using rater-independent digital animal tracking systems.

  • Three Chamber Social Test
  • Autogrooming Test
  • The Reeperbahn Test

QPS Neuropharmacology provides a wide range of  social behavior tests for various indications. Most tests are evaluated using rater-independent digital animal tracking systems.

  • Three Chamber Social Test
  • Autogrooming Test
  • The Reeperbahn Test
Show less

ic

Histological Staining

Price on request

Staining Techniques and Applications

We routinely perform both fluorescent and chromogenic immunostainings as well as general histological stainings and stainings for special applications. Additionally, we are happy to establish and optimize customized staining protocols for your specific... Show more »

Staining Techniques and Applications

We routinely perform both fluorescent and chromogenic immunostainings as well as general histological stainings and stainings for special applications. Additionally, we are happy to establish and optimize customized staining protocols for your specific needs.

Our Expertise Includes:

  • Hundreds of established staining protocols
  • Antibody testing and optimization
  • Target validation of viral infections
  • Target validation in transgenic models
  • Compound detection

Multichannel Immunofluorescence

  • 4-channel immunofluorescence plus DAPI labeling of nuclei
  • Numerous validated antibody combinations for mouse, rat and human tissue

General Stainings

  • Hematoxilin-Eosin
  • Cresyl violet (Nissl)
  • Luxol fast blue
  • … and many more

Special Stainings

  • Thioflavin S or Congo Red (amyloid plaques, tau tangles)
  • Golgi-Cox silver impregnation
  • Prussian Blue (microbleedings)
Show less

ic

Common Histochemical Stains

Price on request

General stainings

  • Hematoxylin & Eosin (H&E) Staining
  • Cresyl Violet Staining
  • Crystal Violet Staining
  • Luxol Fast Blue Staining
  • Prussian Blue Staining
  • Periodic Acid-Schiff (PAS) Staining
  • Jones' Staining

General stainings

  • Hematoxylin & Eosin (H&E) Staining
  • Cresyl Violet Staining
  • Crystal Violet Staining
  • Luxol Fast Blue Staining
  • Prussian Blue Staining
  • Periodic Acid-Schiff (PAS) Staining
  • Jones' Staining
Show less

ic

Immunostaining

Price on request

Staining Techniques and Applications

We routinely perform both fluorescent and chromogenic immunostainings as well as general histological stainings and stainings for special applications. Additionally, we are happy to establish and optimize customized staining protocols for your specific... Show more »

Staining Techniques and Applications

We routinely perform both fluorescent and chromogenic immunostainings as well as general histological stainings and stainings for special applications. Additionally, we are happy to establish and optimize customized staining protocols for your specific needs.

Our Expertise Includes:

  • Hundreds of established staining protocols
  • Antibody testing and optimization
  • Target validation of viral infections
  • Target validation in transgenic models
  • Compound detection


Multichannel Immunofluorescence

  • 4-channel immunofluorescence plus DAPI labeling of nuclei
  • Numerous validated antibody combinations for mouse, rat and human tissue

 

Show less
immunohistochemistry antibody validation

ic

Microscopy

Price on request

Multidimensional Image Acquisition

What we offer:

  • Automated and comprehensive multidimensional image acquisition
  • Mosaic (tiled) high-resolution images for systematic quantifications
  • Up to 5-channel epifluorescence imaging (green, red, infrared, far red, and nuclear dye... Show more »

Multidimensional Image Acquisition

What we offer:

  • Automated and comprehensive multidimensional image acquisition
  • Mosaic (tiled) high-resolution images for systematic quantifications
  • Up to 5-channel epifluorescence imaging (green, red, infrared, far red, and nuclear dye DAPI)
  • Systematic uniform random sampling available
    (For explanation see: http://www.stereology.info/sampling/)

Appropriate Imaging Controls

Autofluorescence is an often times neglected, yet serious problem. Most tissues exhibit a certain level of autofluorescence that might be mistaken as specific staining. The unspecific signal usually increases with age and with the size of neuronal cells; this is therefore a common nuisance in human brain samples.

To control for this phenomenon, we often devote one of the four available fluorescent channels to image the „intrinsic“  fluorescence. Subtraction of this channel from the „labeled“ channels allows for determination of the specific signal deriving from targeted structures.

Show less

ic

Protein Expression Visualization

Price on request
Request a quote for more information about this service.

ic

Toxicology

Price on request
Request a quote for more information about this service.

ic

Pharmacology & Toxicology

Price on request
Request a quote for more information about this service.

ic

Biomarkers

Price on request

QPS Austria’s expertise lies within the field of neurodegenerative diseases. We provide a state of the art research environment (AAALAC certified) for testing and evaluating new potential treatment approaches. Besides offering a broad spectrum of transgenic models and applications, we offer the establishment of new and... Show more »

QPS Austria’s expertise lies within the field of neurodegenerative diseases. We provide a state of the art research environment (AAALAC certified) for testing and evaluating new potential treatment approaches. Besides offering a broad spectrum of transgenic models and applications, we offer the establishment of new and customized assays that suit your special needs.

Research Fields

  • Alzheimer's Disease
  • Parkinson's Disease
  • Tauopathies
  • Orphan Diseases
  • Lysosomal Storage Diseases
  • Psychiatric Diseases
  • Inflammation

Applications

  • Gene & Protein Expression
  • Enzyme Activity Assays
  • Customized Cloning
  • Cytokine Profile
  • Lipid Profile
  • A4 Assay
Show less
Huntington's Disease Neurodegenerative diseases Alzheimers Disease Multiple sclerosis (MS) Parkinson's disease (PD) Dementia Rare Disease Neuroinflammation psychiatric disorders Lysosomal Storage Disorders Orphan Diseases Neurodegeneration Niemann-Pick Neurofilament Light Chain (NF-L) Show 14 more tags Show less

ic

Biospecimens

Price on request

QPS Austria’s well characterized and validated in vivo and in vitro models are useful tools to push your CNS drug discovery research forward. We are happy to support your research activities with sample material from our biobank composed of various specimen derived from our in-house in vivo and in vitro... Show more »

QPS Austria’s well characterized and validated in vivo and in vitro models are useful tools to push your CNS drug discovery research forward. We are happy to support your research activities with sample material from our biobank composed of various specimen derived from our in-house in vivo and in vitro models.

Various transgenic and non-transgenic in vivo models are readily available on various age groups as well as brain tissue, CSF and plasma samples derived from these animals. In vitro systems e.g. cellular lysates of primary hippocampal neurons and manifold overexpressing cell lines are rapidly available upon request.

Show less

ic

Data Services

Price on request

Statistical Data Analysis

  • Professional statistical data analysis (unbiased and representative) performed by our team of scientists and biostatisticians
  • Conscientious quality checks of measurements and results


Reporting of Experiments and... Show more »

Statistical Data Analysis

  • Professional statistical data analysis (unbiased and representative) performed by our team of scientists and biostatisticians
  • Conscientious quality checks of measurements and results


Reporting of Experiments and Results

At the end of each study our customers receive a full study report including all experimental procedures, qualitative and quantitative assessment of the results, as well a comprehensive statistical analysis. Constant updates throughout the study are provided if desired.

Show less
Biostatistics Data analysis

ic

Bioanalysis

Price on request
Request a quote for more information about this service.

ic

In vitro Toxicity Testing

Price on request

QPS Austria provides in vitro research services with numerous standardized cell culture systems including transgenic and non-transgenic cell lines, glial cells, primary chicken and rat peripheral and central nervous system neurons of different developmental stages and organotypic brain slices. New models are developed and... Show more »

QPS Austria provides in vitro research services with numerous standardized cell culture systems including transgenic and non-transgenic cell lines, glial cells, primary chicken and rat peripheral and central nervous system neurons of different developmental stages and organotypic brain slices. New models are developed and validated on request.

In our cell culture systems we mimic disease related lesions for Alzheimer’s Disease, Parkinson’s Disease, Huntington’s Disease, Ischemia and other neuro-degenerative events. In addition, we perform assays for drug safety and have several systems available to test secretase modulators and inhibitors.

Send us a request to develop a straightforward strategy to support your development program.

Show less

ic

Cell Death Assays

Price on request

Cell lines and primary neurons can be exposed to different toxins and examined for cell death.

  • YO-PRO™-1 Iodide assay
  • Caspase assay
  • Propidium Iodide (PI) assay

Can’t find what you are looking for? We are constantly establishing new methods and would be glad to develop assays according to your requirements.

Cell lines and primary neurons can be exposed to different toxins and examined for cell death.

  • YO-PRO™-1 Iodide assay
  • Caspase assay
  • Propidium Iodide (PI) assay

Can’t find what you are looking for? We are constantly establishing new methods and would be glad to develop assays according to your requirements.

Show less
Apoptosis assay Caspase Assay

ic

RT-PCR

Reverse transcription polymerase chain reaction
Price on request

If you are interested in gene expression and mRNA analysis, we can investigate your samples with:

  • Quantitative real-time PCR/gene expression analysis for any gene of interest
  • Standard PCR for any gene of interest

Furthermore, customized assays can be set up and validated.

If you are interested in gene expression and mRNA analysis, we can investigate your samples with:

  • Quantitative real-time PCR/gene expression analysis for any gene of interest
  • Standard PCR for any gene of interest

Furthermore, customized assays can be set up and validated.

Show less
Real time qPCR qRT-PCR RT-PCR real time PCR mRNA

ic

Biospecimen Management and Storage

Price on request

QPS Austria’s well characterized and validated in vivo models are useful tools to push your CNS drug discovery research forward. We are happy to support your research activities with sample material from our biobank composed of various specimen derived from our in-house in vivo models. Tissues of transgenic and... Show more »

QPS Austria’s well characterized and validated in vivo models are useful tools to push your CNS drug discovery research forward. We are happy to support your research activities with sample material from our biobank composed of various specimen derived from our in-house in vivo models. Tissues of transgenic and non-transgenic animals of various age groups are readily available such as brain tissue, CSF and plasma samples.

Show less

ic

Drug Discovery & Development

Price on request

As a leading CRO for CNS drug development, QPS Austria is the premier provider for services with transgenic animals. The enterprise gained experience in generating, characterizing and maintaining transgenic disease models and using them for drug testing projects for more than 15 years.

The mouse and rat models... Show more »

As a leading CRO for CNS drug development, QPS Austria is the premier provider for services with transgenic animals. The enterprise gained experience in generating, characterizing and maintaining transgenic disease models and using them for drug testing projects for more than 15 years.

The mouse and rat models available for drug development in Alzheimer’s Disease (AD), Parkinson’s Disease (PD), Huntington’s Disease (HD), Niemann-Pick Disease, Amyotrophic Lateral Sclerosis (ALS) , Autism Spectrum Disorder (ASD), Schizophrenia, Frontotemporal Lobar Degeneration (FTLD), and other neurodegenerative diseases allow the quantitative evaluation of compound interactions with amyloid, tau, inflammation related markers, mitochondrial deficiency and other pathologies.

Show less

ic

Drug Development

Price on request

As a leading CRO for CNS drug development, QPS Austria is the premier provider for services with transgenic animals. The enterprise gained experience in generating, characterizing and maintaining transgenic disease models and using them for drug testing projects for more than 15 years.

The mouse and rat models... Show more »

As a leading CRO for CNS drug development, QPS Austria is the premier provider for services with transgenic animals. The enterprise gained experience in generating, characterizing and maintaining transgenic disease models and using them for drug testing projects for more than 15 years.

The mouse and rat models available for drug development in Alzheimer’s Disease (AD), Parkinson’s Disease (PD), Huntington’s Disease (HD), Niemann-Pick Disease, Amyotrophic Lateral Sclerosis (ALS) , Autism Spectrum Disorder (ASD), Schizophrenia, Frontotemporal Lobar Degeneration (FTLD), and other neurodegenerative diseases allow the quantitative evaluation of compound interactions with amyloid, tau, inflammation related markers, mitochondrial deficiency and other pathologies.

Show less

ic

Clinical Research

Price on request
Request a quote for more information about this service.

ic

Clinical Laboratory Services

Price on request
Request a quote for more information about this service.

ic

Neuroscience

Price on request

QPS Neuropharmacology is the division of QPS that focuses on preclinical studies in CNS diseases, Orphan Diseases and Mental Disorders. The on-site availability of highly predictive disease models and unparalleled experience with studies performed for biopharmaceutical companies of all sizes makes QPS Neuropharmacology the... Show more »

QPS Neuropharmacology is the division of QPS that focuses on preclinical studies in CNS diseases, Orphan Diseases and Mental Disorders. The on-site availability of highly predictive disease models and unparalleled experience with studies performed for biopharmaceutical companies of all sizes makes QPS Neuropharmacology the first choice for most CNS drug development needs.

Validated transgenic and non-transgenic in vitro and in vivo models cover most targets of Alzheimer’s Disease (AD), Parkinson’s Disease (PD), Amyotrophic Lateral Sclerosis (ALS), Frontotemporal Dementia (FTD), Niemann-Pick Disease, Autism Spectrum Disorder (ASD), Schizophrenia, Lewy Body Dementia (LBD) and other neurodegenerative diseases.

Show less
CNS/Neurology Neurodegenerative diseases Alzheimers Disease Parkinson's disease (PD) Amyotrophic Lateral Sclerosis (ALS) Neuroinflammation cognition Lysosomal Storage Disorders Gaucher Alport Niemann-Pick histology Biochemistry molecular biology behavioral assay animal model development Show 16 more tags Show less

Not finding what you're looking for?

Get info on this provider's capabilities without requesting a quote.
EA

Ewald Auer

Director of Business Development
CH

Christina Hoeller

Business Development Associate
JK

Jan Kehr

CEO of Pronexus
TL

Tina Löffler

Head of In-Vitro Research
JN

Joerg Neddens

Head of Histology
VN

Vera Niederkofler

Head of In-Vivo Research
RR

Roland Rabl

Deputy Head of In-Vivo Research

QPS Austria GmbH has not received any reviews.

QPS Austria GmbH has not received any endorsements.