PureHoney Technologies

PureHoney Technologies is a contract research organization that helps pharmaceutical and biotech discovery teams accelerate drug discovery research by enabling intractable targets. Founded by the original developers of the RapidFire MS instrumentation, PureHoney Tech uses the high-throughput mass spectrometry platform to perform analyses of challenging analytes across a broad range of therapeutic areas.

PureHoney Tech applies mass spectrometry-based screening to a wide range of targets, including those with substrates such as lipids, fatty acids, phospholipids, steroids, prostaglandins, and other compounds not generally amenable to conventional screening techniques. They offer a broad range of early stage services including: enzymology and characterization of targets, custom HTS assay development, hit identification, fragment-based screening, hit validation, SAR screening and in vitro ADME sample screening.

PureHoney Technologies headquarters and screening laboratories are located in Acton, Massachusetts.

Select Publications

• Kheng B Lim, Can C Ozbal, Daniel B Kassel, High-Throughput Mass Spectrometric Cytochrome P450 Inhibition Screening. Methods in molecular biology (Clifton, N.J.) 987:25-50, March 2013. 
  
• Peter T Rye, Lauren E Frick, Can C Ozbal, William A Lamarr, Advances in Label-Free Screening Approaches for Studying Sirtuin-Mediated Deacetylation. Journal of Biomolecular Screening 16(10):1217-26, September 2011.
  
• Peter T Rye, Lauren E Frick, Can C Ozbal, William A Lamarr, Advances in Label-Free Screening Approaches for Studying Histone Acetyltransferases. Journal of Biomolecular Screening 16(10):1186-95, September 2011.
  
• Andrew D Wagner, Janet M Kolb, Can C Ozbal, John J Herbst, Timothy V Olah, Harold N Weller, Tatyana A Zvyaga, Wilson Z Shou, Ultrafast mass spectrometry based bioanalytical method for digoxin supporting an in vitro P‐glycoprotein (P‐gp) inhibition screen. Rapid Communications in Mass Spectrometry 25(9):1231-40, May 2011.
  
• Kheng B Lim, Can C Ozbal, Daniel B Kassel, Development of a High-Throughput Online Solid-Phase Extraction/Tandem Mass Spectrometry Method for Cytochrome P450 Inhibition Screening. Journal of Biomolecular Screening 15(4):447-52, March 2010.