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PureHoney Technologies

Billerica, Massachusetts, US

PureHoney Technologies is a contract research organization that helps pharmaceutical and biotech discovery teams accelerate drug discovery research by enabling intractable targets. Founded by the original developers of the RapidFire MS instrumentation, PureHoney Tech uses the high-throughput mass spectrometry platform to perform analyses of challenging analytes across a broad range of therapeutic areas.

PureHoney Tech applies mass spectrometry-based screening to a wide range of targets, including those with substrates such as lipids, fatty acids, phospholipids, steroids, prostaglandins, and other compounds not generally amenable to conventional screening techniques. They offer a broad range of early stage services including: enzymology and characterization of targets, custom HTS assay development, hit identification, fragment-based screening, hit validation, SAR screening and in vitro ADME sample... Show more »

PureHoney Technologies is a contract research organization that helps pharmaceutical and biotech discovery teams accelerate drug discovery research by enabling intractable targets. Founded by the original developers of the RapidFire MS instrumentation, PureHoney Tech uses the high-throughput mass spectrometry platform to perform analyses of challenging analytes across a broad range of therapeutic areas.

PureHoney Tech applies mass spectrometry-based screening to a wide range of targets, including those with substrates such as lipids, fatty acids, phospholipids, steroids, prostaglandins, and other compounds not generally amenable to conventional screening techniques. They offer a broad range of early stage services including: enzymology and characterization of targets, custom HTS assay development, hit identification, fragment-based screening, hit validation, SAR screening and in vitro ADME sample screening.

PureHoney Technologies headquarters and screening laboratories are located in Acton, Massachusetts.

Select Publications

  • Kheng B Lim, Can C Ozbal, Daniel B Kassel, High-Throughput Mass Spectrometric Cytochrome P450 Inhibition Screening. Methods in molecular biology (Clifton, N.J.) 987:25-50, March 2013. 
  • Peter T Rye, Lauren E Frick, Can C Ozbal, William A Lamarr, Advances in Label-Free Screening Approaches for Studying Sirtuin-Mediated Deacetylation. Journal of Biomolecular Screening 16(10):1217-26, September 2011.
  • Peter T Rye, Lauren E Frick, Can C Ozbal, William A Lamarr, Advances in Label-Free Screening Approaches for Studying Histone Acetyltransferases. Journal of Biomolecular Screening 16(10):1186-95, September 2011.
  • Andrew D Wagner, Janet M Kolb, Can C Ozbal, John J Herbst, Timothy V Olah, Harold N Weller, Tatyana A Zvyaga, Wilson Z Shou, Ultrafast mass spectrometry based bioanalytical method for digoxin supporting an in vitro P‐glycoprotein (P‐gp) inhibition screen. Rapid Communications in Mass Spectrometry 25(9):1231-40, May 2011.
  • Kheng B Lim, Can C Ozbal, Daniel B Kassel, Development of a High-Throughput Online Solid-Phase Extraction/Tandem Mass Spectrometry Method for Cytochrome P450 Inhibition Screening. Journal of Biomolecular Screening 15(4):447-52, March 2010.
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Cell-Based Compound Screening
Price on request

Simply send us your quenched assay plates and we’ll do the rest. We can help develop new assays or use your existing assay to screen your compound libraries quickly, efficiently and inexpensively. The expert scientists at PureHoney Tech will provide you with high-quality, label-free data in a fraction of the time required for most... Show more »

Simply send us your quenched assay plates and we’ll do the rest. We can help develop new assays or use your existing assay to screen your compound libraries quickly, efficiently and inexpensively. The expert scientists at PureHoney Tech will provide you with high-quality, label-free data in a fraction of the time required for most other label-free technologies, getting your project moving through the drug discovery pipeline.

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Fragment Screening
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  • Singleton or compressed library screening
  • Fragment-based screening
  • Singleton or compressed library screening
  • Fragment-based screening
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Mass Spectrometry Method Development
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Method development services for biochemical assays and mass spectrometric analysis.

Method development services for biochemical assays and mass spectrometric analysis.

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Assay Development
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Our scientists have analyzed millions of wells spanning a variety of challenging targets across a broad array of therapeutic areas. We are specialists in label free assay development and screening using native substrates on mass spectrometers. With more than 30 years combined experience, we can help get your investigations done... Show more »

Our scientists have analyzed millions of wells spanning a variety of challenging targets across a broad array of therapeutic areas. We are specialists in label free assay development and screening using native substrates on mass spectrometers. With more than 30 years combined experience, we can help get your investigations done fast and rich with accurate data.

You receive personalized attention and counsel working directly with one of our Ph.D.’s to develop a customized assay solution for your specified target. Mass spectrometry-based screening can be applied to a wide range of targets, including those intractable targets with substrates such as lipids, fatty acids, phospholipids, steroids, prostaglandins, and other compounds not generally amenable to conventional screening techniques.

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RapidFire Mass Spectrometry
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Our drug discovery research services are conducted using the Agilent RapidFire platform. The ability of mass spectrometry to selectively and accurately quantify native analytes directly, without the requirement of antibodies or optically active labels, allows PureHoney Tech to develop new assays for the most challenging of... Show more »

Our drug discovery research services are conducted using the Agilent RapidFire platform. The ability of mass spectrometry to selectively and accurately quantify native analytes directly, without the requirement of antibodies or optically active labels, allows PureHoney Tech to develop new assays for the most challenging of targets. The throughput and capacity of the RapidFire system enables our scientists to provide you dependable mass spectrometry based data with unparalleled turnaround times.

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Agilent RapidFire
HPLC-MS
High Performance Liquid Chromatography Coupled Mass Spectrometry
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Mass Spectrometry
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Spectroscopy
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Experimental Design
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Project Management, Consulting, & Support Services
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Imaging & Spectroscopy
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Liquid Chromatography Coupled Mass Spectrometry Methods
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Pharmacology & Toxicology
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In vitro ADME
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High Throughput Screening (HTS)
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Assay Plates
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Contract Research
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Hit Identification
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Drug Discovery & Development
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Specialty Mass Spectrometry Methods
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Drug Discovery
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2017-10-11 10:14:00 -1000

Net Promoter Score of 10 received for Cell-Based Compound Screening.

Additional Ratings: satisfaction with deliverable: 8, satisfaction with timeliness: 10.
2017-06-20 09:09:17 -1000

Net Promoter Score of 10 received for Cell-Based Compound Screening.

Additional Ratings: satisfaction with deliverable: 9, satisfaction with timeliness: 9.
2017-06-20 09:07:25 -1000

Net Promoter Score of 10 received for Lentivirus production.

Additional Ratings: satisfaction with deliverable: 9, satisfaction with timeliness: 9.
2017-06-08 10:08:06 -1000

Net Promoter Score of 10 received for Cell-Based Compound Screening.

Additional Ratings: satisfaction with deliverable: 9, satisfaction with timeliness: 9.
2017-06-08 10:07:39 -1000

Net Promoter Score of 10 received for Cell-Based Compound Screening.

Additional Ratings: satisfaction with deliverable: 9, satisfaction with timeliness: 9.
2017-06-08 10:07:02 -1000

Net Promoter Score of 10 received for Cell-Based Compound Screening.

Additional Ratings: satisfaction with deliverable: 9, satisfaction with timeliness: 9.
2017-05-24 09:59:45 -1000

Net Promoter Score of 10 received for Cell-Based Compound Screening.

Additional Ratings: satisfaction with deliverable: 9, satisfaction with timeliness: 10.

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