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PTM BIO LLC

Chicago, Illinois, US

PTM BIO provides the researchers the access to the latest mass spectrometry technology (Thermo QE and Fusion) to accelerate your understanding of the molecular basis of biological activities through the application of robust, quantitative, proteomic technologies, and workflows.

Our products and services have been profoundly expediting breakthroughs in the fields of protein post translational modifications (PTMs), epigenetics, drug target screening, and biomarker discovery.

Recent Publications

  • Xiong et al. (2016). A comprehensive catalog of the lysine-acetylation targets in rice (Oryza sativa) based on proteomic analyses. Journal of proteomics.
  • Zhu et al. (2016). Quantitative Analysis of Global Proteome and Lysine Acetylome Reveal the Differential Impacts of VPA and SAHA on HL60 Cells. Scientific reports 6, 19926.
  • He et al. (2016). Global Proteome Analyses of Lysine Acetylation and... Show more »

PTM BIO provides the researchers the access to the latest mass spectrometry technology (Thermo QE and Fusion) to accelerate your understanding of the molecular basis of biological activities through the application of robust, quantitative, proteomic technologies, and workflows.

Our products and services have been profoundly expediting breakthroughs in the fields of protein post translational modifications (PTMs), epigenetics, drug target screening, and biomarker discovery.

Recent Publications

  • Xiong et al. (2016). A comprehensive catalog of the lysine-acetylation targets in rice (Oryza sativa) based on proteomic analyses. Journal of proteomics.
  • Zhu et al. (2016). Quantitative Analysis of Global Proteome and Lysine Acetylome Reveal the Differential Impacts of VPA and SAHA on HL60 Cells. Scientific reports 6, 19926.
  • He et al. (2016). Global Proteome Analyses of Lysine Acetylation and Succinylation Reveal the Widespread Involvement of both Modification in Metabolism in the Embryo of Germinating Rice Seed. Journal of proteome research.
  • Fang et al. (2015). Global analysis of lysine acetylation in strawberry leaves. Frontiers in plant science 6, 739.
  • Kwon et al. (2015). Global analysis of phosphoproteome dynamics in embryonic development of zebrafish (Danio rerio). Proteomics.
  • Colak et al. (2015) Proteomic and biochemical studies of lysine malonylation suggests its malonic aciduria-associated regulatory role in mitochondrial function and fatty acid oxidation.pii: mcp.M115.048850.
  • Nie et al. (2015). Comprehensive profiling of lysine acetylation suggests the widespread function is regulated by protein acetylation in the silkworm, Bombyx mori. Proteomics.
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Biomarker Analysis
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LC-MS/MS
Monoclonal Antibody (mAb) Production
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PTMs and their corresponding effects on protein activity drive protein activities and function. Our understanding in the field of PTMs is largely hindered by the limited availability of high-quality antibodies against specific PTMs. PTMs antibodies are challenging to make and often have the insufficient specificity. Several... Show more »

PTMs and their corresponding effects on protein activity drive protein activities and function. Our understanding in the field of PTMs is largely hindered by the limited availability of high-quality antibodies against specific PTMs. PTMs antibodies are challenging to make and often have the insufficient specificity. Several reason contribute to the difficulty including subtle chemical difference, high-level similarity of sequence surrounding the different modification sites, and interference from unmodified protein sequence.

PTM offers a proprietary custom mouse monoclonal antibody generation service against ALL the PTMs that you can name it. Since 2010, we in-house produced over 250 PTM antibodies. Our custom antibody production service, includes: immunogen design & synthesis, immunization, antibody purification, and validation. Contact our Scientist TODAY to discuss your antibody needs for your PTM project here!

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Histone Modification Analysis
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We provide unbiased mass spectrometry based histone modification screening/quantification in cell or tissue samples.

We provide unbiased mass spectrometry based histone modification screening/quantification in cell or tissue samples.

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Phosphoproteomics
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We apply TiO2 enrichment to select for phosphorylated peptides in native samples. The phosphorylated peptides can be quantified in a single sample or monitored for differential analysis across multiple samples.

We apply TiO2 enrichment to select for phosphorylated peptides in native samples. The phosphorylated peptides can be quantified in a single sample or monitored for differential analysis across multiple samples.

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Quantitative Proteomics
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Quantitative proteomics is a powerful approach to understand global proteomic dynamics in a cell, tissue or organism. We offer quantitative proteomic solutions to meet your diverse needs, utilizing in vivo labeling (SILAC), in vitro labeling (iTRAQ/TMT), and label free technologies. Our high quality datesets help understand the... Show more »

Quantitative proteomics is a powerful approach to understand global proteomic dynamics in a cell, tissue or organism. We offer quantitative proteomic solutions to meet your diverse needs, utilizing in vivo labeling (SILAC), in vitro labeling (iTRAQ/TMT), and label free technologies. Our high quality datesets help understand the underlying molecular mechanisms behind biological processes, disease states, and drug treatment.

This service involves sample digestion with appropriate enzymes prior to LC-MS/MS analysis. Fractionation will be performed if necessary. The resulting MS/MS data are searched against protein sequence databases. This approach maximizes the sequence coverage observed for your proteins.

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Polyclonal Antibody Production
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PTMs and their corresponding effects on protein activity drive protein activities and function. Our understanding in the field of PTMs is largely hindered by the limited availability of high-quality antibodies against specific PTMs. PTMs antibodies are challenging to make and often have the insufficient specificity. Several... Show more »

PTMs and their corresponding effects on protein activity drive protein activities and function. Our understanding in the field of PTMs is largely hindered by the limited availability of high-quality antibodies against specific PTMs. PTMs antibodies are challenging to make and often have the insufficient specificity. Several reason contribute to the difficulty including subtle chemical difference, high-level similarity of sequence surrounding the different modification sites, and interference from unmodified protein sequence.

PTM offers a proprietary custom antibody generation service against ALL the PTMs that you can name it. Since 2010, we in-house produced over 250 PTM antibodies. Our custom antibody production service, includes: immunogen design & synthesis, immunization, antibody purification, and validation. Contact our Scientist TODAY to discuss your antibody needs for your PTM project here!

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Protein Identification
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We provide the best protein ID solution with our high-sensitivity mass spectrometry technology. We help identify a purified protein, proteins in a complex mixture, interacting proteins, and differences between 2 (or more) complex protein mixtures, as well as determine molecular mass for peptides or proteins.

Proteins are... Show more »

We provide the best protein ID solution with our high-sensitivity mass spectrometry technology. We help identify a purified protein, proteins in a complex mixture, interacting proteins, and differences between 2 (or more) complex protein mixtures, as well as determine molecular mass for peptides or proteins.

Proteins are digested with trypsin and the resulting peptides are analyzed by LC-MS/MS. The peptides are fragmented in a mass spectrometer to yield diagnostic MS/MS patterns that can be matched to protein sequence databases via computer algorithms. The sensitivity of this technique is about 0.05ng for a gel sample. Customer-specific methods can be established, developed or advanced by request.

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Proteomics Data Analysis
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Proteomes are highly complex and identifying low abundance proteins could be a challenging issue. We provide MS-based proteomic services to characterize proteins at the whole proteome level. It produces high-quality datasets with extended bioinformatic analysis to aid your quest for novel insights into biological functions.... Show more »

Proteomes are highly complex and identifying low abundance proteins could be a challenging issue. We provide MS-based proteomic services to characterize proteins at the whole proteome level. It produces high-quality datasets with extended bioinformatic analysis to aid your quest for novel insights into biological functions. Customized analyses are available to investigate particular proteome fractions of your interests, such as nuclear proteins, histone proteins, mitochondrial proteins, membrane proteins, and more…

This service involves sample digestion with appropriate enzymes prior to LC-MS/MS analysis. Fractionation will be performed if necessary. The resulting MS/MS data are searched against protein sequence databases. Our approach maximizes the sequence coverage observed for your proteins.

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Antibody Products
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Antibodies targeting specific PTM pathways and histone codes are among the hardest-to-make reagents. Their limited availability has hindered the research of epigenetics for decades. PTM Biolabs is pioneering in the creation of high quality PTM reagents. Our product line represents the world’s largest collection of PTM pan and histone antibodies.

Antibodies targeting specific PTM pathways and histone codes are among the hardest-to-make reagents. Their limited availability has hindered the research of epigenetics for decades. PTM Biolabs is pioneering in the creation of high quality PTM reagents. Our product line represents the world’s largest collection of PTM pan and histone antibodies.

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Post-Translational Modification Analysis
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The analysis of protein post translational modifications (PTMs) is challenging. Regular analysis often leads to incomplete amino acid sequence coverage and insufficient understanding of the crosstalk and selectivity of different PTMs and their impacts on cellular regulatory networks.

Over the years, we have developed highly... Show more »

The analysis of protein post translational modifications (PTMs) is challenging. Regular analysis often leads to incomplete amino acid sequence coverage and insufficient understanding of the crosstalk and selectivity of different PTMs and their impacts on cellular regulatory networks.

Over the years, we have developed highly efficient MS based proteomics technology for system-wide identification and quantification of PTM substrate proteins and mapping their PTM sites. We established the bioinformatics platform for understanding the functional relevance of the PTMs in cellular physiology. This integrated platform has profoundly benefited biomedical and pharmaceutical research, as demonstrated by continuous high profile publications and long-term collaborations with top drug discovery organizations.

The goal of our service is to make our cutting-edge technology accessible to the wider academic and industrial researchers. We are determined to help you achieve discoveries, whether you are seeking an understanding of mode-of-action for a drug candidate, enzyme substrate screening, biomarker discovery, or drug target screening.

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Omics
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Data Services
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Epigenetic Analysis
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Protein Sequencing
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Computational Modeling
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Protein Services
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Biology
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Protein Characterization Services
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Proteomics
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DNA
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Pharmacology & Toxicology
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Therapeutic Monoclonal Antibody (mAb) Development
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Bioanalysis
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Antibody Services
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Biomarkers
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Biochemistry & Molecular Biology
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Nucleic Acid Services
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