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Proteomics/Mass Spec Facility

Rensselaer, New York, US

CFG core laboratories teamed with the UAlbany RNA Institute provide services to the research community on a fee-for-service basis. These services are available to investigators at the University at Albany, other academic institutions, and commercial entities.

The CFG specializes in the identification of individual proteins, characterization of entire protein complexes or biosimilars, global analysis to discover changes in the proteomes of different samples, and RNA modifications. The laboratory also specializes in the development of custom assays for quantitation of specific molecules in complex clinical samples. The technologies above are available as core services. The CFG provides basic laboratory services to hundreds of bioscience researchers at companies, universities, and government agencies around the world, helping them create robust, reliable results quickly and affordably.

We handle projects of any... Show more »

CFG core laboratories teamed with the UAlbany RNA Institute provide services to the research community on a fee-for-service basis. These services are available to investigators at the University at Albany, other academic institutions, and commercial entities.

The CFG specializes in the identification of individual proteins, characterization of entire protein complexes or biosimilars, global analysis to discover changes in the proteomes of different samples, and RNA modifications. The laboratory also specializes in the development of custom assays for quantitation of specific molecules in complex clinical samples. The technologies above are available as core services. The CFG provides basic laboratory services to hundreds of bioscience researchers at companies, universities, and government agencies around the world, helping them create robust, reliable results quickly and affordably.

We handle projects of any size, from single sample analyses to long-term work as collaborators or subcontractors on NIH grants. Each client is assigned a Ph.D.-level scientist to coordinate their project, meeting budget and deadline needs. CFG also has a strategic alliance with Commonwealth Biotechnologies, Inc. for projects that need to meet FDA requirements for submission of data in support of new drug applications.

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Quantitative Analysis of RNA Modifications
Price on request

Ultra-pressure liquid chromatography coupled with tandem mass spectrometry is used to analyze RNA modifications at different stages during cell differentiation or disease progression.There are about 112 modified nucleosides in our database. We can monitor about 40 nucleosides in a single LC-MS/MS run through Waters Xevo TQ-S system.

Ultra-pressure liquid chromatography coupled with tandem mass spectrometry is used to analyze RNA modifications at different stages during cell differentiation or disease progression.There are about 112 modified nucleosides in our database. We can monitor about 40 nucleosides in a single LC-MS/MS run through Waters Xevo TQ-S system.

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Cancer
HPLC
UPLC
LC-MS/MS
neurodegenerative diseases
Drug-Gene Regulation
Central Nervous System
lncRNA
mRNA
miRNA
Intact Mass Analysis
Price on request

Analysis and characterization of intact mass of bio-molecules including protein, RNA, DNA and antibody using an optimized LC-MS workflow based on customized column coupled online with a ESI TOF mass spectrometer. Raw and deconvoluted spectra for the major peaks are provided.

Analysis and characterization of intact mass of bio-molecules including protein, RNA, DNA and antibody using an optimized LC-MS workflow based on customized column coupled online with a ESI TOF mass spectrometer. Raw and deconvoluted spectra for the major peaks are provided.

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Antibodies
Protein
RNA
DNA
Protein Identification
Starting at $180.00 per sample
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Antibody Variant Analysis
Price on request

QTOF instrument is used to determine the intact mass of the antibody followed by sequencing the heavy and light chains of the antibody after deglycosylation. Multiple proteases are used in the procedure so as to obtain a "complete" sequencing coverage. Mascot and Proteinpilot mapping results are provided.
Deliverables:... Show more »

QTOF instrument is used to determine the intact mass of the antibody followed by sequencing the heavy and light chains of the antibody after deglycosylation. Multiple proteases are used in the procedure so as to obtain a "complete" sequencing coverage. Mascot and Proteinpilot mapping results are provided.
Deliverables: amino acid sequences of heavy and light chains; comprehensive report of experiments and analyses.

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Drug discovery
Antibodies
Protein
FPLC
Fast Performance liquid chromatography
Price on request
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milligram
Antibodies
Protein
RNA
DNA
HPLC
High Performance Liquid Chromatography
Starting at $35.00 per hour

Agilent
$35 per hour
$85 per day

Agilent
$35 per hour
$85 per day

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Agilent
Waters
Protein Purification
Starting at $35.00 per hour

Let the Proteomics/Mass Spec group purify your protein using a purification protocol of your choice or one that we develop for you. Protein purification projects are typically completed in two-four weeks depending on services required. Chromatographic services include ion exchange, HIC, size exclusion, affinity tag and RP-HPLC.... Show more »

Let the Proteomics/Mass Spec group purify your protein using a purification protocol of your choice or one that we develop for you. Protein purification projects are typically completed in two-four weeks depending on services required. Chromatographic services include ion exchange, HIC, size exclusion, affinity tag and RP-HPLC. Standard QC assays include SDS-PAGE, western blot, and mass spectrometry.

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Protein AQUA
Price on request

Ultra sensitive quantitation of pg/ml level of protein with trap-and-elute micro-flow LC-MS/MS. The protein quantification is based on isotope dilution LC-MS/MS and Multiple or selective Reaction Monitoring (MRM, SRM) of specific peptides from the protein(s) of interest. This is a well-established approach for quantification of... Show more »

Ultra sensitive quantitation of pg/ml level of protein with trap-and-elute micro-flow LC-MS/MS. The protein quantification is based on isotope dilution LC-MS/MS and Multiple or selective Reaction Monitoring (MRM, SRM) of specific peptides from the protein(s) of interest. This is a well-established approach for quantification of peptides and small molecules, and has now been adapted for absolute quantification of proteins in very complex mixtures.

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AB Sciex QTRAP 6500 system
Shimadzu UHPLC MS/MS Detector
Structure Determination
Starting at $100.00 per sample
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Impurity Analysis
Starting at $200.00 per sample

The combination of LC-UV-MS is used to assay the impurities of compound.

The combination of LC-UV-MS is used to assay the impurities of compound.

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Qtof Mass Spectrometry
High Resolution Mass Spectrometry
Starting at $85.00 per sample
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LC-MS
Liquid Chromatography-Coupled Mass Spectrometry
Starting at $100.00 per sample

Intact protein molecular weight - $100
Protein ID - $180

Intact protein molecular weight - $100
Protein ID - $180

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Isothermal Titration Calorimetry (ITC)
Price on request

The MicroCal VP-ITC (Isothermal Titration Calorimeter) unit directly measures heat evolved or absorbed in liquid samples as a result of mixing precise amounts of reactants. A spinning syringe is utilized for injecting and mixing of reactants. Origin® software is used to analyze the ITC data using fitting models to calculate... Show more »

The MicroCal VP-ITC (Isothermal Titration Calorimeter) unit directly measures heat evolved or absorbed in liquid samples as a result of mixing precise amounts of reactants. A spinning syringe is utilized for injecting and mixing of reactants. Origin® software is used to analyze the ITC data using fitting models to calculate reaction stoichiometry (n), binding constant (KD), enthalpy (ΔH) and entropy (ΔS).

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MicroCal VP-ITC
MALDI TOF MS
Matrix-assisted laser desorption ionization time-of-flight mass spectrometry
Starting at $50.00 per sample
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PAGE
Polyacrylamide Gel Electrophoresis
Starting at $150.00 per sample

IPG Strip

SDS-PAGE Starting at $60/sample

IPG Strip

SDS-PAGE Starting at $60/sample

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MRM/SRM
Multiple Reaction Monitoring/Selected Reaction Monitoring Mass Spectrometry
Starting at $200.00 per run

We used a QTRAP 6500 mass spectrometer coupled with UHPLC for the analysis. The setup fee (parameter optimization) is $200 then $35 per sample injection.

We used a QTRAP 6500 mass spectrometer coupled with UHPLC for the analysis. The setup fee (parameter optimization) is $200 then $35 per sample injection.

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MudPIT Analysis
Multidimensional Protein Identification Technology
Starting at $100.00 per sample

per step

per step

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Peptide mapping
Starting at $75.00 per hour

de novo

de novo

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Protein Digestion
Starting at $100.00 per sample

Enzymatic Digest

Enzymatic Digest

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iTRAQ Protein Labeling
Isobaric Tags for Relative and Absolute Quantitation
Starting at $4,000.00 per sample

4 plex $4000 (> 25 fractions)
8 plex (> 25 fractions)
Phosphoprotein profiling using TiO2

4 plex $4000 (> 25 fractions)
8 plex (> 25 fractions)
Phosphoprotein profiling using TiO2

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Phosphopeptide mapping
Starting at $680.00 per sample

The service includes tryptic digest, TiO2 enrichment, LC-MS/MS analysis for flow through and enriched fraction, and Mascot sequencing mapping.

The service includes tryptic digest, TiO2 enrichment, LC-MS/MS analysis for flow through and enriched fraction, and Mascot sequencing mapping.

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MIDAS
Multiple Reaction Monitoring-Initiated Detection and Sequencing
Starting at $280.00 per sample

Targeted detection and quantitation, also called multiple reaction monitoring-initiated detection and sequencing (MIDAS). Multiple reaction monitoring (MRM) is used as an extremely sensitive MS survey scan for the targeted peptide from a known protein. This is automatically followed by peptide sequencing confirmation. The method... Show more »

Targeted detection and quantitation, also called multiple reaction monitoring-initiated detection and sequencing (MIDAS). Multiple reaction monitoring (MRM) is used as an extremely sensitive MS survey scan for the targeted peptide from a known protein. This is automatically followed by peptide sequencing confirmation. The method is capable of detecting and sequencing peptides at low femtomole levels with high selectivity. The MIDAS workflow is extremely useful for biomarker validation and cellular analysis particularly when a monoclonal antibody is not available or western blot is inclusive. (Molecular &Cellular Proteomics 4:1134–1144, 2005).

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Gel Imaging
Starting at $40.00 per gel
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Gel Staining
Starting at $20.00 per gel

SYPRO Ruby staining

  • Use plastic tray as staining container
  • Rinse the gel 3 times with ddH2O
  • Fix the gel with 10% methanol, 7 % acetic acid, and 83% H2O for 60 min
  • Stain the gel in SYPRO Ruby solution which is at least 10 times the volume of the gel
  • Gently shake for at least 3 hour for maximal sensitivity or... Show more »

SYPRO Ruby staining

  • Use plastic tray as staining container
  • Rinse the gel 3 times with ddH2O
  • Fix the gel with 10% methanol, 7 % acetic acid, and 83% H2O for 60 min
  • Stain the gel in SYPRO Ruby solution which is at least 10 times the volume of the gel
  • Gently shake for at least 3 hour for maximal sensitivity or overnight
  • Wash the gel with 10% methanol, 7 % acetic acid, and 83% H2O for 30-60 minto decrease background fluorescence
  • Wash the gel 3 times - 5 min with ddH2O
  • Acquire gel image under a blue light transilluminator (image can be seen by hand-held UV source)
  • Store the gel in 1-2% acetic acid

Note that use SYPRO Ruby displays difficult to stain glycoproteins and lipoproteins

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Analytical Chemistry Services
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Biochemistry & Molecular Biology
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Specialty Mass Spectrometry Methods
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Liquid Chromatography Coupled Mass Spectrometry Methods
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Biology
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Tandem Mass Spectrometry Methods
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Omics
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Electrophoresis
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Protein Characterization Services
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Other Mass Spectrometry Methods
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Calorimetry
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Spectroscopy
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Physical Analysis Methods
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Nucleic Acid Services
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Chromatography
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MALDI Mass Spectrometry Methods
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Mass Spectrometry
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Protein Sequencing
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Purification Services
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Antibody Services
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Protein Purification and Quantification
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Liquid Chromatography
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Imaging & Spectroscopy
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Nucleic Acid Analysis
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Protein Services
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Proteomics
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Chemistry and Materials
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Gel Electrophoresis
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Protein Quantification
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2017-07-20 19:02:48 +0100

Net Promoter Score of 10 received for LC-MS.

Additional Ratings: satisfaction with deliverable: 10, satisfaction with timeliness: 10.
2017-07-20 19:02:09 +0100

Net Promoter Score of 10 received for LC-MS.

Additional Ratings: satisfaction with deliverable: 10, satisfaction with timeliness: 10.
2017-07-20 18:58:37 +0100

Net Promoter Score of 10 received for HPLC.

Additional Ratings: satisfaction with deliverable: 10, satisfaction with timeliness: 10.
May 8, 2017

Positive review received for LC-MS:

"Dr Lin analyzed and produced the results within 3 days of receiving the sample. His price was competitive and was quick to respond to several questions. We definitely recommend this lab."

2017-02-24 19:02:30 +0000

Net Promoter Score of 7 received for FPLC.

Additional Ratings: satisfaction with deliverable: 7, satisfaction with timeliness: 10.
2017-02-24 19:01:39 +0000

Net Promoter Score of 7 received for HPLC.

Additional Ratings: satisfaction with deliverable: 7, satisfaction with timeliness: 10.
2017-02-24 18:46:12 +0000

Net Promoter Score of 7 received for FPLC.

Additional Ratings: satisfaction with deliverable: 7, satisfaction with timeliness: 10.
November 14, 2016

Positive review received for MALDI TOF MS:

"We have just completed our fist project with Science Exchange Service and Proteomics/Mass from Univ. of Albany. We are completely satisfied! Great support, fast turn-around results, expertise in analysis recommendation and execution. We definitely recommend, and will work again with Proteomics group again. Michael Quintero, MS SMG Prod. Manager/Research Scientist King Industries, Inc."

October 13, 2015

Positive review received for HPLC:

"Absolutely excellent and professional service, friendly staff, will definitely use again."

August 10, 2015

Positive review received for Peptide mapping:

"Quick response, excellent work, very satisfied."

May 4, 2015

Positive review received for High Resolution Mass Spectrometry:

"Qishan is extremely prompt and helpful."

April 20, 2015

Positive review received for High Resolution Mass Spectrometry:

"Qishan is extremely prompt and helpful."

July 17, 2014

Positive review received for HPLC:

"Machine was down but he pulled through anyways"

November 20, 2012

Positive review received for MALDI TOF MS:

"Excellent service all around!"

August 6, 2012

Positive review received for Mass Spectrometry:

"Excellent service and turnaround time"

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