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Proteomics Core

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Indianapolis, Indiana, US

About Proteomics Core

Indiana University School of Medicine Proteomics Core Facility provides protein and proteomic analysis services for protein identification, characterization, and quantification. The Core encourages collaborations that apply the tools of proteomics to cutting-edge biomedical research.

Established in 2001, the... Show more »

Indiana University School of Medicine Proteomics Core Facility provides protein and proteomic analysis services for protein identification, characterization, and quantification. The Core encourages collaborations that apply the tools of proteomics to cutting-edge biomedical research.

Established in 2001, the Core has become a center not only for services but also for collaborative research and development of new technological platforms for proteomic research. The Core is available to Indiana Universities and the wider research community.

Over the years, our facility has worked with many pharmaceutical and biotech companies, and developed a number of SOPs for biomarker discovery, mass spec-based protein assays, and biomarker candidate validation.

Our major platforms are label-free protein quantification for biomarker discovery and multiple-reaction-monitoring (MRM) for protein assays and biomarker validation.

Our goal is to deliver value to our investigators and our community as a world-class proteomics core lab providing services to meet the critical needs of biomedical researchers in life science industries and academia.

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Our Services (31)


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Bioinformatics

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Biomarker Analysis

Price on request

Bone biology: single protein assay for P1NP or P3NP, human, rat, dog

Cardiovascular diseases: multiplexed assay for 12 different apolipoproteins: ApoA1, ApoA2, ApoA4, ApoB100, ApoC1, ApoC2, ApoC3, ApoE, ApoF, ApoM, PON1, PON3

Neuroscience: multiple forms of Abeta peptides: Abeta1-37, Abeta1-39, Abeta1-40, Abeta1-42... Show more »

Bone biology: single protein assay for P1NP or P3NP, human, rat, dog

Cardiovascular diseases: multiplexed assay for 12 different apolipoproteins: ApoA1, ApoA2, ApoA4, ApoB100, ApoC1, ApoC2, ApoC3, ApoE, ApoF, ApoM, PON1, PON3

Neuroscience: multiple forms of Abeta peptides: Abeta1-37, Abeta1-39, Abeta1-40, Abeta1-42

Inflammation: single protein assay for orosomucoid
Toxicity (cardiac): multiplexed assay for FABP3, MYL3, and troponin 1

Alcoholism: multiplexed assay for ADH gamma 1 and gamma 2

Obesity/Diabetes: single assay for active and inactive Ghrelin

Others: vitamin D2/D3 LC/MS/MS-based assays

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Biostatistical Analysis

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Protein Depletion

Starting at $80.00 per sample

GenWay or Sigma columns

GenWay or Sigma columns

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LC-MS

Liquid Chromatography-Coupled Mass Spectrometry
Starting at $120.00 per sample

LC-MS/MS analysis for protein identification for simple protein mixture (e.g., TAP or IP sample) $120/sample

LC-MS/MS analysis for protein identification for complex protein mixture (e.g., subcellular fraction sample) $180/sample

LC-MS/MS analysis for protein identification for simple protein mixture (e.g., TAP or IP sample) $120/sample

LC-MS/MS analysis for protein identification for complex protein mixture (e.g., subcellular fraction sample) $180/sample

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Mass Spectrometry Data Analysis

Price on request

Advanced data analysis (post-translational modification studies, differentiating isoforms, bioinformatics, and biostatistics, etc.)

Advanced data analysis (post-translational modification studies, differentiating isoforms, bioinformatics, and biostatistics, etc.)

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MudPIT Analysis

Multidimensional Protein Identification Technology
Starting at $2,500.00 per sample

MudPIT protein profiling $2,500/sample

MudPIT protein profiling $2,500/sample

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Targeted Mass Spectrometry (MRM/SRM)

Multiple Reaction Monitoring/Selected Reaction Monitoring Mass Spectrometry
Price on request

SRM/MRM for targeted proteomic analysis / assay development (biomarker verification/validation)

SRM/MRM for targeted proteomic analysis / assay development (biomarker verification/validation)

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Post-Translational Modification Analysis

Starting at $1,200.00 per sample

Post-translational modification analysis (up to 3 sites) $1,200/sample

Post-translational modification analysis (up to 3 sites) $1,200/sample

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Protein Identification

Starting at $800.00 per sample

LC/MS-based label-free quantitative protein profiling (including statistical analysis) (for biomarker discovery) $800/sample

LC/MS-based label-free quantitative protein profiling (including statistical analysis) (for biomarker discovery) $800/sample

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iTRAQ Protein Labeling

Isobaric Tags for Relative and Absolute Quantitation
Price on request

ICAT/iTRAQ quantitative proteomic analysis

ICAT/iTRAQ quantitative proteomic analysis

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Bioanalysis

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Liquid Chromatography Coupled Mass Spectrometry Methods

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Biochemistry & Molecular Biology

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Tandem Mass Spectrometry Methods

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Protein Characterization

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Omics

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Protein Services

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Protein Purification

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Spectroscopy

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Biomarkers

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Protein Sequencing

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Mass Spectrometry

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Biology

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Computational Modeling

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Data Services

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Drug Discovery & Development

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Drug Discovery & Development Services

Drug Discovery & Development Services

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Pharmacology & Toxicology

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Biostatistics & Bioinformatics

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Imaging & Spectroscopy

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Proteomics

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Mu Wang

Director

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