1383845848739 3e67cba7e4420916c3fad7cfcc75e16c

Proteomics Core

Belfield, Dublin, IE

Professor Matthias Wilm directs the UCD Conway Proteomics Core, which involves the large scale study of proteins and their modifications that play important roles in the fundamental biology of health and disease. Our instrumentation is capable of covering all aspects of modern proteomic science including quantitative proteomics, protein post-translational modifications and protein-protein interactions. We offer the dedicated strategic support of our team, both on the analytical and bioinformatics side, to enable our research and commercial partners to take full advantage of their results.

Proteomics Core has not listed any services.

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LC-MALDI MS/MS
Liquid Chromatography Matrix assisted laser desorption/ionization tandem mass spectrometry
Price on request

The Mass Spectrometry Resource (MSR) is a state-of-the-art biologic mass spectrometry facility providing access to all the necessary instrumentation for high-throughput, high accuracy protein identification, quantification and characterisation.


Instrumentation:
In terms of equipment, MSR avails of several mass... Show more »

The Mass Spectrometry Resource (MSR) is a state-of-the-art biologic mass spectrometry facility providing access to all the necessary instrumentation for high-throughput, high accuracy protein identification, quantification and characterisation.


Instrumentation:
In terms of equipment, MSR avails of several mass spectrometers in order to be able to cover almost all possible experimental workflows in mass spectrometry-based proteomics. These include:

  • Thermo Fisher Q-Exactive
  • Thermo Fisher Orbitrap
  • Thermo Fisher LTQ ion trap
  • Agilent 6520 Quadrupole-ToF
  • Agilent 6460 Triple Quadrupole
  • ABI 4800 Ultra MALDI/ToF-ToF with CovalX HM2 high-mass range detector
  • Bruker HCTUltra II ETD ion trap.

The AB Sciex 4800 MALDI-Tof/Tof mass spectrometer with a CovalX HM2 high mass-range detector is applied to gel-based and off-line liquid chromatography (LC)-based, high throughput MALDI-MS/MS proteomic workflows or, in linear mode, to accurate determination of the mass of intact proteins or protein complexes up to 1.2 Megadaltons.

The Q-Exactive, LTQ-Orbitrap, the ion traps, the quadrupole time-of-flight and a triple quadrupole mass spectrometers cover all possible needs in liquid-chromatography-tandem mass spectrometry.

Furthermore, the MSR offers access to LC-based workflows supporting the multi-dimensional protein identification technology (MudPIT) and a nano-LC system coupled to a MALDI target loading robot to support off-line LC MALDI-MS.

Software suite
Raw data files generated by each mass spectrometer are subjected to database search with the appropriate algorithm (Mascot, TurboSequest, Spectrum Mill) and database.

« Show less
Agilent 6460
Thermo Fisher Q-Exactive
Thermo Fisher Orbitrap
Thermo Fisher LTQ
Agilent 6520
ABI 4800 Ultra
Bruker HCTUltra II ETD
MALDI TOF-TOF MS
Matrix-assisted laser desorption ionization time-of-flight tandem mass spectrometry
Price on request

The Mass Spectrometry Resource (MSR) is a state-of-the-art biologic mass spectrometry facility providing access to all the necessary instrumentation for high-throughput, high accuracy protein identification, quantification and characterisation.


Instrumentation:
In terms of equipment, MSR avails of several mass... Show more »

The Mass Spectrometry Resource (MSR) is a state-of-the-art biologic mass spectrometry facility providing access to all the necessary instrumentation for high-throughput, high accuracy protein identification, quantification and characterisation.


Instrumentation:
In terms of equipment, MSR avails of several mass spectrometers in order to be able to cover almost all possible experimental workflows in mass spectrometry-based proteomics. These include:

  • Thermo Fisher Q-Exactive
  • Thermo Fisher Orbitrap
  • Thermo Fisher LTQ ion trap
  • Agilent 6520 Quadrupole-ToF
  • Agilent 6460 Triple Quadrupole
  • ABI 4800 Ultra MALDI/ToF-ToF with CovalX HM2 high-mass range detector
  • Bruker HCTUltra II ETD ion trap.

The AB Sciex 4800 MALDI-Tof/Tof mass spectrometer with a CovalX HM2 high mass-range detector is applied to gel-based and off-line liquid chromatography (LC)-based, high throughput MALDI-MS/MS proteomic workflows or, in linear mode, to accurate determination of the mass of intact proteins or protein complexes up to 1.2 Megadaltons.

The Q-Exactive, LTQ-Orbitrap, the ion traps, the quadrupole time-of-flight and a triple quadrupole mass spectrometers cover all possible needs in liquid-chromatography-tandem mass spectrometry.

Furthermore, the MSR offers access to LC-based workflows supporting the multi-dimensional protein identification technology (MudPIT) and a nano-LC system coupled to a MALDI target loading robot to support off-line LC MALDI-MS.

Software suite
Raw data files generated by each mass spectrometer are subjected to database search with the appropriate algorithm (Mascot, TurboSequest, Spectrum Mill) and database.

« Show less
Agilent 6460
Thermo Fisher Q-Exactive
Thermo Fisher Orbitrap
Thermo Fisher LTQ
Agilent 6520
ABI 4800 Ultra
Bruker HCTUltra II ETD
Mass Spectrometry
Price on request

The Mass Spectrometry Resource (MSR) is a state-of-the-art biologic mass spectrometry facility providing access to all the necessary instrumentation for high-throughput, high accuracy protein identification, quantification and characterisation.


Instrumentation:
In terms of equipment, MSR avails of several mass... Show more »

The Mass Spectrometry Resource (MSR) is a state-of-the-art biologic mass spectrometry facility providing access to all the necessary instrumentation for high-throughput, high accuracy protein identification, quantification and characterisation.


Instrumentation:
In terms of equipment, MSR avails of several mass spectrometers in order to be able to cover almost all possible experimental workflows in mass spectrometry-based proteomics. These include:

  • Thermo Fisher Q-Exactive
  • Thermo Fisher Orbitrap
  • Thermo Fisher LTQ ion trap
  • Agilent 6520 Quadrupole-ToF
  • Agilent 6460 Triple Quadrupole
  • ABI 4800 Ultra MALDI/ToF-ToF with CovalX HM2 high-mass range detector
  • Bruker HCTUltra II ETD ion trap.

The AB Sciex 4800 MALDI-Tof/Tof mass spectrometer with a CovalX HM2 high mass-range detector is applied to gel-based and off-line liquid chromatography (LC)-based, high throughput MALDI-MS/MS proteomic workflows or, in linear mode, to accurate determination of the mass of intact proteins or protein complexes up to 1.2 Megadaltons.

The Q-Exactive, LTQ-Orbitrap, the ion traps, the quadrupole time-of-flight and a triple quadrupole mass spectrometers cover all possible needs in liquid-chromatography-tandem mass spectrometry.

Furthermore, the MSR offers access to LC-based workflows supporting the multi-dimensional protein identification technology (MudPIT) and a nano-LC system coupled to a MALDI target loading robot to support off-line LC MALDI-MS.

Software suite
Raw data files generated by each mass spectrometer are subjected to database search with the appropriate algorithm (Mascot, TurboSequest, Spectrum Mill) and database.

« Show less
Agilent 6460
Thermo Fisher Q-Exactive
Thermo Fisher Orbitrap
Thermo Fisher LTQ
Agilent 6520
ABI 4800 Ultra
Bruker HCTUltra II ETD
Protein Digestion
Price on request

The Protein Separations Laboratory (PSL) is a facility dedicated to electrophoretic gel separation of proteins prior to their identification by downstream mass spectrometric analysis, with particular expertise in the running and subsequent analysis of large format 2D-DIGE gels.


Instrumentation:
Full equipment... Show more »

The Protein Separations Laboratory (PSL) is a facility dedicated to electrophoretic gel separation of proteins prior to their identification by downstream mass spectrometric analysis, with particular expertise in the running and subsequent analysis of large format 2D-DIGE gels.


Instrumentation:
Full equipment for protein separation by 2-D gel electrophoresis (2-DE) including
- IPGphorII and IPGphor3
- Ettan Dalt 6 and 12
- BioRad Protean Plus Dodeca cell

Imagers (both visible and fluorescent):
- Typhoon 9410 variable mode imager (for 2D-DIGE)
- BioRad GS800

Image analysis software:
- Progenesis SameSpots v4
- DeCyder v6


Expertise & Services:
The Protein Separations Laboratory provides expertise and full training in two dimensional gel electrophoresis (2D-E)

  • Advice on experimental design for 2D-DIGE
  • Sample preparation for 2-DE and 2D-DIGE (including fluorescent labelling for DIGE)
  • Full training in all aspects of running 2-DE (both mini and large formats)
  • Training on Typhoon variable imager
  • Training on image analysis software and interpretation of results
« Show less
QTOF-MS
Quadrupole Time of Flight Mass Spectrometry
Price on request

The Mass Spectrometry Resource (MSR) is a state-of-the-art biologic mass spectrometry facility providing access to all the necessary instrumentation for high-throughput, high accuracy protein identification, quantification and characterisation.


Instrumentation:
In terms of equipment, MSR avails of several mass... Show more »

The Mass Spectrometry Resource (MSR) is a state-of-the-art biologic mass spectrometry facility providing access to all the necessary instrumentation for high-throughput, high accuracy protein identification, quantification and characterisation.


Instrumentation:
In terms of equipment, MSR avails of several mass spectrometers in order to be able to cover almost all possible experimental workflows in mass spectrometry-based proteomics. These include:

  • Thermo Fisher Q-Exactive
  • Thermo Fisher Orbitrap
  • Thermo Fisher LTQ ion trap
  • Agilent 6520 Quadrupole-ToF
  • Agilent 6460 Triple Quadrupole
  • ABI 4800 Ultra MALDI/ToF-ToF with CovalX HM2 high-mass range detector
  • Bruker HCTUltra II ETD ion trap.

The AB Sciex 4800 MALDI-Tof/Tof mass spectrometer with a CovalX HM2 high mass-range detector is applied to gel-based and off-line liquid chromatography (LC)-based, high throughput MALDI-MS/MS proteomic workflows or, in linear mode, to accurate determination of the mass of intact proteins or protein complexes up to 1.2 Megadaltons.

The Q-Exactive, LTQ-Orbitrap, the ion traps, the quadrupole time-of-flight and a triple quadrupole mass spectrometers cover all possible needs in liquid-chromatography-tandem mass spectrometry.

Furthermore, the MSR offers access to LC-based workflows supporting the multi-dimensional protein identification technology (MudPIT) and a nano-LC system coupled to a MALDI target loading robot to support off-line LC MALDI-MS.

Software suite
Raw data files generated by each mass spectrometer are subjected to database search with the appropriate algorithm (Mascot, TurboSequest, Spectrum Mill) and database.

« Show less
Agilent 6460
Thermo Fisher Q-Exactive
Thermo Fisher Orbitrap
Thermo Fisher LTQ
Agilent 6520
ABI 4800 Ultra
Bruker HCTUltra II ETD
QQQ-MS
Triple Quadrupole Mass Spectrometry
Price on request

The Mass Spectrometry Resource (MSR) is a state-of-the-art biologic mass spectrometry facility providing access to all the necessary instrumentation for high-throughput, high accuracy protein identification, quantification and characterisation.


Instrumentation:
In terms of equipment, MSR avails of several mass... Show more »

The Mass Spectrometry Resource (MSR) is a state-of-the-art biologic mass spectrometry facility providing access to all the necessary instrumentation for high-throughput, high accuracy protein identification, quantification and characterisation.


Instrumentation:
In terms of equipment, MSR avails of several mass spectrometers in order to be able to cover almost all possible experimental workflows in mass spectrometry-based proteomics. These include:

  • Thermo Fisher Q-Exactive
  • Thermo Fisher Orbitrap
  • Thermo Fisher LTQ ion trap
  • Agilent 6520 Quadrupole-ToF
  • Agilent 6460 Triple Quadrupole
  • ABI 4800 Ultra MALDI/ToF-ToF with CovalX HM2 high-mass range detector
  • Bruker HCTUltra II ETD ion trap.

The AB Sciex 4800 MALDI-Tof/Tof mass spectrometer with a CovalX HM2 high mass-range detector is applied to gel-based and off-line liquid chromatography (LC)-based, high throughput MALDI-MS/MS proteomic workflows or, in linear mode, to accurate determination of the mass of intact proteins or protein complexes up to 1.2 Megadaltons.

The Q-Exactive, LTQ-Orbitrap, the ion traps, the quadrupole time-of-flight and a triple quadrupole mass spectrometers cover all possible needs in liquid-chromatography-tandem mass spectrometry.

Furthermore, the MSR offers access to LC-based workflows supporting the multi-dimensional protein identification technology (MudPIT) and a nano-LC system coupled to a MALDI target loading robot to support off-line LC MALDI-MS.

Software suite
Raw data files generated by each mass spectrometer are subjected to database search with the appropriate algorithm (Mascot, TurboSequest, Spectrum Mill) and database.

« Show less
Agilent 6460
Thermo Fisher Q-Exactive
Thermo Fisher Orbitrap
Thermo Fisher LTQ
Agilent 6520
ABI 4800 Ultra
Bruker HCTUltra II ETD
Spectroscopy
Price on request
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Protein Services
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Biology
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Protein Characterization Services
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Imaging & Spectroscopy
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MALDI Mass Spectrometry Methods
Price on request
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Tandem Mass Spectrometry Methods
Price on request
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Liquid Chromatography Coupled Mass Spectrometry Methods
Price on request
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Biochemistry & Molecular Biology
Price on request
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