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Proteome Sciences plc

London, GB

Proteome Sciences plc is a leader in Mass Spectrometry analysis of Proteins, Modified Proteins and Peptides

We are a CRO who specialises in unbiased total proteomic analysis via Mass Spectrometry. We use high sensitivity proprietary mass spectrometers to detect biomarkers across major human diseases and sample types. We report at the protein level and that from various PTM's like glycosylation, phosphorylation, amino acid modifications and others.

Our services deliver a report where we highlight major protein differences between disease and heathy samples, pre- and post- drug treatment etc. When these differences are seen, we can set up SRM assays to measure from 1 to 50 proteins in a single sample via a multiplexed mass spectrometry assay. We would report out either absolute or relative abundances of each of the searched biomarkers in the samples at levels of sensitivity approaching or equal to... Show more »

Proteome Sciences plc is a leader in Mass Spectrometry analysis of Proteins, Modified Proteins and Peptides

We are a CRO who specialises in unbiased total proteomic analysis via Mass Spectrometry. We use high sensitivity proprietary mass spectrometers to detect biomarkers across major human diseases and sample types. We report at the protein level and that from various PTM's like glycosylation, phosphorylation, amino acid modifications and others.

Our services deliver a report where we highlight major protein differences between disease and heathy samples, pre- and post- drug treatment etc. When these differences are seen, we can set up SRM assays to measure from 1 to 50 proteins in a single sample via a multiplexed mass spectrometry assay. We would report out either absolute or relative abundances of each of the searched biomarkers in the samples at levels of sensitivity approaching or equal to ELISA

We run under ISO9000-2008 and GCLP accreditation.
Our proteomics expertise provides complementary and enabling content and insight for our strategic partners to develop more effective, time and cost-efficient healthcare solutions.

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Proteome Sciences plc has not listed any services.

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Tandem Mass Tags
Tandem Mass Tags
Price on request

Tandem Mass Tags (TMT)
We developed and manufacture these tags and sell them via our exclusive reseller Thermo Scientific. We also use them internally for our unbiased protein services. Given our knowledge in this area there is no provider better in providing TMT based mass spectrometric analysis for you. We offer LS/MS2,... Show more »

Tandem Mass Tags (TMT)
We developed and manufacture these tags and sell them via our exclusive reseller Thermo Scientific. We also use them internally for our unbiased protein services. Given our knowledge in this area there is no provider better in providing TMT based mass spectrometric analysis for you. We offer LS/MS2, LC/MS3, SysQuant®, TMTcalibrator™ and targeted SRM and TMT-SRM assays as a service provider. Please see our other Service Details for a more complete description

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Immunoassays
Price on request

Are your Immunoassays delivering the data you need?

Does the ELISA EIA kit you need exist?
Does the kit report the right protein biomarker.
What about serum interferences?
Mono vs polyconal antibodies always avaiallable?
Are the kits or antibodies good as they claim?
Reliability of the commercial source?
Can your... Show more »

Are your Immunoassays delivering the data you need?

Does the ELISA EIA kit you need exist?
Does the kit report the right protein biomarker.
What about serum interferences?
Mono vs polyconal antibodies always avaiallable?
Are the kits or antibodies good as they claim?
Reliability of the commercial source?
Can your immunoassay be multiplexed at the level you need?
Are epitopes the same animal to animal?
Can you reliably cope with translational issues?
Can you say to 100% there is no cross reactivity with the vast proteome?

Consider a total unbiased proteome assay from Proteome Sciences.
We measure and report what is there in your sample, not what you think you might be measuring

« Show less
Biomarker Discovery
Starting at $1,300.00 per sample

Measuring Proteins For Better Medicines

Specialized services to enhance discovery and validation of mechanistic biomarkers in peripheral fluids

Precision Medicine requires close integration between targeted drugs and biomarkers providing early and actionable clinical information. Ideally, such biomarkers are mechanistically... Show more »

Measuring Proteins For Better Medicines

Specialized services to enhance discovery and validation of mechanistic biomarkers in peripheral fluids

Precision Medicine requires close integration between targeted drugs and biomarkers providing early and actionable clinical information. Ideally, such biomarkers are mechanistically related to disease and treatment mechanisms, predictive of outcome and measurable in accessible samples, typically body fluids.

For new biomarker discovery we have two key technologies to improve your chances of finding the most useful proteins in your sample matrix of choice. TMTcalibrator™  combines protein and fluid proteomics to identify tissue proteins with evidenced availability for peripheral detection. If you only have fluid samples, using TMT®MS3 with abundant protein depletion improves quantitative accuracy over other proteomics methods. Irrespective of the analytical method, our suite of bioinformatics tools simplify discovery of new biomarker candidates.

If you already have candidate biomarkers at the protein or peptide level please visit our Assay Development page to learn more about our range of targeted mass spectrometry solutions.

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Phosphoproteomics
Starting at $2,000.00 per sample

Next-Generation Phosphoproteomic Services

SysQuant® delivers actionable knowledge on key biological processes driving disease and response to treatment

Precision Medicine could transform treatment outcomes but requires deeper understanding of disease biology, drug-target interaction and a system-wide view of mechanisms of... Show more »

Next-Generation Phosphoproteomic Services

SysQuant® delivers actionable knowledge on key biological processes driving disease and response to treatment

Precision Medicine could transform treatment outcomes but requires deeper understanding of disease biology, drug-target interaction and a system-wide view of mechanisms of action and resistance. Global phosphoproteomics profiling of tissues and cells can identify new targets and candidate biomarkers for early diagnosis, drug selection and monitoring of treatment outcomes. Combining TMT®10plex labeling with the fastest, most accurate mass spectrometers, SysQuant® provides the most comprehensive analysis of protein activity across regulatory and signaling pathways.

The SysQuant® Global Phosphoproteomic Workflow Offers:

Unbiased survey of cell signaling pathways regulated by phosphorylation
Combined power of TMT®10plex reagents and Orbitrap Fusion Tribrid™ mass spectrometry
~1,000,000 quantitative data points per TMT®10plex
>35,000 proteins and ~40,000 phosphorylation sites*
>8,000 unique protein groups and >12,000 unique phosphorylation sites*
Standardized data outputs in Excel and CSV files
Automated annotation of biological features from GO terms, KEGG, Phosphosite Plus, UniProt & Drugbank
Common protocol for all sample types
Results in 4 weeks (based on 10 sample study)
Optional statistical analysis and biological interpretation packages

*The difference between the number of proteins and unique protein groups reflects redundancy in peptide sequences between protein forms. A peptide that is common to the eight isoforms of tau will be counted 8 times for the number of proteins but only once for the number of unique protein groups. It is now widely considered that typical cells/tissues express between 8 and 10,000 protein groups.

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Clinical Biomarkers
Starting at $500.00 per sample

Now GcLP certified so can handle samples and report absolute and relative biomarker data as part of a clinical trial

Specialized services to enhance discovery and validation of mechanistic biomarkers in peripheral fluids

Precision Medicine requires close integration between targeted drugs and biomarkers providing early and... Show more »

Now GcLP certified so can handle samples and report absolute and relative biomarker data as part of a clinical trial

Specialized services to enhance discovery and validation of mechanistic biomarkers in peripheral fluids

Precision Medicine requires close integration between targeted drugs and biomarkers providing early and actionable clinical information. Ideally, such biomarkers are mechanistically related to disease and treatment mechanisms, predictive of outcome and measurable in accessible samples, typically body fluids.

For new biomarker discovery we have two key technologies to improve your chances of finding the most useful proteins in your sample matrix of choice. TMTcalibrator™  combines protein and fluid proteomics to identify tissue proteins with evidenced availability for peripheral detection. If you only have fluid samples, using TMT®MS3 with abundant protein depletion improves quantitative accuracy over other proteomics methods. Irrespective of the analytical method, our suite of bioinformatics tools simplify discovery of new biomarker candidates.

If you already have candidate biomarkers at the protein or peptide level please visit our Assay Development page to learn more about our range of targeted mass spectrometry solutions.

« Show less
Biomarker Analysis
Starting at $1,300.00 per sample

Measuring Proteins For Better Medicines

Specialized services to enhance discovery and validation of mechanistic biomarkers in peripheral fluids

Precision Medicine requires close integration between targeted drugs and biomarkers providing early and actionable clinical information. Ideally, such biomarkers are mechanistically... Show more »

Measuring Proteins For Better Medicines

Specialized services to enhance discovery and validation of mechanistic biomarkers in peripheral fluids

Precision Medicine requires close integration between targeted drugs and biomarkers providing early and actionable clinical information. Ideally, such biomarkers are mechanistically related to disease and treatment mechanisms, predictive of outcome and measurable in accessible samples, typically body fluids.

For new biomarker discovery we have two key technologies to improve your chances of finding the most useful proteins in your sample matrix of choice. TMTcalibrator™  combines protein and fluid proteomics to identify tissue proteins with evidenced availability for peripheral detection. If you only have fluid samples, using TMT®MS3 with abundant protein depletion improves quantitative accuracy over other proteomics methods. Irrespective of the analytical method, our suite of bioinformatics tools simplify discovery of new biomarker candidates.

If you already have candidate biomarkers at the protein or peptide level please visit our Assay Development page to learn more about our range of targeted mass spectrometry solutions.

TMT®MS2 delivers excellent proteome coverage with quantitative results appropriate for biomarker discovery

TMT®MS2 is the standard method for analyzing cells and tissues when no phosphopeptide enrichment is required. Typically, the TMT®10plex reagents are used to allow multiplexing across study cohorts. A common study reference is included in all TMT®10plexes to allow measurement and removal of batch effects and calculation of expression ratios. Using MS2 fragmentation provides the broadest and deepest analysis of the proteome with excellent precision. For more complex samples such as plasma, or where the highest quantitative accuracy is essential we recommend use of TMT®MS3.

TMT®MS2 data is processed through an integrated bioinformatics pipeline providing data integration and pre-processing (DIANA), statistical analysis (FeaST) and functional analysis (FAT) with outputs suitable for further client-led analysis and presentation to management.

The TMT®MS2 Workflow Offers:

Unbiased survey of regulated biological processes in cell lysates and tissue samples with the highest proteome coverage
Unbiased biomarker discovery in peripheral fluids with the highest coverage
Combined power of TMT®10plex reagents and Orbitrap Fusion™ mass spectrometers
Can be combined with a wide range of sample preparation techniques including fractionation and enrichment strategies
Standardized data outputs in Excel and ‘TSV’ files
Automated annotation of biological features from UniProtKB, Entrez IDs and Reactome
Results in 4 weeks (based on 10 sample study)
Simple report highlighting key biological events and regulated features enriched in the study
Suitable for enhancing drug discovery, biomarker discovery, pre-clinical and clinical diagnostic assay applications

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Drug Development
Price on request

Proteomics Taking you Beyond The Genome

Mapping protein expression and modifications that define biological processes to improve research outcomes

Developing drugs in the post-genomic era faces new challenges to enable faster regulatory approval and development of precision medicine. Proteome Sciences has developed an... Show more »

Proteomics Taking you Beyond The Genome

Mapping protein expression and modifications that define biological processes to improve research outcomes

Developing drugs in the post-genomic era faces new challenges to enable faster regulatory approval and development of precision medicine. Proteome Sciences has developed an analytical proteomic pipeline to provide broad biological context of targets and drug mechanisms based on unbiased analysis of protein expression and phosphorylation (SysQuant®), statistical data modeling (FeaST) and a novel functional analysis tool (FAT). SysQuant® proteomics is the perfect tool to support smarter target discovery and validation, characterization of disease models and determination of complete mechanisms of action.

Protein expression and regulation of pathway activity cannot be inferred from genomic or transcriptomic data but hold the key in understanding how new agents affect their targets and wider disease biology. Our specialized proteomics workflows can be applied across all aspects of drug development to deliver deeper insights, discover biomarker candidates and enable better decision making.

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Quantitative Proteomics
Starting at $1,300.00 per sample

Measuring Proteins For Better Medicines

Specialized services to enhance discovery and validation of mechanistic biomarkers in peripheral fluids

Precision Medicine requires close integration between targeted drugs and biomarkers providing early and actionable clinical information. Ideally, such biomarkers are mechanistically... Show more »

Measuring Proteins For Better Medicines

Specialized services to enhance discovery and validation of mechanistic biomarkers in peripheral fluids

Precision Medicine requires close integration between targeted drugs and biomarkers providing early and actionable clinical information. Ideally, such biomarkers are mechanistically related to disease and treatment mechanisms, predictive of outcome and measurable in accessible samples, typically body fluids.

For new biomarker discovery we have two key technologies to improve your chances of finding the most useful proteins in your sample matrix of choice. TMTcalibrator™  combines protein and fluid proteomics to identify tissue proteins with evidenced availability for peripheral detection. If you only have fluid samples, using TMT®MS3 with abundant protein depletion improves quantitative accuracy over other proteomics methods. Irrespective of the analytical method, our suite of bioinformatics tools simplify discovery of new biomarker candidates.

If you already have candidate biomarkers at the protein or peptide level please visit our Assay Development page to learn more about our range of targeted mass spectrometry solutions.

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Bioinformatics
Price on request

New Tools for TMT® Data Analysis

A new set of bioinformatics tools to improve data integration, select regulated features and map to biological processes

Proteomics experiments generate highly complex data matrices and must be planned, executed and analyzed with extreme care to ensure the most accurate and relevant... Show more »

New Tools for TMT® Data Analysis

A new set of bioinformatics tools to improve data integration, select regulated features and map to biological processes

Proteomics experiments generate highly complex data matrices and must be planned, executed and analyzed with extreme care to ensure the most accurate and relevant knowledge can be obtained. We take a modular approach allowing clients to enter and exit the pipeline at any stage, whilst ensuring seamless integration of each module. Our team of highly qualified and experienced scientists, bioinformaticians and biostatisticians will work with you throughout to provide a comprehensive service – from initial careful study design and planning through to detailed interpretation of your results.

Computational MS, QC and data integration are standard components. Feature selection and functional analysis are optional components and strongly recommended for clients with limited experience of processing proteomics data

Data Integration and Pre-Processing

We have developed separate modules to integrate and process Proteome Discoverer output data for each of our core workflows. SQuaT (SysQuant®), CalDIT (TMTcalibrator™) and DIANA (TMT®MS3) perform similar functions including isotopic correction, removal of peptides lacking TMT® quantitative values, data normalization within each TMT®10plex, calculation of expression ratio and functional annotation. The output is used for feature selection (FeaST) and is included in the QuantSheet™, an Excel file that is provided to our clients.

Statistical and Exploratory Analysis

The Feature selection module FeaST takes the output from SQuaT, CalDIT or DIANA and applies data normalization between TMT®10plexes to remove batch effects before calculating relative fold-change and significance of differential expression between groups (p-value, adjusted p-value). FeaST also performs quality assessment to remove any outlier samples and exploratory analysis before applying multivariate statistical models (LIMMA) to the processed data matrix to identify the main peptide and protein features that drive separation between experimental groups. Each iteration of the model removes features exhibiting variance due to technical or confounding clinical features (age, gender etc.) unrelated to the key biological question.

Functional Analysis Tool

The Functional Analysis Tool is an optional, bespoke bioinformatics package that provides biological context around regulated proteins and peptides within each experiment. Analysis is performed following data processing by FeaST to reveal detailed information on regulatory and signaling pathways affected by disease or treatment aiding compound prioritization. In the case of fluid biomarkers, the tool can identify which aspects of disease biology are represented in the proteomics data, providing detailed knowledge of disease and drug mechanisms and supporting selection of pharmacodynamics markers of drug mechanisms. Outputs can include biological pathway and Gene Ontology enrichment and protein interaction network maps. More specialist analyses include kinase substrate and functional domain enrichments. As each experiment is different, the functional analysis package is tailored to individual requirements in consultation with the client.

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Assay Development
Price on request

Mass Spectrometry Methods For Biomarker Panels

Alternative mass spectrometry methods can reduce the time and cost of assay development for biomarker validation

Biomarker discovery identifies multiple candidates which need validating before being taken into clinical studies. When antibodies are not readily available... Show more »

Mass Spectrometry Methods For Biomarker Panels

Alternative mass spectrometry methods can reduce the time and cost of assay development for biomarker validation

Biomarker discovery identifies multiple candidates which need validating before being taken into clinical studies. When antibodies are not readily available selective reaction monitoring (SRM) offers a rapid, cost effective way to generate validated multiplex assays that are optimized to specifically monitor your candidate biomarkers at a sensitivity suitable for your sample type. PS Biomarker Services™ Assay Development module produces validated SRM assays using any of the established methods and our expert scientists will help you select the optimum strategy to validate your panel of candidates.

TMT®SRM Assay Development

Provides a seamless switch from TMT® based discovery into biomarker validation, without purchasing AQUA peptides, by combining isotopic TMT® peptide labelling with SRM. Suitable for the measurement of 5 - 50 candidate biomarkers in all sample types. Quantitation is relative to a defined, characterized universal reference. Learn More.

SRM Assay Development

Proteome Sciences has extensive expertise in the development of classical SRM assays using heavy AQUA peptides for a wide range of applications. Where possible, peptide selection will be based on empirical data from our extensive database of proteomics discovery studies. Our expert team will guide you in the best assay method for your target proteins and the samples in which you want to routinely measure them in.

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Alzheimer's Disease screening platform
Price on request
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CNS/Neurology Animal Models
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Elisa Kit Development
Price on request

Are your Immunoassays delivering the data you need? For the same level of investment as contract ELISA kit development we can set you up with a assay measuring up to 50 biomarkers and report the data in relative or absolute quantification. The sensitivity will be approx the same as conventional ELISA, and not be based on... Show more »

Are your Immunoassays delivering the data you need? For the same level of investment as contract ELISA kit development we can set you up with a assay measuring up to 50 biomarkers and report the data in relative or absolute quantification. The sensitivity will be approx the same as conventional ELISA, and not be based on antibody interaction...

Does the ELISA EIA kit you need exist?
Does the kit report the right protein biomarker.
What about serum interferences?
Mono vs polyconal antibodies always avaiallable?
Are the kits or antibodies good as they claim?
Reliability of the commercial source?
Can your immunoassay be multiplexed at the level you need?
Are epitopes the same animal to animal?
Can you reliably cope with translational issues?
Can you say to 100% there is no cross reactivity with the vast proteome?

Consider a total unbiased proteome assay from Proteome Sciences.
We measure and report what is there in your sample, not what you think you might be measuring

« Show less
Glycosylation Analysis
Price on request
Request a quote for more information about this service.
High Throughput Protein Expression
Price on request

We typically see many 1,000's of proteins in customer samples. Our Bioinformatics then drills this down to the major protein shifts (up or down) from healthy to disease, or say pre- to post drug treatment. We can set an assay up using tissue (brain, tumour, CSF etc) to trigger the Mass Spectrometer to detect these relevant... Show more »

We typically see many 1,000's of proteins in customer samples. Our Bioinformatics then drills this down to the major protein shifts (up or down) from healthy to disease, or say pre- to post drug treatment. We can set an assay up using tissue (brain, tumour, CSF etc) to trigger the Mass Spectrometer to detect these relevant protein biomarkers in more clinical relevant matrices like serum or plasma.

No other proteomic approach for high-throughput analyses of hundreds to thousands of samples exists.

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iTRAQ Protein Labeling
Isobaric Tags for Relative and Absolute Quantitation
Price on request
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LC-MS
Liquid Chromatography-Coupled Mass Spectrometry
Price on request

Proteins are digested with trypsin and the resulting peptides are TMT labeled and finally are analyzed by LC/MS/MS or LC/MS/MS/MS. The peptides are fragmented in the mass spectrometer to yield diagnostic patterns that can be matched to protein sequence databases via computer algorithms and database searches. The sensitivity of... Show more »

Proteins are digested with trypsin and the resulting peptides are TMT labeled and finally are analyzed by LC/MS/MS or LC/MS/MS/MS. The peptides are fragmented in the mass spectrometer to yield diagnostic patterns that can be matched to protein sequence databases via computer algorithms and database searches. The sensitivity of this technique is 1ng or less starting material for a given protein. Once targeted assays are set up the overall sensitivity as a single plex or multiplex assay can be equivalent to that of conventional ELISA

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MRM Assay Panels
Multiple Reaction Monitoring Assay Panels
Price on request
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MRM/SRM
Multiple Reaction Monitoring/Selected Reaction Monitoring Mass Spectrometry
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Peptide mapping
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Protein Arrays
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Protein-Protein Interaction Analysis
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Post-Translational Modification Analysis
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Phosphorylation, glycosylation etc with or without enrichment techniques to increase sensitivity to the lower abundance proteins.

Phosphorylation, glycosylation etc with or without enrichment techniques to increase sensitivity to the lower abundance proteins.

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SILAC
Stable Isotope Labeling by Amino Acids in Cell Culture
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Proteomics
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Protein Characterization Services
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Spectroscopy
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Computational Modeling
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Clinical Chemistry
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Drug Discovery & Development
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Tandem Mass Spectrometry Methods
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Biostatistics & Bioinformatics
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Mass Spectrometry
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Pharmacology & Toxicology
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Biology
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Experimental Design
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Protein Sequencing
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Imaging & Spectroscopy
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Project Management, Consulting, & Support Services
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Omics
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Cells and Tissues
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Bioanalysis
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Biochemistry & Molecular Biology
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ELISA Kits
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Antibody/Antigen Detection Based Testing
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Biomolecular Interaction Analysis
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In vitro Disease Models
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Protein Services
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Animal Models and Studies
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Clinical Research
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Clinical Laboratory Services
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Liquid Chromatography Coupled Mass Spectrometry Methods
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Protein Quantification
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Animal Models of Disease
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Biomarkers
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Protein Expression
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