Pronexus Analytical AB is a preclinical contract research organization (CRO) offering advanced services and collaborative projects in CNS and PNS pharmacology and neurochemistry in experimental disease models. Pronexus core expertise is focused on in vivo monitoring and screening tests using microdialysis and allied bioanalytical techniques, biosensor recordings, PK/PD studies and evaluation of drug delivery systems.
Simultaneous microdialysis and behavioral monitoring
Motor activity, turning activity tests run simultaneously with microdialysis sampling.
Microsurgery, stereotaxic surgery on small rodents
Injection/infusion cannulas including microdialysis probes, syringe minipump-based continuous/discontinuous drug infusions for up to 4 weeks, Alzet osmotic pumps.
Biosensors - fast monitoring of glutamate release
Recordings of tonic and phasic L-glutamate levels in awake rats.
HPLC and enzymatic spectrophotometric assays for clinical microdialysates
Amino acid analysis, lactate, pyruvate, glycerol, glucose, enzymes and clinical biomarkers
Ultra-sensitive detection of monoamines
Unique fluorescence derivatization/HPLC methods developed for simultaneous determination of noradrenaline, dopamine and serotonin down to 10 -11 M [100 atmol/20 µl] and for histamine [300 atmol/20 µl]
HPLC techniques optimized for determination of neurotransmitters, neuromodulators and related molecules in the microdialysates
Serotonin, noradrenaline, dopamine and their metabolites, acetylcholine, GABA, aspartate and glutamate, glycine, physiological amino acids, histamine, adenosine and other purines, cAMP, cGMP, kynurenic acid, radical oxygen species (ROS), NO2-/NO3-, Mg2+, Ca2+and other ions
Determination of neurotransmitters or specified biomolecules, drug levels in plasma, CSF and tissue extracts
Microdialysis protocols on anesthetized or awake rats and mice
"Proof-of-concept" studies, monitoring neurotransmitters and other surrogate markers, PK/PD studies, drug delivery through BBB, targeted bioavailability.
Lesion models of neurodegenerative diseases.
6-OHDA, MPTP-lesion models of Parkinson´s disease.
192IgG-saporin lesions of cholinergic neurons.
Ibotenic acid lesions.
Pharmacokinetics and drug brain delivery
Triple microdialysis - PK profiles of unbound drug concentrations in blood and brain compartments.
Targeted drug delivery through the BBB
PD profiles - effects of drugs on neurotransmitter release, uptake and metabolism.
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