1331503499000

Pronexus

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Stockholm, SE

About Pronexus

Founded: 2003 Type: Privately Held Size: 1-10 employees

Pronexus Analytical AB is a preclinical contract research organization (CRO) offering advanced services and collaborative projects in CNS and PNS pharmacology and neurochemistry in experimental disease models. Pronexus core expertise is focused on in vivo monitoring and screening tests using microdialysis and allied bioanalytical techniques, biosensor recordings, PK/PD studies and evaluation of drug delivery systems.

Our Services (33)


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Hydrolyzed Amino Acid Analysis

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Animal Behavior Studies

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Simultaneous microdialysis and behavioral monitoring
Motor activity, turning activity tests run simultaneously with microdialysis sampling.


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Animal Surgery

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Microsurgery, stereotaxic surgery on small rodents
Injection/infusion cannulas including microdialysis probes, syringe minipump-based continuous/discontinuous drug infusions for up to 4 weeks, Alzet osmotic pumps.


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Animal Microsensor Studies

Price on request

Biosensors - fast monitoring of glutamate release
Recordings of tonic and phasic L-glutamate levels in awake rats.


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Enzymatic Spectrophotometric Assays

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HPLC and enzymatic spectrophotometric assays for clinical microdialysates

Amino acid analysis, lactate, pyruvate, glycerol, glucose, enzymes and clinical biomarkers


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HPLC

High Performance Liquid Chromatography
Price on request

Ultra-sensitive detection of monoamines

Unique fluorescence derivatization/HPLC methods developed for simultaneous determination of noradrenaline, dopamine and serotonin down to 10 -11 M [100 atmol/20 µl] and for histamine [300 atmol/20 µl]

HPLC techniques optimized for determination of neurotransmitters, neuromodulators and related molecules in the microdialysates

Serotonin, noradrenaline, dopamine and their metabolites, acetylcholine, GABA, aspartate and glutamate, glycine, physiological amino acids, histamine, adenosine and other purines, cAMP, cGMP, kynurenic acid, radical oxygen species (ROS), NO2-/NO3-, Mg2+, Ca2+and other ions


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LC-MS

Liquid Chromatography-Coupled Mass Spectrometry
Price on request

Determination of neurotransmitters or specified biomolecules, drug levels in plasma, CSF and tissue extracts


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Animal Microdialysis

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Microdialysis protocols on anesthetized or awake rats and mice

"Proof-of-concept" studies, monitoring neurotransmitters and other surrogate markers, PK/PD studies, drug delivery through BBB, targeted bioavailability.


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Parkinsons Disease Animal Models

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Lesion models of neurodegenerative diseases.
6-OHDA, MPTP-lesion models of Parkinson´s disease.
192IgG-saporin lesions of cholinergic neurons.
Ibotenic acid lesions.


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In vivo PK/PD Studies

Price on request

Pharmacokinetics and drug brain delivery
Triple microdialysis - PK profiles of unbound drug concentrations in blood and brain compartments.
Targeted drug delivery through the BBB
PD profiles - effects of drugs on neurotransmitter release, uptake and metabolism.


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Separation/Purification Services

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Animal Physiology Analyses

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Spectrophotometry

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Analytical Chemistry Services

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Chemistry and Materials

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Imaging & Spectroscopy

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Protein Sequencing

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Biology

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Biochemistry & Molecular Biology

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CNS/Neurology Animal Models

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Animal Cognition & Behavior Tests

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Liquid Chromatography (LC)

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Animal Model in vivo Analyses

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Mass Spectrometry

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Animal Models and Studies

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Spectroscopy

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Pharmacology & Toxicology

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Animal Models of Disease

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Chromatography

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Animal Learning, Memory, and Behavior Tests

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ADME/DMPK Studies

Drug Metabolism and Pharmacokinetics
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Protein Services

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Liquid Chromatography Coupled Mass Spectrometry Methods

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JK

Jan Kehr

senior scientist, group leader

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