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Preclinical Electrophysiology Consulting, LLC

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Mattapoisett, Massachusetts, US

About Preclinical Electrophysiology Consulting, LLC

Preclinical Electrophysiology Consulting provides professional scientific services in support of preclinical drug safety, with a focus on electrophysiology, seizure liability derisking and CNS drug safety. We partner with pharmaceutical companies and CROs, providing services tailored for each... Show more »

Preclinical Electrophysiology Consulting provides professional scientific services in support of preclinical drug safety, with a focus on electrophysiology, seizure liability derisking and CNS drug safety. We partner with pharmaceutical companies and CROs, providing services tailored for each sector.

Recent Publications

  • Under review: Bradley, JA, Luithardt, H.H., Metea, M.R., Strock, C.J., (submitted Oct 2017 to Toxicological Science) In vitro Screening for Seizure Liability Using Microelectrode Array Technology.
  • Metea, M.R., Appleby, C., Kearney, K. Characterization of Alfaxalone-Induced Seizures in Dogs upon Emergence from Sedation (2017). Safety Pharmacology Society Meeting, Berlin, Germany.
  • Metea, M.R, Litwak, M., and Arezzo, J. (2015), Assessment of seizure risk in pre-clinical studies: Strengths and limitations of the electroencephalogram (EEG). J. of Pharmacological and Toxicological Methods, 75.135-142. Peer-Reviewed Article
  • Metea, M.R., EEG data analysis in toxicology studies. (2014) Continuing education course through Safety Pharmacology Society (presenter).
  • Metea, M.R. (2014), Advantages and limitations of computerized methods for detecting seizures using telemetry EEG Safety Pharmacology Society Meeting, Washington D.C.
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Diversity Certificates

Small business Woman owned business Woman owned small business

Our Services (10)


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IND-Enabling Studies

Price on request
Request a quote for more information about this service.

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Animal Electroencephalography (EEG)

Price on request

Detailed, expert electroencephalography (EEG) study setup and analyses

Assessment of seizure potential and detection of premonitory signs of seizure

Discovery EEG screening setup and analyses

Assistance in setting up screening capabilities at your facility

Video-telemetry data analysis capabilities with multiple... Show more »

Detailed, expert electroencephalography (EEG) study setup and analyses

Assessment of seizure potential and detection of premonitory signs of seizure

Discovery EEG screening setup and analyses

Assistance in setting up screening capabilities at your facility

Video-telemetry data analysis capabilities with multiple preclinical collection systems (DSI, EMKA, Biopac,etc.)

Custom automated detection algorithms for screening are available

Expertise with multiple preclinical species

Clinical EEG experience

Model development and surgery assessments ​

Quantitative electroencephalography (qEEG)

Polysomnography and EEG Sleep Scoring

Pharmaco-sleep investigates the effects of drugs on the central nervous system and sleep-wake cycles.

Sleep/wake cycle detection (sleep scoring or polysomnography/PSG) is adapted after guidelines outlined in "The AASM Manual for the Scoring of Sleep and Associated Events" published by the American Academy of Sleep Medicine, and is performed using spectral analyses/qEEG specific to preclinical models.

Seizure Liability

EEG assessments of seizure potential and detection of premonitory signs of seizure in small and large animals

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Electroencephalography (EEG) Data Analysis

Price on request

Telemetry and external EEG scoring in small and large animals.

Telemetry and external EEG scoring in small and large animals.

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Electroencephalogram (EEG) Models

Price on request
Request a quote for more information about this service.

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Ocular Toxicology

Price on request

On-site electrophysiological assessments of ocular toxicity

  • ERG (electroretinography) and visual evoked potentials (VEP)

On-site electrophysiological assessments of ocular toxicity

  • ERG (electroretinography) and visual evoked potentials (VEP)
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Safety Pharmacology

Price on request

Safety Pharmacology outsourcing and monitoring services

Best-fit CRO or vendor selection

Facilities and capabilities audits

Technical audits

Establishing preferred vendor contracts and capabilities

In-depth assessments of data collection systems

GLP compliance

Study monitoring

Study design

On-site... Show more »

Safety Pharmacology outsourcing and monitoring services

Best-fit CRO or vendor selection

Facilities and capabilities audits

Technical audits

Establishing preferred vendor contracts and capabilities

In-depth assessments of data collection systems

GLP compliance

Study monitoring

Study design

On-site monitoring

Adherence to protocols, regulatory guidance, and timelines

Data management and QC

Statistics and data interpretation

Report writing​ and review

ICH S7A Core Battery and Supplemental Studies

The core battery of safety pharmacology studies is required for IND-enabling programs in order to assess the acute and potentially life-threatening risks of novel pharmaceuticals.

Cardiovascular System

Blood pressure, heart rate, electrocardiograms (ECGs), left ventricular pressure

Dual pressure/contractility

Respiratory System

Respiratory rate and volume in small and large animals

Central Nervous System (CNS)

Functional observation battery (FOB), modified Irwin screen, body temperature, neurological evaluations

Integrated studies

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Pharmacology & Toxicology

Price on request

Pharmacology & Toxicology Services

Pharmacology & Toxicology Services

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Assay Development

Price on request

Experimental Design Services

Experimental Design Services

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Project Management

Price on request

Project Management & Consulting Services

Project Management & Consulting Services

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Animal Polysomnography

Price on request

Polysomnography study design and Sleep Scoring

Pharmaco-sleep investigates the effects of drugs on the central nervous system and sleep-wake cycles.

Sleep/wake cycle detection (sleep scoring or polysomnography/PSG) is adapted after guidelines outlined in "The AASM Manual for the Scoring of Sleep and Associated Events"... Show more »

Polysomnography study design and Sleep Scoring

Pharmaco-sleep investigates the effects of drugs on the central nervous system and sleep-wake cycles.

Sleep/wake cycle detection (sleep scoring or polysomnography/PSG) is adapted after guidelines outlined in "The AASM Manual for the Scoring of Sleep and Associated Events" published by the American Academy of Sleep Medicine, and is performed using spectral analyses/qEEG specific to preclinical models.

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Monica Metea

Principal Consultant

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