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Precision NanoSystems

Vancouver, British Columbia, CA

Precision NanoSystems Inc. (“PNI”), PNI offers services for the development and manufacture of nanoparticles for the delivery of drugs and research tools. Nanoparticle types include liposomes, lipid nanoparticles for RNA delivery, polymer nanoparticles, and others.

PNI’s mission is to accelerate the development of transformative medicines. PNI’s proprietary technologies solve critical challenges in discovering, developing and manufacturing nanotechnology delivered drugs. PNI is working with leading pharmaceutical, biotechnology, and academic groups to develop novel nanomedicines and bring these cutting edge therapeutics to patients.

For users of Science Exchange, PNI can help users in the development and manufacture of drug formulations. Additionally, PNI provides users with RNA (siRNA, microRNA, mRNA, etc.) loaded into an advanced lipid nanoparticle delivery vehicles for the delivery of RNA in primary cells... Show more »

Precision NanoSystems Inc. (“PNI”), PNI offers services for the development and manufacture of nanoparticles for the delivery of drugs and research tools. Nanoparticle types include liposomes, lipid nanoparticles for RNA delivery, polymer nanoparticles, and others.

PNI’s mission is to accelerate the development of transformative medicines. PNI’s proprietary technologies solve critical challenges in discovering, developing and manufacturing nanotechnology delivered drugs. PNI is working with leading pharmaceutical, biotechnology, and academic groups to develop novel nanomedicines and bring these cutting edge therapeutics to patients.

For users of Science Exchange, PNI can help users in the development and manufacture of drug formulations. Additionally, PNI provides users with RNA (siRNA, microRNA, mRNA, etc.) loaded into an advanced lipid nanoparticle delivery vehicles for the delivery of RNA in primary cells in vitro and in vivo. This allows our users to study gene function in i) hard-to-transfect cell types including primary neurons, primary glia cell, primary hepatocytes, primary cardiomyocytes, stem cells, iPS derived neurons and other iPS derived cell types; and ii) in vivo to the CNS, liver, and other tissue types.

Recent Publications

  • Li B, Luo X, Deng B, Wang J, McComb DW, Shi Y, Gaensler KM, Tan X, Dunn AL, Kerlin BA, Dong Y. An Orthogonal Array Optimization of Lipid-like Nanoparticles for mRNA Delivery in Vivo. Nano Letters. 2015 Dec 9;15(12):8099-107. doi: 10.1021.
  • Yamamoto Y, Lin PJ, Beraldi E, Zhang F, Kawai Y, Leong J, Katsumi H, Fazli L, Fraser R, Cullis PR, Gleave M. siRNA Lipid Nanoparticle Potently Silence Clusterin and Delay Progression when Combined with Androgen Receptor Co-Targeting in Enzalutamide Resistant Prostate Cancer. Clinical Cancer Research. 2015 Nov 1; 21(21):4845-55. doi: 10.1158/1078-0432.
  • Pattni BS, Chupin VV, Torchilin VP. New Developments in Liposomal Drug Delivery. Chemical Reviews. 2015 Oct 14;115(19):10938-66. doi: 10.1021.
  • Ramishetti S, Kedmi R, Goldsmith M, Leonard F, Sprague AG, Godin B, Gozin M, Cullis PR, Dykxhoorn DM, Peer D. Systemic Gene Silencing in Primary T Lymphocytes Using Targeted Lipid Nanoparticles. ACS Nano. Jun 10, 2015; 9(7):6706-16. doi: 10.1021.
  • Rungta RL, Choi HB, Tyson JR, Malik A, Dissing-Olesen L, Lin PJ, Cain SM, Cullis PR, Snutch TP, MacVicar BA. The Cellular Mechanisms of Neuronal Swelling Underlying Cytotoxic Edema. Cell. 2015 Apr 23; 161(3),610–621. doi:10.1016/j.cell.2015.03.029.
  • Bassit ACF, Moffatt P, Gaumond MH, Hamdy R. The Potential Use of Nanoparticles for Noggin siRNA Delivery to Accelerate Bone Formation in Distraction Osteogenesis. Journal of Nanomedicine and Nanotechnology 2015 Jan 1; 6(1), 1–8. doi:10.4172/2157-7439.1000257.
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Formulation Services
Price on request

Formulation Solutions leverages Precision NanoSystems’ research facilities, technical team and NanoAssemblr Platform to design flexible, custom nanomedicine formulation and nanoparticle manufacturing process development solutions. Formulation Solutions projects span the entire nanoparticle formulation development continuum – from... Show more »

Formulation Solutions leverages Precision NanoSystems’ research facilities, technical team and NanoAssemblr Platform to design flexible, custom nanomedicine formulation and nanoparticle manufacturing process development solutions. Formulation Solutions projects span the entire nanoparticle formulation development continuum – from proof-of-concept nanoparticle formulations in early discovery, to advancing lead candidate development in scale-up, to optimization and technology transfer of nanoparticle manufacturing processes to CMO/manufacturing sites for cGMP production.

The Precision NanoSystems team uses proprietary NanoAssemblr microfluidic technology to develop optimized process parameters for manufacture of lipid-or polymer-based nanomedicines that meet target specifications.

Examples of Formulation Solutions projects and deliverables include:

Nanoparticle formulation(s) suitable for proof-of-concept and pre-clinical testing
Manufacturing support for NanoAssemblr Benchtop and Blaze users
Tech transfer plan and manufacturing support to CMO/manufacturing site (for 8X NanoAssemblr Scale-Up System)
Standard Operating Protocols for nanoparticle manufacture using the NanoAssemblr platform and products
Standard Operating Protocols for downstream (ultrafiltration and diafiltration) processing of nanoparticles
Analysis of nanoparticle physicochemical and biological properties

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Nanoparticle Synthesis
Price on request

Precision NanoSystems Inc. (“PNI”), PNI offers services for the development and manufacture of nanoparticles for the delivery of drugs and research tools. Nanoparticle types include liposomes, lipid nanoparticles for RNA delivery, polymer nanoparticles, and others. For users of Science Exchange, PNI can help users in the... Show more »

Precision NanoSystems Inc. (“PNI”), PNI offers services for the development and manufacture of nanoparticles for the delivery of drugs and research tools. Nanoparticle types include liposomes, lipid nanoparticles for RNA delivery, polymer nanoparticles, and others. For users of Science Exchange, PNI can help users in the development and manufacture of drug formulations. Additionally, PNI provides users with RNA (siRNA, microRNA, mRNA, etc.) loaded into an advanced lipid nanoparticle delivery vehicles for the delivery of RNA in primary cells in vitro and in vivo. This allows our users to study gene function in i) hard-to-transfect cell types including primary neurons, primary glia cell, primary hepatocytes, primary cardiomyocytes, stem cells, iPS derived neurons and other iPS derived cell types; and ii) in vivo to the CNS, liver, and other tissue types.

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Liposome Formulation
Price on request
Request a quote for more information about this service.
Chemistry and Materials
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Request a quote for more information about this service.
Materials Science
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Materials Science Services

Materials Science Services

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