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Precision for Medicine

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Bethesda, Maryland, US

About Precision for Medicine

Founded: 2013 Type: Privately Held Size: 501-1000 employees

Precision’s specialty in vitro and ex vivo assays achieve a variety of research, safety, efficacy, and biomarker objectives. Meticulous sample handling and sophisticated global logistics are fundamental for achieving high-quality, accurate study results. Our services include research and clinical trial support,... Show more »

Precision’s specialty in vitro and ex vivo assays achieve a variety of research, safety, efficacy, and biomarker objectives. Meticulous sample handling and sophisticated global logistics are fundamental for achieving high-quality, accurate study results. Our services include research and clinical trial support, backed by our repository, cell biology, sample processing, and molecular capabilities—all with industry-leading quality systems, including GxP, ISO 9001, ISO 13485, College of American Pathology (CAP), and Clinical Laboratory Improvement Amendments (CLIA).

Precision for Medicine large inventory of extensively characterized cryopreserved cells are ready for immediate delivery. Human Peripheral Blood Mononuclear Cells (PBMCs) and purified cell subsets are available from healthy and donors with a variety of medical conditions: autoimmune, infectious disease and cancers. Precision can provided custom curated specimens based on your specific desired donor and cell population.

Our other services include:
Advanced custom assays. We build our custom cell-based assays using cell lines or primary cells (both normal and patient-derived). We also deliver novel ligand-binding assay approaches for greater ease of validation and scalability. Our assays are run routinely to support preclinical and clinical studies.

Global biorepositories and biobanking. Precision manages 25 million + biospecimens—with samples from over 100 active clinical trials on 6 continents. We house samples in LN 2 , at -80; -20; +4ºC; and ambient temperature—all conditions that are replicated in our biorepositories worldwide to ensure accurate, consistent research results.

Consistent specimen collection. With real-time sample processing occurring in over 50 countries on 6 continents, we are able to manage the sample from draw to assay, streamlining handling and ensuring sample preservation, integrity, and consistency.

Clinical immune monitoring. Our comprehensive assessment of immune status and function informs preclinical and clinical trials and post-market surveillance. Our technology platforms include flow cytometry, ELISpot, Nanostring, and multiplexed cytokine assessments that can be implemented consistently at scale.

Bioanalytical services for large molecules. Our renowned scientific leadership helped establish the basis of FDA and EMA guidance in immunogenicity. Our passions include assays for PEGylated proteins, ADCs, bispecifics, gene therapies, CAR-T’s novel techniques such as drug-specific IgE assays, and assessments of complement activation.

fully integrated CRO devoted to oncology and rare disease. Precision’s uniquely integrated offering enables the science of precision medicine by combining novel clinical trial designs, industry-leading operational and medical experts, advanced biomarker solutions, and an unequivocal passion for rare diseases and oncology.

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Our Services (75)


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Normal Human Peripheral Blood Mononuclear Cells (PBMCs)

Starting at $125.00 per unit

Normal Human PBMC Purified, Characterized

10 Million cells/vial- $125.00 per vial
50 Million cells/vial - $250.00 per vial

Cryopreserved and available for immediate purchase
Basic demographics: age, gender, ethnicity, height, weight
HLA Class-I and Class-II type information
IFN-γ ELISpot responses against... Show more »

Normal Human PBMC Purified, Characterized

10 Million cells/vial- $125.00 per vial
50 Million cells/vial - $250.00 per vial

Cryopreserved and available for immediate purchase
Basic demographics: age, gender, ethnicity, height, weight
HLA Class-I and Class-II type information
IFN-γ ELISpot responses against PHA, CEF, and CMV stimulants
MTT-based proliferation index
ADCC testing results for select lots
Tested negative for HIV, HBV, and HCV

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Human pbmc Primary Cells normal human controls

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Diseased Human Peripheral Blood Mononuclear Cells (PBMCs)

Starting at $550.00 per unit

PBMCs from donors with Acne, Asthma, Celiac Disease, CLL, COPD, Crohn's Disease, Diabetes Type I&II, HIV, Lupus (SLE), Psoriasis, Rheumatoid Arthritis, Ulcerative Colitis available in inventory.

Available in 10 million cells/vial
Data includes donor demographics, date of diagnosis, and current medications
HLA Class-I and... Show more »

PBMCs from donors with Acne, Asthma, Celiac Disease, CLL, COPD, Crohn's Disease, Diabetes Type I&II, HIV, Lupus (SLE), Psoriasis, Rheumatoid Arthritis, Ulcerative Colitis available in inventory.

Available in 10 million cells/vial
Data includes donor demographics, date of diagnosis, and current medications
HLA Class-I and Class-II information available
Match plasma aliquots available for each lot

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Human Rheumatoid Arthritis Chronic Lymphocytic Leukemia (CLL) Systemic Lupus Erythematosus (SLE) Diabetes Psoriasis Chronic obstructive pulmonary disease (COPD) Asthma Ulcerative colitis Crohn's disease PBMC's Show 11 more tags Show less

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Human Biospecimens

Price on request

Precision provides a wide range of material type collections including apheresis, whole blood, plasma, serum, urine, saliva, sputum and tissues. All specimens are collected with informed consent and under IRB approved protocols. Access to collect samples from the following indications:
Alzheimer’s Disease
Cancer
Cardiovascular... Show more »

Precision provides a wide range of material type collections including apheresis, whole blood, plasma, serum, urine, saliva, sputum and tissues. All specimens are collected with informed consent and under IRB approved protocols. Access to collect samples from the following indications:
Alzheimer’s Disease
Cancer
Cardiovascular Disease
Crohn’s Disease
Diabetes
Endocrine Disorders
HPV
HBV
HCV
HIV/AIDS
Lupus
Multiple Sclerosis (MS)
Psoriasis
Rheumatoid Arthritis
and more

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Human Oncology Infectious Disease Cancer Systemic Lupus Erythematosus (SLE) Colorectal cancer Neurodegenerative diseases Psoriasis Breast cancer Hepatitis B Hepatitis C Alzheimers Disease Multiple sclerosis (MS) HIV Ulcerative colitis Crohn's disease Autoimmune disease Urine B-cells serum plasma Blood sputum Lithium Heparin Plasma PBMC's pre-treatment samples post-treatment samples EDTA Plasma Show 28 more tags Show less

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Human Whole Blood & PBMCs

Price on request

Precision can isolate a wide range of specimen material types, including leukopaks, whole blood, and cord blood, from both healthy and diseased donors into PBMCs, cell subsets such as Monocytes, CD4+ T-cells and NK cells in large quantities and cryopreserved.

Precision can isolate a wide range of specimen material types, including leukopaks, whole blood, and cord blood, from both healthy and diseased donors into PBMCs, cell subsets such as Monocytes, CD4+ T-cells and NK cells in large quantities and cryopreserved.

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Diseased Human Leukopak

Starting at $3,995.00 per unit

Our facilities have access to donors with various disease states including COPD, Diabetes Type I&II, HIV, Lupus, Rheumatoid Arthritis, Crohn’s Disease, Celiac Disease, Ulcerative Colitis, Diabetes, Multiple Sclerosis and other autoimmune disorders.

Half-packs available
Average 4 billion leukocytes
Option to characterize by HLA Class I & Class II available

Our facilities have access to donors with various disease states including COPD, Diabetes Type I&II, HIV, Lupus, Rheumatoid Arthritis, Crohn’s Disease, Celiac Disease, Ulcerative Colitis, Diabetes, Multiple Sclerosis and other autoimmune disorders.

Half-packs available
Average 4 billion leukocytes
Option to characterize by HLA Class I & Class II available

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Human CD8+ T-Cells

Starting at $350.00 per unit

Human CD8+ T-Cells, Negatively Selected, 5-8 million

Human CD8+ T-Cells, Negatively Selected, 5-8 million

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Normal Human Leukopak

Starting at $2,595.00 per unit

Fresh Human Leukopak, Normal, Full Pack

Each leukopak has roughly 10 billion leukocytes and up to 200 to 300 mL of matched plasma from a single healthy donor.

Average 10 billion leukocytes
Option to characterize by HLA Class I & Class II available

Fresh Human Leukopak, Normal, Full Pack

Each leukopak has roughly 10 billion leukocytes and up to 200 to 300 mL of matched plasma from a single healthy donor.

Average 10 billion leukocytes
Option to characterize by HLA Class I & Class II available

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Human CD19+ B-Cells

Starting at $395.00 per unit

Human CD19+ B-Cells, Negatively Selected, 5-8 million

Human CD19+ B-Cells, Negatively Selected, 5-8 million

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Human Plasma and Serum

Starting at $80.00 per unit

Human Normal Plasma, 10 mL

Human Normal Plasma, 10 mL

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Human

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Human Monocytes

Starting at $350.00 per unit

Human CD14+ Monocytes, Negatively Selected, 5-8 million post-thaw per vial

Basic demographics: age, gender, ethnicity, height, weight
FACs purity analysis for purified PBMC subsets
Tested negative for HIV, HBV, and HCV

Human CD14+ Monocytes, Negatively Selected, 5-8 million post-thaw per vial

Basic demographics: age, gender, ethnicity, height, weight
FACs purity analysis for purified PBMC subsets
Tested negative for HIV, HBV, and HCV

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Flow Cytometry

Price on request

Flow cytometry (and immunophenotyping) for high-throughput, multi-parameter analysis of cell subsets (up to 18 colors, research, and CLIA).

Flow cytometry (and immunophenotyping) for high-throughput, multi-parameter analysis of cell subsets (up to 18 colors, research, and CLIA).

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Human Biobanking

Price on request

Precision manages 25 million + biospecimens—with samples from over 100 active clinical trials on 6 continents. We house samples in LN 2 , at -80; -20; +4ºC; and ambient temperature—all conditions that are replicated in our biorepositories worldwide to ensure accurate, consistent research results.

Precision manages 25 million + biospecimens—with samples from over 100 active clinical trials on 6 continents. We house samples in LN 2 , at -80; -20; +4ºC; and ambient temperature—all conditions that are replicated in our biorepositories worldwide to ensure accurate, consistent research results.

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Immunoinformatics

Price on request

Flow cytometry and immunosequencing produce high-content data, which can be complex to mine—especially manually; our team infuses your research with efficiency and reproducibility.

Flow cytometry and immunosequencing produce high-content data, which can be complex to mine—especially manually; our team infuses your research with efficiency and reproducibility.

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Bioanalytical Assays

Price on request

Our renowned scientific leadership helped establish the basis of FDA and EMA guidance in immunogenicity. Our passions include assays for PEGylated proteins, ADCs, bispecifics, gene therapies, CAR-T’s novel techniques such as drug-specific IgE assays, and assessments of complement activation.

Our renowned scientific leadership helped establish the basis of FDA and EMA guidance in immunogenicity. Our passions include assays for PEGylated proteins, ADCs, bispecifics, gene therapies, CAR-T’s novel techniques such as drug-specific IgE assays, and assessments of complement activation.

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ELISA

Enzyme-linked immunosorbent assay
Price on request

We provide services under GLP and FDA guidelines for:

• ELISA based assays
• Cell based immunoassays

Capabilities:
- Kit-based, custom designed ELISA
- Sandwich, competitive, and bridging formats
- Optimization of protocols for commercial ELISA kits
- Analyze serum, plasma, celline supernatant's, cell lysates
-... Show more »

We provide services under GLP and FDA guidelines for:

• ELISA based assays
• Cell based immunoassays

Capabilities:
- Kit-based, custom designed ELISA
- Sandwich, competitive, and bridging formats
- Optimization of protocols for commercial ELISA kits
- Analyze serum, plasma, celline supernatant's, cell lysates
- Analyze fluorescent/chemiluminescent/chromogenic/substrates

Equipment:
-Perkin Elmer, Envision/Enspire
-Multi-channel pipets

Number of samples processed in a single experiment: 72

Typical turn-around: 5 days

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Bioinformatics Data Analysis

Price on request

Biomarker Statistics

Stratify patients, identify a novel drug target, or understand an MoA. Our team of experts deploys novel algorithms and strategies to uncover hidden insights.

Biomarker Statistics

Stratify patients, identify a novel drug target, or understand an MoA. Our team of experts deploys novel algorithms and strategies to uncover hidden insights.

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Clinical Biomarkers

Price on request
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Biomarker Data Management

Price on request

Rapidly harmonize, synthesize, and visualize specialty lab data from multiple vendors and diverse assays.

Rapidly harmonize, synthesize, and visualize specialty lab data from multiple vendors and diverse assays.

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ELISpot Assays

Enzyme-Linked ImmunoSpot Assays
Price on request

ELISpot testing across multiple phases of clinical trials

ELISpot testing across multiple phases of clinical trials

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Assay Development

Price on request

At Precision for Medicine we understand that the route from assay development to commercialization is complex. So, our comprehensive suite of solutions is designed expressly to help your advanced in vitro, laboratory-developed, and companion diagnostics take the shortest path from test concept through clinical trial development,... Show more »

At Precision for Medicine we understand that the route from assay development to commercialization is complex. So, our comprehensive suite of solutions is designed expressly to help your advanced in vitro, laboratory-developed, and companion diagnostics take the shortest path from test concept through clinical trial development, and over regulatory hurdles to reimbursement and market uptake.

We focus on the end from the very beginning, cutting through clutter and helping you reach your goal faster. Our integrated team understands how the pieces fit together, and ensures that learnings from each stage inform the rest of the process. The result: We’ve delivered more than 250 market clearances and approvals along with numerous favorable coverage and payment decisions for hundreds of diagnostic products—including many game-changing, first-to-market innovations

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NanoString nCounter Analysis

Price on request
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NAb Assays

Neutralizing Antibody Assays
Price on request

Neutralizing antibody (cell- or non cell-based)

Neutralizing antibody (cell- or non cell-based)

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Cell Viability Assays

Price on request

Cell viability, apoptosis / necrosis

Cell viability, apoptosis / necrosis

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Human Pan-T Cells

Starting at $395.00 per unit

Human Pan-T Cells, Negatively Selection, 5 million

Human Pan-T Cells, Negatively Selection, 5 million

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GPCR Screening and Profiling

Price on request

Reporter gene analysis GPCRs function

Reporter gene analysis GPCRs function

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Custom Cell-Based Assay Development

Price on request

We build our custom cell-based assays using cell lines or primary cells (both normal and patient-derived). We also deliver novel ligand-binding assay approaches for greater ease of validation and scalability. Our assays are run routinely to support preclinical and clinical studies.

We build our custom cell-based assays using cell lines or primary cells (both normal and patient-derived). We also deliver novel ligand-binding assay approaches for greater ease of validation and scalability. Our assays are run routinely to support preclinical and clinical studies.

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Enzyme-Linked Immunosorbent Spot

Price on request

ELISpot testing across multiple phases of clinical trials

ELISpot testing across multiple phases of clinical trials

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Immunophenotyping

Price on request

via flow cytometry (up to 18 colors, research, and CLIA)

via flow cytometry (up to 18 colors, research, and CLIA)

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Bioinformatics

Price on request

Whether you have high-throughput genomic data or high-content data for immune monitoring, we can meet the challenges of managing, analyzing, and synthesizing it to accelerate new discoveries, identify drug targets, characterize MoAs, and develop biomarkers for patient selection. This work is grounded in passion: For translational... Show more »

Whether you have high-throughput genomic data or high-content data for immune monitoring, we can meet the challenges of managing, analyzing, and synthesizing it to accelerate new discoveries, identify drug targets, characterize MoAs, and develop biomarkers for patient selection. This work is grounded in passion: For translational informatics and data science. For genomics and computational biology. For biostatistics. Throughout, we accelerate decision making by leveraging our translational informatics platform, PATH™.

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T Cell Activation and Proliferation Assays

Price on request

T- and B-cell proliferation

T- and B-cell proliferation

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In vitro Immune Function Testing

Price on request

Immune function (T, B, NK, NKT, Treg, Neutrophils)

Immune function (T, B, NK, NKT, Treg, Neutrophils)

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Clinical Immune Monitoring

Price on request

Tailored solutions—from custom assays to standard panels across multiple platforms—implemented at a global scale to achieve your trial objectives

Tailored solutions—from custom assays to standard panels across multiple platforms—implemented at a global scale to achieve your trial objectives

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Antibody Services

Price on request
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Clinical Chemistry

Price on request
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Cell-Based Assays

Price on request
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Computational Modeling

Price on request
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Cell Viability & Proliferation Assays

Price on request
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Clinical Immunology Tests

Price on request
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Biostatistics & Bioinformatics

Price on request
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Bioanalysis

Price on request
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Biospecimens

Price on request
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Protein Quantification

Price on request
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Protein Services

Price on request
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Pharmacology & Toxicology

Price on request
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Human Primary Cells

Price on request
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Immune Cell Assays

Price on request
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Cell-Based Screening Methods

Price on request
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Project Management

Price on request
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Immunoassays

Price on request
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Antibody/Antigen Detection Based Testing

Price on request
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Clinical Research

Price on request
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Clinical Laboratory Services

Price on request
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Specialized Cell-Based Assays

Price on request
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Functional & Cell Type Specific Assays

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Data Management

Price on request

Biomarker data management is a key step in every clinical bioinformatics study. Approximately 40% of the overall analysis time is dedicated to these tasks, which are crucial for the quality of the overall analysis.

Biomarker data management involves the integration and consistency checking of data collected from different... Show more »

Biomarker data management is a key step in every clinical bioinformatics study. Approximately 40% of the overall analysis time is dedicated to these tasks, which are crucial for the quality of the overall analysis.

Biomarker data management involves the integration and consistency checking of data collected from different domains. These can range from patient data provided by the clinics, to data generated in the lab by biological analysis platforms. The data management solutions developed by Quartz Bio allow to flexibly integrate data from different origins and formats. Consitency checks are then performed by analysts with a biotechnological knowledge of the data. All the data management processes are documented, auditable and reproducible. Robust data management ensures that the data analyses are developed on a solid ground.

Biomarker data management involves different steps:

  • Parse of the different files and integration into a “biomarker database”
  • Verification of the consistency of the identifiers (subject ids, visits, biomarkers, etc) across the different datasets
  • Standardisation of the variable names
  • Check of formats and variable ranges (compared to data specifications)
  • Derivation of variables specific to the biomarker data analysis

Quality Control

Biomarker data are heterogeneous. Technology-specific quality controls must be applied in order to identify possible sources of bias that could impact the analysis. The biology behind the assay and the sample logistics in clinical settings are two of the most important factors that can impact the biomarker data quality.

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Sequencing Experimental Design

Price on request

Each drug discovery program and each company has its own processes. Furthermore, it is not rare that multiple partners and collaborators are involved.

At Quartz Bio, we can also bring our biological and computational expertise to customize methods and applications to your own needs to facilitate data management and subsequent... Show more »

Each drug discovery program and each company has its own processes. Furthermore, it is not rare that multiple partners and collaborators are involved.

At Quartz Bio, we can also bring our biological and computational expertise to customize methods and applications to your own needs to facilitate data management and subsequent analysis.

Non exhaustive list of Methods development projects developed at Quartz Bio:

  • RNASeq quality control pipeline
  • Fluidigm qPCR data analysis pipeline and R package
  • Pipeline for analysis of immune-repertoire sequencing data
  • Data extraction form back-log of PDF files
  • Query and visualization tool for genotoxicity tests database
  • Transmart DB maintainer for EU industrial programs
  • Evaluation of bioinformatic databases
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Biospecimen Management and Storage

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Biomarker Study Design

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In every study, the design is key. It is particularly true in exploratory biomarker studies, where statistical power cannot be controlled and where sample logisitics can have an important impact on input data quality and availability.

Quartz Bio data scientists have analysed numerous biomarker studies and have experienced many... Show more »

In every study, the design is key. It is particularly true in exploratory biomarker studies, where statistical power cannot be controlled and where sample logisitics can have an important impact on input data quality and availability.

Quartz Bio data scientists have analysed numerous biomarker studies and have experienced many cases where design flaws impacted negatively the analysis.

This expertise is routinely used a posteriori in the Quality Control process, but could also better be used before generating the data, i.e. at the design stage. Thus, reviewing the exploratory part of the Clinical Study Protocol and affiliated documents such as Analytical Plans or Manual of Operations could permit optimising the biomarker study design.

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Data Services

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Flow Cytometry Data Analysis

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In vitro Immunogenicity Assays

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Biomarkers

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DNA Sequencing

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DNA Sequencing Services

DNA Sequencing Services

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DNA Services

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DNA Services

DNA Services

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Nucleic Acid Services

Price on request

Nucleic Acid Services

Nucleic Acid Services

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Statistical Analysis

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Statistical Analysis Services

Statistical Analysis Services

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Pharmacology

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Pharmacology Services

Pharmacology Services

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FACS

Fluorescence Activated Cell Sorting
Price on request
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DNA Quantification

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Human Immune Cell Assays

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Genotyping Services

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Genotyping Services

Genotyping Services

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DNA Profiling

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Cryostorage and Cryoprocessing

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DNA Extraction and Purification

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Structural Equation Modeling

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Biomarker Brief.pdf

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Biomaterials Brochure 2017.pdf

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Biomaterials Sell Sheet 2017.pdf

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PFM-Dx-Brochure.pdf

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Precision-Biospecimen-Solutions.pdf

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Translational Informatics Overview.pdf

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