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Planta Analytica

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New Milford, Connecticut, US

About Planta Analytica

Planta Analytica LLC is a leading provider in high performance separation services and compound isolation. We offer a range services for the dietary, supplemental, pharmaceutical and agrochemical markets, including and not limited to process development, impurity isolation, and large scale... Show more »

Planta Analytica LLC is a leading provider in high performance separation services and compound isolation. We offer a range services for the dietary, supplemental, pharmaceutical and agrochemical markets, including and not limited to process development, impurity isolation, and large scale purifications for biological assays. Planta Analytica was founded in 1999 to fill a void which had overtaken the pharmaceutical market since the 1980s. Big pharmaceutical companies abandoned natural products research in favor of High Throughput Screening which promised high efficiency in developing target specific molecules, however the reality has proven much the opposite. We understood that natural products research still offered enormously untapped potential for the discovery of new biologically active components. Our ideology is that if nature has been adapting its biological processes since plants came into existence, it has with absolute certainty already made the compounds we need. We just need to start asking the right questions… Over the years, be it through the projects which we perform for clients, or our own research, we are pushing forward with this ideology. We are using our expertise in chromatographic and seperatory sciences to delve into natural products that historically had medical application, foods specific to various cultures and new synthetic and biologically derived components that are sculpting the world around us. Since our beginnings, our business has grown to accommodate a wider scope of projects across different industries. We provide impurity isolation services for agrochemical markets, compound standardization services for the food industry, and we have greatly expanded our research in the natural products and nutraceutical industry.

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Diversity Certificates

Small business

Our Services (31)


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Nutraceutical & Herbal Product Testing Services

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Subcellular Fractionation

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Extract fractionation services for target elucidation and high throughput screening. Fractionation can be performed on conventional silica based phases, chromatographic resins or using centrifugal partition chromatography.

Extract fractionation services for target elucidation and high throughput screening. Fractionation can be performed on conventional silica based phases, chromatographic resins or using centrifugal partition chromatography.

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ThermoSavant Speedvac DNA120-115 Centrifugal Partition Chromatography High Throughput Screening Reverse Phase HPLC Botanicals

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Impurity Separation

Price on request

When bringing a product to market, regulatory approval requires the isolation and characterization of structures for all impurities exceeding 0.1% concentration in the technical material. Very often, the impurities belong to the same family of substances as the main component. The close structural similarity of the impurities and... Show more »

When bringing a product to market, regulatory approval requires the isolation and characterization of structures for all impurities exceeding 0.1% concentration in the technical material. Very often, the impurities belong to the same family of substances as the main component. The close structural similarity of the impurities and their low natural concentration add up to the difficulty of such projects.

Service Outline

  • Isolation of low level impurities in quantities sufficient for structural elucidation and for the required study
  • Ability to resolve and isolate components that co-elute in HPLC
  • Specialization in isolation of closely related synthetic products
  • Structural elucidation, component identification and documentation of impurities

Regulatory Approval?

To be able to sell, use, or biologically test your product the regulations set forth by various agencies such as the FDA, USDA must be met. The regulatory approval process requires the isolation and characterization of structures for all impurities exceeding 0.1% concentration in the technical material. To ensure accurate structural elucidation we work with cutting-edge laboratories to acquire high resolution NMR data, accurate mass spectroscopy and UV-VIS spectrum.

Impurity Isolation vs. Small Molecule Isolation

Although impurity isolation generally falls into small molecule isolation, it has its own distinctive character. Before the impurities can be purified by preparative chromatography their relative concentration must be brought up at least into a minimum range of 10 – 30% by the enrichment techniques, which comprise chromatographic as well as non-chromatographic methods. This usually constitutes the most difficult and time consuming stage requiring experience and skill. The final step is often done by preparative HPLC and often looks like a formality. Moreso, when dealing with bacterially derived products such as agrochemicals, the product comprises a single major component and several impurities that are structurally very similar. The structural similarity as well as the large disparity in concentration between main component and impurities requires non-conventional approaches.

Specialization in Wide Range of Agrochemicals

We have developed an extensive expertise in impurity isolation for some of those most challenging agrochemical products including abamectins, emamectins, pyrethrins, azadirachtins and others.

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UV Detectors ELSD Preparative HPLC Centrifugal Partition Chromatography Mass Spectrometry Reverse Phase HPLC Botanicals Agrochemicals Show 8 more tags Show less

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Process and Scale-Up Chemistry

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DEVELOPMENT OF HPLC METHODS AND SCALING-UP FOR INDUSTRIAL PRODUCTION AND Q.C.

-Analytical and Prep-Scale Methods
-Multi-gram to kilogram pilot-plant scaling
-Q.C. Methods for Large Scale Processes
Environmentally Friendly Processes
We can help you take your lab-bench isolation process, and develop a process that can be... Show more »

DEVELOPMENT OF HPLC METHODS AND SCALING-UP FOR INDUSTRIAL PRODUCTION AND Q.C.

-Analytical and Prep-Scale Methods
-Multi-gram to kilogram pilot-plant scaling
-Q.C. Methods for Large Scale Processes
Environmentally Friendly Processes
We can help you take your lab-bench isolation process, and develop a process that can be scaled to meet industry demands. Our processes our designed with several core principles:\

Simplicity!
The less steps a process involves, the smaller the chance for errors in the production line. It is also possible that we will be able to find money-savings short cut to your process. And, importantly, is to ensure reproducibility of the process

Cost Effective Economy
We try to refine every process to the simplest operations and implement the lowest cost technologies to maximize your margins.

Environmentally Friendly
Coming from the natural products industry, we understand the importance of ensuring the conservation of our ecosystems. We aim to protect it with processes that are the greenest and have the smallest footprint possible.

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UV Detectors ELSD Cardiovascular Hepatology Preparative HPLC Centrifugal Partition Chromatography Mass Spectrometry Reverse Phase HPLC Botanicals Agrochemicals gram milligram kilogram Drug Discovery Show 14 more tags Show less

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Product Development Consulting

Price on request

COSULTATION FOR DEVELOPMENT OF PRODUCT FROM TARGETED BOTANICALS

-Full service package for development of natural product
-Targeting and determination of active components
-Isolation of active components for biological testing
-Structural elucidation of active components
-Determination of best approach to bring product... Show more »

COSULTATION FOR DEVELOPMENT OF PRODUCT FROM TARGETED BOTANICALS

-Full service package for development of natural product
-Targeting and determination of active components
-Isolation of active components for biological testing
-Structural elucidation of active components
-Determination of best approach to bring product to market
-Conduct necessary testing
Our service will help you take your idea and produce a tangible product by:

Identification of Activity in Your Botanical Source
Before getting involved, some basic exploratory experiments can help verify the biological activity for the components in your botanical source.

Isolation of Active Components for Identification and Biological Testing
Once the targets are verified, the compounds must be isolated and identified. Suitable quantities must be isolated of each target to facilitate elucidation and biological testing.

Determination of Product’s to Market Feasibility
With all the experimental data available on the target, market research can be performed to determine return on investment and market potential for the product.

Develop Scale-up Methods for Market Demands
Once everything is green-lit, scale-up method development can begin to move the product to market. We will help you produce a pilot-scale process that is efficient, cost-effective and ecologically-friendly.

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Analytical HPLC Oncology Psychiatry/Mental Health Cardiovascular Metabolism and Endocrinology Nutrition HPLC Preparative HPLC Mass Spectrometry High Throughput Screening UV/Vis Spectrophotometry Reverse Phase HPLC Agrochemicals Biopharmaceuticals/Biologics gram milligram kilogram Show 17 more tags Show less

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Compound Purification

Price on request

SMALL MOLECULE ISOLATION

  • High purity isolated compounds (reference grade)
  • Milligram to multi-gram orders
  • Isolation of highly-labile compounds
  • Q.C. including specialized analytical methods

Isolation of your target compound at high purity opens up a natural sequence of steps facilitating options for continued R&D... Show more »

SMALL MOLECULE ISOLATION

  • High purity isolated compounds (reference grade)
  • Milligram to multi-gram orders
  • Isolation of highly-labile compounds
  • Q.C. including specialized analytical methods

Isolation of your target compound at high purity opens up a natural sequence of steps facilitating options for continued R&D leading to the final product. Firstly, it allows a detailed physicochemical characterization that positively confirms the identity and purity level allowing it to be used as a reference standard. This guarantees the quality of data from biological testing, and precursor for product synthesis. Through our service, not only will you get your target compounds with exceptionally high purity, but you'll get them sooner with less worry.

After being in operation over 17 years in the business of separation sciences we have completed many complex research projects. Some, were documented in scientific publications. Satisfied customers and a catalogue of our own reference standards, offer confidence that we have developed an expansive knowledge for small molecule isolation. Compound isolation, purification, and fractionation in search of bioactivity have been our most sought after services. As a result, we have worked with countless compounds of both natural and synthetic origin.

Capabilities

Our expertise with a wide range of chromatographic tools allows us to isolate anywhere from milligrams to tens of grams of individual compounds. Often, we are called upon for the most demanding isolations with starting materials containing less than 0.1% of the target compound or in other cases, where the target compound is very difficult to be resolved even by analytical methods. We also have an ability to work with highly labile substances that are strongly affected by typical solid chromatographic stationary phases. In such cases, we often utilize one of our Centrifugal Partition Chromatographs in a suitable mode of operation.

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Analytical HPLC Kromaton Aging Cardiovascular Hepatology Nutrition Diabetes Alzheimers Disease HPLC Preparative HPLC Centrifugal Partition Chromatography Mass Spectrometry High Throughput Screening Reverse Phase HPLC gram milligram kilogram Drug Discovery Toxicology Show 19 more tags Show less

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Compound Sourcing and Management

Price on request

Compound Sourcing and Management Services

Compound Sourcing and Management Services

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Compound Management

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Flash Chromatography

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Clinical Trials, Consulting, and Management

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Clinical Trials, Consulting, and Management Services

Clinical Trials, Consulting, and Management Services

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Clinical Research

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Clinical Research Services

Clinical Research Services

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Clinical Development Strategy

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Laboratory Equipment and Facility Management Services

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Laboratory and Facility Management Services

Laboratory and Facility Management Services

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Industrial Design

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Process Consulting

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In vivo Pharmacology Studies

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In vivo Pharmacology Studies Services

In vivo Pharmacology Studies Services

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Pharmacology

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Pharmacology Services

Pharmacology Services

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Safety Pharmacology

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Analytical Method Development

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Analytical Chemistry Services

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Business Development Services

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Business Development Services

Business Development Services

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Business Development, Marketing & Operations

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Business Development, Marketing & Operations Services

Business Development, Marketing & Operations Services

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Feasibility Studies

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Impurity Analysis

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Drug Discovery & Development

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Drug Discovery & Development Services

Drug Discovery & Development Services

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Pharmacology & Toxicology

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Regulatory Affairs Services

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Chromatography Consulting

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Liquid Chromatography (LC)

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Product Development, Testing, and Packaging

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Product Development, Testing, and Packaging Services

Product Development, Testing, and Packaging Services

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Product Testing Services

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Product Testing Services

Product Testing Services

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Vitold Glinski

Director of Operations

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