Pion Inc. are experts in the area of physical chemical property measurement. Through a suite of innovative instrumentation, assays and services, Pion has been serving the drug development industry for 20 years. Whether your interests are dissolution, solubility, permeability or ionization, Pion has the capabilities and expertise to exceed your expectations.
Founded in 1996 by Dr. Alex Avdeef, Pion were innovators of the PAMPA assay and hold several patents in this research field. Gastrointestinal, Blood Brain Barrier and Skin PAMPA models provide a rugged, robust, and affordable assay to screen a drug substance for passive membrane permeability. Expansion of the PAMPA model to the new µFLUX instrument gives customers the ability to test the kinetics of solubility and permeability of a formulation or dosage form in the same experiment.
Pion Rainbow Fiber Optics celebrates 15 years in the pharmaceutical industry this year! Used by 20 out of the top 20 global pharmaceutical companies, the Rainbow system continues to provide comprehensive in situ UV data to the dissolution industry. The small volume µDiss system allows the end user to scale their experiment down to save precious active pharmaceutical ingredient and bio-relevant media.
The PULSE is Pion's latest release and offers a cost-effective solution for pKa and log P/D analysis. This potentiometric system is available with both UV and autosampler optional to meet the needs and budget of every company. Powered by Pion Attain and Refine software, this platform was designed and developed by our team of scientists with decades of experience in the area of ionization.
Combine all of Pion's experience, technology and expertise into your drug development plan. Allow Pion to be your partner as you look to optimize your drug substance for its physical chemical properties. Pion's team of technical professionals, and state of the art laboratory are the perfect add-on to assist any size company in the optimization and determination of solubility, permeability, FLUX and ionization.
Pion PAMPA, currently available in GIT, BBB and Skin models, is the most scientifically robust commercial model available today. Utilize Pion PAMPA (Parallel Artificial Membrane Permeability Assay) for the determination of a compounds passive permeability. With close to two decades of experience, publications and hands-on experience, choose Pion for all of your passive permeability screening needs.
The precise monitoring of a drug products dissolution rate is an area where Pion technology and experience can benefit your formulation method development. Utilizing a variety of industry standard USP 1 and 2 systems, Pion's Analytical Lab is equipped to provide you the maximum amount of information for all of your dissolution profiling needs.
Utilizing Pion's small volume shake flask solubility method, Pion can deliver to you, the customer, accurate and robust solubility data utilizing a minimal amount of costly API. Performed within a well-plate format, the Pion µSOL method allows for screening across multiple pHs, screening across multiple buffers and bio relevant systems, and even screening formulation vehicles for enhancement of permeability through an increase in solubility.
Pion’s expertise in the area of pKa, log P/D and potentiometric solubility determination is unsurpassed. Services are also available with in situ UV detection for low soluble compounds. The Pion PULSE instrument is the perfect solution for all of your ionization and lipophilicity needs. With hardware and software designed and developed within Pion’s own analytical laboratory, Pion is sure to provide your lab with robust data and comprehensive reporting.
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