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Photon Biosciences

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Spokane, Washington, US

About Photon Biosciences

Photon Biosciences, LLC was founded in 2017 to develop and market entirely new classes of genetically expressible phosphorescent proteins that never photobleach and have luminocities that rival GFP.


Our core technology is a new ultrasensitive detection platform that combines bioengineered proteins with a unique in vivo biomineralization process that results in a number of different genetically expressible luminescent bionanoparticles that are non-bleaching and non-blinking with luminescence intensities that rivals and surpasses many fluorescent organic molecules. The excitation and emission wavelengths of these expressible bionanoparticles can be tuned with the composition of the mineralization process and span much of the visible and near infrared regions of the electromagnetic spectrum. Because of its unique photophysical properties, PBS® has been developed into new ultrasensitive probes for biomolecular research, detection technologies, and cellular imaging.

Our Services (8)


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Testing of Cell Lines

Price on request

Bovine polyomavirus (BPyV) Testing


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Cell Line Characterization

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CELL LINE CHARACTERIZATION  (Cytogenetic Analysis)

SERVICES
PBS.CCP.2 – Standard Cytogenetic Analysis (with Species Identification)
• Cell culture and harvest of chromosomes
• Analysis of 5 karyotypes (includes species identification)
• Chromosome aberration analysis (100 cells)
• Chromosome count and determination of modal chromosome number (100 cells)
PBS.CCP.9 – Standard Cytogenetic Analysis (Aberration & Count Analysis Only
• Cell culture and harvest of chromosomes
• Chromosome aberration analysis (100 cells or 50 cells per 9CFR 113.52.g)
• Chromosome count and determination of modal chromosome number (100 cells or 50 cells per 9CFR 113.52.g)
PBS.CCP.15 - Fluorescence In Situ Hybridization (FISH) Analysis
• Cell culture and harvest of chromosomes
• Probe design and production (alternately, Sponsor may submit unlabeled BAC DNA for PBS to label or labeled probe ready for use)
• Hybridization and analysis of 200 interphase cells and/or 20 metaphase cells • Turnaround time and pricing depend on probe design and availability.
Please contact PBS to discuss FISH study design and obtain a quote.
PBS.CCP.16 – Standard Cytogenetic Analysis (with Species Identification) and Fluorescence In Situ Hybridization (FISH) Analysis
•    Cell culture and harvest of chromosomes
•    Analysis of 5 karyotypes (includes species identification)
•    Chromosome aberration analysis (100 cells)
•    Chromosome count and determination of modal chromosome number (100 cells)
•    Probe design and production (alternately, Sponsor may submit either prelabeled probe or BAC DNA for PBS to label)
•    Hybridization and analysis of 200 interphase cells and/or 20 metaphase cells
PBS.QAPR.1 - Human Stem Cell Cytogenetic Analysis
• Cell culture and harvest of chromosomes
• Analysis of 2 karyotypes
• Full analysis of the chromosome complement (i.e., chromosome identification in addition to count and aberration analysis) and determination of modal chromosome number (20 cells)
PBS.QAPR.2 - Streamlined Cytogenetic Analysis
• Cell culture and harvest of chromosomes
• Analysis of 2 karyotypes
• Chromosome aberration analysis (20 cells)
• Chromosome count and determination of modal chromosome number (20 cells)
NOTES:
1.    “PBS.CCP” protocols are performed according to GLP guidelines and their Final Reports are intended for submission to the FDA.
2.    “PBS.QAPR” protocols are performed according to PBS’s Quality Assurance Program for Research and their reports are intended for internal research purposes.
3.    All karyotypes provided (under both PBS.CCP and PBS.QAPR) are suitable for publication.
4.    Cell lines with a modal chromosome number greater than 80 chromosomes will receive 3 karyotypes instead of 5 (PBS.CCP.2, PBS.CCP.16) or 1 karyotype instead of 2 (PBS.QAPR.1, PBS.QAPR.2).

Genomics Cytogenetics

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COVID 19 Tranport Media

Price on request

FDA Approved - Primestore MTM

The only FDA-cleared inactivation media proven effective for SARS-CoV-2 testing.


SARS COVID-19 Sample Collection and Transport Media
Molecular Transport Media
Inactivates the virus while preserving the virus RNA for qPCR, NGS or gene sequencing.


Please note: PrimeStore MTM should not be used with the Hologic Panther System due to a disinfecting step involving bleach that is specific to that platform.  PrimeStore MTM, like most lysis buffers and nucleic acid purification reagents, contains Guanidine.  Bleach and guanidine create cyanide gas which is why most molecular lab protocols use ethanol based decontamination and cleaning solutions rather than bleach.    To take advantage of the microbial inactivation and RNA stabilization qualities of PrimeStore MTM, users can safely test on a wide variety of high throughput platforms from Roche, Thermo Fisher, Abbott, Siemens, Luminex, BioRad, PSS, Promega, and BioMerieux, as well as the Cepheid GeneXpert point of care platform.

COVID-19

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Fusion Proteins

Price on request
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Next Generation Sequencing (NGS)

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Shotgun DNA Sequencing

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ELISA

Enzyme-linked immunosorbent assay
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Custom Cell Culture Media

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