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Phosphorex, Inc.

Hopkinton, Massachusetts, US

In recent years, it has become increasingly clear that many drugs on the market or in development are simply not optimized for clinical use. For example, conventional oral drug administration usually does not offer control over the rate of drug release or the ability to target specific tissues in the body. Meanwhile, about half of existing drugs and most of newly identified small molecules are insoluble, and therefore are not effectively absorbed into the bloodstream. Due to these limitations, high doses are often required to achieve the desired therapeutic effect, increasing the risk of adverse outcomes in patients.

To address these problems, Phosphorex is harnessing the potential of polymer microspheres and nanoparticles for enhanced drug delivery and has developed a full range of drug delivery solutions that can be customized for a variety of applications.

Leveraging our experience and proprietary... Show more »

In recent years, it has become increasingly clear that many drugs on the market or in development are simply not optimized for clinical use. For example, conventional oral drug administration usually does not offer control over the rate of drug release or the ability to target specific tissues in the body. Meanwhile, about half of existing drugs and most of newly identified small molecules are insoluble, and therefore are not effectively absorbed into the bloodstream. Due to these limitations, high doses are often required to achieve the desired therapeutic effect, increasing the risk of adverse outcomes in patients.

To address these problems, Phosphorex is harnessing the potential of polymer microspheres and nanoparticles for enhanced drug delivery and has developed a full range of drug delivery solutions that can be customized for a variety of applications.

Leveraging our experience and proprietary technologies, we encapsulate drugs into microspheres or nanoparticles to enable sustained release, protection of therapeutic agents from degradation, as well as targeted drug delivery. Moreover, we have pioneered state-of-the-art techniques to improve the solubility of both new and existing drugs.

At Phosphorex, we work closely with customers and collaborators to find the drug delivery solution that best fits their needs and our experts support clients though all stages of the development process, from formulation development to clinical trials.

We are excited about partnering with our customers in the development and growth of new cutting-edge applications. Through these partnerships, we look forward to further using our capabilities and expertise to propel research and development programs forward and optimize the clinical results of both new and existing drugs.

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Phosphorex has a comprehensive approach to optimize drug delivery for a variety of needs. For example, the surface of the microspheres and nanoparticles can be engineered to promote entry of the drugs into cells, increase the ability of drugs to target specific tissues, and enable the therapeutic molecules to cross the blood-brain... Show more »

Phosphorex has a comprehensive approach to optimize drug delivery for a variety of needs. For example, the surface of the microspheres and nanoparticles can be engineered to promote entry of the drugs into cells, increase the ability of drugs to target specific tissues, and enable the therapeutic molecules to cross the blood-brain barrier. Meanwhile, the drug release profile can be precisely controlled by optimizing the chemical composition, molecular weight, and surface properties of the microspheres and nanoparticles.

To improve drug solubility, Phosphorex has developed several solutions: nanosizing, solid dispersion, and microemulsion. The absorption of an insoluble drug into the bloodstream can be significantly enhanced by reducing its size, processing it into a mixture of oil and water, or dispersing it in a water-soluble polymer matrix.

Together, these tailored solutions can optimize a drug’s solubility, release rate and targeting ability. As a result, lower doses would be required to achieve the desired therapeutic effect, potentially reducing the risk of adverse effects in patients. To date, Phosphorex has demonstrated the success of its approach for everything from pain management to the treatment of cancer.

Sustained Release

Encapsulating drug molecules into microspheres enables controlled and sustained release. As microspheres can provide a sustained therapeutic effect, dosing frequency can be reduced and therefore patient compliance is improved.

Targeting and Stability Enhancement

Polymeric nanoparticles are versatile drug carriers and have shown great potentials in cancer therapy. Biodegradable polymers such as polylactide (PLA), poly(lactic-co-glycolic acid) (PLGA), polycaprolactone (PCL) and polyethylene glycol (PEG) are frequently used to encapsulate APIs into nanoparticles for a variety of drug delivery applications.

Solubility and Bioavailability Optimization

Insoluble drugs make up an overwhelming 40-50% of existing drug molecules and 90% of newly found molecules. This results in low bioavailability and difficult drug administration.

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