The 21st century is the era of life science and it has made possible the analysing and harnessing of the innate potential of living organisms for the purpose of developing more advanced medical therapies and medicines.
We at PhoenixBio wish to play our part in this development by focusing our efforts on the research and application of the immense intrinsic potential of the human cell and the preservation of this potential outside the human body. We have succeeded in developing technologies for mass propagation of human cells and in transplanting these propagated cells into laboratory animals, enabling us to provide business services that make possible the wide and easy application of the vast potential the human cell has to offer.
Since human hepatocytes retain and exhibit normal function in the PXB-Mouse liver, the toxicities of the test articles to the human hepatocytes can be observed directly.
The PXB-Mouse has a big advantage to other animal models – the histological observation of the PXB-Mouse liver allows us to directly observe the toxicities to the human hepatocytes, as well as a simultaneous comparison of rodent hepatocytes.
The liver toxicities are detected by serum biomarkers such as the enzyme activities of ALT and AST. Additionally, since PhoenixBio recently developed our proprietary method to measure human ALT1 protein, the human specific liver toxicity can be detected from the PXB-Mouse serum unaffected by the deviation enzymes from the host animal hepatocytes.
Over 95% of mRNAs which express in the normal human liver also express in the PXB-Mouse liver. The change of the expression of human specific mRNA and/or micro RNA by the administration of test articles can be observed.
Human liver toxicity can be predicted via the exhaustive search of microarray analysis of the expression level of each gene in the PXB-Mouse liver, as well as by pathway analysis such as Apoptosis, Inframation (NF-kB signaling), etc.
Hepatitis B and C viruses both exhibit great species differences with the chimpanzees being the only non-human species susceptible to infection. This lack of variety in usable animal models creates a hurdle for designing in vivo experiments for the research and development of novel therapies and the analysis of virus replication and infection mechanisms.
The Most Robust in vivo Model for Hepatitis Viruses
Since the chimeric mouse with human heptocytes has the liver nearly completely repopulated with normal human hepatocytes, it can be persistently infected with HBV and HCV. This infection model can be used for anti-Hepatitis virus drug efficacy studies, studies comparing virus replication efficiency, or virus prophylactic studies.
PXB-Mouse is the most robust chimeric mouse model for hepatitis virus studies worldwide.
PXB-mouse studies can be conducted using the same dosing and material sampling methods as other in vivo studies. The in-house study service of PhoenixBio consists of conducting the in-life phase trials and the collection of samples which are then sent to the client for evaluation. Upon request we also perform chemical analysis of the samples. PhoenixBio also offers an additional service which includes the measurement of human Albumin levels within the mouse serum, as well as the expression and activity of metabolic enzymes and blood biochemical measurements.
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