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PhenoVista Biosciences

San Diego, California, US

PhenoVista Biosciences offers cell-based assay development and screening services for biopharma discovery needs.

PhenoVista Biosciences LLC is a privately held company formed in 2014 by a pair of cell biologists, James G. Evans and Anthony Essex. We are headquartered in the Sorrento Mesa district of San Diego, California. Our facilities include state-of-the-art wet labs with tissue culture and automated liquid handling capabilities. Our analytical capabilities include several best of brand automated fluorescence microscopes and high content screening (HCS) instruments coupled with proprietary analysis and visualization software developed in-house and with our technology partners.

Our goal is simple: enable our clients to discover better drugs.

We are focused on changing the way that Phenotypic Screening is done. We're combining the latest, most relevant technology into cohesive services tailored to your... Show more »

PhenoVista Biosciences offers cell-based assay development and screening services for biopharma discovery needs.

PhenoVista Biosciences LLC is a privately held company formed in 2014 by a pair of cell biologists, James G. Evans and Anthony Essex. We are headquartered in the Sorrento Mesa district of San Diego, California. Our facilities include state-of-the-art wet labs with tissue culture and automated liquid handling capabilities. Our analytical capabilities include several best of brand automated fluorescence microscopes and high content screening (HCS) instruments coupled with proprietary analysis and visualization software developed in-house and with our technology partners.

Our goal is simple: enable our clients to discover better drugs.

We are focused on changing the way that Phenotypic Screening is done. We're combining the latest, most relevant technology into cohesive services tailored to your research. Our platform enables us to offer unique services that meet your demanding needs on time and on budget.

Our technology:
- Quantitative imaging
- Primary & Stem cell derived cultures
- Tissue-matched substrate stiffness
- Liquid handling automation
- Interpreted informatics geared to your audience

Phenotypic screening or Phenotypic drug discovery (PPD) is an approach that measures functional characteristics of the model used, whether it be a whole organism or a cell culture. Functional characteristics may include the morphology of the cells, their ability to synthesize a particular molecule, or even their ability to proliferate. Essentially, phenotypic approaches treat the biological system as a black box where compounds are added and a change in the behavior of the model is quantified.

Certification: Research grade services

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PhenoVista Biosciences has not listed any services.

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Cell Uptake/Transporter Assays
Price on request
Request a quote for more information about this service.
Subcellular Localization Studies
Starting at $50.00 per sample

Measure uptake of biomolecules such as therapeutic antibodies, proteins or fluorescently-labelled small molecules by mammalian cells (cell lines, primary cells or iPS-derived lines). Receive quantification of overall uptake as well as the candidate molecules distribution across subcellular structures such as nucleus, nucleolus,... Show more »

Measure uptake of biomolecules such as therapeutic antibodies, proteins or fluorescently-labelled small molecules by mammalian cells (cell lines, primary cells or iPS-derived lines). Receive quantification of overall uptake as well as the candidate molecules distribution across subcellular structures such as nucleus, nucleolus, mitochondria, lysosomes, Golgi and plasma membrane.
Turnaround 4 weeks.

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Thermo Scientific CX-7 CellInsight HCS reader
Thermo Scientific Arrayscan VTi HCS reader
Neuronal Assays
Starting at $50.00 per sample

Quantitative imaging based assay using cell lines or iPS-derived neurons. Measurement of endpoints for mitochondrial structure and function, apoptosis, necrosis and neurite morphology. Custom endpoints available upon request

Quantitative imaging based assay using cell lines or iPS-derived neurons. Measurement of endpoints for mitochondrial structure and function, apoptosis, necrosis and neurite morphology. Custom endpoints available upon request

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Thermo Scientific CX-7 CellInsight HCS reader
Thermo Scientific Arrayscan VTi HCS reader
Mitochondrial Stress Tests
Starting at $50.00 per sample

Quantitative imaging based assay measuring structural and metabolic end-points in response to reference stressors. Multiple cell types available.

Quantitative imaging based assay measuring structural and metabolic end-points in response to reference stressors. Multiple cell types available.

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Thermo Scientific CX-7 CellInsight HCS reader
Thermo Scientific Arrayscan VTi HCS reader
RNAi Screening
Starting at $2,500.00 per plate

Using proprietary technology from Persomics Inc we are the only certified provider of genome wide RNAi combined with imaging-based phenotypic assays.

Using proprietary technology from Persomics Inc we are the only certified provider of genome wide RNAi combined with imaging-based phenotypic assays.

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Persomics ImageArray
Neuronal Assays
Starting at $10.00 per sample

Measure outgrowth of neurites in a variety of supported cell types including PC-12 and iPS-derived neurons.

Measure outgrowth of neurites in a variety of supported cell types including PC-12 and iPS-derived neurons.

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Thermo Scientific CX-7 CellInsight HCS reader
Thermo Scientific Arrayscan VTi HCS reader
Cell-Based Compound Screening
Starting at $10.00 per sample

High throughput imaging-based screens available in a wide range of biological systems including those using iPS-derived, ES and human primary cells.

High throughput imaging-based screens available in a wide range of biological systems including those using iPS-derived, ES and human primary cells.

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Thermo Scientific CX-7 CellInsight HCS reader
Thermo Scientific Arrayscan VTi HCS reader
High Content Screening
Price on request

Phenovista Biosciences offers customized High Content Screening (HCS) as well as multiparametric high content imaging assays and phenotype screening. Contact us to discuss what you would like your assay to measure.

Phenovista Biosciences offers customized High Content Screening (HCS) as well as multiparametric high content imaging assays and phenotype screening. Contact us to discuss what you would like your assay to measure.

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Thermo Scientific CX-7 CellInsight HCS reader
Thermo Scientific Arrayscan VTi HCS reader
Drug Potency and Efficacy Testing
Starting at $50.00 per sample

Phenotypic assays available to assess quantitatively the efficacy of drug candidates in a wide range of therapeutic areas.

Phenotypic assays available to assess quantitatively the efficacy of drug candidates in a wide range of therapeutic areas.

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Widefield Fluorescence Microscopy
Starting at $50.00 per sample

Imaging using widefield microscopes, adherent and suspension cells supported.

Imaging using widefield microscopes, adherent and suspension cells supported.

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High Content Screening Training
Starting at $150.00 per hour

Available by experts with decades of experience using a variety of imaging platforms, analysis software packages and data visualization approaches.

Available by experts with decades of experience using a variety of imaging platforms, analysis software packages and data visualization approaches.

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FRAP
Fluorescence recovery after photobleaching
Starting at $250.00 per sample

Quantify dynamic cellular processes using this classical approach.

Quantify dynamic cellular processes using this classical approach.

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Adherent Cell Cytometry
Starting at $50.00 per sample

Custom biomarker analysis of adherent cell types using brightfield or fluorescence microscopy. Quantitative analysis available.

Custom biomarker analysis of adherent cell types using brightfield or fluorescence microscopy. Quantitative analysis available.

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Apoptosis Assays
Starting at $25.00 per sample

Imaging-based analysis of apoptotic marker expression in a variety of cell types.

Imaging-based analysis of apoptotic marker expression in a variety of cell types.

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Thermo Scientific CX-7 CellInsight HCS reader
Thermo Scientific Arrayscan VTi HCS reader
Cell Viability Assays
Starting at $25.00 per sample

Various levels of assay complexity from simple dye-exclusion to annexin V and other apoptotic markers. Adherent and suspension cells supported.

Various levels of assay complexity from simple dye-exclusion to annexin V and other apoptotic markers. Adherent and suspension cells supported.

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In vitro Wound Healing Assay
Starting at $250.00 per sample

Analysis of cell migration during wound healing in scalable imaging-based format. Various cell types supported.

Analysis of cell migration during wound healing in scalable imaging-based format. Various cell types supported.

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Chemotaxis Assays
Starting at $250.00 per sample

Wound healing and chemical gradient based analyses of cell migration. Various cell types available including B and T cells, endothelial cells and epithelial cells.

Wound healing and chemical gradient based analyses of cell migration. Various cell types available including B and T cells, endothelial cells and epithelial cells.

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Deconvolution Microscopy
Starting at $150.00 per sample

Deconvolution of widefield, confocal, multiphoton and other imaging modalities using Huygens software. Quantitative analysis and 3D visualization available.

Deconvolution of widefield, confocal, multiphoton and other imaging modalities using Huygens software. Quantitative analysis and 3D visualization available.

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Confocal Microscopy
Starting at $100.00 per sample

Confocal imaging of fluorescent samples. Quantitative analysis available.

Confocal imaging of fluorescent samples. Quantitative analysis available.

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Immunocytochemistry
Starting at $50.00 per sample

Antibody staining of adherent cells and fluorescence imaging. Quantitative analysis available.

Antibody staining of adherent cells and fluorescence imaging. Quantitative analysis available.

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Cellular Metabolism Assays
Starting at $299.00 per sample

Various cell based models including human primary cells and cell lines used to monitor metabolic pathways and energy utilization/storage. All assays are performed in 384 well plates and are fully customizable. Turnaround is 4-8 weeks.

Various cell based models including human primary cells and cell lines used to monitor metabolic pathways and energy utilization/storage. All assays are performed in 384 well plates and are fully customizable. Turnaround is 4-8 weeks.

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Custom Cell-Based Assays
Starting at $5,000.00 per unit

Custom development of phenotypic and hybrid assays that incorporate target-based readouts. Fully quantitative and scalable. $1000

Optimization of cell type, culture conditions, antibodies and controls. Development and validation of assay methodology including imaging, image analysis and data analysis. All assays are performed... Show more »

Custom development of phenotypic and hybrid assays that incorporate target-based readouts. Fully quantitative and scalable. $1000

Optimization of cell type, culture conditions, antibodies and controls. Development and validation of assay methodology including imaging, image analysis and data analysis. All assays are performed in 384 well plates and fully scalable. Turnaround time highly dependent on assay complexity but typically 2-10 weeks with regular updates and milestones. Pricing discounted aggressively for customers who commit to a screening project based on the developed assay. Starting at $5000.

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Neuronal Assays
Starting at $499.00 per sample

iPS-derived neurons and co-culture options. Multiple measurements available related to CNS diseases. All assays are performed in 384 well plates and fully scalable. Turnaround is 8 weeks for up to 1000 compounds with dose-response profiling. Custom development options are available.

iPS-derived neurons and co-culture options. Multiple measurements available related to CNS diseases. All assays are performed in 384 well plates and fully scalable. Turnaround is 8 weeks for up to 1000 compounds with dose-response profiling. Custom development options are available.

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Induced Pluripotent Stem Cell (iPSC) Differentiation
Starting at $299.00 per sample

Custom phenotypic analyses of iPS cell differentiation using high content imaging and customer-defined outputs. Common markers of pluripotency can be combined with functional and morphological outputs. Dose-response testing of up to 1000 compounds within 8-12 weeks depending on assay design. All assays are performed in 384 well plates and fully scalable.

Custom phenotypic analyses of iPS cell differentiation using high content imaging and customer-defined outputs. Common markers of pluripotency can be combined with functional and morphological outputs. Dose-response testing of up to 1000 compounds within 8-12 weeks depending on assay design. All assays are performed in 384 well plates and fully scalable.

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Cell Art
Starting at $250.00 per sample

Custom art work made to order using cells and stains of choice - perfect for your company's lobby or your office wall. Contact us for options.

Custom art work made to order using cells and stains of choice - perfect for your company's lobby or your office wall. Contact us for options.

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Imaging & Spectroscopy
Price on request
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Cell Viability & Proliferation Assays
Price on request
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Specialized Cell-Based Assays
Price on request
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Cell-Based Assays
Price on request
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Mammalian Cell Culture
Price on request
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Hit Identification
Price on request
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Microscopy
Price on request
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Cellular Health & Metabolism Assays
Price on request
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Optical Microscopy
Price on request
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Transporter & Cell Uptake Assays
Price on request
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Cell Invasion & Migration Assays
Price on request
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Protein Expression Visualization
Price on request
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Angiogenesis & Endothelial Cell Assays
Price on request
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Cell-Based Screening Methods
Price on request
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In vitro Disease Models
Price on request
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Functional & Cell Type Specific Assays
Price on request
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Cell Death Assays
Price on request
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Immunostaining
Price on request
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Cytometry
Price on request
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Fluorescence-Based Microscopy
Price on request
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Human Synapse Formation Assay
Starting at $499.00 per sample

Human iPS-derived neurons, high resolution phenotypic assay that is fully customizable to a range of disease models. This assay is performed in 384 well plates and is fully scalable.Turnaround within 8-12 weeks.

Human iPS-derived neurons, high resolution phenotypic assay that is fully customizable to a range of disease models. This assay is performed in 384 well plates and is fully scalable.Turnaround within 8-12 weeks.

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2018-06-29 16:45:10 -0400

Net Promoter Score of 8 received for High Content Screening.

Additional Ratings: satisfaction with deliverable: 9, satisfaction with timeliness: 7.
2018-06-04 14:43:55 -0400

Net Promoter Score of 8 received for Angiogenesis & Endothelial Cell Assays.

Additional Ratings: satisfaction with deliverable: 8, satisfaction with timeliness: 6.
2018-03-08 19:08:30 -0500

Net Promoter Score of 10 received for Neuronal Assays.

Additional Ratings: satisfaction with deliverable: 10, satisfaction with timeliness: 10.
October 17, 2016

Positive review received for Custom Cell-Based Assays:

"Had a great experience with PhenoVista. They were rigorous, timely and collaborative in setting up and optimizing a HCA assay for us. They really went out of their way to make sure we discussed all the controls and conditions to ensure the experiment got run exactly the way we wanted it to. They have wealth of experience and expertise in HCA and they had very helpful suggestions. I would highly recommend them, and I will use them again myself."

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2017-12-12 15:38:07 -0500

I discovered PhenoVista Biosciences in a search for a lab that could high-throughput neuron toxicity screening assays with iCell Neurons. I am really happy with the throughput
and results we received from them for our initial screen with the ICell Neurons and look forward to conducting more work with this lab. Really appreciate the one-on-one teleconferences and study design help that they offer. I recommend them to researchers needing an outsourcing option to run assays for in vitro neurotoxicity.

Missing Avatar
2017-07-20 22:55:02 -0400

I discovered PhenoVista thru Science Exchange, when they responded with a quote for a project I posted. Boy am I glad they did! They were extremely knowledgeable and made several great suggestions for setting up the assay. They quickly grasped the scientific question we were asking and interacted as collaborators more than as a "CRO". The work was done on time and included all the controls and conditions required to make a clear decision. They had great images, masked perfectly for good analysis.
I highly recommend them to anyone considering a study in their area. I will definitely use them again when possible.

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