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Pharmaron, Inc.

528 Orders Completed
Louisville, Kentucky, US

About Pharmaron, Inc.

Pharmaron (Stock Code: 300759.SZ/3759.HK) is a leading fully-integrated pharmaceutical R&D service platform supporting the life science industry. Founded in 2004, Pharmaron has invested in its people and facilities and established its comprehensive service offerings throughout the pharmaceutical R&D life cycle. With operations in China, US and UK staffed by over 7,500 employees, Pharmaron has an excellent track record in delivering R&D solutions to its partners in North America, Europe, Japan and China. For more information: www.pharmaron.com

Key highlights of Pharmaron’s diverse R&D service capabilities:
• Synthetic, medicinal and analytical chemistry
• in vitro and in vivo Biology
• ADME/DMPK
• Pharmacology
• Drug safety assessment
• Radiochemistry and isotopically labelled metabolism
• Chemical & pharmaceutical development
• Clinical development, including applications of 14C microtracer AMS technology

Certifications & Qualifications

AAALAC FDA Inspected GLP

Diversity Certificates

Minority owned business

Our Services (188)


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In vitro Immunotoxicity Testing

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Prostate Xenograft

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Pancreas Xenograft

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Ovarian Xenograft

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Osteosarcoma Xenograft

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Multiple Myeloma Xenograft

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Melanoma Xenograft

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Lymphoma Xenograft

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Lung Non-small Cell Xenograft

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Liver Xenograft

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Leukemia Xenograft

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Kidney Xenograft

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Glioma Xenograft

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Gastric Xenograft

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Epidermoid Carcinoma Xenograft

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Colorectal Xenograft

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Breast Xenograft

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Stroke Animal Models

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Custom Hematology Animal Models

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Acute Inflammatory Pain Animal Models

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Neuropathic Pain Animal Models

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Chronic Kidney Disease Models

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Compound Libraries

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Wound Healing Animal Models

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Acute Kidney Failure Models

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Anemia Animal Models

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Diabetes Animal Models

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db/db Diabetic Mice

Mouse

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Obesity Animal Models

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Histology and Pathology Services

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Respiratory Toxicology

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In vivo Cardiotoxicity Screening

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Gastrointestinal Toxicology

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Cognition and Behavior Animal Models

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Drug Abuse Liability Testing

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In vitro Oncology Models

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Drug Target Identification

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Nuclear Receptor Assays

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Ion Channel Screening Assays

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QSAR Studies

Quantitative Structure-Activity Relationship Studies
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In vivo Protein Binding Assays

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GPCR Assays

G-Protein Coupled Receptor Assay
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Homology Modeling

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Computational Drug Discovery

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Pharmacophore Modeling

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Alzheimer's Disease Animal Models

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Electrophysiology Animal Models

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Kinase Assays

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Angiogenesis Animal Models

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qPCR

Quantitative PCR
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Assay Development

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Validation, Services

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UV-VIS Spectroscopy

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R&D Services

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Quality Assurance

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Recombinant Protein Expression

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Drug Preformulation

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In vivo Drug Efficacy Testing

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Preclinical Study Design

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Pilot-Scale Filling

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Nutritional Analysis

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Nonclinical Research

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In vitro Metabolic Stability Assays

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Medicinal Chemistry

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Mass Spectrometry

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Oligonucleotide Synthesis

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Plant and Animal Metabolism Studies

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Non-Sterile Manufacturing

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Ecotoxicity Testing

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Pharmaceutical Manufacturing

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Environmental Fate Studies

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Mammalian Cell Culture

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Dermal Pharmacology & Efficacy Studies

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Lyophilization

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In vitro Percutaneous Absorption Studies

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Hit to Lead and Lead Optimization

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Drug Transporter Assays

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Animal Model in vivo Analyses

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In vitro Drug-Drug Interaction Studies

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In vivo Immunotoxicity Testing

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Plasma Protein Binding

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HPLC

High Performance Liquid Chromatography
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CYP Induction Assay

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Pharmaceutical Formulation

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CYP Inhibition Assay

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Feasibility Studies

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UDP-Glucuronosyltransferases (UGT) Assays

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Metabolite Profiling

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Drug Discovery

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Bioanalysis

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Drug Development

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Quantitative Whole Body Autoradiography (QWBA)

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Drug Induced Phospholipidosis (PLD) Assay

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Microautoradiography

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Custom Manufacturing

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Radioisotope Production

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Contract Research

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In vitro Drug Safety Evaluation

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Drug safety issue is a major reason for drug attrition. Pharmaron offers a comprehensive panel of in vitro safety screening services to help identify drug safety issues at the early stage of drug discovery. A team of well-trained scientists with the state-of-the-art technologies allow for high quality data to be generated rapidly and cost-effectively. We offer both standardized and customized services. Our in vitro safety screening services can be contracted individually or combined with Chemistry, in vitro ADME and Biology as part of a fully integrated program.

Non-high content safety screening

  • Cell viability
  • Mitochondrial toxicity
  • Phototoxicity
  • AhR activation

High content safety screening

  • Phospholipidosis
  • AhR activation
  • Mitochondrial biogenesis
  • Drug induced liver injury

Ion Channel safety screening

  • K+ channel (hERG): The screen identifies the inhibitors of hERG which causes QT interval prolongation resulting in potentially fatal ventricular tachyarrhythmia.
    • automated patch-clamp
    • manual patch-clamp
  • Na+ channel
    • automated patch-clamp
    • manual patch-clamp


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Clinical Sample Analysis

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Biomarker Analysis

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Gene sequence or analysis (DNA / RNA)

Gene expression, mutation, regulation

  • Deep sequencing
  • RNA sequencing
  • Cancer hotspot panel
  • Expression profiling
  • high content analysis
  • PCR / RT-PCR / qPCR

Apoptosis analysis

  • Cell death Elisa (CDE)
  • TUNEL
  • Click-iT® EdU
  • Enzyme analysis
  • DNA Gel electrophoresis
  • Caspase activation assay

Protein expression and modification

  • Western blot analysis
  • MSD
  • ELISA
  • AlphaLISA/AlphaScreen
  • ELISpot
  • Histology and Immunohistochemistry
  • FACS

Cytokine level

  • ELISA
  • MSD
  • Luminex
  • FACS

Histology

  • Frozen tissue block preparation
  • Paraffin block preparation
  • TMA
  • Sectioning
  • DNA/RNA extraction from frozen or paraffin embedded tissue samples
  • Histological staining including all special histo-chemical staining
  • Immunohistochemistry on frozen or paraffin sections
  • Single, double or multiple antigen-antibody labeling
  • Enzyme/fluorescent labelling

Immune cell activation analysis on PBMC or lymph tissue

  • T/B cell function assay
  • FACS (CD markers)
  • Cytokine production

Other analysis

  • Hematology (CBC count)
  • Blood chemistry (full panel)
  • Urine analysis (volume, Osmolality or chemistry…)
  • Fecal electrolyte, lipid extract and analysis (cholesterol and bile acid, P, Na, Cl, or Ca)
  • CSF (including sample from small rodent) analysis
  • BAF (body aspirate fluid) analysis


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In vivo Toxicity Testing

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Mouse Rat

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Medicinal Chemistry

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ADME/DMPK Studies

Drug Metabolism and Pharmacokinetics
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Pharmaron offers comprehensive in vivo pharmacokinetic (PK), toxicokinetics, GLP bioanalytical (for detail for GLP and GCP bioanalytical services, please see Safety Assessment / GLP/GCP Bioanalytical Services), discovery bioanalytical, and formulation services to our partners. All in-life work of PK/TK studies are conducted in AAALAC-approved animal facilities and follow IACUC-approved study protocols. We offer high quality (FDA/OECD/EPA accepted) and fast turnaround GLP and non-GLP bioanalytical services to support drug discovery, pre-clinical and clinical development for small molecules, peptides, nucleosides/nucleotides and biologics. Our formulation services are offered either as part of the PK study or as a standalone service.


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Combinatorial Chemistry

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In vitro Disease Models

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In vitro Biology

Pharmaron Biology provides a spectrum of high quality services to support various stages of drug discovery and development. With state-of-the art facilities and instrumentation, proprietary data management systems – CEDAR™, we offer services in assay development, compound screening, PD/biomarkers, bioreagents and structural biology, and in vitro toxicity.

We have a team of experienced scientists that are familiar with drug discovery processes, and understand how and where biology services can help our clients succeed in target validation, hit identification, hit to lead, lead optimization, and selection of preclinical candidates. These services are provided either as standalone services, or as a part of integrated projects that also include components such as medicinal chemistry, DMPK, in vivo pharmacology and toxicology.

  • Excellent team of cell biologists, molecular biologists, enzymologists, protein biochemists, structure biologists and electrophysiologists
  • Experienced with major target classes
  • Established a process for rigorous assay development, validation, & execution
  • Good track record of successful delivery of drug candidates for our partners


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Chemical Analysis

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Compound Management

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Pharmaron has established a state-of-the-art compound management system with the following features:

Industry-leading software (Mosaic)

  • Used by the most of the major biopharma companies
  • Mosaic is used extensively in the pharma and biopharma sector to manage the preparation, storage and distribution of compounds, capable of handling efficient sample management, covering inventory tracking, ordering, sample processing, lab automation integration, and shipping.
  • Used at Pharmaron end-to-end (workflows flexible to partner’s needs)
  • Mosaic has been implemented to streamline compound management at Pharmaron, tight joint of compound information between partners and Pharmaron became perfect. Mosaic is scalable and offers the flexibility needed to meet partners’ requirement.
  • Audit trail function built in (IP protection)
  • Integration with storage, liquid handlers, balances etc.

Top-notch equipment

  • Online Tecans (Mosaic controlled)
  • Compound solubilization integrated balances can trace the entire process.
  • Compound transfer to 2D barcoded tubes
  • Compound plate preparation
  • Bar coding system allows for storage tracking
  • Echo acoustic liquid handers for transfer to assay plates
  • State-of-the-art technology
  • Capable of dispensing down to 2.5 nL of samples
  • Improved assay performance

Barcode scanning at all levels

  • Tecan
  • Vials, racks of matrix tubes, and plates
  • 2D barcode scanner
  • Matrix tubes and racks
  • Balances
  • Vials
  • Echo Acoustic dispenser
  • Plates

Tight climate control

  • Temperature and humidity of the entire laboratory are controlled, monitored and recorded by multiple devices, to ensure compounds are well stored at Pharmaron. Backup AC units and high capacity dehumidifiers are in place.

Secured compound storage

  • 24 hour surveillance cameras
  • Multi-layered key card access

Dedicated UPS in labs

  • Uninterruptible Power Supply ensures the storage condition remains stable even when electricity is off for hours.


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Central Lab Services

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In vivo PK/PD Studies

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Drug Metabolism and Pharmacokinetics

Rodent and large animal PK studies in Beijing

Mouse Rat

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Animal Blood Collection

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In vitro ADME/DMPK Studies

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Drug Metabolism and Pharmacokinetics

in vitro ADME assays in Beijing


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Safety Pharmacology

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Radiolabeling/Radiosynthesis

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Synthesis of 3H and 14C labeled compounds and radiolabeled metabolism studies


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Biomarker Discovery

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Compound Sourcing and Management

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In vivo Pharmacology Studies

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Mouse Rat

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Biology

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With strong training in biochemistry, molecular and cellular biology, our teams are highly experienced, and focused on customer assay development, compound evaluation using cell-free biochemical assays, cell culture models, and biomarker discovery.


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Radiochemistry

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Radiochemistry Services


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Biomarkers

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In vitro Toxicity Testing

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Biochemical and cell-based assays


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Bioanalytical Analysis LC/MS/MS

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Chemical Synthesis

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Discovery Process Chemistry

gram kilogram

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Cells and Tissues

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Solubility and Dissolution Testing

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Biochemical Assays

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Pharmacology & Toxicology

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Animal Model Housing and Maintenance

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Chemistry and Materials

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Cell-Based Assays

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Cells and Tissues Services


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Analytical Method Validation

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Materials Science

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Veterinary Laboratory Services

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Oncology Animal Models

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PCR

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In vitro Bioavailability/Bioequivalence Studies

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Immunology Animal Models

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Clinical Research

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Lead Identification and Validation

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Computational Modeling

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Pain/Neuropathy Animal Models

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Peptide Synthesis

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Business Development Consulting

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Project Management

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Clinical and Anatomic Pathology

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Clinical Ancillary and Sample Services

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Animal Models and Studies

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Cognitive, Behavioral, and Psychiatric Animal Models

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Drug Discovery & Development

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Drug Discovery & Development Services


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Hematology Animal Models

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Toxicology

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Toxicology Services


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Cytotoxicity Assays

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Cytotoxicity Assays Services


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Xenograft Models

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Spectroscopy

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Nucleic Acid Services

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Liquid Chromatography (LC)

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Regulatory Affairs Services

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Pharmacology

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Pharmacology Services


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Product Quality Control

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Metabolomics

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In vivo ADME/DMPK Studies

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In vivo ADME/DMPK Studies Services


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Formulation Services

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Computational Chemistry

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In vitro Pharmacology Studies

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In vitro Pharmacology Studies Services


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Epidemiology, Healthcare, and Post-Authorization Studies

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CNS/Neurology Animal Models

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Receptor Assays

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Analytical Chemistry Services

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Analytical Chemistry Services


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Protein Production

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Animal Models of Disease

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Product Development, Testing, and Packaging

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Omics

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Biochemistry & Molecular Biology

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Protein Services

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Nephrology Animal Models

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Imaging & Spectroscopy

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Chromatography

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Separation/Purification Services

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In vitro Ion Channel Assays

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Clinical Laboratory Services

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Synthetic Chemistry

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Biomolecular Interaction Analysis

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Veterinary Research & Diagnostics

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Chiral Resolution

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Enzyme Assays

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Spectrophotometry

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Manufacturing Services

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Metabolic Animal Models

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Bioanalytical Assays

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DNA Services

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  • Positive review for Pharmacology:

    November 2018

    "Did great job"

  • Positive review for Cell-Based Assays:

    June 2018

    "Pharmaron did very good job in delivery of high-quality on time. When I have some question for the data, they replied in a timely fashion, and perform trouble shooting and assay optimization accordingly."

  • Positive review for In vivo PK/PD Studies:

    May 2018

    "Excellent service, very high quality, great employees"

  • Positive review for In vivo PK/PD Studies:

    May 2018

    "My experience was excellent. Pharmaron showed great flexibility and speed. The data quality was excellent. I would continue to work with Pharmaron any time and would recommend to colleagues without hesitation. Thanks for all the support you provide to our projects! I also appreciate your friendliness and professionalism. Best regards, Maria"

Pharmaron, Inc. has not received any endorsements.