1352601204726 7fffb663120dd173020ed4b9bc223583

Perelman School of Medicine

Philadelphia Pennsylvania
1352601298307 7fffb663120dd173020ed4b9bc223583

Penn Molecular Profiling Facility

Philadelphia Pennsylvania
No Reviews Available

The Penn Microarray Facility provides instrumentation and expertise for RNA transcript profiling.The Facility supports oligonucleotide arrays synthesized by Affymetrix Inc.

1352601184186 7fffb663120dd173020ed4b9bc223583

DNA Sequencing Facility

Philadelphia Pennsylvania
4 Orders Completed
100% Positive

The DNA Sequencing Facility is an Abramson Cancer Center Shared Resource that is approved and partially funded by the National Cancer Institute.

1408031576574 56c666a9839efe03267d49f99f5a79ee

Stem Cell and Xenograft Core

Philadelphia Pennsylvania
1 Order Completed

The Stem Cell and Xenograft Core (SCXC) is a comprehensive resource laboratory that integrates a viable tissue bank of normal human hematopoietic cells and hematopoietic malignancies with a full range of xenograft services.

The SCXC is committed to facilitating and promoting... Show more »

The Stem Cell and Xenograft Core (SCXC) is a comprehensive resource laboratory that integrates a viable tissue bank of normal human hematopoietic cells and hematopoietic malignancies with a full range of xenograft services.

The SCXC is committed to facilitating and promoting translational research involving viable primary human hematopoietic tissues. Our core offers adult whole bone marrow from healthy donors and umbilical cord blood. Mononuclear and CD34+ cells from normal bone marrow and cord blood are available, and other cell fractions can be provided by arrangement. We maintain a large tissue bank of cells from hematopoietic malignancies including AML, ALL, CML, MDS and MPDs. All samples are fully annotated and frozen as viable cells. We also offer access to an immunomagnetic cell sorter (Miltneyi AutoMacs). Expertise in primary human hematopoietic stem/progenitor and leukemic cell culture and manipulation is available. For consultation or questions, please contact Martin Carroll.

The SCXC offers a wide variety of xenograft services from training to full-service experiments. The Core maintains a large breeding colony of immune-deficient (NSG) mice for users' xenograft studies. We also offer human immune system (CD34-transplanted) NSG mice for a wide variety of studies ranging from gene therapy to HIV. Experimental animals are housed in dedicated BSL-2 animal barrier space equipped for whole body irradiation and all necessary procedures and survival surgeries. Currently established xenograft models include normal human CD34 and leukemia engraftment, human iPS and ES-derived teratomas, human skin grafting, orthotopic human ovarian, hepatic and pancreatic tumor cell injections, renal capsule implantation. We also offer access to a dedicated optical/fluorescence (IVIS Spectrum) imaging system located within the Core's BSL-2 space.

Certifications:
BSL-2

Relevant publications:
- Chacko AM, Li C, Pryma DA, Brem S, Coukos G, Muzykantov V: Targeted delivery of antibody-based therapeutic and imaging agents to CNS tumors: crossing the blood-brain barrier divide. Expert opinion on drug delivery 2013, 10(7):907-926.
- de Pater E, Kaimakis P, Vink CS, Yokomizo T, Yamada-Inagawa T, van der Linden R, Kartalaei PS, Camper SA, Speck N, Dzierzak E: Gata2 is required for HSC generation and survival. The Journal of experimental medicine 2013, 210(13):2843-2850.
- Didigu CA, Wilen CB, Wang J, Duong J, Secreto AJ, Danet-Desnoyers GA, Riley JL, Gregory PD, June CH, Holmes MC et al: Simultaneous zinc-finger nuclease editing of the HIV coreceptors ccr5 and cxcr4 protects CD4+ T cells from HIV-1 infection. Blood 2014, 123(1):61-69.

Standard sample shipment requests:
Next Day Air for banked samples

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