PC SAS - Prestwick Chemical

Prestwick Chemical has more than 15 years of experience in custom chemistry services and is recognized worldwide for its capacity to meet customer requirements. Prestwick Chemical chemists are particularly expert in synthesis presenting some degree of complexity i.e. multi-step synthesis or synthesis associated with sophisticated methodology.

Typical compound requested:

• Reagents and building blocks
  
• Advanced intermediates
  
• Reference compounds
  
• New analogues for SAR studies
  
• Metabolites / Contaminants
  

Scale:

• From milligram up to multi-grams
  

Quality:

• Purity > 95%; up to 98%
  
• Certificate of analysis delivered
  

High experience in:

• Multi-step organic synthesis
  
• Stereospecific synthesis
  
• Heterocyclic chemistry
  
• High-degree of complexity synthesis
  

Following:

• Existing methodologies (from customer or literature)
  
• Specific chemical routes designed at Prestwick
  

Free and rapid quote under request including:

• Feasibility
  
• Fixed price or FTE basis
  
• Delivery time
  

Computational chemistry at Prestwick Chemical is fully integrated in drug discovery projects or might be offered for exploratory chemistry. We work closely with medicinal chemists and biologists to support the design of novel compounds and accelerate projects. We offer a full range of services using dedicated tools:

• Pharmacophore modelling (Ligand-based and Structure-based)
  
• Pharmacophore-based virtual screening (hit finding, scaffold hopping)
  
• Docking (SAR, binding mode analysis)
  
• ADME and physicochemical property prediction
  
• Data mining and data visualization & analysis
  
• In silico profiling (off-targets activity)
  
• Bioinformatics (homology modelling, active site identification)
  
• Design and enumeration of chemical libraries

Starting from a validated lead, our medicinal chemists initiate the optimization process in order to identify a pre-clinical drug candidate.

The research strategy implies iterative cycles of design and assessment using:

• Systematic SAR study taking into account in-house know-how to identify productive directions for analogue design
  
• Design of new analogues directed towards multidimensional optimization (potency, selectivity and improvement of the ADME-Tox profile)
  
• Scaffold-hopping to identify new chemotypes
  
• Consolidation of the IP position
  
• Synthetic route improvement suitable for development
  
• Scale-up to support profiling studies

Out of biological screenings, our medicinal chemists help selecting the most promising scaffolds for progression into lead optimization by:

• Re-synthesis of the identified hits to confirm structure and activity
  
• Delivery of close analogues to consolidate the starting hits
  
• Synthesis of related analogues to establish early Structure Activity Relationships (SAR)
  
• Multi-parameter optimization using calculated and experimental ADME properties

Prestwick Chemical accelerates hit discovery process through:

• Smart Chemical Screening Libraries supplemented by hit follow-up services
  
• Full range of molecular modeling services including powerful virtual screening methodology, performed by double-skilled medicinal chemists

Prestwick Chemical provides full medicinal chemistry services from hit discovery to pre-clinical candidate keeping customer satisfaction at the core of its activity. Teams of experienced chemists with strong scientific background strive towards accelerating drug discovery workflow. Objectives are usually reached in 12-18 months.
All projects are supported by specific skills in molecular modeling, distinctive know-how in organic chemistry with a continuous acute eye on ADME-Tox profile.
Prestwick Chemical expertise is awarded by outstanding track record of achievements which positions the company as the privileged and reliable partner.